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Computational Biophysics of the Skin

Computational Biophysics of the Skin Author Bernard Querleux
ISBN-10 9789814463850
Release 2016-04-19
Pages 558
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The accessibility of the skin in vivo has resulted in the development of non-invasive methods in the past 40 years that offer accurate measurements of skin properties and structures from microscopic to macroscopic levels. However, the mechanisms involved in these properties are still only partly understood. Similar to many other domains, including biomedical engineering, numerical modeling has appeared as a complementary key actor for improving our knowledge of skin physiology. This book presents, for the first time, the contributions that focus on scientific computing and numerical modeling to offer a deeper understanding of the mechanisms involved in skin physiology. The book is structured around some skin properties and functions, including optical and biomechanical properties and skin barrier function and homeostasis, with—for each of them—several chapters that describe either biological or physical models at different scales.



Light and Skin Interactions

Light and Skin Interactions Author Gladimir V. G. Baranoski
ISBN-10 0123786444
Release 2010-03-04
Pages 200
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Light and Skin Interactions immerses you in one of the most fascinating application areas of computer graphics: appearance simulation. The book first illuminates the fundamental biophysical processes that affect skin appearance, and reviews seminal related works aimed at applications in life and health sciences. It then examines four exemplary modeling approaches as well as definitive algorithms that can be used to generate realistic images depicting skin appearance. Despite its wide scope of simulation approaches, the book’s content is presented in a concise manner, focusing on relevant practical aspects. What’s more, these approaches can be successfully applied to a wide range of additional materials, such as eye tissue, hair, and water. Allows you to understand and predict the qualitative and quantitative behavior of complex natural systems A general background on tissue optics clarifies several confusing conceptual issues, saving you valuable time in the early stages of research Includes complete code and data sources for the BioSpec model



Computational Biochemistry and Biophysics

Computational Biochemistry and Biophysics Author Oren M. Becker
ISBN-10 020390382X
Release 2001-02-09
Pages 512
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Covering theoretical methods and computational techniques in biomolecular research, this book focuses on approaches for the treatment of macromolecules, including proteins, nucleic acids, and bilayer membranes. It uses concepts in free energy calculations, conformational analysis, reaction rates, and transition pathways to calculate and interpret biomolecular properties gleaned from computer-generated membrane simulations. It also demonstrates comparative protein structure modeling, outlines computer-aided drug design, discusses Bayesian statistics in molecular and structural biology, and examines the RISM-SCF/MCSCF approach to chemical processes in solution.



Coarse Grained Modeling of Biomolecules

Coarse Grained Modeling of Biomolecules Author Garegin A. Papoian
ISBN-10 9781466576179
Release 2017-10-30
Pages 430
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"The chapters in this book survey the progress in simulating biomolecular dynamics.... The images conjured up by this work are not yet universally loved, but are beginning to bring new insights into the study of biological structure and function. The future will decide whether this scientific movement can bring forth its Picasso or Modigliani." –from the Foreword by Peter G. Wolynes, Bullard-Welch Foundation Professor of Science, Rice University This book highlights the state-of-art in coarse-grained modeling of biomolecules, covering both fundamentals as well as various cutting edge applications. Coarse-graining of biomolecules is an area of rapid advances, with numerous new force fields having appeared recently and significant progress made in developing a systematic theory of coarse-graining. The contents start with first fundamental principles based on physics, then survey specific state-of-art coarse-grained force fields of proteins and nucleic acids, and provide examples of exciting biological problems that are at large scale, and hence, only amenable to coarse-grained modeling. Introduces coarse-grained models of proteins and nucleic acids. Showcases applications such as genome packaging in nuclei and understanding ribosome dynamics Gives the physical foundations of coarse-graining Demonstrates use of models for large-scale assemblies in modern studies Garegin A. Papoian is the first Monroe Martin Associate Professor with appointments in the Department of Chemistry and Biochemistry and the Institute for Physical Science and Technology at the University of Maryland.



