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Biofabrication Author Gabor Forgacs
ISBN-10 9781455730049
Release 2013-03-18
Pages 288
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Biofabrication is a practical guide to the novel, inherently cross-disciplinary scientific field that focuses on biomanufacturing processes and a related range of emerging technologies. These processes and technologies ultimately further the development of products that may involve living (cells and/or tissues) and nonliving (bio-supportive proteins, scaffolds) components. The book introduces readers to cell printing, patterning, assembling, 3D scaffold fabrication, cell/tissue-on-chips as a coherent micro-/nano-fabrication toolkit. Real-world examples illustrate how to apply biofabrication techniques in areas such as regenerative medicine, pharmaceuticals and tissue engineering. In addition to being a vital reference for scientists, engineers and technicians seeking to apply biofabrication techniques, this book also provides an insight into future developments in the field, and potential new applications. Discover the multi-disciplinary toolkit provided by biofabrication and apply it to develop new products, techniques and therapies Covers a range of important emerging technologies in a coherent manner: cell printing, patterning, assembling, 3D scaffold fabrication, cell/tissue-on-chips... Readers develop the ability to apply biofabrication technologies through practical examples


Nanotechnology Author Jeremy Ramsden
ISBN-10 9780323393140
Release 2016-05-11
Pages 358
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Nanotechnology: An Introduction, Second Edition, is ideal for the newcomer to nanotechnology, someone who also brings a strong background in one of the traditional disciplines, such as physics, mechanical or electrical engineering, or chemistry or biology, or someone who has experience working in microelectromechanical systems (MEMS) technology. This book brings together the principles, theory, and practice of nanotechnology, giving a broad, yet authoritative, introduction to the possibilities and limitations of this exciting and rapidly developing field. The book's author, Prof Ramsden, also discusses design, manufacture, and applications and their impact on a wide range of nanotechnology areas. Provides an overview of the rapidly growing and developing field of nanotechnology Focuses on key essentials, and structured around a robust anatomy of the subject Brings together the principles, theory, and practice of nanotechnology, giving a broad, yet authoritative, introduction to the possibilities and limitations of this exciting and rapidly developing field

Essentials of 3D Biofabrication and Translation

Essentials of 3D Biofabrication and Translation Author Anthony Atala
ISBN-10 9780128010150
Release 2015-07-17
Pages 440
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Essentials of 3D Biofabrication and Translation discusses the techniques that are making bioprinting a viable alternative in regenerative medicine. The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction. Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine. Provides a new and versatile method to fabricating living tissue Discusses future applications for 3D bioprinting technologies, including use in the cardiac, skeletal, and nervous systems, and organ construction Describes current approaches and future challenges for translational science Runs the gamut of topics related to the subject, from hydrogels and polymers to nanotechnology, toxicity testing, and drug screening platforms


Biofabrication Author Qudus Hamid
ISBN-10 9780128090565
Release 2013-03-18
Pages 288
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Micro-electro-mechanical systems (MEMS) have revolutionized computation power due to their capabilities to develop advanced micro-architectures. MEMS technologies illustrate the potential for many applications in the field of tissue engineering, regenerative medicine, and life sciences. The fabrication of tissue models integrates the multidisciplinary field of life sciences and engineering. Presently, monolayer cell cultures are frequently used to investigate potential anticancer agents. These monolayer cultures give limited feedback on the effects of the microenvironment on chemotherapeutic and the heterogeneity of the tumor. A microenvironment, which mimics that of the cancerous tissue, will eliminate the limitations of the traditional mainstays of cancer research. The fabrication of such microenvironments requires a thorough investigation of the actual target organ, tissue, and/or tumor. Conventional MEMS technologies are developed for the fabrication of integrated circuits (ICs) on silicone wafers. Conventional MEMS technologies are very expensive and are not developed for biological applications. The digital micro-mirroring microfabrication (DMM) system eliminates the need for an expensive chrome mask by incorporating a dynamic maskless fabrication technique. The DMM is designed to utilize its digital micro-mirrors to fabricate biological devices. This digital microfabrication-based system provides a platform for the fabrication of economic biological models that are specifically designed to mimic the in vivo conditions of the tissue of interest.


Biofabrication Author Gulden Camci-Unal
ISBN-10 9780128090510
Release 2013-03-18
Pages 288
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Microscale hydrogels are potentially useful materials for controlling cellular behavior to mimic native microenvironments for tissue engineering applications. In this chapter, various fabrication techniques to generate microscale hydrogels and their applications in tissue engineering have been outlined. In addition, we provide examples of microscale hydrogels with different physical and chemical properties for generation of tissue constructs. Finally, we discuss potential future directions in fabrication of hydrogels to address challenges in tissue engineering. It is expected that these techniques will enable engineering of three-dimensional (3D) structures with controlled features for the formation of functional tissues and organs.


