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Liposomes in Analytical Methodologies

Liposomes in Analytical Methodologies Author Katie A. Edwards
ISBN-10 9789814669276
Release 2016-03-30
Pages 480
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Liposomes have been widely explored in the drug delivery realm over the past decades. Many of the properties that made them well suited for drug delivery applications, such as the internal space to encapsulate a large payload of molecules and the inherent protection from exterior stresses, have also been exploited in various analytical techniques. Liposomes in Analytical Methodologies provides an extensive coverage of their utility, ranging from historic developments to actively researched techniques written by expert investigators. The introductory chapter serves as a primer on the fundamentals of liposomes for analytical purposes and provides an overview of various applications, while subsequent chapters provide in-depth coverage of selected areas. With techniques ranging from liposome PCR to electrophoretic separations, readers will gain an appreciation for the versatility that liposomes can add to the analytical toolbox.



Analytical Methods in Supramolecular Chemistry

Analytical Methods in Supramolecular Chemistry Author Christoph A. Schalley
ISBN-10 9783527329823
Release 2012
Pages 369
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Analytical Methods in Supramolecular Chemistry has been writing in one form or another for most of life. You can find so many inspiration from Analytical Methods in Supramolecular Chemistry also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Analytical Methods in Supramolecular Chemistry book for free.



Liposome Technology

Liposome Technology Author Gregory Gregoriadis
ISBN-10 084939726X
Release 2016-04-19
Pages 324
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Liposome Technology, Volume I: Liposome Preparation and Related Techniques, Third Edition, is a thoroughly updated and expanded new edition of a classic text in the field. Including step-by-step technical details, Volume I illustrates numerous methods for liposome preparation and auxiliary techniques necessary for the stabilization and characterization of liposomes. This source also offers critical discussions of the methodologies of each technology described so that readers can examine the benefits and limitations and compare it to other approaches.



Antisense Drug Technology

Antisense Drug Technology Author Stanley T. Crooke
ISBN-10 9780849387951
Release 2007-07-25
Pages 848
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Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generation drugs, the book evaluates the technology as a whole and offers new directions and avenues of research and development. Divided into five parts, the book begins with a thorough introduction to the mechanism of antisense drug action including the RNase H mechanism, small RNA silencing pathways, and the potential therapeutics of splice switching oligonucleotides. Leading researchers demonstrate the basics of oligonucleotide therapeutics in part two by delineating medicinal chemistry, pharmacokinetics, and delivery routes such as liposomal formulations for nucleic acid delivery. Part three details hybridization based drugs and considers the dramatic advances represented by 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA drugs. Other chemical classes of drugs and mechanisms of action are described in part four with further discussions on improving the second generation antisense drugs. The final part delves deeply into therapeutic applications. Contributing authors examine the potential of antisense drugs for the alleviation of cardiovascular diseases, metabolic diseases, inflammatory diseases, cancer, neurological disorders, and immune modulation. Presenting a highly detailed, lucid discussion of the remarkable advances in the field, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition provides the platform for researchers to continue to aggressively pursue the great opportunity represented by this exciting technology.



Liposome Technology

Liposome Technology Author Gregory Gregoriadis
ISBN-10 UOM:39015064793089
Release 2007
Pages 324
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A thoroughly updated and expanded new edition of a classic text in the field. Including step-by-step technical details, Volume I illustrates numerous methods for liposome preparation and auxiliary techniques necessary for the stabilization and characterization of liposomes. Volume II describes procedures for the incorporation of drugs and other materials into liposomes for a variety therapeutics, chosen because of their relevance to current trends in liposome applications or because they represent groups of active pharmaceutical ingredients with similar physical and chemical properties. Volume III describes technologies for yielding liposomes that can function in a targeted fashion, and highlights methods for studying the interaction of liposomes within the biological environment to be applied in the detection, therapy, or prevention of disease. This source also offers critical discussions of the methodologies of each technology described so that readers can examine the benef.



Chromatographic Methods in Metabolomics

Chromatographic Methods in Metabolomics Author Tuulia Hyotylainen
ISBN-10 9781849737272
Release 2013-09-06
Pages 350
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The concept of a metabolic profile was introduced in 1971, when gas chromatography demonstrated a range of compounds present in human samples. Now termed metabolomics, the field is still emerging, and chromatography remains an essential tool for determining metabolites in a living system. This is the first book to present the chromatographic techniques used in metabolomics in a fundamental way. Sample preparation and quality control are described in detail, and all forms of chromatography applied to metabolomics are included. The editors present guidelines on selecting the most appropriate methodology, making the book an accessible guide to anyone entering the field. Handling data and applications are also described. This is an essential handbook for any laboratory looking to embark on a metabolomics research programme and includes the fundamentals of chromatography alongside the latest developments in the field.



