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Intracellular Traffic and Neurodegenerative Disorders

Intracellular Traffic and Neurodegenerative Disorders Author Peter H. St.George-Hyslop
ISBN-10 9783540879411
Release 2009-02-03
Pages 184
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Many adult onset neurodegenerative diseases arise from the accumulation of misfolded peptides. This book examines the role sub-cellular trafficking pathways play in the pathological accumulation of these misfolded proteins and in attempts to clear them.



Neurodegenerative Disorders Loss of Function Through Gain of Function

Neurodegenerative Disorders  Loss of Function Through Gain of Function Author K. Beyreuther
ISBN-10 3540412182
Release 2001-03-13
Pages 189
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Neurodegenerative Disorders Loss of Function Through Gain of Function has been writing in one form or another for most of life. You can find so many inspiration from Neurodegenerative Disorders Loss of Function Through Gain of Function also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Neurodegenerative Disorders Loss of Function Through Gain of Function book for free.



Two Faces of Evil Cancer and Neurodegeneration

Two Faces of Evil  Cancer and Neurodegeneration Author Thomas Curran
ISBN-10 3642166024
Release 2010-12-16
Pages 166
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Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes



Fatal Attractions Protein Aggregates in Neurodegenerative Disorders

Fatal Attractions  Protein Aggregates in Neurodegenerative Disorders Author V.M.-Y. Lee
ISBN-10 3540671722
Release 2000-07-14
Pages 140
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Fatal Attractions Protein Aggregates in Neurodegenerative Disorders has been writing in one form or another for most of life. You can find so many inspiration from Fatal Attractions Protein Aggregates in Neurodegenerative Disorders also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Fatal Attractions Protein Aggregates in Neurodegenerative Disorders book for free.



Neurodegenerative Disorders

Neurodegenerative Disorders Author Orla Hardiman
ISBN-10 9783319233093
Release 2016-03-29
Pages 336
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This new edition provides an accessible guide to the commonest neurodegenerative diseases, outlining the main clinical features, treatment options and outcomes of the conditions most frequently encountered in clinical practice. Beginning with an overview of the general principles that underlie degeneration, and the contribution of established and new diagnostics techniques, the book goes on to describe the most common neurodegenerative conditions and, new for the second edition, also HIV dementia and multiple sclerosis. Final chapters cover important management issues including the use of palliative care strategies, biomarkers and neuropsychology. Written by experts in the field internationally Neurodegenerative Disorders, Second Edition is a practical guide for clinicians that will be indispensable for the management of these conditions.



Synaptic Plasticity and the Mechanism of Alzheimer s Disease

Synaptic Plasticity and the Mechanism of Alzheimer s Disease Author Dennis J. Selkoe
ISBN-10 3540763309
Release 2008-01-08
Pages 183
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A biochemical hypothesis - that Alzheimer’s disease (AD) is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies. This volume serves as a record focused on bringing together investigators at the forefront of elucidating the structure and function of hippocampal synapses with investigators focused on understanding how early assemblies of Ab may compromise some of these synapses.



Alzheimer 100 Years and Beyond

Alzheimer  100 Years and Beyond Author Mathias Jucker
ISBN-10 9783540376521
Release 2006-11-22
Pages 544
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Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in Tübingen. The celebratory event "Alzheimer 100 Years and Beyond" was organized through the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen. This volume, a collection of articles by the invited speakers and of a few other prominent researchers, is published as a record of those events.



Metal based Neurodegeneration

Metal based Neurodegeneration Author Robert Crichton
ISBN-10 9780470022566
Release 2006-05-01
Pages 238
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This exciting new book opens a window into the causes of debilitating neurological disorders such as Parkinson’s disease, CJD and Huntington’s disease, and gives indications of the prospects for therapy, based on the understanding of molecular defects involved in these diseases. Looking at each specific neurological disorder in turn, the book outlines the role of metals in human biology, in particular in the brain and explores tools for testing potential therapeutic strategies. It concludes with an overview of the potential of both chelation and antioxidant therapy and outlines some perspectives for the future.



Oxidative Energy Metabolism in Neurodegenerative Disorders

Oxidative Energy Metabolism in Neurodegenerative Disorders Author John Blass
ISBN-10 1573312096
Release 1999
Pages 443
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The topic of energy metabolism in diseases of the brain has re-emerged during the last few years as an area of intense scientific and medical interest. This book brings together basic and clinical investigators in an effort to move studies in this burgeoning area to a more basic mechanistic research level. Neurodegenerative disorders in which there is solid evidence of abnormalities in oxidative/energy metabolism include Alzheimer's disease, Parkinson's disease, Huntington's disease, and other early-onset hereditary disorders, as well as stroke. The authors show that specific neurodegenerative disorders are characterized by particular abnormalities, although within this group of disorders there are also common final paths of tissue damage.



