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Carbon 13 NMR Spectroscopy of Biological Systems

Carbon 13 NMR Spectroscopy of Biological Systems Author Nicolau Beckmann
ISBN-10 9780080528557
Release 1995-04-06
Pages 334
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This book is intended to provide an in-depth understanding of 13C NMR as a tool in biological research. 13C NMR has provided unique information concerning complex biological systems, from proteins and nucleic acids to animals and humans. The subjects addressed include multidimensional heteronuclear techniques for structural studies of molecules in the liquid and solid states, the investigation of interactions in model membranes, the elucidation of metabolic pathwaysin vitro and in vivo on animals, and noninvasive metabolic studies performed on humans. The book is a unique mix of NMR methods and biological applications which makes it a convenient reference for those interested in research in this interdisciplinary area of physics, chemistry, biology, and medicine. An interdisciplinary text with emphasis on both 13C NMR methodology and the relevant biological and biomedical issues State-of-the-art 13C NMR techniques are described; Whenever possible, their advantages over other approaches are emphasized The chapters constitute comprehensive reviews and are written by acknowledged experts in their fields Chapters are written in a clear style, and include a large number of illustrations and comprehensive references

Encyclopedia of Spectroscopy and Spectrometry

Encyclopedia of Spectroscopy and Spectrometry Author
ISBN-10 9780128032251
Release 2016-09-22
Pages 3584
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This third edition of the Encyclopedia of Spectroscopy and Spectrometry provides authoritative and comprehensive coverage of all aspects of spectroscopy and closely related subjects that use the same fundamental principles, including mass spectrometry, imaging techniques and applications. It includes the history, theoretical background, details of instrumentation and technology, and current applications of the key areas of spectroscopy. The new edition will include over 80 new articles across the field. These will complement those from the previous edition, which have been brought up-to-date to reflect the latest trends in the field. Coverage in the third edition includes: Atomic spectroscopy Electronic spectroscopy Fundamentals in spectroscopy High-Energy spectroscopy Magnetic resonance Mass spectrometry Spatially-resolved spectroscopic analysis Vibrational, rotational and Raman spectroscopies The new edition is aimed at professional scientists seeking to familiarize themselves with particular topics quickly and easily. This major reference work continues to be clear and accessible and focus on the fundamental principles, techniques and applications of spectroscopy and spectrometry. Incorporates more than 150 color figures, 5,000 references, and 300 articles for a thorough examination of the field Highlights new research and promotes innovation in applied areas ranging from food science and forensics to biomedicine and health Presents a one-stop resource for quick access to answers and an in-depth examination of topics in the spectroscopy and spectrometry arenas

Advances in Biological Solid State NMR

Advances in Biological Solid State NMR Author Frances Separovic
ISBN-10 9781849739108
Release 2014
Pages 608
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Advances in Biological NMR brings the reader up to date with chapters from international leaders of this growing field, covering the most recent developments in the methodology and applications of solid state NMR to studies of membrane interactions and molecular motions.

Fundamentals of Protein NMR Spectroscopy

Fundamentals of Protein NMR Spectroscopy Author Gordon S. Rule
ISBN-10 9781402035005
Release 2006-02-16
Pages 532
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NMR spectroscopy has proven to be a powerful technique to study the structure and dynamics of biological macromolecules. Fundamentals of Protein NMR Spectroscopy is a comprehensive textbook that guides the reader from a basic understanding of the phenomenological properties of magnetic resonance to the application and interpretation of modern multi-dimensional NMR experiments on 15N/13C-labeled proteins. Beginning with elementary quantum mechanics, a set of practical rules is presented and used to describe many commonly employed multi-dimensional, multi-nuclear NMR pulse sequences. A modular analysis of NMR pulse sequence building blocks also provides a basis for understanding and developing novel pulse programs. This text not only covers topics from chemical shift assignment to protein structure refinement, as well as the analysis of protein dynamics and chemical kinetics, but also provides a practical guide to many aspects of modern spectrometer hardware, sample preparation, experimental set-up, and data processing. End of chapter exercises are included to emphasize important concepts. Fundamentals of Protein NMR Spectroscopy not only offer students a systematic, in-depth, understanding of modern NMR spectroscopy and its application to biomolecular systems, but will also be a useful reference for the experienced investigator.

