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MACPF CDC Proteins Agents of Defence Attack and Invasion

MACPF CDC Proteins   Agents of Defence  Attack and Invasion Author Gregor Anderluh
ISBN-10 9789401788816
Release 2014-05-05
Pages 329
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This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques. The focus is on the MACPF/CDC protein super family that was originally discovered because of unexpected structural similarity between a domain present in bacterial cholesterol-dependent cytolysins (CDC) and proteins of the membrane attack complex/perforin (MACPF) family. Members of the MACPF/CDC super family are crucial for many biological processes, being efficient agents of development, defence, attack and invasion of cells and tissues. However, their best-known role is in bacterial pathogenesis and the proper functioning of the vertebrate immune system, via formation of transmembrane pores in target cell membranes. The book contains chapters on the distribution of MACPF/CDC proteins and on aspects of their evolution and structural properties, the similarities between different super family members and functional properties of some of the best known examples. The book also contains an overview of biophysical approaches that may be used in the future to provide further insights into how these interesting proteins function.

Electrophysiology of Unconventional Channels and Pores

Electrophysiology of Unconventional Channels and Pores Author Anne H Delcour
ISBN-10 9783319201498
Release 2015-10-23
Pages 385
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This book is dedicated to the channels and pores that belong to an eclectic and ubiquitous class of unconventional - perhaps at times strange - pore-forming molecules, which nevertheless play fundamental roles in various organisms. These non-canonical channels may take on various and sometimes complex architectures, such as large beta-barrels or lipid-containing pores. They may originate from bacteria, viruses or intracellular organelles. For some of them, the physiologically relevant substrate may indeed be ions, and for others folded polypeptides. Some are released by cells in a soluble form that has the ability to insert into biological membranes to exert its permeabilizing effect. Many of these unconventional pores have been investigated by electrophysiology, which, by its virtue of focusing on a few or even a single unit, has provided invaluable insight into the mechanisms and structure-function relationships of these remarkable membrane entities. The chapters of this book highlight a representative set of these interesting investigations.

Membrane Protein Complexes Structure and Function

Membrane Protein Complexes  Structure and Function Author J. Robin Harris
ISBN-10 9789811077579
Release 2018-02-20
Pages 459
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This edited book contains a compilation of 14 advanced academic chapters dealing with the structure and function of membrane protein complexes. This rapidly advancing important field of study closely parallels those on soluble protein complexes, and viral protein and nucleoprotein complexes. Diverse topics are included in this book, ranging from membrane–bound enzymes to ion channels, proton pumps and photosystems. Data from X-ray crystallography, cryo-electron microscopy and other biophysical and biochemical techniques are presented throughout the book. There is extensive use of colour figures of protein structures. Throughout the book structure and function are closely correlated. The two editors, Egbert Boekema and J. Robin Harris, have worked on aspects of membrane and soluble proteins throughout their scientific careers and also have much publishing experience. The Subcellular Biochemistry series has expanded considerably in recent years, including several related volumes. The theme of protein complexes will be continued within several future volumes, thereby creating encyclopaedic coverage. The chapter topics within this book are particularly relevant to those involved in the biological and biomedical sciences. It is aimed at the advanced undergraduates, postgraduates and established researchers within this broad field. It is hoped that the book will be of interest and use to those involved with the study of cellular membranes and their associated proteins.

Skin and Arthropod Vectors

Skin and Arthropod Vectors Author Nathalie Boulanger
ISBN-10 9780128114377
Release 2018-02-02
Pages 516
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Recent research on skin immunity and the skin microbiome reveals the complexity of the skin and its importance in the development of immunity against arthropod-borne diseases. In diseases such as malaria, borreliosis, leishmaniasis, trypanosomiasis, etc., the skin interface has been shown as an essential site for pathogens to hide from the immune system, and as a potential site of persistence. Only very few vaccines have been successfully developed so far against these diseases, likely because of an insufficient understanding on the development of skin immunity against pathogens. Skin and Arthropod Vectors expands our knowledge on the role of the skin interface during the transmission of arthropod-borne diseases and particularly its immunity. This work may support researchers who strive for developing more efficient diagnostic tools and vaccines. It also gives scientists and advanced students working in related areas a better insight on how humans and animals are attractive to arthropods to develop better repellents, or to set up transgenic arthropods. Offers the only compilation of research focusing on both the skin interface and arthropod vectors, with contributions from international experts Advances research in the effort toward generating more effective diagnostic tools and vaccines focusing on the skin interface Can also serve as supplemental material for dermatology lectures or specialized lectures on medical entomology and skin immunity

Non Coding RNAs in Plants

Non Coding RNAs in Plants Author Volker A. Erdmann
ISBN-10 3642194540
Release 2011-07-20
Pages 510
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In the most recent years, each of the RNA silencing pathways of plants have appeared to generate ncRNAs with dedicated functions, specialized biological activities and specific functional scopes. RNA silencing plays a crucial role in coordinating the expression, stability, protection and inheritance of eukaryotic genomes. It compromises several mechanisms, that invariably depend on core small non coding RNAs and that achieve dedicated sequence-specific functions. RNA silencing has been recognized to carry critical developmental, stress-response and bodyguard functions be coordinating the expression, protection, stability and inheritance of virtually all eukaryotic genomes. Thus, the ncRNAs encompass a wide set of mechanisms that achieve specialized functions.


Bioprobes Author H. Osada
ISBN-10 9784431659273
Release 2012-12-06
Pages 319
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Rapid advances in the study of the molecular basis of mammalian cell proliferation, differentiation, and apoptosis have made it possible to develop new screening systems for isolating from microbial metabolites specific inhibitors of mammalian cell functions. "Bioprobes" is the term used to describe these inhibitors, which are extremely useful agents in investigating the molecular and chemical regulation of eukaryotic cell function and apoptosis. Another area where bioprobes are playing an important role is research into immune cell function. This book is the first to present the groundbreaking applications of bioprobes as tools for biochemical research. A large appendix contains the chemical structure, origin, function, key references, and other essential data for more than 80 important bioprobes. The information for each bioprobe is shown in a two-page display, in an easy-to-use format for identifying specific bioprobes for investigation of cell function.

Animal Toxins

Animal Toxins Author Findlay E. Russell
ISBN-10 9781483186108
Release 2016-04-19
Pages 444
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Animal Toxins is a collection of papers that tackles the advancement in studies that aim to enhance the contemporary understanding of animal toxins. The materials in the text are organized according to the organism they cover. The first section tackles the concerns with venomous arthropods, such as the structure of the venom gland of the black widow spider Latrodectus mactans and the biochemical-immunochemical aspects of the venom from the scorpion Centruroides sculpturatus. Next, articles about poisonous marine animals are presented, which include differentiation of the poisons of fish, shellfish, and plankton and block of sensory nerve conduction in the cat by mussel poison and tetrodotoxin. In Section III, the selection reviews papers about snakes and amphibians, such as epidemiological methods in studying venomous snakebites and chemistry of cytotoxic substances in amphibian toxins. The book will be of great interest to toxicologists, zoologists, and biochemists.

Pharmaceutical Suspensions

Pharmaceutical Suspensions Author Alok K. Kulshreshtha
ISBN-10 1441910875
Release 2009-11-05
Pages 327
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The suspension dosage form has long been used for poorly soluble active ingre- ents for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. A good understanding of the fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of a s- pension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, visco- ters, particle size analyzers, etc.) must be utilized to properly characterize the s- pension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require cli- cal trials to establish the safety and efficacy of the drug product. All of this devel- ment work should culminate into a regulatory filing in accordance with the regulatory guidelines. Pharmaceutical Suspensions, From Formulation Development to Manufacturing, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system – poorly soluble active pharmaceutical ingredients s- pended in a suitable vehicle.

Intracellular Delivery II

Intracellular Delivery II Author Aleš Prokop
ISBN-10 9789401788960
Release 2014-05-20
Pages 479
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This volume is a continuation of Volume 1 following the previously published Editorial. More emphasis is given to novel nanocarrier designs, their characterization and function, and applications for drug discovery and treatment. A number of chapters will deal with nanofibers as a new major application within the biomedical field with a very high success rate particularly in wound healing and diabetic foot and spine injuries. A major new subdivision will deal with mathematical methods for the assembly of nanocarriers both for simulation and function.

Hemorheology and Hemodynamics

Hemorheology and Hemodynamics Author Giles Cokelet
ISBN-10 9781615041626
Release 2011-07-27
Pages 142
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From the perspective of blood flow, blood has some unusual properties: it is a suspension of blood cells of which the red blood cells are most numerous and are both deformable (at moderate and high flow rates) and will aggregate under conditions of slow flow. Also, the cellular volume concentration is high (about 40-45%). These features cause blood to have variable viscosity, dependent on flow conditions, and cause both red blood cell sedimentation and syneresis effects under slow flow conditions (which can lead to rheological artifacts). These effects also cause unusual flow phenomena when blood flows in systems of small diameter vessels (especially for diameters of about 500 m or less). These phenomena are seen in non-uniform cell distributions in vessel cross sections, a cell-poor layer of mostly blood plasma at vessels walls, non-proportionate cellular distribution during blood flow through vascular bifurcations, which leads to a very wide distribution of vessel cellular concentrations (from zero to systemic values) in the smaller vessels of the microcirculation, etc. All these phenomena are discussed in this book, as well as the difficulties presented by in vivo microvessels having non-ideal geometries. Table of Contents: Introduction / The Composition of Blood / Viscometers / Constitutive Equations / At Last, Experimental Data! / Some In Vitro Blood Flows / The Fahraeus Effect / The Fahreus-Lindqvist Effect / In Vitro Arterial-Type Bifurcation Experimental Data / In Vivo Experimental Bifurcation Data / Flow in Microvascular Networks / Optimization / Concluding Statement / References"

The ELISA Guidebook

The ELISA Guidebook Author John R. Crowther
ISBN-10 9781592590490
Release 2000
Pages 436
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John R. Crowther provides today's bestselling practical guide to the understanding and application of ELISA. This important work introduces chapters on such major new topics as checkerboard titrations, quality control of testing, kit production and control, novel monoclonal antibodies, validation of assays, and statistical requirements for data examination. With its numerous worked examples, detailed instructions, and extensive illustrations, The ELISA Guidebook offers a powerful synthesis of all the basic concepts and practical experimental details investigators need to understand, develop, and apply the new ELISA methodology.

The New Microbiology

The New Microbiology Author Pascale Cossart
ISBN-10 1683670108
Release 2018
Pages 200
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In The New Microbiology, Pascale Cossart tells a splendid story about the revolution in microbiology, especially in bacteriology.

Cancer Cell Signalling

Cancer Cell Signalling Author Amanda Harvey
ISBN-10 9781118527757
Release 2013-09-11
Pages 232
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A focused, accessible introduction to this key aspect of cancer biology. It covers the individual cell signalling pathways that are known to be involved in cancer development, and, most important, includes the cross- interactions between the pathways together with the current therapeutic approaches. This is a ‘must-have’ for advanced undergraduate and postgraduate students studying and researching within the field of cancer biology.

Innate Immunity and Inflammation

Innate Immunity and Inflammation Author Ruslan Medzhitov
ISBN-10 1621820297
Release 2014-10-01
Pages 240
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The innate immune system is rapidly activated in response to infection and injury. It is a generic rather than pathogen-specific response that recruits immune cells, promotes inflammation, and mobilizes the adaptive immune system. Excessive or chronic inflammation may cause tissue damage, so a careful balance is required to restore homeostasis. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the cellular and molecular mechanisms involved in innate immunity and all types of inflammation. The contributors examine the cell types that make up the innate immune system, their use of pattern recognition receptors (e.g., Toll-like receptors) to identify pathogens and damaged tissues, and how they trigger signaling pathways that culminate in inflammation, pathogen destruction, and tissue repair. The numerous chemical signals and factors involved in innate immunity and inflammation are described, as are those that keep inflammation in check. The authors also discuss the diseases that can result when these processes go awry, such as rheumatoid arthritis and cancer. This volume is therefore a valuable reference for all immunologists, cell biologists, and medical scientists wishing to understand these protective processes and their implications for human health and disease.

Animals and Human Society

Animals and Human Society Author Colin G. Scanes
ISBN-10 9780128054383
Release 2017-09-18
Pages 540
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Animals and Human Society provides a solid, scientific, research-based background to advance understanding of how animals impact humans. As a resource for both science and non-science majors (including students planning to major in or studying animal science, pre-veterinary medicine, animal behavior, conservation biology, ecotoxicology, epidemiology and evolutionary biology), the book can be used as a text for courses in Animals and Human Society or Animal Science, or as supplemental material for an Introduction to Animal Science. The book offers foundational background to those who may have little background in animal agriculture and have focused interest on companion animals and horses. Animals have had profound effects on people from the earliest times, ranging from zoonotic diseases, to the global impact of livestock, poultry and fish production, to the influences of human-associated animals on the environment (on extinctions, air and water pollution, greenhouse gases, etc.), to the importance of animals in human evolution and hunter-gatherer communities. The volume introduces livestock production (including poultry and aquaculture) but also includes coverage of companion and lab animals. In addition, animal behavior and animal perception are covered. It can also function as a reference or recommended reading for a capstone class on ethical and public policy aspects related to animals. This book is likewise an excellent resource for researchers, academics or students newly entering a related field or coming from another discipline and needing foundational information, as well as interested laypersons looking to augment their knowledge on the many impacts of animals in human society. Features research-based and pedagogically sound content, with learning goals and textboxes to provide key information Challenges readers to consider issues based on facts rather than polemics Poses ethical questions and raises overall societal impacts Balances traditional animal science with companion animals, animal biology, zoonotic diseases, animal products, environmental impacts and all aspects of human/animal interaction Includes access to PowerPoints that facilitate easy adoption and/or use for online classes

The Fungal Kingdom

The Fungal Kingdom Author Joseph Heitman
ISBN-10 1555819583
Release 2018
Pages 1161
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Fungi research and knowledge grew rapidly following recent advances in genetics and genomics.

Medical Research and Technology

Medical Research and Technology Author Morris, Alexandra
ISBN-10 9781680770933
Release 2016-01-01
Pages 112
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Thrilling new discoveries in science and technology are announced almost daily. Cutting-Edge Science and Technology keeps readers at the forefront of new research. Medical Research and Technology covers a wide range of cutting-edge medical topics, from growing organs for transplant and fighting cancer to gene therapy, personal data tracking, and robots in medicine. High-impact photos and explanatory graphics and charts bring scientific concepts to life. Features include essential facts, a glossary, selected bibliography, websites, source notes, and an index. Aligned to Common Core Standards and correlated to state standards. Essential Library is an imprint of Abdo Publishing, a division of ABDO.