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Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods

Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods Author
ISBN-10 9780128052419
Release 2016-08-24
Pages 212
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Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Written by authorities in their respective fields Targeted to a wide audience of researchers, specialists, and students



Structural and Mechanistic Enzymology

Structural and Mechanistic Enzymology Author
ISBN-10 9780123983183
Release 2012-10-22
Pages 472
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Both strategies for investigation (computational and experimental) in structural and mechanistic Enzymology have developed to some extent independently. However, over the last few years a trend has emerged for strengthening their integration. This combination not only brings together computations and experiments focused on the same enzymatic problems, but also provides complementary insights into the investigated properties and has a powerful synergy effect. This thematic volume of Advances in Protein Chemistry and Structural Biology focuses on the recent success in structural and mechanistic enzymology and has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches. The selected contributions demonstrate how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design. Focuses on the recent success in structural and mechanistic enzymology Has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches Demonstrates how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design



Comprehensive Medicinal Chemistry III

Comprehensive Medicinal Chemistry III Author
ISBN-10 9780128032015
Release 2017-06-03
Pages 4536
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Comprehensive Medicinal Chemistry III provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs



Computational Approaches to Protein Dynamics

Computational Approaches to Protein Dynamics Author Monika Fuxreiter
ISBN-10 9781482297867
Release 2014-12-24
Pages 479
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The Latest Developments on the Role of Dynamics in Protein Functions Computational Approaches to Protein Dynamics: From Quantum to Coarse-Grained Methods presents modern biomolecular computational techniques that address protein flexibility/dynamics at all levels of theory. An international contingent of leading researchers in chemistry, physics, and biology show how these advanced methods provide insights into dynamic aspects of biochemical processes. A particular focus is on intrinsically disordered proteins (IDPs), which lack a well-defined three-dimensional structure and function as dynamic ensembles. The book covers a wide spectrum of dynamics, from electronic structure-based to coarse-grained techniques via multiscaling at different levels. After an introduction to dynamics and historical overview of basic methodologies, the book addresses the following issues: Is there a quantitative relationship between enzymatic catalysis and protein dynamics? Which are the functionally relevant motions of proteins? How can structural properties and partner recognition mechanisms of IDPs be simulated? How can we speed up molecular dynamics? How can we describe conformational ensembles by the synergistic effort of computations and experiments? While dynamics is now considered essential for interpreting protein action, it is not yet an integral component in establishing structure–function relationships of proteins. Helping to reshape this classical view in biochemistry, this groundbreaking book explores advances in computational methodology and contributes to the new, ensemble way of studying proteins.



Computational Approaches for Studying Enzyme Mechanism

Computational Approaches for Studying Enzyme Mechanism Author
ISBN-10 9780128111086
Release 2016-08-03
Pages 514
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Computational Approaches for Studying Enzyme Mechanism, Part B is the first of two volumes in the Methods in Enzymology series that focuses on computational approaches for studying enzyme mechanism. The serial achieves the critically acclaimed gold standard of laboratory practices and remains one of the most highly respected publications in the molecular biosciences. Each volume is eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 550 volumes, the series remains a prominent and essential publication for researchers in all fields of the life sciences and biotechnology, including biochemistry, chemical biology, microbiology, synthetic biology, cancer research, genetics, and other fields of study. Focuses on computational approaches for studying enzyme mechanism Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in intermediate filament associated proteins, and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers



Scientific Report

Scientific Report Author Scripps Research Institute
ISBN-10 UOM:39015045484543
Release 2000
Pages
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Scientific Report has been writing in one form or another for most of life. You can find so many inspiration from Scientific Report also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Scientific Report book for free.



Structural and Mechanistic Enzymology

Structural and Mechanistic Enzymology Author
ISBN-10 9780128118771
Release 2017-07-17
Pages 366
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Structural and Mechanistic Enzymology, Volume 109, the latest release in the Advances in Protein Chemistry and Structural Biology series, is an essential resource for protein chemists. Chapters in this new volume include Collagenolytic Matrix Metalloproteinase Structure–Function Relationships: Insights from Molecular Dynamics Studies, Computational Glycobiology: Mechanistic Studies of Carbohydrate-Active Enzymes and Implication for Inhibitor Design, Computational Biochemistry─Enzyme Mechanisms Explored, and A Paradigm for C─H Bond Cleavage: Structural and Functional Aspects of Transition State Stabilization by Mandelate Racemase. This series presents new information on protocols and analysis of proteins, with each volume guest edited by leading experts in a broad range of protein-related topics. This volume presents state-of-the-art contributions, providing insights into the relationship between enzyme structure, catalysis, and function. Provides cutting-edge developments in protein chemistry and structural biology Features new information about protocols and analysis of proteins Contains chapters written by authorities in their respective fields Targeted to a wide audience of researchers, specialists and students



Handbook of Computational Chemistry

Handbook of Computational Chemistry Author Jerzy Leszczynski
ISBN-10 9789400707115
Release 2012-01-13
Pages 1430
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This handbook is a guide to current methods of computational chemistry, explaining their limitations and advantages and providing examples of their applications. The first part outlines methods, the balance of volumes present numerous important applications.



