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Immune System Modelling and Simulation

Immune System Modelling and Simulation Author Filippo Castiglione
ISBN-10 9781466597495
Release 2015-04-07
Pages 286
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The book describes a computational model of the immune system reaction, C-ImmSim, built along the lines of the computer model known as the Celada-Seiden model (CS-model). The computational counterpart of the CS-model is called IMMSIM which stands for IMMune system SIMulator. IMMSIM was written in 1992 by the physicist Phil E. Seiden and the immunologist Franco Celada. This model was built around the idea of developing a computerized system to perform experiments similar in vivo experiments; a tool developed to help biologists testing theories and hypothesis about how the immune system works. C-ImmSim is best viewed as a collection of models in a single program. It incorporates the principal core facts of today’s immunological knowledge, such as the diversity of specific elements, MHC restriction, clonal selection, thymic education of T cells, antigen processing and presentation (both the cytosolic and endocytic pathways are implemented), cell-cell cooperation, homeostasis of cells created by the bone marrow, hyper mutation of antibodies, maturation of the cellular and humoral response, and memory. Besides, an antigen can represent a bacterium, a virus, or an allergen or a tumor cell. C-ImmSim has been recently customized to simulate the HIV-1 infection. Moreover, it can simulate the immunotherapy for cancer. These features are all present in the code and people can choose to turn them on and off at compiling time. The book presents the basic model as well as the various customizations to implement the description of different diseases and the way they have been used in practice to produce new knowledge either from hypothesis or from lab-experiment data. In this respect, the book can be used as a practical guide to implement a computational model with which to study a specific disease and to try to address realistic clinical questions.



A Survey of Models for Tumor Immune System Dynamics

A Survey of Models for Tumor Immune System Dynamics Author John Adam
ISBN-10 9780817681197
Release 2012-10-06
Pages 344
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Mathematical Modeling and Immunology An enormous amount of human effort and economic resources has been directed in this century to the fight against cancer. The purpose, of course, has been to find strategies to overcome this hard, challenging and seemingly endless struggle. We can readily imagine that even greater efforts will be required in the next century. The hope is that ultimately humanity will be successful; success will have been achieved when it is possible to activate and control the immune system in its competition against neoplastic cells. Dealing with the above-mentioned problem requires the fullest pos sible cooperation among scientists working in different fields: biology, im munology, medicine, physics and, we believe, mathematics. Certainly, bi ologists and immunologists will make the greatest contribution to the re search. However, it is now increasingly recognized that mathematics and computer science may well able to make major contributions to such prob lems. We cannot expect mathematicians alone to solve fundamental prob lems in immunology and (in particular) cancer research, but valuable sup port, however modest, can be provided by mathematicians to the research aspirations of biologists and immunologists working in this field.



Artificial Immune Systems

Artificial Immune Systems Author Pietro Lio
ISBN-10 9783642223716
Release 2011-07-06
Pages 468
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This book constitutes the refereed proceedings of the 10th International Conference on Artificial Immune Systems, ICARIS 2011, held in Cambridge, UK, in July 2011. The 37 revised full papers were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on immunoinformatics and computational immunology; theory of immunological computation; and applied immunological computation.



Artificial Immune Systems

Artificial Immune Systems Author Carlos A. Coello-Coello
ISBN-10 9783642337574
Release 2012-08-27
Pages 293
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This book constitutes the refereed proceedings of the 11th International Conference on Artificial Immune Systems, ICARIS 2012, held in Taormia, Italy, in August 2012. The 19 revised selected papers presented were carefully reviewed and selected for inclusion in this book. In addition 4 papers of the workshop on bio and immune inspired algorithms and models for multi-level complex systems are included in this volume. Artificial immune systems (AIS) is a diverse and maturing area of research that bridges the disciplines of immunology, biology, medical science, computer science, physics, mathematics and engineering. The scope of AIS ranges from modelling and simulation of the immune system through to immune-inspired algorithms and in silico, in vitro and in vivo solutions.



Life System Modeling and Simulation

Life System Modeling and Simulation Author Minrui Fei
ISBN-10 9783540747710
Release 2007-08-24
Pages 288
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This book is part of a two-volume work that constitutes the refereed proceedings of the International Conference on Life System Modeling and Simulation, LSMS 2007, held in Shanghai, China, September 2007. Coverage includes modeling and simulation of societies and collective behavior, computational methods and intelligence in biomechanical systems, tissue engineering and clinical bioengineering, computational intelligence in bioinformatics and biometrics, and brain stimulation.



Artificial Immune Systems

Artificial Immune Systems Author Pietro Lio
ISBN-10 9783642223716
Release 2011-07-06
Pages 468
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This book constitutes the refereed proceedings of the 10th International Conference on Artificial Immune Systems, ICARIS 2011, held in Cambridge, UK, in July 2011. The 37 revised full papers were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on immunoinformatics and computational immunology; theory of immunological computation; and applied immunological computation.



Cancer Modelling and Simulation

Cancer Modelling and Simulation Author Luigi Preziosi
ISBN-10 020349489X
Release 2003-06-18
Pages 454
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Understanding how cancer tumours develop and spread is vital for finding treatments and cures. Cancer Modelling and Simulation demonstrates how mathematical modelling and computer simulation techniques are used to discover and gain insight into the dynamics of tumour development and growth. It highlights the benefits of tumour modelling, such as discovering optimal tumour therapy schedules, identifying the most promising candidates for further clinical investigation, and reducing the number of animal experiments. By examining the analytical, mathematical, and biological aspects of tumour growth and modelling, the book provides a common language and knowledge for professionals in several disciplines.



Soft Computing and Industry

Soft Computing and Industry Author Rajkumar Roy
ISBN-10 9781447101239
Release 2012-12-06
Pages 852
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Soft computing embraces various methodologies for the development of intelligent systems that have been successfully applied to a large number of real-world problems. Soft Computing in Industry contains a collection of papers that were presented at the 6th On-line World Conference on Soft Computing in Industrial Applications that was held in September 2001. It provides a comprehensive overview of recent theoretical developments in soft computing as well as of successful industrial applications. It is divided into seven parts covering material on: keynote papers on various subjects ranging from computing with autopoietic systems to the effects of the Internet on education; intelligent control; classification, clustering and optimization; image and signal processing; agents, multimedia and Internet; theoretical advances; prediction, design and diagnosis. The book is aimed at researchers and professional engineers who develop and apply intelligent systems in computer engineering.



First Complex Systems Digital Campus World E Conference 2015

First Complex Systems Digital Campus World E Conference 2015 Author Pierre Parrend
ISBN-10 9783319459011
Release 2016-12-24
Pages 424
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This book contains the proceedings as well as invited papers for the first annual conference of the UNESCO Unitwin Complex System Digital Campus (CSDC), which is an international initiative gathering 120 Universities on four continents, and structured in ten E-Departments. First Complex Systems Digital Campus World E-Conference 2015 features chapters from the latest research results on theoretical questions of complex systems and their experimental domains. The content contained bridges the gap between the individual and the collective within complex systems science and new integrative sciences on topics such as: genes to organisms to ecosystems, atoms to materials to products, and digital media to the Internet. The conference breaks new ground through a dedicated video-conferencing system – a concept at the heart of the international UNESCO UniTwin, embracing scientists from low-income and distant countries. This book promotes an integrated system of research, education, and training. It also aims at contributing to global development by taking into account its social, economic, and cultural dimensions. First Complex Systems Digital Campus World E-Conference 2015 will appeal to students and researchers working in the fields of complex systems, statistical physics, computational intelligence, and biological physics.



Agent based Modeling and Simulation

Agent based Modeling and Simulation Author S. Taylor
ISBN-10 9781137453648
Release 2014-08-27
Pages 314
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Operational Research (OR) deals with the use of advanced analytical methods to support better decision-making. It is multidisciplinary with strong links to management science, decision science, computer science and many application areas such as engineering, manufacturing, commerce and healthcare. In the study of emergent behaviour in complex adaptive systems, Agent-based Modelling & Simulation (ABMS) is being used in many different domains such as healthcare, energy, evacuation, commerce, manufacturing and defense. This collection of articles presents a convenient introduction to ABMS with papers ranging from contemporary views to representative case studies. The OR Essentials series presents a unique cross-section of high quality research work fundamental to understanding contemporary issues and research across a range of Operational Research (OR) topics. It brings together some of the best research papers from the esteemed Operational Research Society and its associated journals, also published by Palgrave Macmillan.



Biomedical systems modelling and simulation

Biomedical systems modelling and simulation Author Jerome Eisenfeld
ISBN-10 UCSD:31822006640924
Release 1989
Pages 207
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Biomedical systems modelling and simulation has been writing in one form or another for most of life. You can find so many inspiration from Biomedical systems modelling and simulation also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Biomedical systems modelling and simulation book for free.



Conceptual Modelling in Computational Immunology

Conceptual Modelling in Computational Immunology Author Martina Husáková
ISBN-10 9788087924020
Release 2015-09-10
Pages 174
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Computational immunology offers in silico strategies for understanding of complex processes occurring in the natural immune system of a living organism that are difficult to explore by traditional in vivo or in vitro techniques. The monograph introduces conceptual languages and approaches for modelling biological processes. The Agent Modelling Language is investigated for conceptualisation of immune processes. AML-based diagrams represent properties and processes occurring in a lymph node.



