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Formulation of Disperse Systems

Formulation of Disperse Systems Author Tharwat F. Tadros
ISBN-10 9783527678303
Release 2014-05-14
Pages 504
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This book presents comprehensively the science and technology behind the formulation of disperse systems like emulsions, suspensions, foams and others. Starting with a general introduction, the book covers a broad range of topics like the role of different classes of surfactants, stability of disperse systems, formulation of different dispersions, evaluation of formulations and many more. Many examples are included, too. Written by the experienced author and editor Tharwart Tadros, this book is indispensable for every scientist working in the field.



Injectable Dispersed Systems

Injectable Dispersed Systems Author Diane J. Burgess
ISBN-10 9780849336997
Release 2005-05-23
Pages 688
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This authoritative guide will serve as the most current source on the design and manufacturing of parenteral dispersed systems-showcasing the utility of dispersed systems in drug delivery, drug targeting, and pharmaceutical engineering.



Pharmaceutical Suspensions

Pharmaceutical Suspensions Author Alok K. Kulshreshtha
ISBN-10 1441910875
Release 2009-11-05
Pages 327
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The suspension dosage form has long been used for poorly soluble active ingre- ents for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. A good understanding of the fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of a s- pension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, visco- ters, particle size analyzers, etc.) must be utilized to properly characterize the s- pension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require cli- cal trials to establish the safety and efficacy of the drug product. All of this devel- ment work should culminate into a regulatory filing in accordance with the regulatory guidelines. Pharmaceutical Suspensions, From Formulation Development to Manufacturing, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system – poorly soluble active pharmaceutical ingredients s- pended in a suitable vehicle.



Product Design and Engineering

Product Design and Engineering Author Ulrich Bröckel
ISBN-10 9783527654765
Release 2013-08-02
Pages 372
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Covering the whole value chain - from product requirements and properties via process technologies and equipment to real-world applications - this reference represents a comprehensive overview of the topic. The editors and majority of the authors are members of the European Federation of Chemical Engineering, with backgrounds from academia as well as industry. Therefore, this multifaceted area is highlighted from different angles: essential physico-chemical background, latest measurement and prediction techniques, and numerous applications from cosmetic up to food industry. Recommended reading for process, pharma and chemical engineers, chemists in industry, and those working in the pharmaceutical, food, cosmetics, dyes and pigments industries.



Colloid and Interface Science in Pharmaceutical Research and Development

Colloid and Interface Science in Pharmaceutical Research and Development Author Hiroyuki Ohshima
ISBN-10 9780444626080
Release 2014-07-23
Pages 532
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Colloid and Interface Science in Pharmaceutical Research and Development describes the role of colloid and surface chemistry in the pharmaceutical sciences. It gives a detailed account of colloid theory, and explains physicochemical properties of the colloidal-pharmaceutical systems, and the methods for their measurement. The book starts with fundamentals in Part I, covering fundamental aspects of colloid and interface sciences as applied to pharmaceutical sciences and thus should be suitable for teaching. Parts II and III treat applications and measurements, and they explains the application of these properties and their influence and use for the development of new drugs. Provides a clear description of the fundamentals of colloid and interface science relevant to drug research and development Explains the physicochemical/colloidal basis of pharmaceutical science Lists modern experimental characterization techniques, provides analytical equations and explanations on analyzing the experimental data Describes the most advanced techniques, AFM (Atomic Force Microscopy), SFA (Surface Force Apparatus) in detail



The Role of Colloidal Systems in Environmental Protection

The Role of Colloidal Systems in Environmental Protection Author Monzer Fanun
ISBN-10 9780444632845
Release 2014-02-08
Pages 720
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The Role of Colloidal Systems in Environmental Protection describes the importance of colloids in many applications that contribute to environmental protection, including drinking water and wastewater treatment, heavy metal remediation, treatment of radioactive materials, corrosion, and energy conversion. Knowledge of the physical and chemical composition of colloids is important to understand and accurately model the relevant processes. The book familiarizes the reader with the technological features of the application of colloids in environmental protection, and provides chemical engineers, researchers, and scientists in academic and corporate communities with the latest developments in this field. Each chapter covers the whole spectrum of the relevant science, from the fundamentals to applications. Provides the applied technological features of colloids in environmental protection Gives insight into the use of bio-solid colloids as contaminant carriers Covers the natural occurrence of biosurfactants in the environment and their applications Provides information on the use of nanoparticles for environmental applications Chapters written by recognized and respected experts in the field from all over the world



Population Balances

Population Balances Author Doraiswami Ramkrishna
ISBN-10 9780080539249
Release 2000-08-08
Pages 355
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Engineers encounter particles in a variety of systems. The particles are either naturally present or engineered into these systems. In either case these particles often significantly affect the behavior of such systems. This book provides a framework for analyzing these dispersed phase systems and describes how to synthesize the behavior of the population particles and their environment from the behavior of single particles in their local environments. Population balances are of key relevance to a very diverse group of scientists, including astrophysicists, high-energy physicists, geophysicists, colloid chemists, biophysicists, materials scientists, chemical engineers, and meteorologists. Chemical engineers have put population balances to most use, with applications in the areas of crystallization; gas-liquid, liquid-liquid, and solid-liquid dispersions; liquid membrane systems; fluidized bed reactors; aerosol reactors; and microbial cultures. Ramkrishna provides a clear and general treatment of population balances with emphasis on their wide range of applicability. New insight into population balance models incorporating random particle growth, dynamic morphological structure, and complex multivariate formulations with a clear exposition of their mathematical derivation is presented. Population Balances provides the only available treatment of the solution of inverse problems essential for identification of population balance models for breakage and aggregation processes, particle nucleation, growth processes, and more. This book is especially useful for process engineers interested in the simulation and control of particulate systems. Additionally, comprehensive treatment of the stochastic formulation of small systems provides for the modeling of stochastic systems with promising new areas of applications such as the design of sterilization systems and radiation treatment of cancerous tumors. A clear and general treatment of population balances with emphasis on their wide range of applicability. Thus all processes involving solid-fluid and liquid-liquid dispersions, biological populations, etc. are encompassed Provides new insight into population balance models incorporating random particle growth, dynamic morphological structure, and complex multivariate formulations with a clear exposition of their mathematical derivation Presents a wide range of solution techniques, Monte Carlo simulation methods with a lucid exposition of their origin and scope for enhancing computational efficiency An account of self-similar solutions of population balance equations and their significance to the treatment of data on particulate systems The only available treatment of the solution of inverse problems essential for identification of population balance models for breakage and aggregation processes, particle nucleation and growth processes and so on A comprehensive treatment of the stochastic formulation of small systems with several new applications



Oil Spill Science and Technology

Oil Spill Science and Technology Author Mervin Fingas
ISBN-10 9780128110966
Release 2016-11-23
Pages 1078
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Oil Spill Science and Technology, Second Edition, delivers a multi-contributed view on the entire chain of oil-spill related topics from oil properties and behaviors, to remote sensing through the management side of contingency planning and communicating oil spill risk perceptions. Completely new case studies are included with special attention to the Deepwater Horizon event, covering the impacts of wetlands and sand beaches, a mass balance approach, and the process for removing petroleum chemicals still trapped near Alabama beaches. Other new information on lingering oil left behind from the Exxon Valdez spill, the emergency system used in the Prestige incident, and coverage on the Heibei Spirit spill in Korea are also included. This updated edition combines technology with case studies to identify the current state of knowledge surrounding oil spills that will encourage additional areas of research that are left to uncover in this critical sector of the oil and gas industry. Updated with new chapters on risk analysis and communication, contingency planning, restoration, and case studies Supported with technological advances evolved from the Deepwater Horizon/BP oil tragedy and events in the Arctic/Antarctic Multi-contributed from various industry experts to provide an extensive background in technical equipment and worldwide procedures used today