Scientific Report

Scientific Report Author
ISBN-10 NWU:35558004475766
Release 2000
Pages
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Scientific Report has been writing in one form or another for most of life. You can find so many inspiration from Scientific Report also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Scientific Report book for free.



Introduction to Protein Structure

Introduction to Protein Structure Author Carl-Ivar Brändén
ISBN-10 9780815323051
Release 1999
Pages 410
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This new edition gives an up-to-date account of the principles of protein structure, with examples of key proteins in their biological context, illustrated in colour to illuminate the structural principles described in the text.



Metalloproteins

Metalloproteins Author Art E. Cho
ISBN-10 9781439813195
Release 2015-04-17
Pages 294
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Numerous essential biological functions involve metalloproteins; therefore, understanding metalloproteins and how to manipulate them is significant in the biological and medical fields. An examination of current research, Metalloproteins: Theory, Calculations, and Experiments explores the interplay between theory and experiment, detailing the role of theoretical modeling in the field and explaining how it aids experiments. The text also presents the current state of computational protein modeling, enabling researchers to adopt computation as an integral component of their studies. This book addresses two different aspects on metalloproteins in unison. It reviews the development of theoretical and computational methods for metalloprotein simulation with specific examples. The authors also present some of the most intriguing and important experimental results on metalloprotein systems. Although a connection can be made between these two aspects of the research, the authors do not do so explicitly. Rather, they provide the platform required to ignite further collaboration between experimentalists and theoreticians. A collection of works from top researchers in this field, the text presents diverse subjects that comprehensively reflect the current state of metalloprotein research. With these advances in structural information, theory and computation are starting to play a more significant role, particularly in identifying the reaction mechanism. The book summarizes some of the recent progress in both experiments and theory/computation showing the synergy that is now developing.



NMR Spectroscopy and Computer Modeling of Carbohydrates

NMR Spectroscopy and Computer Modeling of Carbohydrates Author J. F. G. Vliegenthart
ISBN-10 0841239533
Release 2006
Pages 337
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Enormous progress has been made in the development of nuclear magnetic resonance (MNR) instruments and techniques during the past 10 years. The application of NMR to carbohydrates and related compounds has opened up a several new possibilities. The present day dissemination of NMR instruments renders it possible for a larger group of glyco-scientists to record and interpret their own NMR spectra. A review of the potency of the techniques in this field is therforeappropriate.



Structure and Mechanism in Protein Science

Structure and Mechanism in Protein Science Author Alan Fersht
ISBN-10 9789813225183
Release 2017-06-28
Pages 652
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This book is a guide for advanced undergraduates, post-graduates and researchers to the fundamental principles in studying kinetics and mechanism of processes concerning proteins. It provides a rare broad overview that concentrates on fundamental principles and understanding underlying the physics and chemistry. It is a single author text by someone who has direct experience in all of the areas covered.



Membrane Structural Biology

Membrane Structural Biology Author Mary Luckey
ISBN-10 9781107729339
Release 2014-02-24
Pages 400
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This textbook provides a strong foundation and a clear overview for students of membrane biology and an invaluable synthesis of cutting-edge research for working scientists. The text retains its clear and engaging style, providing a solid background in membrane biochemistry, while also incorporating the approaches of biophysics, genetics and cell biology to investigations of membrane structure, function and biogenesis to provide a unique overview of this fast-moving field. A wealth of new high resolution structures of membrane proteins are presented, including the Na/K pump and a receptor-G protein complex, offering exciting insights into how they function. All key tools of current membrane research are described, including detergents and model systems, bioinformatics, protein-folding methodology, crystallography and diffraction, and molecular modeling. This comprehensive and up-to-date text, emphasising the correlations between membrane research and human health, provides a solid foundation for all those working in this field.



The Dynamics of Enzymatic Reactions

The Dynamics of Enzymatic Reactions Author Lishan Yao
ISBN-10 MSU:31293028454290
Release 2006
Pages 568
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The Dynamics of Enzymatic Reactions has been writing in one form or another for most of life. You can find so many inspiration from The Dynamics of Enzymatic Reactions also informative, and entertaining. Click DOWNLOAD or Read Online button to get full The Dynamics of Enzymatic Reactions book for free.



Theoretical Biochemistry

Theoretical Biochemistry Author Leif A. Eriksson
ISBN-10 0080542700
Release 2001-02-19
Pages 720
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Theoretical chemistry has been an area of tremendous expansion and development over the past decade; from an approach where we were able to treat only a few atoms quantum mechanically or make fairly crude molecular dynamics simulations, into a discipline with an accuracy and predictive power that has rendered it an essential complementary tool to experiment in basically all areas of science. This volume gives a flavour of the types of problems in biochemistry that theoretical calculations can solve at present, and illustrates the tremendous predictive power these approaches possess. A wide range of computational approaches, from classical MD and Monte Carlo methods, via semi-empirical and DFT approaches on isolated model systems, to Car-Parinello QM-MD and novel hybrid QM/MM studies are covered. The systems investigated also cover a broad range; from membrane-bound proteins to various types of enzymatic reactions as well as inhibitor studies, cofactor properties, solvent effects, transcription and radiation damage to DNA.



Down Syndrome

Down Syndrome Author Mara Dierssen
ISBN-10 9780444542991
Release 2012
Pages 262
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Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist