Download or read online books in PDF, EPUB and Mobi Format. Click Download or Read Online button to get book now. This site is like a library, Use search box in the widget to get ebook that you want.

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease Author P. Michael Conn
ISBN-10 9780128096994
Release 2017-06-20
Pages 1198
Download Link Click Here

Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives, and animal ethics Covers a broad range of animal models used in research for human disease Contributed by leading experts across the globe Expanded coverage of diabetes and neurological diseases



Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease Author P. Michael Conn
ISBN-10 9780128096994
Release 2017-06-20
Pages 1198
Download Link Click Here

Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives, and animal ethics Covers a broad range of animal models used in research for human disease Contributed by leading experts across the globe Expanded coverage of diabetes and neurological diseases



Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease Author P. Michael Conn
ISBN-10 9780124159129
Release 2013-05-29
Pages 1108
Download Link Click Here

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease



Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease Author P. Michael Conn
ISBN-10 0128094680
Release 2017-06-08
Pages 1182
Download Link Click Here

Animal Models for the Study of Human Disease, Second Edition provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives, and animal ethics Covers a broad range of animal models used in research for human disease Contributed by leading experts across the globe Expanded coverage of diabetes and neurological diseases



Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease Author Ryuta Koyama
ISBN-10 9780128072264
Release 2013-05-29
Pages 1108
Download Link Click Here

Epilepsy is a nervous system disorder characterized by recurrent seizures that commonly affects infants and children. It has been suggested that prolonged seizures in early life could affect the developing brain. Thus, adequate animal models for studying the causality and outcome of early-life seizures are necessary to facilitate the development of drugs and therapeutic strategies. Among early-life seizures, febrile seizures are the most common type of convulsive events in humans between 3 months and 5 years of age. Although febrile seizures are benign in most cases, it remains controversial whether complex febrile seizures are associated with the development of epilepsy later in life. To address this concern, animal models of febrile seizures have been developed and utilized to characterize the mechanisms and consequences underlying febrile seizure-induced alterations in the structure and function of neural circuits. In this chapter, the accumulated findings from experimental models of febrile seizures will be introduced and discussed.



Spontaneous Animal Models of Human Disease

Spontaneous Animal Models of Human Disease Author Edwin J. Andrews
ISBN-10 9780323138284
Release 2012-12-02
Pages 324
Download Link Click Here

This two-volume work gathers together the diverse information presently available on spontaneous animal models of human disease. In addition to providing a comprehensive review of existing models, the book presents many previous unpublished new models. The scope of this work is limited to spontaneous models. Neoplasia, infectious diseases including parasitism, and nutritionally induced or other types of experimental models have not been included. The sixteen parts of the book are alphabetically arranged according to organ system with over 230 authors contributing to the overall effort. In addition to many illustrations, the book features an extensive bibliography.



Spontaneous Animal Models of Human Disease

Spontaneous Animal Models of Human Disease Author Edwin J. Andrews
ISBN-10 9780323138284
Release 2012-12-02
Pages 324
Download Link Click Here

This two-volume work gathers together the diverse information presently available on spontaneous animal models of human disease. In addition to providing a comprehensive review of existing models, the book presents many previous unpublished new models. The scope of this work is limited to spontaneous models. Neoplasia, infectious diseases including parasitism, and nutritionally induced or other types of experimental models have not been included. The sixteen parts of the book are alphabetically arranged according to organ system with over 230 authors contributing to the overall effort. In addition to many illustrations, the book features an extensive bibliography.



Sourcebook of Models for Biomedical Research

Sourcebook of Models for Biomedical Research Author P. Michael Conn
ISBN-10 9781588299338
Release 2007-12-11
Pages 778
Download Link Click Here

The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.