Aulton s Pharmaceutics

Aulton s Pharmaceutics Author Michael E. Aulton
ISBN-10 9780702042904
Release 2013
Pages 894
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Pharmaceutics is one of the most diverse subject areas in all of pharmaceutical science. In brief, it is concerned with the scientific and technological aspects of the design and manufacture of dosage forms or medicines. An understanding of pharmaceutics is therefore vital for all pharmacists and those pharmaceutical scientists who are involved with converting a drug or a potential drug into a medicine that can be delivered safely, effectively and conveniently to the patient. Now in its fourth edition, this best-selling textbook in pharmaceutics has been brought completely up to date to reflect the rapid advances in delivery methodologies by eye and injection, advances in drug formulations and delivery methods for special groups (such as children and the elderly), nanomedicine, and pharmacognosy. At the same time the editors have striven to maintain the accessibility of the text for students of pharmacy, preserving the balance between being a suitably pitched introductory text and a clear reflection of the state of the art. provides a logical, comprehensive account of drug design and manufacture includes the science of formulation and drug delivery designed and written for newcomers to the design of dosage forms New to this edition New editor: Kevin Taylor, Professor of Clinical Pharmaceutics, School of Pharmacy, University of London. Twenty-two new contributors. Six new chapters covering parenteral and ocular delivery; design and administration of medicines for the children and elderly; the latest in plant medicines; nanotechnology and nanomedicines, and the delivery of biopharmaceuticals. Thoroughly revised and updated throughout.



Interfacial Phenomena and Colloid Stability

Interfacial Phenomena and Colloid Stability Author Tharwat F. Tadros
ISBN-10 9783110283433
Release 2015-05-19
Pages 358
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Interfacial Phenomena and Colloid Stability deals with the fundamental aspects of interfacial phenomena, which form the basis of applications of interface and colloid science to various disperse systems. These include suspensions, emulsions, nano-dispersions, wetting, spreading, deposition and adhesion of particles to surfaces. This book is valuable for research scientists and PhDs. investigating various aspects of interface and colloid science.



Surfactant Science and Technology

Surfactant Science and Technology Author Drew Myers
ISBN-10 9780471746065
Release 2005-11-11
Pages 448
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A general introduction to surfactants, surface activity, and surfactant applications Important advances in the tools available for studying the activity of surfactants has significantly increased scientific understanding of interfaces at the molecular level. However, there is still much to be learned. In this Third Edition of the successful classic, author and expert Drew Myers combines the latest information available in the field of surfactants with his original, accessible text on the subject. Now fully updated to reflect recent developments in working with surfactants in both model and practical systems, the Third Edition of Surfactant Science and Technology provides a solid introduction to the field of surfactant science. Written especially for beginners and nonspecialists who would like a practical but not necessarily comprehensive knowledge of the field, this clear, cogent text conveys the most fundamental and useful concepts of surfactant action and application. New chapters bring readers up to date on current biological and medical applications of surfactants, as well as applications in food science, cosmetics, and other areas. In addition to new chapters, Surfactant Science and Technology includes illustrative problems at the end of each chapter. These problems explain concepts discussed and stimulate imaginative solutions on the part of the reader. A helpful bibliography of supplementary resources for readers who desire more detail has also been included. Surfactant Science and Technology, Third Edition is an invaluable resource for surface and polymer chemists, chemical and industrial engineers, and a wide range of chemistry students.



Nanostructures for Oral Medicine

Nanostructures for Oral Medicine Author Ecaterina Andronescu
ISBN-10 9780323477215
Release 2017-04-11
Pages 1034
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Nanostructures for Oral Medicine presents an up-to-date examination of the applications and effects of nanostructured materials in oral medicine, with each chapter addressing recent developments, specific applications, and uses of nanostructures in the oral administration of therapeutic agents in dentistry. The book also includes coverage of the biocompatibility of nanobiomaterials and their remarkable potential in improving human health and in reducing environmental pollution. Emerging advances, such as Dr. Franklin Tay's concept of a new nanotechnology process of growing extremely small, mineral-rich crystals and guiding them into the demineralized gaps between collagen fibers to prevent the aging and degradation of resin-dentin bonding is also discussed. This work will be of great value to those who work in oral medicine, providing them with a resource to gain a greater understanding of how nanotechnology can help them create more efficient, cost-effective products. In addition, it will be of great interest to those who work in materials science who wish to gain a greater appreciation of how nanostructured materials are applied in this field. Outlines the major uses of nanostructured materials for oral medicine, including the properties of each material discussed and how it should best be applied Explores how nanostructured materials enable the creation of more effective drug delivery systems in oral medicine Discusses how novel uses of nanostructured materials may be applied in oral medicine to create more effective devices



Handbook of Cosmetic Science and Technology

Handbook of Cosmetic Science and Technology Author André O. Barel
ISBN-10 9780824741396
Release 2001-07-13
Pages 904
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This state-of-the-art reference provides comprehensive multidisciplinary coverage of the most recent information on cosmetic ingredients, finished products, target organs, delivery systems, and current technology in safety, toxicology, and dermatological testing. Discussing modern innovations such as active cosmetics for the hair, skin, and teeth, the Handbook of Cosmetic Science and Technology highlights Cosmetics for infant and elderly consumers The formulation of skin cleansing products New delivery systems, including cosmetic patches and iontophoresis The anatomy and physiology of body targets for cosmetics Principles and mechanisms of unwanted reactions to cosmetics With contributions by more than 100 leading experts in the field, the Handbook of Cosmetic Science and Technology is an essential tool for cosmetic, fragrance, pharmaceutical, organic, medicinal, physical, surface, colloid, and detergent chemists and biochemists; dermatologists; toxicologists and microbiologists; skin physiologists; and upper-level undergraduate and graduate students in these disciplines.



Advanced and Emerging Polybenzoxazine Science and Technology

Advanced and Emerging Polybenzoxazine Science and Technology Author Hatsuo Ishida
ISBN-10 9780128041857
Release 2017-01-18
Pages 1126
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Advanced and Emerging Polybenzoxazine Science and Technology introduces advanced topics of benzoxazine resins and polybenzoxazines as presented through the collaboration of leading experts in the benzoxazine community, representing the authoritative introduction to the subjects. Broad topics covered include the recent development and improved understanding of the subjects, including low temperature cure, aerogels and carbon aerogels, smart chemistry in fire retarding materials and coatings, metal containing benzoxazines, rational design of advanced properties, and materials from natural renew. In the past twenty years, the number of papers on polybenzoxazine has continuously increased at an exponential rate. During the past three years, the number of papers published is more than the previous 17 years combined. The material is now part of only a few successfully commercialized polymers in the past 35 years. Therefore, interest in this material in both academia and industry is very strong. Includes the latest advancements in benzoxazine chemistry Describes advanced materials, such as aerogels, carbons, smart coatings, nanofibers, and shape memory materials Includes additional characterization data and techniques, such as FT-IR, Raman, NMR, DSC, and TGA analyses



Sterile Drug Products

Sterile Drug Products Author Michael J. Akers
ISBN-10 9781420020564
Release 2016-04-19
Pages 516
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Sterile Drug Products: Formulation, Packaging, Manufacturing, and Quality teaches the basic principles of the development and manufacture of high quality sterile dosage forms. The author has 38 years of experience in the development and manufacture of sterile dosage forms including solutions, suspensions, ophthalmics and freeze dried products. This book is based on the courses he has delivered for over three decades, to over 3000 participants, and is intended to remain relevant for the indefinite future even as new technologies and new applications of old technologies become common. This is an ideal reference book for those working directly and indirectly with sterile dosage forms, be it product development (formulation, package, process, analytical), manufacturing, quality control, quality assurance, regulatory, purchasing, or project management. This book is also intended as an educational resource for the pharmaceutical and biopharmaceutical industry and pharmacy schools, providing basic knowledge and principles in four main areas of parenteral science and technology: Product development, including formulation, packaging, and process development. Manufacturing, including basic teaching on all the primary unit operations involved in preparation of sterile products and the underlying importance of contamination control. Quality and regulatory, including the application of good manufacturing practice regulations, aseptic processing guidelines, and unique quality control testing methods for the sterile dosage form Clinical aspects, including administration, potential hazards, and biopharmaceutics of sterile products in a clinical setting.



Encapsulation Technologies and Delivery Systems for Food Ingredients and Nutraceuticals

Encapsulation Technologies and Delivery Systems for Food Ingredients and Nutraceuticals Author Nissim Garti
ISBN-10 9780857095909
Release 2012-10-19
Pages 640
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Improved technologies for the encapsulation, protection, release and enhanced bioavailability of food ingredients and nutraceutical components are vital to the development of future foods. Encapsulation technologies and delivery systems for food ingredients and nutraceuticals provides a comprehensive guide to current and emerging techniques. Part one provides an overview of key requirements for food ingredient and nutraceutical delivery systems, discussing challenges in system development and analysis of interaction with the human gastrointestinal tract. Processing technologies for encapsulation and delivery systems are the focus of part two. Spray drying, cooling and chilling are reviewed alongside coextrusion, fluid bed microencapsulation, microencapsulation methods based on biopolymer phase separation, and gelation phenomena in aqueous media. Part three goes on to investigate physicochemical approaches to the production of encapsulation and delivery systems, including the use of micelles and microemulsions, polymeric amphiphiles, liposomes, colloidal emulsions, organogels and hydrogels. Finally, part four reviews characterization and applications of delivery systems, providing industry perspectives on flavour, fish oil, iron micronutrient and probiotic delivery systems. With its distinguished editors and international team of expert contributors, Encapsulation technologies and delivery systems for food ingredients and nutraceuticals is an authoritative guide for both industry and academic researchers interested in encapsulation and controlled release systems. Provides a comprehensive guide to current and emerging techniques in encapsulation technologies and delivery systems Chapters in part one provide an overview of key requirements for food ingredient and nutraceutical delivery systems, while part two discusses processing technologies for encapsulation and delivery systems Later sections investigate physicochemical approaches to the production of encapsulation and delivery systems and review characterization and applications of delivery systems



Characterization of Liquids Dispersions Emulsions and Porous Materials Using Ultrasound

Characterization of Liquids  Dispersions  Emulsions  and Porous Materials Using Ultrasound Author Andrei S. Dukhin
ISBN-10 9780444639073
Release 2017-08-08
Pages 590
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Characterization of Liquids, Dispersions, Emulsions and Porous Materials Using Ultrasound, Third Edition, presents a scientific background for novel methods of characterizing homogeneous and heterogeneous liquids (dispersions, emulsions, and gels) as well as porous materials. Homogeneous liquids are characterized in rheological terms, whereas particle-size distribution and zeta potential are parameters of heterogeneous liquids. For porous materials, porosity, pore size, and zeta potential are output characteristics. These methods are based on ultrasound, which opens an opportunity for simplifying the sample preparation by eliminating dilution. This in turn, makes measurements faster, easier, precise, suitable for accurate quality control, PAT, and formulation of complex systems. This book provides theoretical background of acoustics, rheology, colloid science, electrochemistry, and other relevant scientific fields, describing principles of existing instrumentation and, in particular, commercially available instruments. Finally, the book features an extensive list of existing applications. Presents a theoretical multi-disciplinary background of several new ultrasound analytical techniques in one place Validates the theoretical basis of several new analytical techniques Compares the efficiency and applications of various ultrasound techniques Lists many ultrasound applications in colloid chemistry Contains an extensive bibliography on this multidisciplinary topic