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Molecular Biology of B Cell Developments

Molecular Biology of B Cell Developments Author Clemens Sorg
ISBN-10 UOM:39015018864820
Release 1990-01-01
Pages 174
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Molecular Biology of B Cell Developments has been writing in one form or another for most of life. You can find so many inspiration from Molecular Biology of B Cell Developments also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Molecular Biology of B Cell Developments book for free.



Molecular Biology of B Cells

Molecular Biology of B Cells Author Tasuku Honjo
ISBN-10 9780123984906
Release 2014-10-09
Pages 600
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Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics. Covers signaling mechanisms regulating B cell differentiation Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab Contains studies on B cell tumors from various stages of B lymphocytes Offers an integrated view of all aspects of B cells to produce a normal immune response



Molecular Biology of B Cell and T Cell Development

Molecular Biology of B Cell and T Cell Development Author John G. Monroe
ISBN-10 9781475727784
Release 2013-03-14
Pages 587
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Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.



B Cell Biology in Autoimmunity

B Cell Biology in Autoimmunity Author David Ahmad Nemazee
ISBN-10 9783805574549
Release 2003
Pages 272
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B cells play a central role not only in adaptive immunity, but also in autoimmunity. To understand how B cells are normally prevented from reacting to self-tissue, what goes wrong in autoimmunity, and how B cells contribute to it is the aim of this book. This volume includes more than a dozen in-depth reviews by researchers specializing in various aspects of basic B cell biology that have relevance to autoimmune diseases. These up-to-date chapters present the latest information on B cell signal transduction, apoptosis, genetics and molecular biology. Also featured are chapters with special reference to particular autoimmune diseases in which B cells have been shown to play a critical role, such as type 1 diabetes, chronic graft-versus-host disease and lupus erythematosus. Further topics covered include the role of the complement system, rheumatoid factors, and anti-DNA autoantibodies as well as important related areas such as natural autoantibodies, B cell immune tolerance, Toll receptor signaling, and the immunobiology of BAFF/BLyS. Both basic researchers and clinician scientists who wish to understand the role of B lymphocytes in immune tolerance and autoimmunity will benefit from this timely publication.



B lymphocytes in human disease

B lymphocytes in human disease Author Angus Graham Bird
ISBN-10 0192615734
Release 1988
Pages 513
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During the past two decades, cells of the B-lymphocyte lineage have been the subject of intensive research. B-lymphocytes and antibodies play a crucial role in the body's defense against infection, but can also be responsible for producing certain diseases. This volume provides an up-to-date discussion of the cellular and molecular biology of antibodies and the cells that produce them. Researchers discuss the fundamentals of B-cell biology that are crucial to understanding how cells and their antibody products generate a range of malignant, autoimmune and immunodeficiency disorders. The discussion of human diseases in the second part of the book provides an interface between recent advances in B-cell biology and B-cell related disease processes.



The Neuron

The Neuron Author David J Maloney Professor and Chair of Neuroscience Irwin B Levitan, Ph.D.
ISBN-10 9780199773893
Release 2015-08-01
Pages 600
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The Fourth Edition of The Neuron provides a comprehensive first course in the cell and molecular biology of nerve cells. The book begins with properties of the many newly discovered ion channels that have emerged through mapping of the genome. These channels shape the way a single neuron generates varied patterns of electrical activity. Covered next are the molecular mechanisms that convert electrical activity into the secretion of neurotransmitter hormones at synaptic junctions between neurons. The following section examines the biochemical pathways that are linked to the action of neurotransmitters and that can alter the cellular properties of neurons or sensory cells that transduce information from the outside world into the electrical code used by neurons. The final section reviews our rapidly expanding knowledge of the molecular factors that induce an undifferentiated cell to become a neuron, and then guide it to form appropriate synaptic connections with its partners. This section also focuses on the role of ongoing experience and activity in shaping these connections, and finishes with an account of mechanisms thought to underlie the phenomena of learning and memory. The book contains scores of color figures and fully updated chapters; online content packaged exclusively with the Fourth Edition includes detailed animations of neural processes, in-depth supplemental reading, and additional full-color figures and tables.



Molecular Biology of the Cell 5th Ed 2008

Molecular Biology of the Cell  5th Ed  2008 Author Garland Science
ISBN-10
Release 2008-06-18
Pages 1725
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In many respects,w e understand the structure of the universeb etter than the workings of living cells. Scientists can calculate the age of the Sun and predict when it will cease to shine, but we cannot explain how it is that a human being may live for eighty years but a mouse for only two. We know the complete genomes equenceso f thesea nd many other speciesb, ut we still cannot predict how a cell will behave if we mutate a previously unstudied gene. Stars may be l0a3 times bigger, but cells are more complex, more intricately structured, and more astonishingp roducts of the laws of physicsa nd chemistry.T hrough heredity and natural selection, operating from the beginnings of life on Earth to the presentd ay-that is, for about 20Voo f the ageo f the universe-living cellsh ave been progressively refining and extending their molecular machinery and recording the results of their experiments in the genetic instructions they pass on to their progeny. With each edition of this book, we marvel at the new information that cell biologists have gathered in just a few years. But we are even more amazed and daunted at the sophistication of the mechanisms that we encounter. The deeper we probe into the cell,t he more we reafizeh ow much remainst o be understood. In the days of our innocence, working on the first edition, we hailed the identification of a single protein-a signal receptol say-as a great step forward' Now we appreciate that each protein is generally part of a complexwith many others, working together as a system, regulating one another's activities in subtle ways, and held in specific positions by binding to scaffold proteins that give the chemical factory a definite spatial structure. Genome sequencing has given us virtually complete molecular parts-lists for many different organisms; genetics and biochemistry have told us a great deal about what those parts are capable of individually and which ones interact with which others; but we have only the most primitive grasp of the dynamics of these biochemical systems, with all their interlocking control loops. Therefore, although there are great achievements to report, cell biologistsf ace eveng reaterc hallengesf or the future. In this edition, we have included new material on many topics, ranging from epigeneticsh, istonem odificationss, mall RNAs,a nd comparativeg enomicst,o geneticn oise,c ytoskeletadl lmamics,c ell-cyclec ontrol, apoptosis,s tem cells, and novel cancer therapies. As in previous editions, we have tried above all to give readers a conceptual framework for the mass of information that we now have about cells. This means going beyond the recitation of facts. The goal is to learn how to put the facts to use-to reason, to predict, and to control the behavior of living systems. To help readers on the way to an active understanding, we have for the first time incorporatede nd-of-chapterp roblems,w ritten by Iohn Wilson and Tim Hunt. These emphasize a quantitative approach and the art of reasoning from experiments.A companion volume, MolecularB iologyo f the CelI,F ifth Edition: TheP roblemsB ook0 SBN9 78-0-8153-4110-9b)y, t he samea uthors,g ivesc omplete answerst o thesep roblemsa nd alsoc ontainsm ore than 1700a dditional problems and solutions. A further major adjunct to the main book is the attached Media DVD-ROM disc. This provides hundreds of movies and animations, including manythat are new in this edition, showing cells and cellular processesin action and bringing the text to life; the disc also now includes all the figures and tables from the main book,p re-loadedin to [email protected] esentationsO. thera ncillariesa vailablefo r the book include a bank of test questions and lecture outlines, available to qualified instructors,a nd a seto f 200f ull-coloro verheadtr ansparencies. Perhaps the biggest change is in the physical structure of the book. In an effort to make the standard Student Edition somewhat more portable, we are providing chapters 2r-25, covering multicellular systems, in electronic (pDF) form on the accompanying disc, while retaining in the printed volume chapters l-20, covering the core of the usual cell biology curriculum. But we should emphasize that the final chapters have been revised and updated as thoroughly as the rest of the book and we sincerely hope that they will be read! A Reference Edition (ISBN9 7s-0-8153-4r11-6c)o, ntainingt he full seto f chaptersa sp rinred pages, is also available for those who prefer it. Full details of the conventions adopted in the book are given in the Note to the Readert hat follows this PrefaceA. s explainedt here,w e have taken a drastic approach in confronting the different rules for the writing of gene names in different species: throughout this book, we use the same style, regardless of speciesa, nd often in defianceo fthe usuals pecies-specifcico nventions. As always,w e are indebted to many people. Full acknowledgmentsfo r scientific help are given separatelyb, ut we must here singleo ut somee xceptionally important contributions: Iulie Theriot is almost entirely responsible for chapters 16 (cytoskeleton)a nd 24 (PathogensI,n fection, and Innate Immunity), and David Morgan likewise for chapter 17 (cell cycle). wallace Marshall and Laura Attardi provided substantialh elp with chapters 8 and 20, respectively,a s did Maynardo lson for the genomicss ectiono f chapter4 ,X iaodongwangf or chapter 18, and Nicholas Harberd for the plant section of Chapter 15. we also owe a huge debt to the staff of Garland science and others who helped convert writers' efforts into a polished final product. Denise schanck directed the whole enterprise and shepherded the wayward authors along the road with wisdom, skill, and kindness. Nigel orme put the artwork into its final form and supervisedt he visuala spectso f the book,i ncluding the backc over,w ith his usual flair. Matthew Mcclements designed the book and its front cover. Emma Jeffcockla id out its pagesw ith extraordinarys peeda nd unflappablee fficiency, d ealingi mpeccablywith innumerablec orrections.M ichaelM oralesm anaged the transformation of a mass of animations, video clips, and other materials into a user-friendly DVD-ROM. Eleanor Lawrence and sherry Granum updatedand enlargedt he glossaryJ. ackieH arbor and SigridM assonk ept us organized. Adam Sendroffkept us aware ofour readers and their needs and reactions. Marjorie Anderson, Bruce Goatly, and sherry Granum combed the text for obscurities, infelicities, and errors. we thank them all, not only for their professional skill and dedication and for efficiency far surpassing our own, but also for their unfailing helpftrlnessa nd friendship:t hey havem adei t a pleasuret o work on the book. Lastly, and with no less gratitude, we thank our spouses, families, friends and colleaguesw. ithout their patient,e ndurings upport,w e couldn ot havep roduced any of the editions of this book. MolecularB iologyo f the Cell BruceA lberts AlexandeJro hnson JulianL ewis Martin Raff Keith Roberts PeteWr alter Withp roblemsb y John Wilson Tim Hunt GarlandS cience Taylo&r FranciGs roup