Biofabrication Author Pranav Soman
ISBN-10 9780128090503
Release 2013-03-18
Pages 288
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Natural tissues have complex structural hierarchy and biological heterogeneity. Tissue engineering utilizes biomaterial scaffolds to mimic various natural properties in order to augment regeneration therapies. Current tissue engineering techniques typically incorporate imprecise scaffold geometries with random cell placement. As a result, little can be known about the specific influences of controlled changes in 3D scaffold properties on cell behavior and therefore making the results less predictive of how cell behaves in a 3D environment. Digital micromirror-assisted projection printing (DMD-PP) technology has become a promising tool to develop user-defined precise 3D microenvironments using complex biological components such as cells and native extracellular matrix (ECM). DMD-PP technology has been used in a variety of applications ranging from tissue engineering to cancer cell migration to neural stem cell culture, with the potential of patterning multiple cells in precise 3D locations. This chapter describes the novel use of DMD-PP technology in developing biomaterial scaffolds with tunable Poisson’s ratio, a fundamental aspect of mechanical property of all biomaterials.


Biofabrication Author Koichi Nakayama
ISBN-10 9780128090480
Release 2013-03-18
Pages 288
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In vitro fabrication of tissues and the regeneration of internal organs are no longer regarded as science fiction but as potential remedies for individuals suffering from chronic degenerative diseases. Tissue engineering has generated much interest from researchers in many fields, including cell and molecular biology, biomedical engineering, transplant medicine, and organic chemistry. Attempts to build tissues or organs in vitro have utilized both scaffold and scaffold-free approaches. Despite considerable progress, fabrication of three-dimensional tissue constructs in vitro remains a challenge. In this chapter, we introduce and discus current concepts of tissue engineering with particular focus on future clinical application.


Biofabrication Author Mohit P. Chhaya
ISBN-10 9780128090572
Release 2013-03-18
Pages 288
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Breast cancer is a major cause of illness for Australian women. Following tumour resection, breast reconstruction is undertaken for cosmetic and psychological reasons. Reconstruction using silicone-based implants leads to complications such as formation of a rigid fibrous tissue surrounding the implant giving a spherical and unnatural appearance to the breast. Reconstruction using autologous tissue is associated with donor site morbidity, tissue resorption and necrosis. Cell-based tissue engineering is an emerging approach to overcome these problems. Fully vascularised adipose tissue can be engineered in vivo with the help of patient-specific bioabsorbable implants fabricated by additive manufacturing. This chapter focuses on a review of such manufacturing techniques and the strategies being developed to engineer long-term fully vascularised and sustainable adipose tissue.

Tissue Engineering

Tissue Engineering Author Steven J. Barnes
ISBN-10 1604562935
Release 2008
Pages 323
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Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physio-chemical factors to improve or replace biological functions. While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, etc.). Often, the tissues involved require certain mechanical and structural properties for proper function. The term has also been applied to efforts to perform specific biochemical functions using cells within an artificially-created support system (e.g. an artificial pancreas, or a bioartificial liver). The term regenerative medicine is often used synonymously with tissue engineering, although those involved in regenerative medicine place more emphasis on the use of stem cells to produce tissues. This book presents recent and important research in the field.

Organ Printing

Organ Printing Author Dong-Woo Cho
ISBN-10 9781681740799
Release 2015-10-01
Pages 97
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This book introduces various 3D printing systems, biomaterials, and cells for organ printing. In view of the latest applications of several 3D printing systems, their advantages and disadvantages are also discussed. A basic understanding of the entire spectrum of organ printing provides pragmatic insight into the mechanisms, methods, and applications of this discipline. Organ printing is being applied in the tissue engineering field with the purpose of developing tissue/organ constructs for the regeneration of both hard (bone, cartilage, osteochondral) and soft tissues (heart). There are other potential application areas including tissue/organ models, disease/cancer models, and models for physiology and pathology, where in vitro 3D multicellular structures developed by organ printing are valuable.

Plasma Nanoscience

Plasma Nanoscience Author Kostya Ostrikov
ISBN-10 3527407405
Release 2008-09-22
Pages 538
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Filling the need for a single work specifically addressing how to use plasma for the fabrication of nanoscale structures, this book is the first to cover plasma deposition in sufficient depth. The author has worked with numerous R&D institutions around the world, and here he begins with an introductory overview of plasma processing at micro- and nanoscales, as well as the current problems and challenges, before going on to address surface preparation, generation and diagnostics, transport and the manipulation of nano units.

Nanotechnologies in Preventive and Regenerative Medicine

Nanotechnologies in Preventive and Regenerative Medicine Author Vuk Uskokovic
ISBN-10 9780323480642
Release 2017-11-22
Pages 616
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Nanotechnologies in Preventative and Regenerative Medicine demonstrates how control at the nanoscale can help achieve earlier diagnoses and create more effective treatments. Chapters take a logical approach, arranging materials by their area of application. Biomaterials are, by convention, divided according to the area of their application, with each chapter outlining current challenges before discussing how nanotechnology and nanomaterials can help solve these challenges This applications-orientated book is a valuable resource for researchers in biomedical science who want to gain a greater understanding on how nanotechnology can help create more effective vaccines and treatments, and to nanomaterials researchers seeking to gain a greater understanding of how these materials are applied in medicine. Demonstrates how nanotechnology can help achieve more successful diagnoses at an earlier stage Explains how nanomaterials can be manipulated to create more effective drug treatments Offers suggestions on how the use of nanotechnology might have future applications to create even more effective treatments

