Download or read online books in PDF, EPUB and Mobi Format. Click Download or Read Online button to get book now. This site is like a library, Use search box in the widget to get ebook that you want.

Neurobiology of Depression

Neurobiology of Depression Author Francisco Lopez-Munoz
ISBN-10 9781439838501
Release 2011-09-09
Pages 526
Download Link Click Here

Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, molecular biology, genomics, psychiatry, psychology, and pharmacology, Neurobiology of Depression discusses the nature of the central nervous system circuits responsible for the modifications of neuronal functioning that lead to depression. The book begins by discussing animal, neurophysiological, and neuropsychological models of depression as well as neural foundations. It explores genetic factors that contribute to depression and describes the effect of monoaminergic systems in the central nervous system. Next, the book profiles the rise of psychopharmacology in the treatment of depression and the research into serotonin and monoamine reuptake inhibitors. It examines the role of the glutamatergic, endocannabinoid, and opioid systems in the pathophysiology of mood disorders, as well as the effect of biological rhythms on the human body. Later chapters review the role of CRF-related ligands, CRF receptors, HPA axis activity, and glucocorticoid receptors in the regulation of the stress response and depression. They also describe cytokine modulation of molecular mechanisms. They examine the role of neuropeptide Y, nitric oxide, beta-arrestins, BDNF, and phosphodiesterases, and discuss the use of tachykinin antagonists in treatment. Finally, they analyze the neurobiological basis for the development of new antidepressant agents. Exploring myriad aspects of a disease that plagues a large percentage of the population worldwide, this volume captures the state of the science of this debilitating disorder, facilitating further research and discovery.



Behavioral Neurobiology of Depression and Its Treatment

Behavioral Neurobiology of Depression and Its Treatment Author Philip J. Cowen
ISBN-10 9783642354250
Release 2014-04-24
Pages 344
Download Link Click Here

The book highlights important new research using current state-of-the-art approaches by prominent researchers in the field of depression. A broad range of topics is covered, beginning with a description of the phenotypic features of clinical depression, followed by chapters on the cellular and molecular basis, functional neuroimaging correlates and information-processing accounts. Finally, existing and novel treatment approaches are covered. In this way the volume brings together the key disciplines involved in the neurobiological understanding of depression to provide an update of the field and outlook to the future. Together, the volume chapters provide focused and critical reviews that span a broad range of topics suitable for both students and established investigators interested in the present state of depression research.



The Neurobiology of Cognition and Behavior

The Neurobiology of Cognition and Behavior Author John Hart, Jr.
ISBN-10 9780190219031
Release 2015-11-27
Pages 256
Download Link Click Here

"Neurobiology of Cognition and Behavior" is one of the initial textbooks of brain mapping in the field of cognitive neuroscience. This well-researched text by a leading expert in the field provides a foundational map of the human brain for cognition and behavior. This comprehensive map of essential human thinking and emotion is based on the explosion in the field of functional neuroimaging studies (fMRI, PET) in the normally functioning human brain. The approach of this text is to confirm the association of these brain regions by verifying that damage to the activated brain area results in a consistent deficit in the cognitive/behavioral operation under investigation. The approach used to form this view of mapping brain and cognition is based on cognitive neuroscience principles of defining dissociable, fine-grained cognitive units and associating these units with brain regions encoding for these units or aspects of the units from both functional imaging and lesion studies. These cognitive-brain relationships are incorporated into clinical syndromes to account for the behavior of these patients after a lesion occurs, with the added feature of presenting patient videos demonstrating the disrupted cognitive behaviors. This comprehensive textbook provides a framework of the basic architecture of cognition in the brain with this combination of activation and lesion study confirmation of the brain-behavior associations. This basic framework is useful for those students studying the interaction of cognitive science and neuroanatomy as well as being relevant to the experienced neuroscientist researcher or clinician.



Neurobiology of Mood Disorders

Neurobiology of Mood Disorders Author Robert M. Post
ISBN-10 UOM:39015011640078
Release 1984
Pages 887
Download Link Click Here

Neurobiology of Mood Disorders has been writing in one form or another for most of life. You can find so many inspiration from Neurobiology of Mood Disorders also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Neurobiology of Mood Disorders book for free.