NMR in Biological Systems

NMR in Biological Systems Author K.V.R. Chary
ISBN-10 9781402066801
Release 2008-04-01
Pages 524
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During teaching NMR to students and researchers, we felt the need for a text-book which can cover modern trends in the application of NMR to biological systems. This book covers the entire area of NMR in Biological Sciences (Biomolecules, cells and tissues, animals, plants and drug design). As well as being useful to researchers, this is an excellent book for teaching a course on NMR in Biological Systems.

NMR of Biomolecules

NMR of Biomolecules Author Ivano Bertini
ISBN-10 9783527328505
Release 2012-04-16
Pages 612
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NMR is one of the most powerful methods for imaging of biomolecules. This book is the ultimate NMR guide for researchers in the biomedical community and gives not only background and practical tips but also a forward looking view on the future of NMR in systems biology.

High Resolution NMR Spectroscopy Understanding Molecules and their Electronic Structures

High Resolution NMR Spectroscopy  Understanding Molecules and their Electronic Structures Author
ISBN-10 9780444594143
Release 2013-06-08
Pages 456
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The progress in nuclear magnetic resonance (NMR) spectroscopy that took place during the last several decades is observed in both experimental capabilities and theoretical approaches to study the spectral parameters. The scope of NMR spectroscopy for studying a large series of molecular problems has notably broadened. However, at the same time, it requires specialists to fully use its potentialities. This is a notorious problem and it is reflected in the current literature where this spectroscopy is typically only used in a routine way. Also, it is seldom used in several disciplines in which it could be a powerful tool to study many problems. The main aim of this book is to try to help reverse these trends. This book is divided in three parts dealing with 1) high-resolution NMR parameters; 2) methods for understanding high-resolution NMR parameters; and 3) some experimental aspects of high-resolution NMR parameters for studying molecular structures. Each part is divided into chapters written by different specialists who use different methodologies in their work. In turn, each chapter is divided into sections. Some features of the different sections are highlighted: it is expected that part of the readership will be interested only in the basic aspects of some chapters, while other readers will be interested in deepening their understanding of the subject dealt with in them. Shows how NMR parameters are useful for structure assignment as well as to obtain insight on electronic structures Emphasis on conceptual aspects Contributions by specialists who use the discussed methodologies in their everyday work

NMR in Molecular Biology

NMR in Molecular Biology Author Oleg Jardetzky
ISBN-10 9781483281858
Release 2013-10-22
Pages 698
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NMR in Molecular Biology provides an introduction to the basic concepts and principles of nuclear magnetic resonance (NMR) that are essential to a critical evaluation of experimental data. It also aims to acquaint readers in some detail with those prototype experiments in which a definite, biologically relevant answer has been obtained. The book opens with a chapter on the historical development of NMR technology. Separate chapters follow on the fundamental principles of NMR; paramagnetic perturbations of NMR spectra; time scales, chemical exchange, and problems of exchange; and characteristics of NMR spectra through investigations of compounds such as amino acids and peptides; and nucleic acid bases, nucleosides, and nucleotides. Subsequent chapters deal with protein NRM spectra, protein-ligand interactions, and the structure and dynamics of membranes. This book is intended for the student or practicing scientist wishing to gain a critical understanding of the applications of NMR to a wide range of problems in molecular biology.