Introduction to Molecular Biology Genomics and Proteomics for Biomedical Engineers

Introduction to Molecular Biology  Genomics and Proteomics for Biomedical Engineers Author Robert B. Northrop
ISBN-10 9781420061215
Release 2008-10-28
Pages 480
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Illustrates the Complex Biochemical Relations that Permit Life to Exist It can be argued that the dawn of the 21st century has emerged as the age focused on molecular biology, which includes all the regulatory mechanisms that make cellular biochemical reaction pathways stable and life possible. For biomedical engineers, this concept is essential to their chosen profession. Introduction to Molecular Biology, Genomics, and Proteomics for Biomedical Engineers hones in on the specialized organic molecules in living organisms and how they interact and react. The book’s sound approach to this intricately complex field makes it an exceptional resource for further exploration into the biochemistry, molecular biology, and genomics fields. It is also beneficial for electrical, chemical, and civil engineers as well as biophysicists with an interest in modeling living systems. This seminal reference includes many helpful tools for self study, including— 143 illustrations, 32 in color, to bolster understanding of complex biochemical relations 20 tables for quick access to precise data 100 key equations Challenging self-study problems within each chapter Conveys Human Progress in the Manipulation of Genomes at the Molecular Level In response to growing global interest in biotechnology, this valuable text sheds light on the evolutionary theories and future trends in genetic medicine and stem cell research. It provides a broader knowledge base on life-permitting complexities, illustrates how to model them quantitatively, and demonstrates how to manipulate them in genomic-based medicine and genetic engineering. Consequently, this book allows for a greater appreciation among of the incredible complexity of the biochemical systems required to sustain life in its many forms. A solutions manual is available for instructors wishing to convert this reference to classroom use.



Molecular Biology of the Cell

Molecular Biology of the Cell Author Bruce Alberts
ISBN-10 0824036956
Release 1989
Pages 1263
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New edition of a text in which six researchers from leading institutions discuss what is known and what is yet to be understood in the field of cell biology. The material on molecular genetics has been revised and expanded so that it can be used as a stand-alone text. A new chapter covers pathogens, infection, and innate immunity. Topics include introduction to the cell, basic genetic mechanisms, methods, internal organization of the cell, and cells in their social context. The book contains color illustrations and charts; and the included CD-ROM contains dozens of video clips, animations, molecular structures, and high-resolution micrographs. Annotation copyrighted by Book News Inc., Portland, OR.



High yield Cell and Molecular Biology

High yield Cell and Molecular Biology Author Ronald W. Dudek
ISBN-10 078176887X
Release 2007
Pages 254
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This completely revised and updated review book consolidates the most important clinical issues that medical students need to know to be prepared for questions on USMLE Step 1. The book reviews key cell biology concepts needed to study molecular biology, and reviews the key concepts of molecular biology necessary for clinical medical practice, Flow charts provide a clear overview of molecular biology techniques and how they are applied in medicine. A chapter on understanding the research literature provides a solid background in molecular biology protocol so that students can understand the purpose and thinking behind published research articles.



Cellular and molecular biology of tumors and potential clinical applications

Cellular and molecular biology of tumors and potential clinical applications Author John D. Minna
ISBN-10 UCAL:B4513958
Release 1988
Pages 323
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Cellular and molecular biology of tumors and potential clinical applications has been writing in one form or another for most of life. You can find so many inspiration from Cellular and molecular biology of tumors and potential clinical applications also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Cellular and molecular biology of tumors and potential clinical applications book for free.



Molecular Biology of Hematopoiesis 6

Molecular Biology of Hematopoiesis 6 Author Nader G. Abraham
ISBN-10 0306461366
Release 1999-11-30
Pages 404
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This volume of Molecular Biology of Hematopoiesis is dedicated to many inter national scientists and clinicians for their contribution to the field of Hematology/ Oncology presented at the 11th International Symposium on Molecular Biology of Hematopoiesis, which was held in Bormio, Italy, June 25-29, 1998. The continuous support of the Presidents of the meeting, Professor F. Takaku, President of Jichi University, and E. D. Thomas, Nobel Laureate, was greatly acknowledged, especially Professor Takaku, for his vision and support for development of gene therapy in Japan. New information on BMT for autoimmune disease and organ transplantation was presented at the symposium and is published in this volume. Several new findings on gene therapy/transfer into HSC were presented by E. F. Vanin and A. Nienhuis, K. Humphries, 1. A. Nolta, H. E. Heslop, and M. K. Brenner. Professors S. Asano and K. Tani presented new studies on gene transfer into primates. Among the highlights were the new papers on gene transfer presented by G. Wage maker, N. G. Abraham, and M. Onoderea from R. M. BJaese's group. The use of BMT for organ transplant and autoim mune disease was updated and a representative paper is presented in this volume.



B Cell Protocols

B Cell Protocols Author Hua Gu (PhD.)
ISBN-10 9781592597963
Release 2004
Pages 289
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A diverse collection of protocols ranging from the latest inventions and applications to some classic, but still frequently used, methods for studying B-lymphocyte development and function in higher animals. These readily reproducible protocols follow the successful Methods in Molecular BiologyTM series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Readily reproducible techniques for studying B-lymphocyte development and function Comprehensive collection of classic and cutting-edge methods Step-by-step instructions that ensure experimental success.



Advances in B Cell Lymphoma Research and Treatment 2012 Edition

Advances in B Cell Lymphoma Research and Treatment  2012 Edition Author
ISBN-10 9781481621458
Release 2012-12-26
Pages 37
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Advances in B-Cell Lymphoma Research and Treatment / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about B-Cell Lymphoma in a concise format. The editors have built Advances in B-Cell Lymphoma Research and Treatment / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about B-Cell Lymphoma in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in B-Cell Lymphoma Research and Treatment / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.



Molecular Biology and Biotechnology

Molecular Biology and Biotechnology Author John M. Walker
ISBN-10 9780854041251
Release 2009-01-01
Pages 604
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This popular textbook has been revised and updated to provide a comprehensive overview and to reflect the latest developments in this rapidly developing area. Continuing with the broad base style of both current molecular and traditional biotechnology, chapters have been updated to reflect current interest and include new areas such as stem cell technology and important areas in drug discovery such as IP and patents. By presenting information in an easily assimilated form, this book makes an ideal undergraduate text for students of biology and chemistry, as well as to postgraduates.



Mast Cells

Mast Cells Author Guha Krishnaswamy
ISBN-10 9781592599677
Release 2006
Pages 439
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The mast cell, long implicated in causing allergic reactions, may also be involved in many other disease processes, including cancer, heart disease, parasitic disease, atherosclerosis, asthma, and arthritis. In Mast Cells: Methods and Protocols, hands-on experts describe in detail their best techniques for the isolation, culture, and study of both activation and signaling in human mast cells. These readily reproducible methods take advantage of the latest advances in molecular biology, technology, and information science. The techniques provide a sound base of methodology for mast cell research and include methods for the identification of mast cells, the development of mast cells in vitro, the study of mast cell signaling and gene expression, and the measurement of mast cell expression of inflammatory mediators. Additional chapters cover methods for studying mast cell interactions with other cell types (endothelial cells, fibroblasts, and B cells), the roles of mast cells in host defense, and mast cell apoptosis. A survey of mast cell biology offers insight into its history and the implications for adaptive immunity. The protocols follow the successful Methods in Molecular Biology series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and highly practical, Mast Cells: Methods and Protocols provides mast cell researchers with reproducible accounts of basic and advanced molecular and cellular techniques used in studying this fascinating, multifunctional cell.



Molecular Biology of the Hepatitis B Virus

Molecular Biology of the Hepatitis B Virus Author Alan McLachlan
ISBN-10 0849355168
Release 1991-10-23
Pages 330
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Molecular Biology of the Hepatitis B Virus presents a comprehensive account of the various molecular aspects of the life cycle of the hepatitis B virus (HBV). Topics covered include the animal model systems, sequence data on the hepadnavirus genomes, the transcripts coded for the biral genome and sequence elements involved in regulating their expression, hepadnavirus replication, and analysis of the various HBV gene products and their role in virion synthesis and assembly. Other important features of the book include its discussions of the consequences of long term exposure to hepadnavirus infection and its association with hepatocellular carcinoma, the use of recombinant technologies in the generation of second generation vaccines, and the utilization of recombinant technologies to analyze an immune mediated disease. Researchers studying hepadnaviruses will find a wealth of information in this essential reference volume.