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Kidney Development Disease Repair and Regeneration

Kidney Development  Disease  Repair and Regeneration Author Melissa Helen Little
ISBN-10 9780128004388
Release 2015-08-06
Pages 614
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Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally Explains the underlying developmental mechanisms which influence the kidney’s inherent repair capacity Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine



Regenerative Nephrology

Regenerative Nephrology Author Michael S. Goligorsky
ISBN-10 0123809290
Release 2010-11-26
Pages 442
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Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts. Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney



Kidney Development and Disease

Kidney Development and Disease Author Rachel K. Miller
ISBN-10 9783319514369
Release 2017-04-13
Pages 373
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Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes. Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes.



Zebrafish at the Interface of Development and Disease Research

Zebrafish at the Interface of Development and Disease Research Author
ISBN-10 9780128033432
Release 2017-03-21
Pages 384
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There are many shared pathways that govern development and also can contribute to disease. Zebrafish have traditionally been used to study vertebrate development, and from decades of work in this system, we have learned details about developmental processes, genes and pathways that are implicated in disease. In each chapter of this book, we interweave how studying zebrafish development has informed our understanding of diseases from the immune system, to the kidney, liver, heart and others. The subject matter is unique - no single volume has pulled together the theme of development and disease with zebrafish as a centerpiece Leading experts in the field - all of them running zebrafish focused labs for each chapter



Essays on Developmental Biology

Essays on Developmental Biology Author Paul M Wassarman
ISBN-10 9780128016169
Release 2016-03-10
Pages 734
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In 2016 Current Topics in Developmental Biology (CTDB) will celebrate its 50th or “golden anniversary. To commemorate the founding of CTDB by Aron Moscona (1921-2009) and Alberto Monroy (1913-1986) in 1966, a two-volume set of CTDB (volumes 116 and 117), entitled Essays on Development, will be published by Academic Press/Elsevier in early 2016. The volumes are edited by Paul M. Wassarman, series editor of CTDB, and include contributions from dozens of outstanding developmental biologists from around the world. Overall, the essays provide critical reviews and discussion of developmental processes for a variety of model organisms. Many essays relate the history of a particular area of research, others personal experiences in research, and some are quite philosophical. Essays on Development provides a window onto the rich landscape of contemporary research in developmental biology and should be useful to both students and investigators for years to come. Covers the area of developmental processes for a variety of model organisms International board of authors Part of two 50th Anniversary volumes proving a comprehensive set of reviews edited by Serial Editor Paul M. Wassarman



Kidney Transplantation Bioengineering and Regeneration

Kidney Transplantation  Bioengineering  and Regeneration Author Giuseppe Orlando
ISBN-10 9780128018361
Release 2017-06-08
Pages 1252
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Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement. In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney. Focuses on the synergy between renal organ transplantation and regenerative medicine, highlighting the advances within transplantation, bioengineering, regeneration, and repair Educates the transplant community on important regenerative medicine research pertinent to kidney transplantation Develops a shared language for clinicians, surgeons, and basic researchers to reach across the fields of transplantation and regenerative medicine, and facilitate more productive investigation and research Catalogs the technologies being developed and methods being implemented to bioengineer or regenerate kidneys to restore function