Light and Skin Interactions

Light and Skin Interactions Author Gladimir V. G. Baranoski
ISBN-10 0123786444
Release 2010-03-04
Pages 200
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Light and Skin Interactions immerses you in one of the most fascinating application areas of computer graphics: appearance simulation. The book first illuminates the fundamental biophysical processes that affect skin appearance, and reviews seminal related works aimed at applications in life and health sciences. It then examines four exemplary modeling approaches as well as definitive algorithms that can be used to generate realistic images depicting skin appearance. Despite its wide scope of simulation approaches, the book’s content is presented in a concise manner, focusing on relevant practical aspects. What’s more, these approaches can be successfully applied to a wide range of additional materials, such as eye tissue, hair, and water. Allows you to understand and predict the qualitative and quantitative behavior of complex natural systems A general background on tissue optics clarifies several confusing conceptual issues, saving you valuable time in the early stages of research Includes complete code and data sources for the BioSpec model



Computational Neuroscience

Computational Neuroscience Author Hanspeter Mallot
ISBN-10 9783319008615
Release 2013-05-23
Pages 135
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Computational Neuroscience - A First Course provides an essential introduction to computational neuroscience and equips readers with a fundamental understanding of modeling the nervous system at the membrane, cellular, and network level. The book, which grew out of a lecture series held regularly for more than ten years to graduate students in neuroscience with backgrounds in biology, psychology and medicine, takes its readers on a journey through three fundamental domains of computational neuroscience: membrane biophysics, systems theory and artificial neural networks. The required mathematical concepts are kept as intuitive and simple as possible throughout the book, making it fully accessible to readers who are less familiar with mathematics. Overall, Computational Neuroscience - A First Course represents an essential reference guide for all neuroscientists who use computational methods in their daily work, as well as for any theoretical scientist approaching the field of computational neuroscience.



Molecular Modeling Basics

Molecular Modeling Basics Author Jan H. Jensen
ISBN-10 9781420075274
Release 2010-04-26
Pages 189
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Molecular modeling is becoming an increasingly important part of chemical research and education as computers become faster and programs become easier to use. The results, however, have not become easier to understand. Addressing the need for a "workshop-oriented" book, Molecular Modeling Basics provides the fundamental theory needed to understand not only what molecular modeling programs do, but also the gist of research papers that describe molecular modeling results. Written in a succinct manner using informal language, the book presents concise coverage of key concepts suitable for novices to the field. It begins by examining the potential energy surface (PES), which provides the connection between experimental data and molecular modeling. It explores ways to calculate energy by molecular and quantum mechanics. It describes molecular properties and the condensed phase, and shows how to extract and interpret information from a program output. The author uses hands-on exercises to illustrate concepts and he supplements the text with a blog containing animated tutorials and interactive figures. Drawn from the author’s own lecture notes from a class he taught for many years at the University of Iowa, this volume introduces topics in such a way that beginners can clearly comprehend molecular modeling results. A perfect supplement to a molecular modeling textbook, the book offers students the "hands-on" practice they need to grasp sophisticated concepts. In addition to his blog, the author maintains a website describing his research and one detailing his seminars.



Computational Modeling of Biological Systems

Computational Modeling of Biological Systems Author Nikolay V Dokholyan
ISBN-10 9781461421450
Release 2012-02-12
Pages 366
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Computational modeling is emerging as a powerful new approach to study and manipulate biological systems. Multiple methods have been developed to model, visualize, and rationally alter systems at various length scales, starting from molecular modeling and design at atomic resolution to cellular pathways modeling and analysis. Higher time and length scale processes, such as molecular evolution, have also greatly benefited from new breeds of computational approaches. This book provides an overview of the established computational methods used for modeling biologically and medically relevant systems.



Computational Models for the Human Body

Computational Models for the Human Body Author Philippe G. Ciarlet
ISBN-10 0444515666
Release 2004
Pages 670
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Provides a better understanding of the physiological and mechanical behaviour of the human body and the design of tools for their realistic numerical simulations, including concrete examples of such computational models. This book covers a large range of methods and an illustrative set of applications.



Computational Methods in Biophysics Biomaterials Biotechnology and Medical Systems Computational methods

Computational Methods in Biophysics  Biomaterials  Biotechnology and Medical Systems  Computational methods Author Cornelius T. Leondes
ISBN-10 1402071078
Release 2003
Pages 1461
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This is the first interdisciplinary reference dedicated to the application of computational methods in biophysics, biomaterials, biotechnology and medical aystems research. (Midwest).



Computational Chemogenomics

Computational Chemogenomics Author Edgar Jacoby
ISBN-10 9789814411400
Release 2013-12-03
Pages 264
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This book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target hopping of chemotypes to identify synergies within related drug discovery projects or to repurpose known drugs, to propose mechanism of action of compounds, or to identify off-target effects by cross-reactivity analysis. Both ligand-based and structure-based in silico approaches, as reviewed in this book, play important roles for all these applications. Computational chemogenomics is expected to increase the quality and productivity of drug discovery and lead to the discovery of new medicines.



