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Comprehensive Analysis of Parasite Biology

Comprehensive Analysis of Parasite Biology Author Sylke M?ller
ISBN-10 9783527339044
Release 2016-10-17
Pages 576
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Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.



Ectoparasites

Ectoparasites Author Charles Q. Meng
ISBN-10 9783527802906
Release 2018-06-01
Pages 720
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This first book specifically dedicated to ectoparasite drug discovery is unique in providing insights from the veterinary as well as the medical perspective, covering research from both industry and academia while paving the way for new synergies between the two research communities. Edited by a team combining 80 years of experience in academic research and industrial antiparasitic drug discovery, this volume of Drug Discovery in Infectious Diseases summarizes current knowledge in this rapidly expanding field. Comprehensive yet concise, this ready reference blends solid background information on ectoparasite biology with the very latest methods in ectoparasite drug discovery. Three major parts cover current ectoparasite control strategies and the threat of drug resistance, screening and drug evaluation, and the new isoxazoline class of ectoparasiticides. The future potential of mechanism-based approaches for repellents and parasiticides is thoroughly discussed, as are strategies for vaccines against ectoparasites, making the book ideal for parasitologists in academia as well as researchers working in the pharmaceutical industry.



Host Pathogen Interaction

Host   Pathogen Interaction Author Gottfried Unden
ISBN-10 9783527682393
Release 2016-03-11
Pages 240
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In light of the rapidity increasing incidence rate of bacterial and fungal infections with multi-resistant pathogens, the metabolic changes associated with host-pathogen interactions offer one of the most promising starting points for developing novel antibiotics. . Part one of this comprehensive guide describes the metabolic adaptation of pathogenic microbes in humans, while part two points to routes for the development of novel antibiotics. This is volume six of the book series on drug discovery in infectious diseases by Paul Selzer.



American Trypanosomiasis Chagas Disease

American Trypanosomiasis Chagas Disease Author Jenny Telleria
ISBN-10 9780128010693
Release 2017-01-18
Pages 844
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American Trypanosomiasis, Chagas Disease: One Hundred Years of Research, Second Edition, provides a comprehensive overview of Chagas disease and discusses the latest discoveries concerning the three elements that compose the transmission chain of the disease, the host, the insect vectors, and the causative parasite. In addition, new insights on the molecular biology and diagnostics of Chagas diseases, the persistence of infections in the host, and the interaction of the parasite and host metabolism are now included in this new and updated edition. Provides a thoroughly revised, updated, and streamlined new edition with contributions from leading authorities and industry experts Informs and updates on all the latest developments of Chagas disease, covering biology, clinical aspects, and human sciences Includes a summarizing chapter that provides key insights of practical significance for prevention efforts



Antiparasitic and Antibacterial Drug Discovery

Antiparasitic and Antibacterial Drug Discovery Author Paul M. Selzer
ISBN-10 9783527323272
Release 2009-06-08
Pages 489
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Mainly addressing parasitic diseases but also focusing on diseases caused by bacteria, this much-needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.



The Nobel Prize Winning Discoveries in Infectious Diseases

The Nobel Prize Winning Discoveries in Infectious Diseases Author David Rifkind
ISBN-10 0080459579
Release 2005-05-20
Pages 160
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This book presents the 24 discoveries in infectious diseases that have merited Nobel Prize recognition since the inception of the awards in 1901. Grouped according to biological groups rather than chronology, each discovery includes a biographical sketch of the laureate(s), a description of the research, and a summary of the current status of the field. In addition, consideration is given to the relevance of the research on the general field of biology and medicine.



Structure based Ligand Design

Structure based Ligand Design Author Klaus Gubernator
ISBN-10 9783527612161
Release 2008-11-21
Pages 167
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Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic paradigm of structure-based ligand design. Although this method first emerged in the 1980s, it has already become a powerful tool for pharmaceutical research. Much has been learned, however, since the first attempts to discover drugs on the basis of available biochemical and structural data. Nowadays, structure-based ligand design is an established method for creating drugs with new structural features, for modifying binding activities and pharmacokinetic properties, and for elucidating binding modes and structure-activity relationships. This volume presents the underlying principles of the approach and highlights real-life applications such as the discovery of HIV-protease inhibitors. It shows that structure-based ligand design has many advantages over other more traditional approaches to designing new drugs, providing it is employed properly and with a thorough knowledge of the pitfalls to avoid. The straightforward presentation and extensive list of references to the original literature as well as numerous color figures illustrating structural relationships make this volume an indispensable tool for every scientist working in the area of drug discovery.



Malaria

Malaria Author Institute of Medicine (U.S.). Committee for the Study on Malaria Prevention and Control: Status Review and Alternative Strategies
ISBN-10 NAP:13766
Release 1991-01-01
Pages 309
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Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.



Bioinformatics and Drug Discovery

Bioinformatics and Drug Discovery Author Richard S. Larson
ISBN-10 9781592599646
Release 2005
Pages 444
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Bioinformatics and Drug Discovery describes the bioinformatic approaches and techniques employed along the pipeline of drug development from genes to proteins to drugs. The book focuses on gene microarray analysis and techniques for target identification and validation. In addition, clinical applications showing how the analysis can be used for prognostication and diagnosis are described. The second section focuses on protein analysis, including target validation and identification using modern proteomic analysis as well as protein modeling techniques. The third section discusses chemoinformatics, including virtual screening and how to computationally approach chemical space.



