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Nanomedicine

Nanomedicine Author Thomas J Webster
ISBN-10 9780857096449
Release 2012-10-19
Pages 704
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Nanotechnology is at the forefront of advances in medicine. Nanomedicine: Technologies and applications provides an important review of this exciting technology and its growing range of applications. After an introduction to nanomedicine, part one discusses key materials and their properties, including nanocrystalline metals and alloys, nanoporous gold and hydroxyapatite coatings. Part two goes on to review nanomedicine for therapeutics and imaging, before nanomedicine for soft tissue engineering is discussed in part three, including organ regeneration, skin grafts, nanotubes and self-assembled nanomaterials. Finally, nanomedicine for bone and cartilage tissue engineering is the focus of part four, with electrically active biocomposites as smart scaffolds investigated, as is cartilage and bone tissue engineering, regeneration and replacement. With its distinguished editor and international team of expert contributors, Nanomedicine: Technologies and applications is an indispensable guide for all those involved in the research, development and application of this exciting technology, whilst providing a comprehensive introduction for students and academics interested in this field. Provides an important review of nanomedicine technology and its growing range of applications Discusses key nanomedicine materials and their properties, including nanocrystalline metals and alloys, nanoporous gold and hydroxyapatite coatings Reviews nanomedicine for therapeutics and imaging and nanomedicine for soft tissue engineering



Self assembling Biomaterials

Self assembling Biomaterials Author Helena S. Azevedo
ISBN-10 9780081020128
Release 2018-04-17
Pages 612
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Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field. Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration. Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community. Explores both theoretical and practical aspects of self-assembly in biomaterials Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials Examines the use of dynamic self-assembling biomaterials



Core Shell Nanostructures for Drug Delivery and Theranostics

Core Shell Nanostructures for Drug Delivery and Theranostics Author Maria Focarete
ISBN-10 9780081021996
Release 2018-07-12
Pages 466
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Core-Shell Nanostructures for Drug Delivery and Theranostics: Challenges, Strategies and Prospects for Novel Carrier Systems contains valuable chapters that deal with the fundamentals of nanotechnology for drug delivery, recent developments and research in core-shell nanoparticles for drug-delivery and theranostic applications, and the potential and applications of core-shell nanofiber. This book is a highly valuable resource for scientists interested in the design and development of innovative drug delivery systems, researchers and graduate/postdoctoral students engaged in biomaterials for drug delivery, and R&D managers in the biomaterials and pharmaceutical industry. Focuses on core-shell nanoparticles and nanofiber for innovative applications, including cancer therapy, controlled release and multi-drug release Considers future prospects and potential new applications of core-shell nanostructures for drug delivery and theranostics Explains the principles and essential concepts of nanotechnology for drug delivery systems



Electrofluidodynamic Technologies EFDTs for Biomaterials and Medical Devices

Electrofluidodynamic Technologies  EFDTs  for Biomaterials and Medical Devices Author Vincenzo Guarino
ISBN-10 9780081017463
Release 2018-01-21
Pages 426
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Electrofluidodynamic Technologies (EFDTs) for Biomaterials and Medical Devices: Principles and Advances focuses on the fundamentals of EFDTs - namely electrospinning, electrospraying and electrodynamic atomization - to develop active platforms made of synthetic or natural polymers for use in tissue engineering, restoration and therapeutic treatments. The first part of this book deals with main technological aspects of EFDTs, such as basic technologies and the role of process parameters. The second part addresses applications of EFDTs in biomedical fields, with chapters on their application in tissue engineering, molecular delivery and implantable devices. This book is a valuable resource for materials scientists, biomedical engineers and clinicians alike. Presents a complete picture of Electrofluidodynamic technologies and their use in biomedicine Provides a comprehensive, professional reference on the subject, covering materials processing, fabrication and the use of novel devices for tissue engineering and therapeutics Focuses on technological advances, with an emphasis on studies and clinical trials



Porous Silicon for Biomedical Applications

Porous Silicon for Biomedical Applications Author Hélder A. Santos
ISBN-10 9780857097156
Release 2014-02-14
Pages 558
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Porous silicon has a range of properties, making it ideal for drug delivery, cancer therapy, and tissue engineering. Porous Silicon for Biomedical Applications provides a comprehensive review of this emerging nanostructured and biodegradable biomaterial. Chapters in part one focus on the fundamentals and properties of porous silicon for biomedical applications, including thermal properties and stabilization, photochemical and nonthermal chemical modification, protein-modified porous silicon films, and biocompatibility of porous silicon. Part two discusses applications in bioimaging and sensing, and explores the optical properties of porous silicon materials; in vivo imaging assessment and radiolabelling of porous silicon; and nanoporous silicon biosensors for DNA sensing and for bacteria detection. Finally, part three highlights drug loading and characterization of porous silicon materials, tumor targeting and imaging, and porous silicon scaffolds for functional tissue engineering, stem cell growth, and osteodifferentiation. With its acclaimed editor and international team of expert contributors, Porous Silicon for Biomedical Applications is a technical resource and indispensable guide for all those involved in the research, development, and application of porous silicon and other biomaterials, while providing a comprehensive introduction for students and academics interested in the field. Comprehensive review of porous silicon focusing on the fabrication and properties of this emerging material Specifically discusses drug delivery and orthopedic applications of porous silicon Aimed at materials researchers and scientists in the biomaterials industry – particularly those concerned with drug delivery and orthopedics



Tissue Engineering Using Ceramics and Polymers

Tissue Engineering Using Ceramics and Polymers Author Aldo R Boccaccini
ISBN-10 9780857097163
Release 2014-06-11
Pages 728
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The second edition of Tissue Engineering Using Ceramics and Polymers comprehensively reviews the latest advances in this area rapidly evolving area of biomaterials science. Part one considers the biomaterials used for tissue engineering. It introduces the properties and processing of bioactive ceramics and glasses, as well as polymeric biomaterials, particularly biodegradable polymer phase nanocomposites. Part two reviews the advances in techniques for processing, characterization, and modeling of materials. The topics covered range from nanoscale design in biomineralization strategies for bone tissue engineering to microscopy techniques for characterizing cells to materials for perfusion bioreactors. Further, carrier systems and biosensors in biomedical applications are considered. Finally, part three looks at the specific types of tissue and organ regeneration, with chapters concerning kidney, bladder, peripheral nerve, small intestine, skeletal muscle, cartilage, liver, and myocardial tissue engineering. Important developments in collagen-based tubular constructs, bioceramic nanoparticles, and multifunctional scaffolds for tissue engineering and drug delivery are also explained. Tissue Engineering Using Ceramics and Polymers is a valuable reference tool for both academic researchers and scientists involved in biomaterials or tissue engineering, including the areas of bone and soft-tissue reconstruction and repair, and organ regeneration. Second edition comprehensively examines the latest advances in ceramic and polymers in tissue engineering Provides readers with general information on polymers and ceramics and looks at the processing, characterization, and modeling Reviews the latest research and advances in tissue and organ regeneration using ceramics and polymers



Bioactive Glasses

Bioactive Glasses Author Heimo Ylänen
ISBN-10 9780081009376
Release 2017-09-15
Pages 426
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Bioactive Glasses: Materials, Properties and Applications, Second Edition provides revised, expanded and updated content on the current status of this unique material, including its properties, technologies and applications. The book is suitable for those active in the biomaterials and bioengineering field, and includes eight new chapters that cover material types, computational modeling, coatings and applications. Chapters deal with the materials and mechanical properties of bioactive glass and the applications of bioactive glasses, covering their uses in wound healing, maxillofacial surgery and bone tissue engineering, among other topics. With its distinguished editor and expert team of international contributors, the book is an invaluable reference for researchers and scientists in the field of biomaterials, both in academia and industry. Provides a detailed review of bioactive glasses, their properties, technologies and applications Comprehensively covers the materials and mechanical properties of bioactive glass and their further applications, including wound healing, maxillofacial surgery and bone tissue engineering Suitable for those active in the biomaterials and bioengineering field



Biomimetic Biomaterials

Biomimetic Biomaterials Author Andrew J Ruys
ISBN-10 9780857098887
Release 2013-09-30
Pages 344
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A significant proportion of modern medical technology has been developed through biomimetics, which is biologically inspired by studying pre-existing functioning systems in nature. Typical biomimetically inspired biomaterials include nano-biomaterials, smart biomaterials, hybrid biomaterials, nano-biocomposites, hierarchically porous biomaterials and tissue scaffolds. This important book summarises key research in this important field. The book is divided into two parts: Part one is devoted to the biomimetics of biomaterials themselves while part two provides overviews and case studies of tissue engineering applications from a biomimetics' perspective. The book has a strong focus on cutting edge biomimetically inspired biomaterials including chitin, hydrogels, calcium phosphates, biopolymers and anti-thrombotic coatings. Since many scaffolds for skin tissue engineering are biomimetically inspired, the book also has a strong focus on the biomimetics of tissue engineering in the repair of bone, skin, cartilage, soft tissue and specific organs. With its distinguished editor and international team of contributors, Biomimetic biomaterials is a standard reference for both the biomaterials research community and clinicians involved in such areas as bone regeneration, skin tissue and wound repair. Places strong focus on cutting edge biomimetically-inspired biomaterials including chitin, hydrogels, calcium phosphates, biopolymers and anti-thrombotic coatings Provides overviews and case studies of tissue engineering applications from a biomimetics perspective Also places focus on the biomimetics of tissue engineering in the repair of bone, skin, cartilage, soft tissue and specific organs



Biomaterials and Devices for the Circulatory System

Biomaterials and Devices for the Circulatory System Author Terence Gourlay
ISBN-10 9780857090553
Release 2010-10-28
Pages 400
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Cardiovascular disease is one of the leading causes of death in the world today. Thanks to major advances in circulatory biomaterials and medical devices over the past few decades, many complications of this prevalent disease can be managed with great success for prolonged periods. Biomaterials and devices for the circulatory system reviews the latest developments in this important field and how they can be used to improve the success and safety in this industry. Part one discusses physiological responses to biomaterials with chapters on tissue response, blood interface and biocompatibility. Part two then reviews clinical applications including developments in valve technology, percutaneous valve replacement, bypass technologies and cardiovascular stents. Part three covers future developments in the field with topics such as nanomedicine, cardiac restoration therapy, biosensor technology in the treatment of cardiovascular disease and vascular tissue engineering. With its distinguished editors and international team of contributors Biomaterials and devices for the circulatory system is a vital reference for those concerned with bioengineering, medical devices and clinicians within this critical field. Reviews the latest developments in this important field and how they can be used to improve success and safety in the industry Both current clinical advances as well as future innovation are assessed taking a progressive view of the role of biomaterials in medical applications An examination of the physiological responses to biomaterials features tissue responses to implanted materials and strategies to improve the biocompatibility of medical devices



Drug Device Combination Products

Drug Device Combination Products Author Andrew Lewis
ISBN-10 9781845697488
Release 2009-12-15
Pages 560
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Drug delivery systems represent a vast area of research and development within biomaterials and medicine and the demand for sophisticated drug delivery devices continues to drive novel product development. Advanced drug delivery devices can offer significant advantages over conventional drugs and devices alone, such as increased efficiency, improved performance and convenience. The purpose of this book is to illustrate how effective drug delivery can be achieved by means other than tablets. The book will provide a thorough analysis of the fundamentals, applications and new technologies of drug-device combination products for use throughout the human body. Part one provides readers with an introduction and background to the field. Chapters in Part two discuss areas of application such as catheter based products, drug eluting stents and beads and anti-biotic loaded cements. Part three covers the development of drug device combination products with chapters on such topics as pre-clinical testing, sterilisation, patent issues and regulation of drug device combination products. With its distinguished editor and team of international contributors, Drug-device combination products: delivery technologies and applications is an invaluable reference for product development specialists, materials scientists and engineers in the biomedical industry and academia as well as those concerned with drug delivery. Illustrates how effective drug delivery can be achieved by means other than tablets providing readers with a comprehensive introduction and background to the field Provides a thorough analysis of the fundamentals, applications and new technologies of drug device combination products Discusses areas of application such as catheter based products and reviews the development of drug device combination products including pre-clinical testing and sterilisation



Biomaterials for Cancer Therapeutics

Biomaterials for Cancer Therapeutics Author Kinam Park
ISBN-10 9780857096760
Release 2013-11-23
Pages 530
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Cancer can affect people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential of biomaterials in treating this prevalent disease. The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Chapters in part two discuss synthetic vaccines, proteins and polymers for cancer therapeutics. Part three focusses on theranosis and drug delivery systems, whilst the final set of chapters look at biomaterial therapies and cancer cell interaction. This extensive book provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. Biomaterials for cancer therapeutics is an essential text for academics, scientists and researchers within the biomedical industry, and will also be of interest to clinicians with a research interest in cancer therapies and biomaterials. A complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer Discusses the fundamentals of biomaterials for cancer therapeutics Discusses synthetic vaccines, proteins and polymers for cancer therapeutics