A Mathematical Approach to Protein Biophysics

A Mathematical Approach to Protein Biophysics Author L. Ridgway Scott
ISBN-10 9783319660325
Release 2017-12-04
Pages 290
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This book explores quantitative aspects of protein biophysics and attempts to delineate certain rules of molecular behavior that make atomic scale objects behave in a digital way. This book will help readers to understand how certain biological systems involving proteins function as digital information systems despite the fact that underlying processes are analog in nature. The in-depth explanation of proteins from a quantitative point of view and the variety of level of exercises (including physical experiments) at the end of each chapter will appeal to graduate and senior undergraduate students in mathematics, computer science, mechanical engineering, and physics, wanting to learn about the biophysics of proteins. L. Ridgway Scott has been Professor of Computer Science and of Mathematics at the University of Chicago since 1998, and the Louis Block Professor since 2001. He obtained a B.S. degree (Magna Cum Laude) from Tulane University in 1969 and a PhD degree in Mathematics from the Massachusetts Institute of Technology in 1973. Professor Scott has published over 130 papers and three books, extending over biophysics, parallel computing and fundamental computing aspects of structural mechanics, fluid dynamics, nuclear engineering, and computational chemistry. Ariel Fernández (born Ariel Fernández Stigliano) is an Argentinian-American physical chemist and mathematician. He obtained his Ph. D. degree in Chemical Physics from Yale University and held the Karl F. Hasselmann Endowed Chair Professorship in Bioengineering at Rice University. He is currently involved in research and entrepreneurial activities at various consultancy firms. Ariel Fernández authored three books on translational medicine and biophysics, and published 360 papers in professional journals. He holds two patents in the field of biotechnology.



Computational Methods in Biophysics Biomaterials Biotechnology and Medical Systems Diagnostic methods

Computational Methods in Biophysics  Biomaterials  Biotechnology and Medical Systems  Diagnostic methods Author Cornelius T. Leondes
ISBN-10 1402071094
Release 2003
Pages 1461
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This is the first interdisciplinary reference dedicated to the application of computational methods in biophysics, biomaterials, biotechnology and medical aystems research. (Midwest).



Biophysics

Biophysics Author Mark C. Leake
ISBN-10 9781498702461
Release 2016-09-15
Pages 410
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An Up-to-Date Toolbox for Probing Biology Biophysics: Tools and Techniques covers the experimental and theoretical tools and techniques of biophysics. It addresses the purpose, science, and application of all physical science instrumentation and analysis methods used in current research labs. The book first presents the historical background, concepts, and motivation for using a physical science toolbox to understand biology. It then familiarizes students from the physical sciences with essential biological knowledge. The text subsequently focuses on experimental biophysical techniques that primarily detect biological components or measure/control biological forces. The author describes the science and application of key tools used in imaging, detection, general quantitation, and biomolecular interaction studies, which span multiple length and time scales of biological processes both in the test tube and in the living organism. Moving on to theoretical biophysics tools, the book presents computational and analytical mathematical methods for tackling challenging biological questions. It concludes with a discussion of the future of this exciting field. Future innovators will need to be trained in multidisciplinary science to be successful in industry, academia, and government support agencies. Addressing this challenge, this textbook educates future leaders on the development and application of novel physical science approaches to solve complex problems linked to biological questions.



Computational Pharmaceutics

Computational Pharmaceutics Author Defang Ouyang
ISBN-10 9781118573969
Release 2015-05-18
Pages 328
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Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems. The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein binding, silica nanoparticles, carbon nanotube-based drug delivery systems, diamond nanoparticles and layered double hydroxides (LDHs) drug delivery systems. Although there are a number of existing books about rational drug design with molecular modeling techniques, these techniques still look mysterious and daunting for pharmaceutical scientists. This book fills the gap between pharmaceutics and molecular modeling, and presents a systematic and overall introduction to computational pharmaceutics. It covers all introductory, advanced and specialist levels. It provides a totally different perspective to pharmaceutical scientists, and will greatly facilitate the development of pharmaceutics. It also helps computational chemists to look for the important questions in the drug delivery field. This book is included in the Advances in Pharmaceutical Technology book series.



Optical Technologies in Biophysics and Medicine

Optical Technologies in Biophysics and Medicine Author Valeriǐ Viktorovich Tuchin
ISBN-10 081944927X
Release 2003
Pages 538
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Optical Technologies in Biophysics and Medicine has been writing in one form or another for most of life. You can find so many inspiration from Optical Technologies in Biophysics and Medicine also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Optical Technologies in Biophysics and Medicine book for free.



Biophysics of DNA

Biophysics of DNA Author Alexander Vologodskii
ISBN-10 9781107034938
Release 2015-03-12
Pages 272
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Surveys the last sixty years of research in the rapidly advancing field of DNA biophysics, addressing key questions and facilitating further research.