Protein Phosphorylation in Parasites

Protein Phosphorylation in Parasites Author Christian Doerig
ISBN-10 9783527675371
Release 2013-10-11
Pages 456
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This is the first book to collect and summarize in one publication the efforts to use kinases or phosphatases for drug development against parasite infections. The editors and contributors comprise the Who is Who in the field, and they are comprehensive in covering every aspect of the topic, from basic research findings to translational approaches in drug development The result will be welcomed by everyone in academia and industry participating in the global effort to finally combat the major diseases caused by eukaryotic parasites. This is volume one of a two-volume treatise, the second being exclusively dedicated to efforts to combat malaria using the same approach.



The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment Author Joerg Bluemel
ISBN-10 9780124171466
Release 2015-03-13
Pages 716
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The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes



Metabolite Safety in Drug Development

Metabolite Safety in Drug Development Author Suzanne L. Iverson
ISBN-10 9781118949658
Release 2016-08-01
Pages 352
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A reference on drug metabolism and metabolite safety in the development phase, this book reviews the analytical techniques and experimental designs critical for metabolite studies. It features case studies of lessons learned and real world examples, along with regulatory perspectives from the US FDA and EMA. • Reviews the analytical techniques and experimental designs critical for metabolite studies • Covers methods including chirality, species differences, mass spectrometry, radiolabels, and in vitro / in vivo correlation • Discusses target pharmacology, in vitro systems aligned to toxicity tests, and drug-drug interactions • Includes perspectives from authors with firsthand involvement in industry and the study of drug metabolites, including viewpoints that have influenced regulatory guidelines



The Application of Functional Genomics Systems Biology and Drug Development to the Study of Infectious Diseases

The Application of Functional Genomics  Systems Biology and Drug Development to the Study of Infectious Diseases Author Jingchun Zhu
ISBN-10 UCAL:X85693
Release 2006
Pages 164
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Genomics is creating a paradigm shift in the research of infectious diseases, transforming it from studying a few targets at a time to a genomic scale. We applied three genomic approaches to the study of malaria and its causative agents, a type of intracellular parasites belonging to the genus Plasmodium.



Antimalarial Chemotherapy

Antimalarial Chemotherapy Author Philip J. Rosenthal
ISBN-10 9781592591114
Release 2001-04-01
Pages 396
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Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.



Safe Handling and Restraint of Animals

Safe Handling and Restraint of Animals Author Stella J. Chapman
ISBN-10 9781119077923
Release 2017-08-16
Pages 312
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Provides all you need to know about the safe and humane handling and restraint of animals. Safe Handling and Restraint of Animals takes a holistic approach to the handling of a wide variety of animal species. This comprehensive resource offers a thorough overview of how to safely handle and restrain a number of commonly encountered species including dogs, cats, small mammals, exotic pets, horses and farm animals. Each chapter discusses the behaviour of the species and then outlines the appropriate handling and restraint methods, including any equipment required, multiple explanatory photographs, and useful further reading. Covers a wide range of species commonly encountered by veterinary staff and those working within animal industries Includes key points and self-assessment questions at the end of each chapter, and a glossary of terms Ideal for students of any animal-related degree or diploma programme, including veterinary medicine, veterinary nursing, and animal studies and husbandry Written for students and professionals who work with animals, Safe Handling and Restraint of Animals: A Comprehensive Guide encompasses all aspects of handling and physical restraint, including biosecurity and welfare issues.



Philosophical Transactions of the Royal Society of London

Philosophical Transactions of the Royal Society of London Author
ISBN-10 IND:30000121555647
Release 2002
Pages
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Philosophical Transactions of the Royal Society of London has been writing in one form or another for most of life. You can find so many inspiration from Philosophical Transactions of the Royal Society of London also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Philosophical Transactions of the Royal Society of London book for free.



ABC Transporters in Microorganisms

ABC Transporters in Microorganisms Author Alicia Ponte-Sucre
ISBN-10 9781904455493
Release 2009
Pages 260
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This concise volume describes the latest, up-to-date theory, methodology, and applications of ABC transporters in microorganisms. The topics include the structure, physiology, and evolution of ABC transporters, as well as their special characteristics in specific microorganisms, including bacteria, yeast, trypanosomes, and malaria parasites. In particular, the book describes the most recent research and innovations relative to the role of ABC transporters in the design of strategies to circumvent drug resistance in microorganisms. Each chapter comprises an exhaustive review of the particular topic and provides insights into the future of the field, both from the scientific and clinical perspective. A skillful selection of topics and a panel of acknowledged experts ensure that this concise volume will be of exceptional importance to everyone involved in DNA superfamily research, as well as scientists interested in microbial physiology and multidrug resistance. It is essential reading for anyone involved in this field, and it is a recommended volume for all microbiology laboratories.