Lipidomics and Bioactive Lipids Specialized Analytical Methods and Lipids in Disease

Lipidomics and Bioactive Lipids  Specialized Analytical Methods and Lipids in Disease Author
ISBN-10 0080560652
Release 2007-11-09
Pages 296
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This volume in the well-established Methods in Enzymology series features methods for the study of lipids using mass spectrometry techniques. Articles in this volume cover topics such as Liquid chromatography mass spectrometry for quantifying plasma lysophospholipids: potential biomarkers for cancer diagnosis; Measurement of eicosanoids in cancer tissues; Noninvasive Assessment of the Role of Cyclooxygenases in Cardiovascular Health A Detailed HPLC/MS/MS Method; Lipidomics in Diabetes and the Metabolic Syndrome; LC-MS-MS Analysis of Neutral Eicosanoids; Quantification Of F2-Isoprostanes In Biological Fluids And Tissues As A Measure Of Oxidant Stress; Measurement of Products of Docosahexaenoic Acid Peroxidation, Neuroprostanes, and Neurofurans; Enantiomeric separation of hydroxy and hydroperoxy eicosanoids by chiral column chromatography; Targeted Chiral Lipidomics Analysis by Liquid Chromatography Electron Capture Atmospheric Pressure Chemical Ionization Mass Spectrometry (LC-ECAPCI/MS); Shotgun Lipidomics by Tandem Mass Spectrometry under Data-Dependent Acquisition Control; Identification of Intact Lipid Peroxides by Ag+ Coordination Ionspray Mass Spectrometry (CIS-MS); Quantification of Cardiolipin by Liquid Chromatography Electrospray Ionization Mass Spectrometry.



Liposomes

Liposomes Author Volkmar Weissig
ISBN-10 STANFORD:36105131253705
Release 2010
Pages
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Liposomes has been writing in one form or another for most of life. You can find so many inspiration from Liposomes also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Liposomes book for free.



Analytical Techniques in the Pharmaceutical Sciences

Analytical Techniques in the Pharmaceutical Sciences Author Anette Müllertz
ISBN-10 9781493940295
Release 2016-08-30
Pages 838
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The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood--from the characteristics of the individual formulation components, to how they act and interact within the formulation, and finally, to how this formulation responds in different biological environments. To achieve this, there is a wide range of analytical techniques that can be adopted to understand and elucidate the mechanics of drug delivery and drug formulation. Such methods include e.g. spectroscopic analysis, diffractometric analysis, thermal investigations, surface analytical techniques, particle size analysis, rheological techniques, methods to characterize drug stability and release, and biological analysis in appropriate cell and animal models. Whilst each of these methods can encompass a full research area in their own right, formulation scientists must be able to effectively apply these methods to the delivery system they are considering. The information in this book is designed to support researchers in their ability to fully characterize and analyze a range of delivery systems, using an appropriate selection of analytical techniques. Due to its consideration of regulatory approval, this book will also be suitable for industrial researchers both at early stage up to pre-clinical research.



PARTITIONING OF AN HOMOLOGOUS SERIES OF ALKYL P AMINOBENZOATES WITHIN LIPOSOMES

PARTITIONING OF AN HOMOLOGOUS SERIES OF ALKYL P AMINOBENZOATES WITHIN LIPOSOMES Author LYOU-FU MA
ISBN-10 UOM:39015022077948
Release 1990
Pages 224
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the bilayer.



LIPOSOMES AS A POTENTIAL ORAL DRUG DELIVERY SYSTEM

LIPOSOMES AS A POTENTIAL ORAL DRUG DELIVERY SYSTEM Author Chia-Ming Chiang
ISBN-10 UOM:39015032289954
Release 1986
Pages 153
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consensus as to either the stability of liposomes in the gastrointestinal tract or the mechanism by which liposomal incorporation may increase drug absorption after oral administration.



Development of a liposome immunomigration strip assay for the determination of potato glycoalkaloids

Development of a liposome immunomigration strip assay for the determination of potato glycoalkaloids Author Patricia Glorio Paulet
ISBN-10 CORNELL:31924076529084
Release 1997
Pages 286
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Development of a liposome immunomigration strip assay for the determination of potato glycoalkaloids has been writing in one form or another for most of life. You can find so many inspiration from Development of a liposome immunomigration strip assay for the determination of potato glycoalkaloids also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Development of a liposome immunomigration strip assay for the determination of potato glycoalkaloids book for free.



