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Cell Signalling

Cell Signalling Author John T. Hancock
ISBN-10 9780199658480
Release 2016-12-15
Pages 456
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Signalling within and between cells is one of the most important aspects of modern biochemistry and cell biology. An understanding of signalling pathways is vital to a wide range of biologists, from those who are investigating the causes of cancer, to those who are concerned about the impactof environmental pollutants on the ecosystem. The way cells adapt to changing environments, and the way cell dysfunction causes disease, is underpinned by cell signalling events. Cell Signalling presents a carefully structured and highly accessible introduction to this intricate and rapidly growing field. Starting with an overview of cell signalling and highlighting its importance in many biological systems, the book goes on to explore the key components of extracellular andintracellular signalling mechanisms, before examining how these components come together to create signalling pathways. A focus on common components and concepts, rather than mechanistic detail, allows the reader to gain a thorough understanding of the principles that underpin cell signalling. Online Resource CentreThe Online Resource Centre to accompany Cell Signalling features:For students:* Links to useful websitesFor registered adopters of the text:* Journal Clubs: suggested research papers and discussion questions linked to topics featured in the book* Figures from the book in electronic format for use in lectures



Cell Signaling

Cell Signaling Author Wendell Lim
ISBN-10 9781317573623
Release 2014-06-16
Pages 416
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Cell Signaling presents the principles and components that underlie all known signaling processes. It provides undergraduate and graduate students the conceptual tools needed to make sense of the dizzying array of pathways used by the cell to communicate. By emphasizing the common design principles, components, and logic that drives all signaling, the book develops a conceptual framework through which students can understand how thousands of diverse signaling proteins interact with each other in vast interconnected networks. The book first examines the common currencies of cellular information processing and the core components of the signaling machinery. It then shows how these individual components link together into networks and pathways to perform more sophisticated tasks. Many specific examples are provided throughout to illustrate common principles, and provide a comprehensive overview of major eukaryotic signaling pathways.



Sphingolipid Metabolism and Cell Signaling

Sphingolipid Metabolism and Cell Signaling Author Alfred H. Merrill
ISBN-10 9780121822132
Release 2000
Pages 648
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This volume contains information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. Its companion Volume 311 presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.



Handbook of Cell Signaling

Handbook of Cell Signaling Author Ralph A. Bradshaw
ISBN-10 9780080920917
Release 2009-11-03
Pages 3048
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KEY FEATURES: * Contains over 350 chapters of comprehensive coverage on cell signaling * Includes discussion on topics from ligand/receptor interactions to organ/organism responses * Provides user-friendly, well-illustrated, reputable content by experts in the field DESCRIPTION: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors.



Cell Signaling Reactions

Cell Signaling Reactions Author Yasushi Sako
ISBN-10 904819864X
Release 2010-11-04
Pages 330
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This book encompasses the exciting developments and challenges in the fast-moving and rapidly expanding research field of single-molecule kinetic analysis of cell signaling that promises to be one of the most significant and exciting areas of biological research for the foreseeable future. Cell signaling is carried out by complicated reaction networks of macromolecules, and single-molecule analyses has already demonstrated its power to unravel complex reaction dynamics in purified systems. To date, most of the published research in the field of single-molecule processes in cells, focus on the dynamic properties (translational movements of the centre of mass) of biological molecules. However, we hope that this book presents as many kinetic analyses of cell signaling as possible. Although single-molecule kinetic analysis of cellular systems is a relatively young field when compared with the analysis of single-molecule movements in cells, this type of analysis is highly important because it directly relates to the molecular functions that control cellular behavior and in the future, single-molecule kinetic analysis will be largely directed towards cellular systems. Thus, we hope that this book will be of interest to all those working in the fields of molecular and cell biology, as well as biophysics and biochemistry.



Transduction Mechanisms in Cellular Signaling

Transduction Mechanisms in Cellular Signaling Author Edward A. Dennis
ISBN-10 9780123838629
Release 2011
Pages 586
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"Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.



Cell cell Signaling in Bacteria

Cell cell Signaling in Bacteria Author Gary M. Dunny
ISBN-10 1555811493
Release 1999-01-01
Pages 367
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"This volume presents the first comprehensive review of bacterial quorum sensing, the signaling processes involved in control of multicellular activities of microbes. It reflects the explosion of knowledge in this area, and the realization that work being done in each of the signaling systems being studied may have important implications for other organisms not closely related by phylogeny or ecological niche."--BOOK JACKET.



Nutrients and Cell Signaling

Nutrients and Cell Signaling Author Janos Zempleni
ISBN-10 9781420028362
Release 2005-04-04
Pages 760
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Cell signaling is at the core of most biological processes from the simplest to the most complex. In addition to unicellular organisms possessing the essential ability to receive inputs with regard to nutrient availability and noxious stimuli, the cells in multicellular organisms require signaling from adjacent, as well as distant cells to maintain normal internal function, including growth, differentiation, and homeostasis. Conversely, the etiology of many disease processes, such as those involving immune system dysfunction and tumor development, have been traced to aberrant cell signaling. Nutrients and Cell Signaling, in presenting contributions from a wide array of experts in the field, fully delineates the role of nutrients in cell signaling. The text emphasizes broad concepts and covers all major groups of nutrients. Contributors discuss the role of carbohydrates, amino acids, lipids, vitamins, minerals, and trace elements in essential processes such as cell proliferation, immune function, and DNA repair. The editors have organized the work to provide select examples organized under these contemporary research areas: Nuclear receptors, transcription factors, and signaling cascades Amino acids, lipids, and glycation Insulin release, signaling, and insulin resistance Calcium-dependent signaling Feeding and nutrient homeostasis Nutrients and Cell Signaling answers the need in the post-genomic era, for an authoritative resource that provides an in-depth understanding of how these complex and dynamic biomolecular networks control cell function. Those professionals and students in molecular biology, nutrition, biochemistry, as well as any branch involved with cell signaling and function will find this book to be an invaluable tool in promoting both understanding and further inquiry.



Lipidomics and Bioactive Lipids Lipids and Cell Signaling

Lipidomics and Bioactive Lipids  Lipids and Cell Signaling Author
ISBN-10 0080554091
Release 2007-11-12
Pages 392
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This volume in the well-established Methods in Enzymology series features methods for the study of lipids using mass spectrometry techniques. Articles in this volume cover topics such as Phospholipase A1 assays using a radio-labeled substrate and mass spectrometry; Real-time Cell Assays of Phospholipases A2 Using Fluorogenic Phospholipids; Analysis and Pharmacological Targeting of Phospholipase C â interactions with G proteins; Biochemical Analysis of Phospholipase D.; Measurement of Autotaxin/Lysophospholipase D Activity; Platelet-Activating Factor; Quantitative measurement of PtdIns(3,4,5)P3; Measuring Phosphorylated Akt And Other Phosphoinositide 3-Kinase-Regulated Phosphoproteins In Primary Lymphocytes; Regulation of Phosphatidylinositol 4-Phosphate 5-Kinase activity by partner proteins; Biochemical Analysis of Inositol Phosphate Kinases; Analysis of the phosphoinositides and their aqueous metabolites; Combination of C17-sphingoid base homologues and mass spectrometry analysis as a new approach to study sphingolipid metabolism; Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo; A rapid and sensitive method to measure secretion of sphingosine-1-phosphate; Ceramide Kinase and Ceramide-1-Phosphate; Measurement of Mammalian Diacylglycerol Kinase Activity in vitro and in Cells; Lipid Phosphate Phosphatases from Saccharomyces cerevisiae.



Handbook of Cell Signaling

Handbook of Cell Signaling Author Ralph A. Bradshaw
ISBN-10 9780080920917
Release 2009-11-03
Pages 3048
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KEY FEATURES: * Contains over 350 chapters of comprehensive coverage on cell signaling * Includes discussion on topics from ligand/receptor interactions to organ/organism responses * Provides user-friendly, well-illustrated, reputable content by experts in the field DESCRIPTION: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors.



Cancer Cell Signaling

Cancer Cell Signaling Author David M. Terrian
ISBN-10 9781592593569
Release 2003
Pages 333
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A collection of readily reproducible experimental methods for studying the subversion of normal cell signaling that leads to cancer. Presented in step-by-step detail to ensure successful results, the methods include proven techniques for the investigation of apoptosis and cell death, complementary protocols for manipulating and/or monitoring oncogenic signals in cancer cells, and techniques for studying protein-protein interactions. Analyze multigene families with readily reproducible techniques Employ laser capture microdissection techniques to target cell populations.



Regulation of Organelle and Cell Compartment Signaling

Regulation of Organelle and Cell Compartment Signaling Author Ralph A. Bradshaw
ISBN-10 9780123822130
Release 2011
Pages 533
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"Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.



Hydrogen Peroxide and Cell Signaling

Hydrogen Peroxide and Cell Signaling Author
ISBN-10 9780124055407
Release 2013-07-11
Pages 384
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This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the third of three volumes on hydrogen peroxide and cell signaling, and includes chapters on such topics as the biological chemistry of hydrogen peroxide, reactive oxygen species in the activation of MAP kinases, and investigating the role of reactive oxygen species in regulating autophagy. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers hydrogen peroxide and cell signaling Contains chapters on such topics as the biological chemistry of hydrogen peroxide, reactive oxygen species in the activation of MAP kinases, and investigating the role of reactive oxygen species in regulating autophagy