Rabbit Biotechnology

Rabbit Biotechnology Author Louis-Marie Houdebine
ISBN-10 9789048122271
Release 2009-04-24
Pages 136
Download Link Click Here

Louis-Marie Houdebine and Jianglin Fan The study of biological functions of proteins and their possible roles in the pathogenesis of human diseases requires more and more relevant animal m- els. Although mice including genetically modified mice offer many possibilities, other non-murine species are absolutely required in some circumstances. Rabbit is one of these species, which has been widely used in biomedical studies. This animal is genetically and physiologically closer to humans including cardiov- cular system and metabolism characteristics. Rabbit is thus more appropriate than mice to study some diseases such as atherosclerosis and lipid metabolism. Because of its larger size, surgery manipulation, bleeding, and turn-over studies are much easier performed in rabbits than in mice. Furthermore, transgenic rabbits can be produced using microinjection and other methods such as lentiviral v- tors. Cloning in rabbits has been proved possible, even though still laborious and time-consuming. Hopefully, functional rabbit ES cell lines will be available in the coming years. Gene deletion or knock-out in rabbits will then become possible.



Animal Models for Neurodegenerative Disease

Animal Models for Neurodegenerative Disease Author Jesus Avila
ISBN-10 9781849731843
Release 2011
Pages 290
Download Link Click Here

This book provides up-to-date information on the use of transgenic mouse models in the study of neurodegenerative disorders. The editors have extensive knowledge and experience in this field and the book is aimed at undergraduates, postgraduates and academics.



Autoimmune Disease Models

Autoimmune Disease Models Author Irun R. Cohen
ISBN-10 9780080917368
Release 2014-06-28
Pages 329
Download Link Click Here

Because autoimmune disorders can wreak havoc in both humans and animals, these disorders are now the objects of intense and focused research. This book details specific animal models for a variety of autoimmune disorders. The contributors are recognized authorities who deal with the panoply of experimentally induced autoimmune disorders, including encephalomyelitis, allergic neuritis, uveoretinitis, myocarditis, and hepatitis. Also included are discussions of spontaneously appearing diseases such as autoimmune thyroiditis and systemic lupus erythematosus. Many other disorders are also covered in this comprehensive guide. Certain to be an aid in the planning of individual experiments and broader research programs, this book will be a valuable addition to the library of all practicing immunologists interested in immune system function and dysfunction.



Handbook of Models for Human Aging

Handbook of Models for Human Aging Author P. Michael Conn
ISBN-10 0080460062
Release 2011-04-28
Pages 1075
Download Link Click Here

The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations



Handbook of Animal Models in Alzheimer s Disease

Handbook of Animal Models in Alzheimer   s Disease Author G. Casadesus
ISBN-10 9781607507338
Release 2011-07-05
Pages 352
Download Link Click Here

Animals have been used to model diseases or test new treatments since around 300 BC, and undoubtedly our ability to model disease in animals – including transgenic animals – has provided major breakthroughs in all fields of biomedical research. Due to their complexity and plurality of pathology and symptomatology, the study of neurodegenerative diseases relies heavily on animal models. These models have been developed in many species in the attempt to undercover the complex nature of the disease mechanisms involved. The ultimate goal is to test promising therapies and to manage, prevent or cure neurodegenerative disease. But because most animal models in this area do not reproduce the full phenotypical disease spectrum and the etiology and clinical presentation of neurodegenerative diseases differ from one patient to the next, the testing of these diseases in animal models often translates poorly to indices of efficacy when applied to the clinical population. Written by experts in the field with these advances and challenges in mind, this handbook provides an updated overview of the animal models being developed and used to study complex disease dynamics. The first part of the book presents an overview of animal models of various species and includes a review of new invertebrate animal models to study neurodegeneration. The second section presents the use of animal models to pinpoint disease mechanisms, and the last part of the handbook examines the various therapeutic interventions being used in models of neurodegenerative disease.



Animal Models in Eye Research

Animal Models in Eye Research Author
ISBN-10 0080921035
Release 2011-04-28
Pages 232
Download Link Click Here

The eye is a complex sensory organ, which enables visual perception of the world. Thus the eye has several tissues that do different tasks. One of the most basic aspects of eye function is the sensitivity of cells to light and its transduction though the optic nerve to the brain. Different organisms use different ways to achieve these tasks. In this sense, eye function becomes a very important evolutionary aspect as well. This book presents the different animal models that are commonly used for eye research and their uniqueness in evaluating different aspects of eye development, evolution, physiology and disease. * Presents information on the major animal models used in eye research including invertebrates and vertebrates * Provides researchers with information needed to choose between model organisms * Includes an introductory chapter on the different types of eyes, stressing possible common molecular machinery



Comparative Physiology Natural Animal Models and Clinical Medicine

Comparative Physiology  Natural Animal Models and Clinical Medicine Author Michael A Singer
ISBN-10 9781908979308
Release 2007-07-27
Pages 292
Download Link Click Here

This book describes a novel and unique approach to the treatment of human diseases based on the study of natural animal models. A natural animal model is defined as an animal group or species that possesses a set of biochemical/physiological characteristics which are natural and adaptive for that animal, but are quite abnormal for humans. For example, how is it that birds can tolerate blood glucose concentrations which in humans are associated with diabetes. The natural animal model is living proof that a biological answer to this question is available. By studying natural animal models, we can gain valuable insights into the treatment of various human clinical disorders. Covering a wide range of disorders, this book describes in detail how medical scientists can take advantage of all the “research” that nature has already performed over billions of years in biological problem solving through extensive animal design testing and selection. Contents:IntroductionDiabetes MellitusChronic Renal FailureAtherosclerotic Vascular DiseaseDisuse Osteoporosis and Disuse Muscle AtrophyAmmonia ToxicityHypoxia/IschemiaEpilogue Readership: Advanced undergraduate and graduate students in biology, medical scientists, comparative physiologists and biologists. Keywords:Comparative;Physiology;Models;Clinical Medicine;NaturalKey Features:Discusses in detail for each of six clinical disorders the current understanding of the pathogenesis of the disorder and how the natural animal model has solved that particular problemSuggests potential research questions based upon what is known and not known about the natural animal modelClearly illustrates that natural animal models not only provide a different perspective from traditional animal models, but also prove that biological solutions currently exist for different human diseasesHighlights the power of a comparative physiological approach to the development of treatments for human diseasesReviews:“This is an interesting and important book … A few of these questions about natural models for disease have been raised before by comparative physiologists, but they have largely been ignored by those involved in medical research. Dr Singer hopes that a presentation by a clinician will correct this situation. I sincerely hope that he is correct for I agree with his basic thesis.”Professor Emeritus William H Dantzler University of Arizona “Michael Singer has produced a marvellous volume of thought provoking observations … This volume presents a tour de force of integrative and comparative physiology to consider the possible answers to such questions … For many reasons, I cannot recommend this splendid book highly enough.”Troels Ring Aalborg Hospital, Denmark “The style is easily readable, with a logical progression from a clinical setting in the Introduction, through a number of common disease entities … There is a satisfying combination of science and art, and a call for further research in each area … The book is suitable for medical professionals of all levels of training and interests, from the Basic Scientist in the laboratory to the Clinician at the bedside.”Professor A R Morton Queen's University, Ontario



Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease Author Alistair McGregor
ISBN-10 9780128072271
Release 2013-05-29
Pages 1108
Download Link Click Here

This chapter reviews the various human herpesviruses (HHVs) and their associated diseases. Animal models have been developed to study some HHVs, and these, as well as development of intervention strategies using these models, are discussed. Additionally, specific protocols are included to enable investigators to use the current state of the art techniques to explore various aspects of viral infection in animal models. The protocols presented in this chapter are a collection of techniques that are generally applicable to the study of all herpesviruses in animal models and can be utilized by both the experienced and inexperienced virologist.



Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease Author Jerrold Tannenbaum
ISBN-10 9780128071915
Release 2013-05-29
Pages 1108
Download Link Click Here

This chapter presents an overview of ethical principles that are essential for the proper conduct, and the continuing progress, of animal research aimed at understanding human disease. The chapter identifies fundamental principles of animal research ethics, and discusses ethical and empirical foundations of these principles. Guidelines are offered for applying these fundamental principles in the design and implementation of animal research projects. The chapter highlights several important ethical issues regarding which the biomedical research community has expressed lack of clarity or disagreement, and suggests considerations that are relevant for resolution of these issues. Recommendations are offered for participation by investigators in ethical discussion of their work, and of biomedical animal research generally. The general themes of the chapter are that investigators play the primary role in assuring the ethical conduct of biomedical animal research, and that a crucial foundation of ethical animal research is sound science.