Electrofluidodynamic Technologies EFDTs for Biomaterials and Medical Devices

Electrofluidodynamic Technologies  EFDTs  for Biomaterials and Medical Devices Author Vincenzo Guarino
ISBN-10 9780081017463
Release 2018-01-21
Pages 426
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Electrofluidodynamic Technologies (EFDTs) for Biomaterials and Medical Devices: Principles and Advances focuses on the fundamentals of EFDTs - namely electrospinning, electrospraying and electrodynamic atomization - to develop active platforms made of synthetic or natural polymers for use in tissue engineering, restoration and therapeutic treatments. The first part of this book deals with main technological aspects of EFDTs, such as basic technologies and the role of process parameters. The second part addresses applications of EFDTs in biomedical fields, with chapters on their application in tissue engineering, molecular delivery and implantable devices. This book is a valuable resource for materials scientists, biomedical engineers and clinicians alike. Presents a complete picture of Electrofluidodynamic technologies and their use in biomedicine Provides a comprehensive, professional reference on the subject, covering materials processing, fabrication and the use of novel devices for tissue engineering and therapeutics Focuses on technological advances, with an emphasis on studies and clinical trials

Nanotechnology Focus

Nanotechnology Focus Author Eugene V. Dirote
ISBN-10 1594542112
Release 2005-01-01
Pages 177
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Nanotechnology is a 'catch-all' description of activities at the level of atoms and molecules that have applications in the real world. A nanometre is a billionth of a meter, about 1/80,000 of the diameter of a human hair, or 10 times the diameter of a hydrogen atom. Nanotechnology is now used in precision engineering, new materials development as well as in electronics; electromechanical systems as well as mainstream biomedical applications in areas such as gene therapy, drug delivery and novel drug discovery techniques. This book presents the latest research in this frontier field.

The Accidental Theorist And Other Dispatches from the Dismal Science

The Accidental Theorist  And Other Dispatches from the Dismal Science Author Paul Krugman
ISBN-10 0393071111
Release 2010-02-18
Pages 204
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"Everything Mr. Krugman has to say is smart, important and even fun to read . . . he is one of a handful of very bright, relatively young economists who do everything well." — Peter Passell, New York Times Book Review In this wonderfully cohesive set of sharp and witty essays, Paul Krugman tackles bad economic ideas from across the political spectrum. In plain English, he enlightens us on the Asian crisis, corporate downsizing, and the globalization of the American economy, among other topics. The writing here brilliantly combines the acerbic style and clever analysis that has made Krugman famous. Imagine declaring New York its own country and you get a better picture of our trade balance with China and Hong Kong. Try reducing the economy to the production of hot dogs and buns and you’ll understand why common beliefs about the impact of production efficiency on labor demand are wrong. This is a collection that will amuse, provoke, and enlighten, in classic Paul Krugman style. "[Paul Krugman] writes better than any economist since John Maynard Keynes." — Rob Norton, Fortune "[Paul Krugman is] probably the most creative economist of his generation." — The Economist Winner of the John Bates Clark Medal

MEMS Materials and Processes Handbook

MEMS Materials and Processes Handbook Author Reza Ghodssi
ISBN-10 0387473181
Release 2011-03-18
Pages 1188
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MEMs Materials and Processes Handbook" is a comprehensive reference for researchers searching for new materials, properties of known materials, or specific processes available for MEMS fabrication. The content is separated into distinct sections on "Materials" and "Processes". The extensive Material Selection Guide" and a "Material Database" guides the reader through the selection of appropriate materials for the required task at hand. The "Processes" section of the book is organized as a catalog of various microfabrication processes, each with a brief introduction to the technology, as well as examples of common uses in MEMs.

Carbon Nanotubes and Graphene

Carbon Nanotubes and Graphene Author Kazuyoshi Tanaka
ISBN-10 9780080982687
Release 2014-07-10
Pages 458
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Carbon Nanotubes and Graphene is a timely second edition of the original Science and Technology of Carbon Nanotubes. Updated to include expanded coverage of the preparation, purification, structural characterization, and common application areas of single- and multi-walled CNT structures, this work compares, contrasts, and, where appropriate, unitizes CNT to graphene. This much expanded second edition reference supports knowledge discovery, production of impactful carbon research, encourages transition between research fields, and aids the formation of emergent applications. New chapters encompass recent developments in the theoretical treatments of electronic and vibrational structures, and magnetic, optical, and electrical solid-state properties, providing a vital base to research. Current and potential applications of both materials, including the prospect for large-scale synthesis of graphene, biological structures, and flexible electronics, are also critically discussed. Updated discussion of properties, structure, and morphology of biological and flexible electronic applications aids fundamental knowledge discovery Innovative parallel focus on nanotubes and graphene enables you to learn from the successes and failures of, respectively, mature and emergent partner research disciplines High-quality figures and tables on physical and mathematical applications expertly summarize key information – essential if you need quick, critically relevant data