Flux Control in Biological Systems

Flux Control in Biological Systems Author Ernst-Detlef Schulze
ISBN-10 9780323139427
Release 2012-12-02
Pages 494
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Comprehending and modelling biomass production, nutrient, and water fluxes in biological systems requires understanding control mechanisms at various levels of organiztion. This new book, with 16 pages of four-colorplates, compares patterns and mechanisms of regulation-starting from enzyme reactions and ending at the population and ecosystem level. By doing so, the book investigates the general principles of how fluxes are adjusted and regulated. Such principles areessential for preparing effective models and for predicting human impacts on ecosystems. Flux Control in Biological Systems: From Enzymes to Populations and Ecosystems will be an essential personal library addition for student and professional environmental biologists, ecologists, physiologists, biochemists, botanists, microbiologists, soil scientists, and zoologists; as well as anyone who investigate patterns of matter and energy transfer in biological systems of different levels of complexity. * Presents the mechanisms of flux control * Explains the similarities of flux control at various levels of complexity and organization * Demonstrates how fluxes are adjusted in complex systems of interacting groups of organisms

Nuclear Magnetic Resonance

Nuclear Magnetic Resonance Author R J Abraham
ISBN-10 9781847553645
Release 2007-10-31
Pages 385
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As a spectroscopic method, Nuclear Magnetic Resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: "NMR of Proteins and Acids" and "NMR of Carbohydrates, Lipids and Membranes". For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an in valuable source of current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.

Topics in Carbon 13 NMR Spectroscopy

Topics in Carbon 13 NMR Spectroscopy Author George C. Levy
ISBN-10 0471028738
Release 1979-04-01
Pages 397
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Topics in Carbon 13 NMR Spectroscopy has been writing in one form or another for most of life. You can find so many inspiration from Topics in Carbon 13 NMR Spectroscopy also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Topics in Carbon 13 NMR Spectroscopy book for free.

Biological NMR Spectroscopy

Biological NMR Spectroscopy Author John L. Markley
ISBN-10 0195357426
Release 1997-01-30
Pages 376
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This book presents a critical assessment of progress on the use of nuclear magnetic resonance spectroscopy to determine the structure of proteins, including brief reviews of the history of the field along with coverage of current clinical and in vivo applications. The book, in honor of Oleg Jardetsky, one of the pioneers of the field, is edited by two of the most highly respected investigators using NMR, and features contributions by most of the leading workers in the field. It will be valued as a landmark publication that presents the state-of-the-art perspectives regarding one of today's most important technologies.

Annual Reports in Medicinal Chemistry

Annual Reports in Medicinal Chemistry Author
ISBN-10 0080583644
Release 1985-09-11
Pages 351
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Annual Reports in Medicinal Chemistry

NMR Spectroscopy in Pharmaceutical Analysis

NMR Spectroscopy in Pharmaceutical Analysis Author Iwona Wawer
ISBN-10 9780080951522
Release 2017-07-07
Pages 528
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For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis. Beside the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples. Combines theory, techniques, and concrete applications—all of which closely resemble the laboratory experience Considers international pharmacopoeias, addressing the concern for licensing Features the work of academics and researchers, appealing to a broad readership

Molecular Spectroscopy XI

Molecular Spectroscopy   XI Author O. Sild
ISBN-10 9781483284750
Release 2017-01-31
Pages 254
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Molecular Spectroscopy–XI provides information pertinent to the fundamental aspects of molecular spectroscopy. This book discusses the modifications of molecular spectra when the density varies as a function of temperature and pressure. Organized into 15 chapters, this book begins with an overview of the several processes concerning triplet excitons leading to magnetic-field sensitive luminescence in organic crystals and related compounds. This text then examines the methods of investigation of the exciton band structures in molecular crystals. Other chapters consider the conditions for the equivalence of Fourier spectroscopy and of slow passage experiments in nuclear magnetic resonance. This book discusses as well the application of computer technology in carbon-13 magnetic resonance spectroscopy. The final chapter deals with the application of high-resolution proton and carbon-13 n.m.r. spectroscopy for the investigation of the molecular conformations in proteins. This book is a valuable resource for organic chemists, biologists, microbiologists, scientists, and research workers.

NMR Spectroscopy of Polymers

NMR Spectroscopy of Polymers Author Tatsuki Kitayama
ISBN-10 3540402209
Release 2004-02-17
Pages 228
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Based on the authors ́ extensive experimental experience, NMR Spectroscopy of Polymers explains the practical use of NMR spectroscopy in polymer chemistry.

Methodologies for Metabolomics

Methodologies for Metabolomics Author Norbert W. Lutz
ISBN-10 9781139619059
Release 2013-01-21
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Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.