Stem Cells Tissue Engineering and Regenerative Medicine

Stem Cells  Tissue Engineering and Regenerative Medicine Author David Warburton
ISBN-10 9789814612791
Release 2014-12-15
Pages 552
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Stem cells, tissue engineering and regenerative medicine are fast moving fields with vastly transformative implications for the future of health care and capital markets. This book will show the state of the art in the translational fields of stem cell biology, tissue engineering and regenerative medicine. The state of developments in specific organ systems, where novel solutions to organ failure are badly needed such as the lungs, kidney and so forth, are discussed in various chapters. These present and future advances are placed in the context of the overall field, offering a comprehensive and quick up-to-date drink from the fountain of knowledge in this rapidly emerging field. This book provides an investigator-level overview of the current field accessible to the educated scientific generalist as well as a college educated readership, undergraduates and science writers, educators and professionals of all kinds. Contents:Developmental Biology, Regenerative Medicine and Stem Cells: The Hope Machine is Justified (David Warburton)Towards Broader Approaches to Stem Cell Signaling and Therapeutics (Edwin Jesudason)Pluripotent Stem Cells from the Early Embryo (Claire E Cuddy and Martin F Pera)The First Cell Fate Decision During Mammalian Development (Melanie D White and Nicolas Plachta)Asymmetric Cell Divisions of Stem/Progenitor Cells (Ahmed HK El-Hashash)Microenvironmental Modulation of Stem Cell Differentiation with Focus on the Lung (Shimon Lecht, Collin T Stabler, Seda Karamil, Athanasios Mantalaris, Ali Samadikuchaksaraei, Julia M Polak and Peter I Lelkes)Smart Matrices for Distal Lung Tissue Engineering (Mark J Mondrinos and Peter I Lelkes)Skin Stem Cells and Their Roles in Skin Regeneration and Disorders (Chao-Kai Hsu, Chao-Chun Yang and Shyh-Jou Shieh)Stem Cell Recruitment and Impact in Skin Repair and Regeneration (Tim Hsu, Tai-Lan Tuan and Yun-Shain Lee)Epigenetic and Environmental Regulation of Skin Appendage Regeneration (Ting-Xin Jiang, Chih-Chiang Chen, Michael W Hughes, Cheng-Ming Chuong and Randall Widelitz)Cranial Neural Crest: An Extraordinarily Migratory and Multipotent Embryonic Cell Population (Samuel G Cox and J Gage Crump)Modeling Neurodegenerative Diseases and Neurodevelopmental Disorders with Reprogrammed Cells (Kate E Galloway and Justin K Ichida)Cytokine Regulation of Intestinal Stem Cells (Philip E Dubé, Unice J K Soh and D Brent Polk)The Intestinal Stem Cell Niche and Its Regulation by ErbB Growth Factor Receptors (Dana Almohazey and Mark R Frey)Tissue Engineering: Intestine (Avafia Y Dossa, Kathy A Schall, Tracy C Grikscheit and Christopher P Gayer)Liver Stem and Progenitor Cells in Development, Disease and Regenerative Medicine (Nirmala Mavila and Kasper S Wang)Lung Mesenchymal Stem Cells (Wei Shi)FGF Signaling in Lung Stem and Progenitor Cells (Soula Danopoulos and Denise Al Alam)Bioengineering Distal Airways (Christine Finck and Todd Jensen)The Isolation and Molecular Characterization of Cancer Stem Cells (Aggressive Endophenotypes) in Individual Lung Cancers (Raj K Batra, Scott Oh and Saroj Basak)Mesenchymal Stromal Cell-Based Therapies for Lung Diseases and Critical Illnesses (Fernanda Cruz, Patricia RM Rocco and Daniel J Weiss)Heart Regeneration and Repair: What We Have Learned from Model Organisms (Laurent Gamba, Michael R Harrison and Ching-Ling Lien)Leveraging Structure-Based Rational Drug Design and Nanotechnology to Destroy Leukemic Stem Cells (Fatih M Uckun, Jianjun Cheng, Cheney Mao and Sanjive Qazi)Placenta-Derived Stem Cells: Development and Preclinical Applications for Regenerative Medicine (Jennifer Izumi Divine, Hee Kyung Jung and Toshio Miki)Stem Cells in the Real World: Environmental Impacts (Theresa M Bastain, Lu Gao and Frank D Gilliland)Establishing a Research Grade Human Pluripotent Stem Cell Laboratory (Laura-Marie Nucho and Victoria Fox) Readership: Stem cell and tissue engineering scientists, patient advocates, educated laypeople, high school science students, undergraduate students, graduate students, physicians and surgeons. Key Features:This book presents up-to-date latest breakthroughs and near future applicationsBench to bedsideThis book features potential curesKeywords:Stem Cells;Tissue Engineering;Regenerative Medicine