Nitric Oxide Cell Signaling and Gene Expression

Nitric Oxide  Cell Signaling  and Gene Expression Author Santiago Lamas
ISBN-10 9781420027167
Release 2005-11-01
Pages 456
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Since the nineteenth century, when engineers were using nitroglycerin to blow up rockbeds, and doctors were prescribing it to relieve angina, scientists have been exploring the incredible and often baffling behavior of nitric oxide. In the 1980s, researchers discovered that nitric oxide had the capacity to regulate vascular tone through cyclic GMP, firmly establishing its role as a physiological mediator. Over the last ten years, still further roles have been discovered that relate to nitric oxide’s unique ability to interact with and modify a wide variety of other molecules and regulators including glutathione, as well as macromolecules such as DNA and proteins. Nitric Oxide, Cell Signaling, and Gene Expression is the first comprehensive work to showcase the highly useful diversity of cellular effects elicited by nitric oxide. A collection of expert contributors provides cutting-edge information on a variety of topics with tremendous implications in the fields of biology and medicine. These include... Nitric oxide-driven cell signaling mediated by cGMP, GTPases, and S-nitrosylation Nitric oxide’s role in hypoxia, gene expression, post-transcriptional control of gene expression, gene regulation in pulmonary pathophysiology, and tumor biology The intriguing concept of mitochondrial nitric oxide synthase as a regulator of mitochondrial bioenergetics and free radical production Modulation of cell metabolism Nitric Oxide, Cell Signaling, and Gene Expression offers cell and molecular biologists, pharmacologists, biochemists, and biomedical researchers, as well as advanced graduate students, the insight and information they need to understand recent developments in this highly fertile area of research.



Cancer Cell Signaling

Cancer Cell Signaling Author Kasirajan Ayyanathan
ISBN-10 9781482299458
Release 2014-06-20
Pages 410
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Cell signaling is a field that studies how cells communicate to control basic activities and respond to their environment. When looking specifically at cancer cells, researchers can gain a better understanding of cancer on a cellular level, an understanding that may have implications for developing new treatments. The current volume provides an overview of the field and how various cell biology techniques are used to better understand cancer on a cellular level. This easily accessible reference volume offers a comprehensive look at the field of cancer cell signaling. Edited by a researcher from Florida Atlantic University, Cancer Cell Signaling: Targeting Signaling Pathways Towards Therapeutic Approaches to Cancer is an authoritative and easy-to-use reference.



Membranes and Cell Signaling

Membranes and Cell Signaling Author Edward Bittar
ISBN-10 0080536115
Release 1997-05-12
Pages 637
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It should not come as too much of a surprise that biological membranes are considerably more complex than lipid bilayers. This has been made quite clear by the fluid-mosaic model which considers the cell membrane as a two-dimensional solution of a mosaic of integral membrane proteins and glycoproteins firmly embedded in a fluid lipid bilayer matrix. Such a model has several virtues, chief among which is that it allows membrane components to diffuse in the plane of the membrane and orient asymmetrically across the membrane. The model is also remarkable since it provokes the right sort of questions. Two such examples are: Does membrane fluidity influence enzyme activity? Does cholesterol regulate fluidity? However, it does not go far enough. As it turns out, there is now another version of this model, the so-called post-fluid mosaic model which incorporates two concepts, namely the existence in the membrane of discrete domains in which specific lipid-lipid, lipid-protein and protein-protein interactions occur and ordered regions that are in motion but remain separate from less ordered regions. We must admit that both are intriguing problems and of importance in guiding our thinking as to what the next model might be. We have chosen not to include the subject of membrane transport in the present volume. This obviously represents a break with convention. However, the intention is to have the topic covered subsequent volumes relating to organ systems. It would be right to regard this as an attempt to strengthen the integrated approach to the teaching of medicine.



Polyamine Cell Signaling

Polyamine Cell Signaling Author Jian-Ying Wang
ISBN-10 9781597451451
Release 2007-11-19
Pages 490
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Polyamines are organic cations found in all eukaryotic cells and intimately involved in, and required for, distinct biological functions. An increasing body of evidence indicates that the regulation of cellular polyamines is a central convergence point for the multiple signaling pathways driving various cellular functions. Over the last decade, considerable progress has been made in und- standing the molecular functions of cellular polyamines. These significant findings provide a fundamental basis to not only define the exact role of polyamines in physiology, but also to develop new therapeutic approaches for cancers and other diseases. The major objective of this book is to provide a timely and long lasting guide for investigators in the fields of polyamines, physiology, pharmacology, and cancer research. It will provide a foundation based on research and address the potential for subsequent applications in clinical practice. Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research is divided into four main parts: Part I: Polyamines in Signal Transduction of Cell Proliferation Part II: Polyamines in Cellular Signaling of Apoptosis, Carcinogenesis, and Cancer Therapy Part III: Polyamines in Cell Motility and Cell–Cell Interactions Part IV: Polyamine Homeostasis and Transport This book not only covers the current state-of-the-art findings relevant to cellular and molecular functions of polyamines, but also provides the underlying conceptual basis and knowledge regarding potential therapeutic targeting of polyamines and polyamine metabolism. These points are addressed by int- nationally recognized experts in their contributions to this book.