Artificial Immune Systems A New Computational Intelligence Approach

Artificial Immune Systems  A New Computational Intelligence Approach Author Leandro Nunes de Castro
ISBN-10 1852335947
Release 2002-09-23
Pages 357
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Recently there has been a growing interest in the use of the biological immune system as a source of inspiration for solving complicated computational problems. The immune system involves many information-processing abilities including pattern recognition, learning, memory and inherent distributed parallel processing and for these, and other reasons, it has received a significant amount of interest as a metaphor within computing. This emerging field is known as Artificial Immune Systems (AIS), and applications of AIS include, machine learning, fault diagnosis, computer security, scheduling, virus detection and optimisation.



Computational Immunology

Computational Immunology Author Josep Bassaganya-Riera
ISBN-10 9780128037157
Release 2015-10-21
Pages 210
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Computational Immunology: Models and Tools encompasses the methodological framework and application of cutting-edge tools and techniques to study immunological processes at a systems level, along with the concept of multi-scale modeling. The book's emphasis is on selected cases studies and application of the most updated technologies in computational modeling, discussing topics such as computational modeling and its usage in immunological research, bioinformatics infrastructure, ODE based modeling, agent based modeling, and high performance computing, data analytics, and multiscale modeling. There are also modeling exercises using recent tools and models which lead the readers to a thorough comprehension and applicability. The book is a valuable resource for immunologists, computational biologists, bioinformaticians, biotechnologists, and computer scientists, as well as all those who wish to broaden their knowledge in systems modeling. Offers case studies with different levels of complexity Provides a detailed view on cutting-edge tools for modeling that are useful to experimentalists with limited computational skills Explores the usage of simulation for hypothesis generation, helping the reader to understand the most valuable points on experimental setting



New Trends in Intelligent Information and Database Systems

New Trends in Intelligent Information and Database Systems Author Dariusz Barbucha
ISBN-10 9783319162119
Release 2015-03-22
Pages 382
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Intelligent information and database systems are two closely related subfields of modern computer science which have been known for over thirty years. They focus on the integration of artificial intelligence and classic database technologies to create the class of next generation information systems. The book focuses on new trends in intelligent information and database systems and discusses topics addressed to the foundations and principles of data, information, and knowledge models, methodologies for intelligent information and database systems analysis, design, and implementation, their validation, maintenance and evolution. They cover a broad spectrum of research topics discussed both from the practical and theoretical points of view such as: intelligent information retrieval, natural language processing, semantic web, social networks, machine learning, knowledge discovery, data mining, uncertainty management and reasoning under uncertainty, intelligent optimization techniques in information systems, security in databases systems, and multimedia data analysis. Intelligent information systems and their applications in business, medicine and industry, database systems applications, and intelligent internet systems are also presented and discussed in the book. The book consists of 38 chapters based on original works presented during the 7th Asian Conference on Intelligent Information and Database Systems (ACIIDS 2015) held on 23–25 March 2015 in Bali, Indonesia. The book is divided into six parts related to Advanced Machine Learning and Data Mining, Intelligent Computational Methods in Information Systems, Semantic Web, Social Networks and Recommendation Systems, Cloud Computing and Intelligent Internet Systems, Knowledge and Language Processing, and Intelligent Information and Database Systems: Applications.



Mathematical Models of Tumor Immune System Dynamics

Mathematical Models of Tumor Immune System Dynamics Author Amina Eladdadi
ISBN-10 9781493917938
Release 2014-11-06
Pages 275
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This collection of papers offers a broad synopsis of state-of-the-art mathematical methods used in modeling the interaction between tumors and the immune system. These papers were presented at the four-day workshop on Mathematical Models of Tumor-Immune System Dynamics held in Sydney, Australia from January 7th to January 10th, 2013. The workshop brought together applied mathematicians, biologists, and clinicians actively working in the field of cancer immunology to share their current research and to increase awareness of the innovative mathematical tools that are applicable to the growing field of cancer immunology. Recent progress in cancer immunology and advances in immunotherapy suggest that the immune system plays a fundamental role in host defense against tumors and could be utilized to prevent or cure cancer. Although theoretical and experimental studies of tumor-immune system dynamics have a long history, there are still many unanswered questions about the mechanisms that govern the interaction between the immune system and a growing tumor. The multidimensional nature of these complex interactions requires a cross-disciplinary approach to capture more realistic dynamics of the essential biology. The papers presented in this volume explore these issues and the results will be of interest to graduate students and researchers in a variety of fields within mathematical and biological sciences.



Artificial Immune Systems

Artificial Immune Systems Author Peter Bentley
ISBN-10 9783540850717
Release 2008-07-25
Pages 436
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This book constitutes the refereed proceedings of the 7th International Conference on Artificial Immune Systems, ICARIS 2008, held in Phuket, Thailand, in August 2008. The 40 revised full papers presented were carefully reviewed and selected from 67 submissions. The papers are organized in topical sections on computational immunology, applied AIS, and theoretical AIS. Position papers and conceptual papers are also included.