Rapid Prototyping of Biomaterials

Rapid Prototyping of Biomaterials Author Roger Narayan
ISBN-10 9780857097217
Release 2014-02-13
Pages 328
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Rapid Prototyping of Biomaterials: Principles and Applications provides a comprehensive review of established and emerging rapid prototyping technologies (such as bioprinting) for medical applications. Rapid prototyping, also known as layer manufacturing, additive manufacturing, solid freeform fabrication, or 3D printing, can be used to create complex structures and devices for medical applications from solid, powder, or liquid precursors. Following a useful introduction, which provides an overview of the field, the book explores rapid prototyping of nanoscale biomaterials, biosensors, artificial organs, and prosthetic limbs. Further chapters consider the use of rapid prototyping technologies for the processing of viable cells, scaffolds, and tissues. With its distinguished editor and international team of renowned contributors, Rapid Prototyping of Biomaterials is a useful technical resource for scientists and researchers in the biomaterials and tissue regeneration industry, as well as in academia. Comprehensive review of established and emerging rapid prototyping technologies (such as bioprinting) for medical applications Chapters explore rapid prototyping of nanoscale biomaterials, biosensors, artificial organs, and prosthetic limbs Examines the use of rapid prototyping technologies for the processing of viable cells, scaffolds, and tissues



Characterization of Biomaterials

Characterization of Biomaterials Author M Jaffe
ISBN-10 9780857093684
Release 2012-12-19
Pages 334
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Biomaterials and medical devices must be rigorously tested in the laboratory before they can be implanted. Testing requires the right analytical techniques. Characterization of biomaterials reviews the latest methods for analyzing the structure, properties and behaviour of biomaterials. Beginning with an introduction to microscopy techniques for analyzing the phase nature and morphology of biomaterials, Characterization of biomaterials goes on to discuss scattering techniques for structural analysis, quantitative assays for measuring cell adhesion, motility and differentiation, and the evaluation of cell infiltration and tissue formation using bioreactors. Further topics considered include studying molecular-scale protein-surface interactions in biomaterials, analysis of the cellular genome and abnormalities, and the use of microarrays to measure cellular changes induced by biomaterials. Finally, the book concludes by outlining standards and methods for assessing the safety and biocompatibility of biomaterials. With its distinguished editors and international team of expert contributors, Characterization of biomaterials is an authoritative reference tool for all those involved in the development, production and application of biomaterials. Reviews the latest methods for analyzing the structure, properties and behaviour of biomaterials Discusses scattering techniques for structural analysis, quantitative assays for measuring cell adhesion, and motility and differentiation Examines the evaluation of cell infiltration and tissue formation using bioreactors



Semiconducting Silicon Nanowires for Biomedical Applications

Semiconducting Silicon Nanowires for Biomedical Applications Author J.L. Coffer
ISBN-10 9780857097712
Release 2014-02-17
Pages 296
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Biomedical applications have benefited greatly from the increasing interest and research into semiconducting silicon nanowires. Semiconducting Silicon Nanowires for Biomedical Applications reviews the fabrication, properties, and applications of this emerging material. The book begins by reviewing the basics, as well as the growth, characterization, biocompatibility, and surface modification, of semiconducting silicon nanowires. It goes on to focus on silicon nanowires for tissue engineering and delivery applications, including cellular binding and internalization, orthopedic tissue scaffolds, mediated differentiation of stem cells, and silicon nanoneedles for drug delivery. Finally, it highlights the use of silicon nanowires for detection and sensing. These chapters explore the fabrication and use of semiconducting silicon nanowire arrays for high-throughput screening in the biosciences, neural cell pinning on surfaces, and probe-free platforms for biosensing. Semiconducting Silicon Nanowires for Biomedical Applications is a comprehensive resource for biomaterials scientists who are focused on biosensors, drug delivery, and tissue engineering, and researchers and developers in industry and academia who are concerned with nanoscale biomaterials, in particular electronically-responsive biomaterials. Reviews the growth, characterization, biocompatibility, and surface modification of semiconducting silicon nanowires Describes silicon nanowires for tissue engineering and delivery applications, including cellular binding and internalization, orthopedic tissue scaffolds, mediated differentiation of stem cells, and silicon nanoneedles for drug delivery Highlights the use of silicon nanowires for detection and sensing



Electrospun Materials for Tissue Engineering and Biomedical Applications

Electrospun Materials for Tissue Engineering and Biomedical Applications Author Tamer Uyar
ISBN-10 0081010222
Release 2017-06-02
Pages 444
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Electrospinning, an electro-hydrodynamic process, is a versatile and promising platform technology for the production of nanofibrous materials for tissue engineering and biomedical applications. Electrospun Materials for Tissue Engineering and Biomedical Applications, examines the rapid development of electrospun materials for use in tissue engineering and biomedical applications. With a strong focus on fundamental materials science and engineering, this book also looks at successful technology transfers to the biomedical industry, highlighting biomedical products already on the market as well as the requirements to successfully commercialize electrospun materials for potential use in tissue engineering and biomedical areas. This book is a valuable resource for materials and biomedical scientists and engineers wishing to broaden their knowledge on the tissue engineering and biomedical applications of electrospun fibrous materials. Provides all-encompassing coverage of fundamental science, technology and industrial case studies Presents guidance on industrial scalability of electrospun biomaterials Written by a multidisciplinary team or researchers from academia and industry, offering a balanced viewpoint on the subject



Biomaterials for Artificial Organs

Biomaterials for Artificial Organs Author Michael Lysaght
ISBN-10 9780857090843
Release 2010-12-20
Pages 320
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The worldwide demand for organ transplants far exceeds available donor organs. Consequently some patients die whilst waiting for a transplant. Synthetic alternatives are therefore imperative to improve the quality of, and in some cases, save people’s lives. Advances in biomaterials have generated a range of materials and devices for use either outside the body or through implantation to replace or assist functions which may have been lost through disease or injury. Biomaterials for artificial organs reviews the latest developments in biomaterials and investigates how they can be used to improve the quality and efficiency of artificial organs. Part one discusses commodity biomaterials including membranes for oxygenators and plasmafilters, titanium and cobalt chromium alloys for hips and knees, polymeric joint-bearing surfaces for total joint replacements, biomaterials for pacemakers, defibrillators and neurostimulators and mechanical and bioprosthetic heart valves. Part two goes on to investigate advanced and next generation biomaterials including small intestinal submucosa and other decullarized matrix biomaterials for tissue repair, new ceramics and composites for joint replacement surgery, biomaterials for improving the blood and tissue compatibility of total artificial hearts (TAH) and ventricular assist devices (VAD), nanostructured biomaterials for artificial tissues and organs and matrices for tissue engineering and regenerative medicine. With its distinguished editors and international team of contributors Biomaterials for artificial organs is an invaluable resource to researchers, scientists and academics concerned with the advancement of artificial organs. Reviews the latest developments in biomaterials and investigates how they can be used to improve the quality and efficiency of artificial organs Discusses commodity biomaterials including membranes for oxygenators and cobalt chromium alloys for hips and knees and polymeric joint-bearing surfaces for total joint replacements Further biomaterials utilised in pacemakers, defibrillators, neurostimulators and mechanical and bioprosthetic heart valve are also explored



Engineering of Biomaterials for Drug Delivery Systems

Engineering of Biomaterials for Drug Delivery Systems Author Anilkumar Parambath
ISBN-10 9780081017517
Release 2018-02-01
Pages 404
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Engineering of Biomaterials for Drug Delivery Systems: Beyond Polyethylene Glycol examines the combined issues of PEGylation and viable biomaterials as alternatives. With a strong focus on polymeric biomaterials, the book first reviews the major issues associated with PEGylation and its use in vivo. Chapters then focus on alternative polymer systems for drug delivery systems. Finally, nanoparticles and future perspectives are examined. This book is a valuable resource for scientists and researchers in biomaterials, pharmaceuticals and nanotechnology, and all those who wish to broaden their knowledge in this field. Provides a self-contained work for the field of biomaterials for drug delivery Summarizes the current knowledge on PEGylation and strategies for bypassing it Presents research on an important, though under-represented issue in biomaterials Written by a world-class team of research scientists, engineers and clinicians