Non Biological Complex Drugs

Non Biological Complex Drugs Author Daan J.A. Crommelin
ISBN-10 9783319162416
Release 2015-06-24
Pages 390
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The rise of bio- and nano-technology in the last decades has led to the emergence of a new and unique type of medicine known as non-biological complex drugs (NBCDs). This book illustrates the challenges associated with NBCD development, as well as the complexity of assessing the effects of manufacturing changes on innovator and follow-on batches of NBCDs. It also touches upon proven marketing authorization requirements for biosimilars that could be effective in evaluating follow-on NBCDs, including a demonstration of control over the manufacturing process and a need for detailed physico-chemical characterization and (pre)clinical tests. This book is meant to be used for years to come as a standard reference work for the development of NBCDs. Moreover, this book aims to stimulate discussions and further our thinking to ensure that decisions regarding the approval of complex drugs are made with relevant scientific data on the table.



Journal of Planar Chromatography modern TLC

Journal of Planar Chromatography  modern TLC Author
ISBN-10 PSU:000014181108
Release 1992
Pages
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Journal of Planar Chromatography modern TLC has been writing in one form or another for most of life. You can find so many inspiration from Journal of Planar Chromatography modern TLC also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Journal of Planar Chromatography modern TLC book for free.



The development of a sequential injection analysis system for the detection of RNA and optimization of liposomes used as analytical amplification systems

The development of a sequential injection analysis system for the detection of RNA and optimization of liposomes used as analytical amplification systems Author Katie Anne Edwards
ISBN-10 CORNELL:31924102824079
Release 2005
Pages 594
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The development of a sequential injection analysis system for the detection of RNA and optimization of liposomes used as analytical amplification systems has been writing in one form or another for most of life. You can find so many inspiration from The development of a sequential injection analysis system for the detection of RNA and optimization of liposomes used as analytical amplification systems also informative, and entertaining. Click DOWNLOAD or Read Online button to get full The development of a sequential injection analysis system for the detection of RNA and optimization of liposomes used as analytical amplification systems book for free.



Liposome Methods and Protocols

Liposome Methods and Protocols Author Subhash C. Basu
ISBN-10 9781592591756
Release 2002
Pages 264
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In vitro utilization of liposomes holds great potential as a powerful tool for drug targeting, gene transport across plasma and nuclear membranes, and enzyme therapy for patients with genetic disorders. In Liposome Methods and Protocols, a panel of skilled researchers describes in step-by-step detail their best laboratory techniques for elucidating liposome biology and realizing this promise. With these readily reproducible methods, investigators can illuminate such critical questions as the attachment of liposomes to cell surfaces, the permeation of liposomes through the plasma membranes, and the stability of liposomes in cellular and nuclear matrices. Each detailed protocol is presented by an investigator who is intimately familiar with its problems and capabilities, and includes a detailed list of materials to be used, troubleshooting tips straight from the benchtop, and notes on pitfalls to avoid. The emphasis is on clearly presenting the technical steps critical to experimental success that are too often omitted from methods published in the primary literature. State-of-the-art and highly practical, Liposome Methods and Protocols provides an indispensable collection of proven techniques and references for researchers across many fields, including glycoproteins, glycolipids, glycosyltransferases, drug transport, viral transport, antibody delivery, synthetic peptide delivery to cells, and protease delivery.



Lipidomics and Bioactive Lipids Mass Spectrometry Based Lipid Analysis

Lipidomics and Bioactive Lipids  Mass Spectrometry Based Lipid Analysis Author
ISBN-10 0080554881
Release 2007-11-26
Pages 432
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This volume in the well-established Methods in Enzymology series features methods for the study of lipids using mass spectrometry techniques. Articles in this volume cover topics such as Qualitative Analysis and Quantitative Assessment of Changes in Neutral Glycerol Lipid Molecular Species within Cells; Glycerophospholipid identification and quantitation by electrospray ionization mass spectrometry; Detection and Quantitation of Eicosanoids via High Performance Liquid Chromatography/Electrospray Ionization Mass Spectrometry; Structure-specific, quantitative methods for "lipidomic" analysis of sphingolipids by tandem mass spectrometry; Analysis of Ubiquinones, Dolichols and Dolichol Diphosphate-Oligosaccharides by Liquid Chromatography Electrospray Ionization Mass Spectrometry; Extraction and Analysis of Sterols in Biological Matrices by High-Performance Liquid Chromatography Electrospray Ionization Mass Spectrometry; The Lipid Maps Initiative in Lipidomics; Basic analytical systems for lipidomics by mass spectrometry in Japan; The European Lipidomics Initiative Enabling technologies; Lipidomic analysis of Signaling Pathways; Bioinformatics for Lipidomics; Mediator Lipidomics: Search Algorithms for Eicosanoids, Resolvins and Protectins; A guide to biochemical systems modeling of sphingolipids for the biochemist; and Quantitation and Standardization of Lipid Internal Standards for Mass Spectroscopy.