RNA Metabolism in Neurodegenerative Diseases

RNA Metabolism in Neurodegenerative Diseases Author Rita Sattler
ISBN-10 3319896881
Release 2018-08-16
Pages 310
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It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes including transcription, pre--‐mRNA splicing, mRNA editing as well as mRNA stability, transport and translation. Dysfunction in any of these processes, often caused by mutations in the coding and non--‐ coding RNAs, can be very destructive to the cellular environment and consequently impair neural viability. The result of this RNA toxicity can lead to a toxic gain of function or a loss of function, depending on the nature of the mutation. For example, in repeat expansion disorders, such as the newly discovered hexanucleotide repeat expansion in theC9orf72 gene found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), a toxic gain of function leads to the formation of RNA foci and the sequestration of RNA binding proteins (RBPs). This in return leads to a loss of function of those RBPs, which is hypothesized to play a significant part in the disease progression of ALS and FTD. Other toxicities arising from repeat expansions are the formation of RNA foci, bi--‐directional transcription and production of repeat associated non--‐ATG (RAN) translation products. This book will touch upon most of these disease mechanisms triggered by aberrant RNA metabolism and will therefore provide a broad perspective of the role of RNA processing and its dysfunction in a variety of neurodegenerative disorders, including ALS, FTD, Alzheimer’s disease, Huntington’s disease, spinal muscular atrophy, myotonic dystrophy and ataxias. The proposed authors are leading scientists in the field and are expected to not only discuss their own work, but to be inclusive of historic as well as late breaking discoveries. The compiled chapters will therefore provide a unique collection of novel studies and hypotheses aimed to describe the consequences of altered RNA processing events and its newest molecular players and pathways.



Environmental Health Perspectives

Environmental Health Perspectives Author
ISBN-10 MINN:30000010711459
Release 1993
Pages
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Environmental Health Perspectives has been writing in one form or another for most of life. You can find so many inspiration from Environmental Health Perspectives also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Environmental Health Perspectives book for free.



The Benefits of Natural Products for Neurodegenerative Diseases

The Benefits of Natural Products for Neurodegenerative Diseases Author M. Mohamed Essa
ISBN-10 9783319283838
Release 2016-09-20
Pages 496
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Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.



Protein Trafficking in Neurons

Protein Trafficking in Neurons Author Andrew J. Bean
ISBN-10 0080465897
Release 2006-10-27
Pages 464
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The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking in Neurons examines mechanisms of protein trafficking and the role of trafficking in neuronal functioning from development to plasticity to disease. The book is divided into seven sections that review mechanisms of protein transport, the role of protein trafficking in synapse formation, exo- and endocytosis, transport of receptors, trafficking of ion channels and transporters, comparison of trafficking mechanisms in neuronal vs. non-neuronal cell types, and the relationship between trafficking and neuronal diseases such as Alzheimer's, Huntington's and Prion Diseases. Provides a comprehensive examination of membrane/protein movement in neuronal function Sections on synapse development, synaptic transmission, and the role of trafficking in neurological disease Includes a focus on Molecular Mechanisms Illustrated with color summary pictures The only book examining protein trafficking and its functional implications, written by leaders in the field



New Perspectives of Central Nervous System Injury and Neuroprotection

New Perspectives of Central Nervous System Injury and Neuroprotection Author
ISBN-10 9780123870162
Release 2012-10-22
Pages 424
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Central nervous system (CNS) diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis affect a large number of populations worldwide for which no suitable cure is currently available. In addition, stroke, nanoparticle intoxication, diabetes, hypertension, and psychostimulant abuse either alone or in combination are capable of inducing potential brain damage. Thus, there is an urgent need to expand our knowledge to find suitable therapeutic strategies to enhance neurorepair processes in such diseases. This volume presents neuroprotection and novel therapeutic strategies developed in the last 5 years by 12 world leaders in the field. The term neuroprotection means rescuing neuronal and non-neuronal cells together. The cerebral endothelium that constitutes the anatomical and physiological site of the blood-brain barrier (BBB) is one of the most important non-neural cells in the CNS. Any distortion of the BBB leads to brain diseases and restoration of the barrier results in neuroprotection. Thus, the BBB appears to be the "gateway" for neurological diseases and neurorepair. However, to treat brain tumors or infarcts, new therapeutic strategies are needed to enhance brain drug delivery using nanotechnology. In addition, apart from conventional drugs, restoration of BBB function could also be achieved by means of antibodies directed against specific proteins, neurotransmitters or exogenous supplement of neurotrophic factors. Since co-morbidity factors e.g., hypertension, diabetes, and exposure of nanoparticles could complicate the pathogenesis of neurological disorders either an enhanced dose of the drug or nanodelivery of a combination of several drugs is needed to achieve neuroprotection. This volume of International Review of Neurobiology is the first to discuss novel therapeutic strategies in situations of neurological disorders in combination with different co-morbidity factors. Reviews written by experts in such a way that provides basic knowledge for beginners and advanced information for researchers and experts New aspects of Neurodegenerative diseases such as; Alzheimer’s Disease, Parkinson’s Disease, Amyotrophic Lateral Sclerosis are presented with the latest therapeutic measures Exacerbation of brain pathology in hypertension or diabetes is discussed for the first time



The Biology of Alzheimer Disease

The Biology of Alzheimer Disease Author Dennis J. Selkoe
ISBN-10 1936113449
Release 2012
Pages 511
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Alzheimer Disease represents an important area of research in neurobiology, cell biology, developmental biology and pathology. Understanding the nature of the changes that occur in neurons as the disease progresses — accumulation of amyloid beta and neurofibrillary tangles — is obviously important as we try to develop therapeutic approaches. Moreover, the normal physiological roles of proteins such as APP and tau, whose processing appears to be altered in Alzheimer Disease, is also an intense area of research.



Basic Neurochemistry

Basic Neurochemistry Author Scott T. Brady
ISBN-10 9780123749475
Release 2012
Pages 1096
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Includes bibliographical references and index.



Genes Environment and Alzheimer s Disease

Genes  Environment and Alzheimer s Disease Author Orly Lazarov
ISBN-10 9780128028858
Release 2016-02-25
Pages 448
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Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease. Provides the first volume to link genetic and environmental risk factors for Alzheimer’s disease and dementia Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer’s disease and cognitive decline Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists