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Molecular Biology of B Cells

Molecular Biology of B Cells Author Tasuku Honjo
ISBN-10 9780123984906
Release 2014-10-09
Pages 600
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Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics. Covers signaling mechanisms regulating B cell differentiation Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab Contains studies on B cell tumors from various stages of B lymphocytes Offers an integrated view of all aspects of B cells to produce a normal immune response



Molecular Biology of B Cell Developments

Molecular Biology of B Cell Developments Author Clemens Sorg
ISBN-10 UOM:39015018864820
Release 1990-01-01
Pages 174
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Molecular Biology of B Cell Developments has been writing in one form or another for most of life. You can find so many inspiration from Molecular Biology of B Cell Developments also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Molecular Biology of B Cell Developments book for free.



Molecular Biology of the Cell

Molecular Biology of the Cell Author Bruce Alberts
ISBN-10 9781317563747
Release 2017-08-07
Pages 1464
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As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.



B Cells

B Cells Author Robert L. Montes
ISBN-10 1628085428
Release 2013
Pages 119
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B cells belong to a group of white blood cells known as lymphocytes, making them a vital part of the immune system. The human body makes millions of different types of B cells each day that circulate in the blood and lymphatic system performing the role of immune surveillance. They do not produce antibodies until they become fully activated. In this book, the authors present current research in the study of the molecular biology, developmental origin and impact on the immune system of B cells. Topics discussed include the role of B cells in intracellular bacterial pathogen infections; dynamic clustering of BCR-lipid rafts in antigen affinity discrimination by B cells; and B cells as a key player in the pathogenesis of multiple sclerosis.



Molecular Biology of B Cell and T Cell Development

Molecular Biology of B Cell and T Cell Development Author John G. Monroe
ISBN-10 9781475727784
Release 2013-03-14
Pages 587
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Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.



Molecular Biology of B Cell and T Cell Development

Molecular Biology of B Cell and T Cell Development Author John G. Monroe
ISBN-10 9781475727784
Release 2013-03-14
Pages 587
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Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.



Regulatory B Cells

Regulatory B Cells Author Gaetano Vitale
ISBN-10 1493911600
Release 2014-07-14
Pages 292
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Regulatory B Cells: Methods and Protocols present the current experimental set-ups and methodologies useful for the identification and characterization of B cells with suppressive functions and for the study of their biological and immunological properties. Organized into four sections, this detailed volume covers the basic methods for the isolation and immunophenotypical characterization of specific B cell subsets from mouse and human tissues, methods for the investigation of the mechanisms of immune suppression operated by B cells, several experimental approaches for the ex vivo generation/expansion of IL-10-producing B cells, as well as procedures for the study of the immune suppressive function of B cells in specific pathological settings. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, Regulatory B Cells: Methods and Protocols serves as an ideal guide for immunologists as well as for cell and molecular biologists interested in the intricacies of B cell biology.



The Neuron

The Neuron Author David J Maloney Professor and Chair of Neuroscience Irwin B Levitan, Ph.D.
ISBN-10 9780199773893
Release 2015-08-01
Pages 600
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The Fourth Edition of The Neuron provides a comprehensive first course in the cell and molecular biology of nerve cells. The book begins with properties of the many newly discovered ion channels that have emerged through mapping of the genome. These channels shape the way a single neuron generates varied patterns of electrical activity. Covered next are the molecular mechanisms that convert electrical activity into the secretion of neurotransmitter hormones at synaptic junctions between neurons. The following section examines the biochemical pathways that are linked to the action of neurotransmitters and that can alter the cellular properties of neurons or sensory cells that transduce information from the outside world into the electrical code used by neurons. The final section reviews our rapidly expanding knowledge of the molecular factors that induce an undifferentiated cell to become a neuron, and then guide it to form appropriate synaptic connections with its partners. This section also focuses on the role of ongoing experience and activity in shaping these connections, and finishes with an account of mechanisms thought to underlie the phenomena of learning and memory. The book contains scores of color figures and fully updated chapters; online content packaged exclusively with the Fourth Edition includes detailed animations of neural processes, in-depth supplemental reading, and additional full-color figures and tables.



B Cell Receptor Signaling

B Cell Receptor Signaling Author Tomohiro Kurosaki
ISBN-10 9783319261331
Release 2015-12-26
Pages 231
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This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.



The Dictionary of Cell and Molecular Biology

The Dictionary of Cell and Molecular Biology Author John M. Lackie
ISBN-10 9780123849328
Release 2012-12-31
Pages 750
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The Dictionary of Cell and Molecular Biology, Fifth Edition, provides definitions for thousands of terms used in the study of cell and molecular biology. The headword count has been expanded to 12,000 from 10,000 in the Fourth Edition. Over 4,000 headwords have been rewritten. Some headwords have second, third, and even sixth definitions, while fewer than half are unchanged. Many of the additions were made to extend the scope in plant cell biology, microbiology, and bioinformatics. Several entries related to specific pharmaceutical compounds have been removed, while some generic entries (“alpha blockers, “NSAIDs, and “tetracycline antibiotics, for example), and some that are frequently part of the experimentalist’s toolkit and probably never used in the clinic, have been retained. The Appendix includes prefixes for SI units, the Greek alphabet, useful constants, and single-letter codes for amino acids. Thoroughly revised and expanded by over 20% with over 12,000 entries in cellular and molecular biology Includes expanded coverage of terms, including plant molecular biology, microbiology and biotechnology areas Consistently provides the most complete short definitions of technical terminology for anyone working in life sciences today Features extensive cross-references Provides multiple definitions, notes on word origins, and other useful features



Cellular and Molecular Biology of Bone

Cellular and Molecular Biology of Bone Author Masaki Noda
ISBN-10 9780080925004
Release 2014-06-28
Pages 567
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Written by well-known experts in their respective fields, this book synthesizes recent work on the biology of bone cells at the molecular level. Cellular and Molecular Biology of Bone covers the differentiation of these cells, the regulation of their growth and metabolism, and their death resorption. The authors' special comprehensive treatment of the cellular and molecular mechanisms of bone metabolism makes this book a unique and valuable tool. Cellular and Molecular Biology of Bone provides interested readers-with concise state-of-the-art reviews in bone biology that will enlarge their scope and increase their appreciation of the field. Research in this area has intensified recently due to the increasing incidence of osteoporosis. The editor hopes an understanding of the basic biology of this disease will prove relevant to its prevention and treatment.



B lymphocytes in human disease

B lymphocytes in human disease Author Angus Graham Bird
ISBN-10 0192615734
Release 1988
Pages 513
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During the past two decades, cells of the B-lymphocyte lineage have been the subject of intensive research. B-lymphocytes and antibodies play a crucial role in the body's defense against infection, but can also be responsible for producing certain diseases. This volume provides an up-to-date discussion of the cellular and molecular biology of antibodies and the cells that produce them. Researchers discuss the fundamentals of B-cell biology that are crucial to understanding how cells and their antibody products generate a range of malignant, autoimmune and immunodeficiency disorders. The discussion of human diseases in the second part of the book provides an interface between recent advances in B-cell biology and B-cell related disease processes.



Cell and Molecular Biology

Cell and Molecular Biology Author Gerald Karp
ISBN-10 9780470483374
Release 2009-10-19
Pages 832
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Karp continues to help biologists make important connections between key concepts and experimentation. The sixth edition explores core concepts in considerable depth and presents experimental detail when it helps to explain and reinforce the concepts. The majority of discussions have been modified to reflect the latest changes in the field. The book also builds on its strong illustration program by opening each chapter with “VIP” art that serves as a visual summary for the chapter. Over 60 new micrographs and computer-derived images have been added to enhance the material. Biologists benefit from these changes as they build their skills in making the connection.



Molecular Mechanisms of Immunological Self Recognition

Molecular Mechanisms of Immunological Self Recognition Author Frederick Alt
ISBN-10 9781483215938
Release 2014-06-28
Pages 274
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Molecular Mechanisms of Immunological Self-Recognition covers the understanding of immunological self-recognition. The introductory chapter of the book summarizes the dawn of the insight into immunological tolerance, and provides an overview of research on the underlying mechanisms. The book addresses the developments in the molecular mechanisms of B and T cell tolerance and describes the failure of tolerance in autoimmunity. The text concludes by furnishing orienting perspectives and highlighting new information presented. The novel findings characterized as impressive advances pertain to the areas of B cell development and the generation of molecular diversity; V gene usage, especially from transgenes, in positive and negative thymic selection; the handling of positive and negative signals by T and B cells; anergy in postthymic T cells; the design of peptide-based therapy for autoimmune diseases; and the design of therapy with the aid of monoclonal antibodies. Immunologists will find the text useful.



Molecular Biology of the Cell

Molecular Biology of the Cell Author John Wilson
ISBN-10 0815335776
Release 2002
Pages 711
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This text is designed to help students appreciate the ways in which experiments and simple calculations can lead to an understanding of how cells work. The new edition of 'A Problems Approach' is completely reorganized and revised to match the fourth edit



Applied Cell and Molecular Biology for Engineers

Applied Cell and Molecular Biology for Engineers Author Gabi Nindl Waite
ISBN-10 0071509526
Release 2007-04-05
Pages 326
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A Guide to the Fundamentals and Latest Concepts of Molecular and Cell Biology Bridging the gap between biology and engineering, Applied Cell and Molecular Biology for Engineers uses clear, straightforward language to introduce you to the cutting-edge concepts of molecular and cell biology. Written by an international team of engineers and life scientists, this vital tool contains “clinical focus boxes” and “applications boxes” in each chapter to link biology and engineering in today's world. To help grasp complex material quickly and easily, a glossary is provided. Applied Cell and Molecular Biology for Engineers features: Clear descriptions of cell structures and functions Detailed coverage of cellular communication In-depth information on cellular energy conversion Concise facts on information flow across generations A succinct guide to the evolution of cells to organisms Inside This Biomedical Engineering Guide Biomolecules: • Energetics • Components of the cell • Cell Morphology: • Cell membranes • Cell organelles • Enzyme Kinetics: • Steady-state kinetics • Enzyme inhibition • Cellular Signal Transduction: • Receptor binding • Apoptosis • Energy Conversion: • Cell metabolism • Cell respiration • Cellular Communication: • Direct • Local • Long distance • Cellular Genetics: • DNA and RNA synthesis and repair • Cell Division and Growth: • Cell cycle • Mitosis • Stem cells • Cellular Development: • Germ cells and fertilization • Limb development • From Cells to Organisms: • Cell differentiation • Systems biology



Molecular Biology

Molecular Biology Author David P. Clark
ISBN-10 9780123785909
Release 2009-10-21
Pages 784
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Molecular Biology: Academic Cell Update provides an introduction to the fundamental concepts of molecular biology and its applications. It deliberately covers a broad range of topics to show that molecular biology is applicable to human medicine and health, as well as veterinary medicine, evolution, agriculture, and other areas. The present Update includes journal specific images and test bank. It also offers vocabulary flashcards. The book begins by defining some basic concepts in genetics such as biochemical pathways, phenotypes and genotypes, chromosomes, and alleles. It explains the characteristics of cells and organisms, DNA, RNA, and proteins. It also describes genetic processes such as transcription, recombination and repair, regulation, and mutations. The chapters on viruses and bacteria discuss their life cycle, diversity, reproduction, and gene transfer. Later chapters cover topics such as molecular evolution; the isolation, purification, detection, and hybridization of DNA; basic molecular cloning techniques; proteomics; and processes such as the polymerase chain reaction, DNA sequencing, and gene expression screening. Up to date description of genetic engineering, genomics, and related areas Basic concepts followed by more detailed, specific applications Hundreds of color illustrations enhance key topics and concepts Covers medical, agricultural, and social aspects of molecular biology Organized pedagogy includes running glossaries and keynotes (mini-summaries) to hasten comprehension