Electrospinning for Tissue Regeneration

Electrospinning for Tissue Regeneration Author L Bosworth
ISBN-10 9780857092915
Release 2011-06-21
Pages 424
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Electrospinning is a simple and highly versatile method for generating ultrathin fibres with diameters ranging from a few micrometres to tens of nanometres. Although most commonly associated with textile manufacturing, recent research has proved that the electrospinning technology can be used to create organ components and repair damaged tissues. Electrospinning for tissue regeneration provides a comprehensive overview of this innovative approach to tissue repair and regeneration and examines how it is being employed within the biomaterials sector. The book opens with an introduction to the fundamentals of electrospinning. Chapters go on to discuss polymer chemistry, the electrospinning process, conditions, control and regulatory issues. Part two focuses specifically on electrospinning for tissue regeneration and investigates its uses in bone, cartilage, muscle, tendon, nerve, heart valve, bladder, tracheal, dental and skin tissue regeneration before concluding with a chapter on wound dressings. Part three explores electrospinning for in vitro applications. Chapters discuss cell culture systems for kidney, pancreatic and stem cell research. With its distinguished editors and international team of expert contributors, Electrospinning for tissue regeneration is a valuable reference tool for those in academia and industry concerned with research and development in the field of tissue repair and regeneration. Provides a comprehensive overview of this innovative approach to tissue repair and regeneration covering issues from polymer chemistry to the regulatory process Examines employment within the biomaterials sector, reviewing extensive applications in areas such as uses in bone, muscle tendon, heart valve and tissue regeneration Explores electrospinning for in vitro applications and discusses cell culture systems for kidney, pancreatic and stem cell research



Factors Influencing Mammalian Kidney Development Implications for Health in Adult Life

Factors Influencing Mammalian Kidney Development  Implications for Health in Adult Life Author Karen Moritz
ISBN-10 3540777687
Release 2008-05-11
Pages 79
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In this monograph the authors have emphasized a number of important concepts in mammalian kidney development. Emphasis has been put on methodology so that the reader can understand how certain results or conclusions were reached and what the optimal methods for reliable results to be obtained are. In addition, as well as descriptions of the morphology there is information on the genetic basis of the structural development. In addition much attention has been paid to how nephron number may be altered by changes in the environment of the developing kidney and to the consequences for the remaining nephron gene expression and kidney function when total nephron number is altered. The consequences for the health of the adult, upon the formation of an adult kidney with altered nephron number and (potentially) gene expression, can be quite serious. The epigenetic mechanisms by which such changes can occur are introduced as a very fertile field for future investigation.



Principles of Tissue Engineering

Principles of Tissue Engineering Author Robert Lanza
ISBN-10 9780123983701
Release 2013-10-17
Pages 1936
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Now in its fourth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fourth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system. As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material science, and engineering, among others, while also emphasizing those research areas that are likely to be of clinical value in the future. This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and other emerging technologies –such as brain-machine interfaces for controlling bionics and neuroprostheses– is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the application of tissue-engineering techniques for food production. The result is a comprehensive textbook that will be useful to students and experts alike. Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves Offers expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems Full-color presentation throughout



Regenerative Biology and Medicine

Regenerative Biology and Medicine Author David L. Stocum
ISBN-10 9780123848611
Release 2012-06-07
Pages 474
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Regenerative Biology and Medicine, Second Edition — Winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — discusses the fundamentals of regenerative biology and medicine. It provides a comprehensive overview, which integrates old and new data into an ever-clearer global picture. The book is organized into three parts. Part I discusses the mechanisms and the basic biology of regeneration, while Part II deals with the strategies of regenerative medicine developed for restoring tissue, organ, and appendage structures. Part III reflects on the achievements of regenerative biology and medicine; future challenges; bioethical issues that need to be addressed; and the most promising developments in regenerative medicine. The book is designed for multiple audiences: undergraduate students, graduate students, medical students and postdoctoral fellows, and research investigators interested in an overall synthesis of this field. It will also appeal to investigators from fields not directly related to regenerative biology and medicine, such as chemistry, informatics, computer science, mathematics, physics, and engineering. Highly Commended 2013 BMA Medical Book Award for Medicine Includes coverage of skin, hair, teeth, cornea, and central neural tissues Provides description of regenetive medicine in digestive, respiratory, urogenital, musculoskeletal, and cardiovascular systems Includes amphibians as powerful research models with discussion of appendage regeneration in amphibians and mammals



Regenerative Medicine Applications in Organ Transplantation

Regenerative Medicine Applications in Organ Transplantation Author Giuseppe Orlando
ISBN-10 9780123985200
Release 2013-10-11
Pages 1050
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Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results. Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration Explains the importance and future potential of regenerative medicine to the transplant community Illustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions



Principles of Regenerative Medicine

Principles of Regenerative Medicine Author Anthony Atala
ISBN-10 0080555950
Release 2011-04-28
Pages 1472
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Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. * Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology * The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine * New discoveries from leading researchers on restoration of diseased tissues and organs



Resident Stem Cells and Regenerative Therapy

Resident Stem Cells and Regenerative Therapy Author Regina Coeli dos Santos Goldenberg
ISBN-10 9780124160125
Release 2012
Pages 270
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In the last 3 decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures. This book will present the main findings to date and the important factors to be considered when considering resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin, and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate. Highlights basic research in tissue specific stem cells, experiments with animal models and clinical trials that are transforming the field of regeneration Provides a clear understanding of endogenous stem cells, their role in current regenerative therapies, and prospects for future research Reports on the main-stream clinical approaches and in vivo experiments published in primary literature to help categorizes the advances in various aspects of regenerative therapy and illustrate opportunities for clinical applications



Translational Regenerative Medicine

Translational Regenerative Medicine Author Anthony Atala
ISBN-10 9780124104570
Release 2014-12-01
Pages 606
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Translational Regenerative Medicine is a reference book that outlines the life cycle for effective implementation of discoveries in the dynamic field of regenerative medicine. By addressing science, technology, development, regulatory, manufacturing, intellectual property, investment, financial, and clinical aspects of the field, this work takes a holistic look at the translation of science and disseminates knowledge for practical use of regenerative medicine tools, therapeutics, and diagnostics. Incorporating contributions from leaders in the fields of translational science across academia, industry, and government, this book establishes a more fluid transition for rapid translation of research to enhance human health and well-being. Provides formulaic coverage of the landscape, process development, manufacturing, challenges, evaluation, and regulatory aspects of the most promising regenerative medicine clinical applications Covers clinical aspects of regenerative medicine related to skin, cartilage, tendons, ligaments, joints, bone, fat, muscle, vascular system, hematopoietic /immune system, peripheral nerve, central nervous system, endocrine system, ophthalmic system, auditory system, oral system, respiratory system, cardiac system, renal system, hepatic system, gastrointestinal system, genitourinary system Identifies effective, proven tools and metrics to identify and pursue clinical and commercial regenerative medicine



Rang Dale s Pharmacology

Rang   Dale s Pharmacology Author Humphrey P. Rang
ISBN-10 9780702045042
Release 2011-04-14
Pages 792
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Rang & Dale’s Pharmacology provides you with all the knowledge you need to get through your pharmacology course and beyond. Drs. Humphrey P. Rang, Maureen M. Dale, James M. Ritter, Rod Flower, and Graeme Henderson present a clear and accessible approach to the analysis of therapeutic agents at the cellular and molecular level through detailed diagrams, full-color illustrations, and pedagogical features. Find and cross-reference information quickly using a color-coded layout that makes navigation easy. Effectively understand and review key concepts through detailed diagrams and full-color illustrations that clarify even the most complex concepts. Reinforce your learning with key points boxes and clinical uses boxes that highlight crucial information and clinical applications. Apply current best practices and clinical applications through thoroughly updated and revised drug information. Stay current with the latest developments in the field thanks to major updates in chapters such as How Drugs Act; Amino Acid Transmitters; Analgesic Drugs; Antidepressant Drugs; and Drug Addiction, Dependence & Abuse. Tap into comprehensive content tailored to your courses with new and reorganized chapters on Host Defense; Inflammatory Mediators; Pharmacogenetics, Pharmacogenomics & Personalized Medicine; Hydroxytoptomine & The Pharmacy of Migraine; and Purines.



Pancreas Kidney and Skin Regeneration

Pancreas  Kidney and Skin Regeneration Author Phuc Van Pham
ISBN-10 9783319556871
Release 2017-06-13
Pages 326
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This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in diabetes, kidney and wound treatment. All chapters are contributed by pre-eminent scientists in the field and covers such topics as stem cells and cell therapy in the treatment of diabetes mellitus, kidney failure, wound and other skin aging diseases, characteristics of some kinds of stem/progenitor cells for therapy, future directions of the discussed therapies and much more. Pancreas, Kidney and Skin Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.