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B Cell Receptor Signaling

B Cell Receptor Signaling Author Tomohiro Kurosaki
ISBN-10 9783319261331
Release 2015-12-26
Pages 231
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This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.



Issues in Allied Fields of Medicine 2011 Edition

Issues in Allied Fields of Medicine  2011 Edition Author
ISBN-10 9781464965838
Release 2012-01-09
Pages 647
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Issues in Allied Fields of Medicine / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Allied Fields of Medicine. The editors have built Issues in Allied Fields of Medicine: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Allied Fields of Medicine in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Allied Fields of Medicine: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.



Current Topics in Microbiology and Immunology

Current Topics in Microbiology and Immunology Author T. Pawson
ISBN-10 3540633960
Release 1998
Pages 368
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Current Topics in Microbiology and Immunology has been writing in one form or another for most of life. You can find so many inspiration from Current Topics in Microbiology and Immunology also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Current Topics in Microbiology and Immunology book for free.



Cell Biology of the B Cell Receptor

Cell Biology of the B Cell Receptor Author Hidde Ploegh
ISBN-10 9780128003633
Release 2014-05-16
Pages 168
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Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. Contributions from leading authorities Informs and updates on all the latest developments in the field



Encyclopedia of Cell Biology

Encyclopedia of Cell Biology Author
ISBN-10 9780123947963
Release 2015-08-07
Pages 3008
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The Encyclopedia of Cell Biology offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences. Fully annotated color images and videos for full comprehension of concepts, with layered content for readers from different levels of experience Includes information on cytokinesis, cell biology, cell mechanics, cytoskeleton dynamics, stem cells, prokaryotic cell biology, RNA biology, aging, cell growth, cell Injury, and more In-depth linking to Academic Press/Elsevier content and additional links to outside websites and resources for further reading A one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences



Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity

Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity Author Akihiko Yoshimura
ISBN-10 9783319689296
Release 2017-11-25
Pages 267
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This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.



Molecular Analysis of B Lymphocyte Development and Activation

Molecular Analysis of B Lymphocyte Development and Activation Author Harinder Singh
ISBN-10 3540230904
Release 2005-02-16
Pages 260
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Molecular Analysis of B Lymphocyte Development and Activation has been writing in one form or another for most of life. You can find so many inspiration from Molecular Analysis of B Lymphocyte Development and Activation also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Molecular Analysis of B Lymphocyte Development and Activation book for free.



Notch Regulation of the Immune System

Notch Regulation of the Immune System Author Freddy Radtke
ISBN-10 9783642242946
Release 2012-09-13
Pages 184
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Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. This special issue on Notch regulation of the immune system summarizes recent advances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system. This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte development and function as well as in T cell leukemia.



Immunoreceptor Tyrosine based Inhibition Motifs

Immunoreceptor Tyrosine based Inhibition Motifs Author Marc Daeron
ISBN-10 9783642585371
Release 2012-12-06
Pages 183
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Novel molecular motifs named Immunoreceptor Tyrosine-based Inhibition Motifs (ITIMs) have recently been recognized in the intracytoplasmic domains of a still-increasing number of receptors which control cell activation and proliferation. Research on ITIM-bearing molecules has developed exponentially during the last three years, generating new concepts with important consequences in basic research and with exciting potential clinical applications. The present volume contains 15 reviews written by authors who all made significant contributions to the identification of ITIM-bearing molecules and the study of their biological properties. It constitutes the first synthesis ever published that is specifically devoted to this emerging topic.



Sphingosine 1 Phosphate Signaling in Immunology and Infectious Diseases

Sphingosine 1 Phosphate Signaling in Immunology and Infectious Diseases Author Michael B. A. Oldstone
ISBN-10 9783319058795
Release 2014-04-11
Pages 184
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This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.



Epigenetic Regulation of Lymphocyte Development

Epigenetic Regulation of Lymphocyte Development Author Cornelis Murre
ISBN-10 9783642241031
Release 2012-02-07
Pages 194
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The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.



Protein Kinase C in Cancer Signaling and Therapy

Protein Kinase C in Cancer Signaling and Therapy Author Marcelo G. Kazanietz
ISBN-10 9781607615439
Release 2010-06-10
Pages 494
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Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents. Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. Moreover, it is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable. This book will have 4 sections. There will be 23 chapters. Each section will have a brief introduction by an expert in the field (~ 1-2 pages).



Signalling from Internalised Growth Factor Receptors

Signalling from Internalised Growth Factor Receptors Author Inger Helene Madshus
ISBN-10 3540210385
Release 2004-07-09
Pages 190
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Signalling from Internalised Growth Factor Receptors has been writing in one form or another for most of life. You can find so many inspiration from Signalling from Internalised Growth Factor Receptors also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Signalling from Internalised Growth Factor Receptors book for free.



Negative Co Receptors and Ligands

Negative Co Receptors and Ligands Author Rafi Ahmed
ISBN-10 3642195458
Release 2011-04-11
Pages 152
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Adaptive immune responses serve as a key defense mechanism for the control of infections in vertebrates. Immune responses must be of sufficient strength to contain invading pathogens, antigen specific responses require regulatory mechanisms to ensure termination or downmodulation to avoid excessive damage to the host tissue. For both branches of the adaptive immune system, regulatory molecules i.e. coreceptors and ligands have been identified that control the signaling cascades initiated by engagement of the T cell and B cell antigen receptors. This book describes biological functions as well as molecular mechanisms of these molecules.



Phosphoinositide 3 kinase in Health and Disease

Phosphoinositide 3 kinase in Health and Disease Author Christian Rommel
ISBN-10 364213663X
Release 2010-10-17
Pages 310
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From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here



Current Concepts in Autoimmunity and Chronic Inflammation

Current Concepts in Autoimmunity and Chronic Inflammation Author Andreas Radbruch
ISBN-10 9783540297147
Release 2006-09-08
Pages 282
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The immune system has been known to be capable of distinguishing self from non-self since the pioneering work of Paul Erhlich more than a century ago. Originally described in experiments studying blood transfusion comp- ibility, the principle of “horror autotoxicus” is still valid, although today the phenomenon is usually described in terms of tolerance or ignorance. A great deal has been learned about the various processes preventing self-reactivity normally. These include processes that operate during immune cell ontogeny and subsequently on reactivity of mature lymphocytes in the periphery. They encompass mechanisms that are intrinsic to potentially reactive lymphocytes and can result in central or peripheral deletion or the alteration of functional potential. In addition, there are in?uences that are extrinsic to potentially auto-reactive lymphocytes, including the function of regulatory cells, d- ferentiation state of antigen-presenting cells, availability of self-antigen, the cytokine and chemokine milieu, as well as the traf?cking patterns involved in generating productive immune interactions. It is clear that the immune system devotes a considerable effort to the avoidance of the development of potentially pathogenic self-reactivity. Despite this, the development of self-reactivity is relatively common. - though the development of autoimmune disease is less frequent, autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, systemic lupus e- thematosus, psoriasis, thyroiditis, and myasthenia gravis, are all too common, and can cause considerable morbidity and even mortality.



Signal Transduction and the Coordination of B Lymphocyte Development and Function I

Signal Transduction and the Coordination of B Lymphocyte Development and Function I Author Louis B. Justement
ISBN-10 9783642570667
Release 2012-12-06
Pages 267
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Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical.