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Genetically Engineered Mice Handbook

Genetically Engineered Mice Handbook Author John P. Sundberg
ISBN-10 9781420039078
Release 2016-04-19
Pages 336
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While mice have always been highly popular laboratory subjects, their suitability for genetic engineering has solidified their position as today's lab animal model of choice. However, their increased use in genetic studies has created a demand for input on phenotyping that is not always easily met. To improve the flow of information on the pathology of mice with spontaneous or genetically engineered mutations, prominent researchers organized a series of meetings. Recognizing other needs, the organizers gradually broadened their focus, until finally they expanded to provide an overview of the entire field of genetically engineered models. The Genetically Engineered Mice Handbook is an extension of those meetings. It offers an introduction for those entering into this area of research, while also serving as a resource for those presently employing mice as laboratory models. Highly comprehensive, this volume covers pertinent aspects of genetically engineered mice, including the use of models for developmental biology and the monitoring of laboratory colonies. With contributions from nearly five-dozen leading researchers, the text presents systematic approaches for analyzing mutant mice for specific medical applications, details a variety of methods for creating mutants and includes information that is particularly hard to access dealing with legal responsibilities. This essential reference examines commonly used traditional, as well as emerging, technologies To address the purpose of the original meeting, the Genetically Engineered Mice Handbook directs researchers to the best public websites, and offers instruction on how to use them. In the past, as their work dictated, researchers would seek out experts on particular organ systems. Now groups of experts work together to generate these websites, providing the latest data as well as discussions over points of debate. These sites do not eliminate the need for a trained pathologist, but they do provide reference materials for those lacking expertise in particular anatomic structures. They also offer much greater numbers of examples than are available in print, from which biomedical researchers can draw.



Transgenic Mouse

Transgenic Mouse Author Marten H. Hofker
ISBN-10 9781592593408
Release 2002
Pages 392
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A collection of readily reproducible methods for working with mice, and particularly for generating mouse models that will enable you to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented. Use effective methods for conditional and inducible gene expression Review mouse models for a wide range of genetic aberrations associated with human disease.



The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals

The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals Author Robert C. Hubrecht
ISBN-10 9781444318784
Release 2010-01-19
Pages 848
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The seminal reference on the care of laboratory and captive animals, The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals is a must-have for anyone working in this field. The UFAW Handbook has been the definitive text since 1947. Written for an international audience, it contains contributions from experts from around the world. The book focuses on best practice principles throughout, providing comprehensive coverage, with all chapters being peer reviewed by anonymous referees. As well as addressing the husbandry of laboratory animals, the content is also of great value to zoos and aquaria. Changes for the eighth edition: Revised and updated to reflect developments since publication of the previous edition. New chapters on areas of growing concern, including: the 3Rs; phenotyping; statistics and experimental design; welfare assessment; legislation; training of people caring for lab animals; and euthanasia. All material combined into one volume for ease of reference. This book is published on behalf of UFAW (The Universities Federation for Animal Welfare), with whom we also publish the UFAW/Wiley-Blackwell Animal Welfare Book Series. This major series of books provides an authoritative source of information on worldwide developments, current thinking and best practice in the field of animal welfare science and technology. For details of all of the titles in the series see www.wiley.com/go/ufaw.



Genetically Engineered Mice for Cancer Research

Genetically Engineered Mice for Cancer Research Author Jeffrey E. Green
ISBN-10 9780387698052
Release 2011-12-09
Pages 632
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Genetically-engineered mouse models for cancer research have become invaluable tools for studying cancer biology and evaluating novel therapeutic approaches. This volume focuses on state-of-the-art methods for generating, analyzing and validating such models for studying aspects of human cancer biology. Additionally, these models are emerging as important pre-clinical systems in which to test cancer prevention and therapeutic strategies in order to select compounds for testing in clinical trials.



Handbook of Laboratory Animal Science Volume I Third Edition

Handbook of Laboratory Animal Science  Volume I  Third Edition Author Jann Hau
ISBN-10 1420084569
Release 2010-12-02
Pages 740
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Laboratory animal testing provides most of our current knowledge of human physiology, microbiology, immunology, pharmacology, and pathology. From studies of genetics in fruit flies to studies of cellular processes in genetically modified mice to recent dramatic developments in genetics, translational research, and personalized medicines, biomedical research involving animals remains absolutely essential for the advancement of the medical, veterinary, agricultural, and biological sciences and all rely on access to high-quality laboratory animals as models for humans. Rooted in the principle that good science can only be performed in environments that promote good animal welfare, this third edition of the bestselling Handbook of Laboratory Animal Science, Vol. 1, Essential Principles and Practices emphasizes the importance of implementing the three R’s: replacing live animals with alternative methods, reducing the number of animals used, and refining techniques to minimize animal discomfort, and integrates these humane principles into almost every chapter. See what's new in the Third Edition: New chapters: Applications of Radio-Telemetry in Small Laboratory Animals, Generation and analysis of genetically modified mice, and Physiological, Hematological, and Clinical Chemistry Parameters Additional mateiral on the international harmonization of practices and on the continued implementation of the refinement, reduction, and replacement of animal usage in laboratories Sixteen page color insert Relevant to virtually all areas of laboratory science and forming the cornerstone of laboratory animal science, each individual chapter focuses on an important subdiscipline of laboratory animal science including humane laws and guidelines; non-surgical, surgical, microsurgical, and post-mortem procedures; genetic modification; nutrition, feeding, and environmental factors; experiment design and alternative methods; and analgesia, anesthesia, and euthanasia. Each chapter can be read in series or as a stand alone text. A truly international effort from world renowned contributors, Handbook of Laboratory Animal Science, Vol. 1, Essential Principles and Practices, Third Edition is useful as a textbook in laboratory animal science courses for postgraduate and undergraduate students, as a handbook for scientists who work with animals in their research, and for university veterinarians, regulators, and other specialists in laboratory animal science.



Mouse Models of Cancer

Mouse Models of Cancer Author Cory Abate-Shen
ISBN-10 1621820033
Release 2013-11-30
Pages 521
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Too often both composition teachers and their students experience knowledge and authority as lying outside their rhetorical interactions with others. Drawing on feminist, cultural, and poststructuralist theory, as well as work in the rhetorical tradition and composition studies, Hill offers less debilitating methods of thinking that teachers can model for their students. Richly illustrated with examples of classroom interactions and student work, the book also shows teachers how to enrich their own intellectual and political lives within the academy.



Handbook of Behavior Genetics

Handbook of Behavior Genetics Author Yong-Kyu Kim
ISBN-10 9780387767277
Release 2009-03-25
Pages 564
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This handbook provides research guidelines to study roles of the genes and other factors involved in a variety of complex behaviors. Utilizing methodologies and theories commonly used in behavior genetics, each chapter features an overview of the selected topic, current issues, as well as current and future research.



Handbook of Mouse Auditory Research

Handbook of Mouse Auditory Research Author James F. Willott
ISBN-10 9781420038736
Release 2001-05-23
Pages 736
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This unique compilation of chapters reviews a broad range of topics at the cutting edge of hearing research. The authors include many of the top auditory scientists in the world as well as some of the brightest rising stars. Although the book obviously focuses on the exciting, revolutionary work being done with mice, the authors have made a strong effort to provide general background information and present the insights gained from the study of mice in the greater context of auditory research. Each section includes specific procedures, potential problems and their solutions, and tricks of the trade gleaned from the authors. The book contains numerous figures and tables, more than 2,000 references, and much data not previously published. Handbook of Mouse Auditory Research: From Behavior to Molecular Biology provides state-of-the-art research with a clear look at what the future holds.



Handbook of Molecular Genetic Techniques for Brain and Behavior Research

Handbook of Molecular Genetic Techniques for Brain and Behavior Research Author Wim E. Crusio
ISBN-10 0080536867
Release 1999-10-18
Pages 962
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The book gives a broad overview of recombinant DNA techniques for the behavioral neuroscientist, with illustrative examples of applications. Species covered include rodents (mainly mice), Drosophila melanogaster, Caenorhabditis elegans and Danio rerio. Experimental techniques required to characterize the behavioral phenotypes of mutant animals is provided. Several aspects of novel molecular-genetic techniques are overviewed and possible research strategies are explained. The sections of the book start with general descriptions of techniques followed by illustrative examples. It is divided into six sections. Section 1, bioinformatics and genomics research. Section 2, top-down strategies, where the researcher starts with the phenotype and then analyzes the associated genes; bottom-up strategies, where the physiological chain leading to a phenotype is analyzed starting from the gene product. Section 3, transgenic approaches in rodents including overexpressing foreign genes and gene-targeting; systemic manipulation approaches directly targeting the central nervous system and methods used with invertebrates. Section 4, methods used to evaluate relevant behavioral phenotypes, including learning and aggression. Section 5, examples on molecular brain research in man. Section 6, ethical aspects of research in this field.



The cancer handbook

The cancer handbook Author Malcolm Alison
ISBN-10 0470018526
Release 2007-06-22
Pages 1573
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The cancer handbook has been writing in one form or another for most of life. You can find so many inspiration from The cancer handbook also informative, and entertaining. Click DOWNLOAD or Read Online button to get full The cancer handbook book for free.



The Guide to Investigation of Mouse Pregnancy

The Guide to Investigation of Mouse Pregnancy Author B. Anne Croy
ISBN-10 9780123947949
Release 2013-12-09
Pages 832
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The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research. Provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications Describes the angiogenic tree the mother’s uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes Educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation Discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success



Cardiovascular Physiology in the Genetically Engineered Mouse

Cardiovascular Physiology in the Genetically Engineered Mouse Author Brian D. Hoit
ISBN-10 9781461516538
Release 2012-12-06
Pages 403
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The enormous advances in molecular biology and genetics coupled with the progress in instrumentation and surgical techniques have produced a voluminous and often bewildering quantity of data. The need for a second edition of Cardiovascular Physiology in the Genetically Engineered Mouse is underscored not only by these rapid advances, but by the increasing numbers of scientists who have focussed their research on genetically engineered mice. It is the primary objective of this second edition to interpret critically the literature and to provide a framework for the enormous amount of information in this burgeoning field. As in the first edition, the monograph serves as a practical guide for the investigator interested in the functional methods used to characterize the murine cardiovascular phenotype. However, this guidebook is a more comprehensive text than its predecessor; although the major objectives enumerated in the first edition have not substantially changed, they have been refined in keeping with the increased sophistication of the molecular biologist, geneticist, and physiologist in each other's discipline. Each chapter has been expanded and updated, richly enhanced with original tables and figures, and in many cases, extensively rewritten. Eight chapters written by internationally recognized experts have been added; this represents a 43 % increase from the first edition.



What s Wrong With My Mouse

What s Wrong With My Mouse Author Jacqueline N. Crawley
ISBN-10 9780470119044
Release 2007-05-11
Pages 544
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Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.



Transgenic Animal Technology

Transgenic Animal Technology Author Carl A. Pinkert
ISBN-10 9780124095366
Release 2014-06-17
Pages 714
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Transgenic animal technologies and the ability to introduce functional genes into animals have revolutionized our ability to address complex biomedical and biological questions. This well-illustrated handbook covers the technical aspects of gene transfer — from molecular methods to whole animal considerations — for important laboratory and domestic animal species. It describes methodologies as employed by leading laboratories and is a key resource for researchers, as well as a tool for training technicians and students. This second edition incorporates updates on a variety of genetic engineering technologies ranging from microinjection and ES cell transfer to nuclear transfer in a broad range of animal modeling systems. Contains a comprehensive collection of transgenic animal and gene transfer methods Discusses background and introduction to techniques and animal systems Teaches practical step-by-step protocols Fully revised with updates to reflect state-of-the-art technology and associated changes to date



Advances in Cancer Research

Advances in Cancer Research Author George F. Vande Woude
ISBN-10 0080912249
Release 2010-06-22
Pages 195
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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including liposome-based chemotherapy and immunotherapy, human polyomaviruses, the role of micro RNAs in CLL, and cancer and cholesterol.



Handbook of Toxicologic Pathology

Handbook of Toxicologic Pathology Author Wanda M. Haschek
ISBN-10 0123302161
Release 2002
Pages 733
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Handbook of Toxicologic Pathology has been writing in one form or another for most of life. You can find so many inspiration from Handbook of Toxicologic Pathology also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Handbook of Toxicologic Pathology book for free.



A Handbook of Mouse Models of Cardiovascular Disease

A Handbook of Mouse Models of Cardiovascular Disease Author Qingbo Xu
ISBN-10 9780470028780
Release 2006-08-04
Pages 402
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The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook enables scientists to develop these models in their own laboratories. A Handbook of Mouse Models of Cardiovascular Disease is the first book to address pathology in mouse models of heart disease, providing the reader with essential information on technical assays in artificially created models. It includes background information on individual cardiovascular diseases, describes detailed methods and materials used for establishing each mouse model, discusses the problems that may appear in the experiments, and provides examples of applications of the model. A Handbook of Mouse Models of Cardiovascular Disease: Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis Features videos of key experimental procedures on the accompanying CD, allowing researchers to learn the techniques by directly watching the whole operational procedure Describes how to establish each experimental model with detailed protocols and tips on dealing with common operational problems Highlights potential applications of each model in areas such as pathogenesis, gene transfer, therapy and pathophysiology This handbook is an invaluable resource for researchers in cardiovascular disease, pathology, physiology, interested in the mechanism of vascular disorders and therapeutic approaches. It is also relevant to clinicians seeking to understand the pathology of cardiovascular disease and the rationale for interventions, and of interest to the pharmaceutical industry and all those involved in drug discovery/development for cardiovascular disease.