New frontiers in the neuropsychopharmacology of mental illness

New frontiers in the neuropsychopharmacology of mental illness Author Thibault Renoir
ISBN-10 9782889194049
Release 2015-01-28
Pages
Download Link Click Here

In recent years, mental illnesses have become recognized as a huge emotional and financial burden to the individual, their relatives and society at large. Stress-related and mood disorders as well as psychoactive substance abuse are among the disorders associated with most disability in high income countries. Suicide, which is often attributed to some underlying mental disorders, is a leading cause of death among teenagers and young adults. At the same time, mental disorders pose some of the toughest challenges in neuroscience research. There are many different categories of mental disorder as defined and classified by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) and the International Statistical Classification of Diseases 10th Revision (ICD-10). Despite the ongoing improvements of those widely used manuals, the validity and reliability of their diagnoses remain a constant debate. However, it has now become accepted by the scientific community that mental disorders can arise from multiple sources. In that regard, both clinical and animal studies looking at gene-environment interactions have helped to better understand the mechanisms involved in the pathophysiology as well as the discovery of treatments for mental disorders. This Research Topic aims to cover recent progress in research studying how genetic make-up and environmental factors (such as stress paradigm or pharmacological treatment) can contribute to the development of mental disorders such as anxiety, depression, and schizophrenia. This Research Topic also seeks to highlight studies looking at affective-like disorders following the intake of drugs of abuse. We also welcome all research articles, review papers, brief communications, and commentary on topics related to the broad field of Neuropsychopharmacology.



The Neurobiological Basis of Suicide

The Neurobiological Basis of Suicide Author Yogesh Dwivedi
ISBN-10 9781439838815
Release 2012-06-25
Pages 482
Download Link Click Here

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.



The Good News about Depression

The Good News about Depression Author Mark S. Gold
ISBN-10 UOM:39015037786160
Release 1995-01-01
Pages 368
Download Link Click Here

An informative guide to new treatments for depression examines key new diagnostic tools and techniqes, examines recent developments in the field of biopsychiatry, details the links between depression and physical ailments, and furnishes valuable self-help advice. Original.



Diet and Exercise in Cognitive Function and Neurological Diseases

Diet and Exercise in Cognitive Function and Neurological Diseases Author Akhlaq A. Farooqui
ISBN-10 9781118840566
Release 2015-02-06
Pages 384
Download Link Click Here

Diet and exercise have long been recognized as important components of a healthy lifestyle, as they have a great impact on improving cardiovascular and cerebrovascular functions, lowering the risk of metabolic disorders, and contributing to healthy aging. As a greater proportion of the world’s population is living longer, there has been increased interest in understanding the role of nutrition and exercise in long-term neurological health and cognitive function. Diet and Exercise in Cognitive Function and Neurological Diseases discusses the role and impact that nutrition and activity have on cognitive function and neurological health. The book is divided into two sections. The first section focuses on diet and its impact on neurobiological processes. Chapters focus on the impacts of specific diets, such as the Mediterranean, ketogenic and vegan diets, as well as the role of specific nutrients, fats, fatty acids, and calorie restriction on neurological health and cognitive function. The second section of the book focuses on exercise, and its role in maintaining cognitive function, reducing neuroinflammatory responses, regulating adult neurogenesis, and healthy brain aging. Other chapters look at the impact of exercise in the management of specific neurological disorders such Multiple Sclerosis and Parkinson’s Disease. Diet and Exercise in Cognitive Function and Neurological Diseases is a timely reference on the neurobiological interplay between diet and exercise on long-term brain health and cognitive function.



Handbook of Depression and Anxiety

Handbook of Depression and Anxiety Author Johan A. Den Boer
ISBN-10 UOM:39015032186663
Release 1994
Pages 691
Download Link Click Here

Handbook of Depression and Anxiety has been writing in one form or another for most of life. You can find so many inspiration from Handbook of Depression and Anxiety also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Handbook of Depression and Anxiety book for free.



Neurological Functions of the Masterswitch Protein Kinase GSK 3

Neurological Functions of the Masterswitch Protein Kinase     GSK 3 Author Oksana Kaidanovich-Beilin
ISBN-10 9782889190478
Release
Pages
Download Link Click Here

The functions of the brain that allow us to think, feel, move, and perceive the world are the result of an exchange of information within a network composed of millions of specialized cells called neurons and glia. Neurons use neurotransmitters and other extracellular messengers to communicate with each other, and to constantly update and re-organize their network of connections in a process known as neural plasticity. In order to respond to these extracellular signals, neurons are equipped with specialized receptors that can recognize a single neurotransmitter a bit like a lock would recognize a key. They do this by activating or inhibiting a class of specialized signaling proteins and second messengers. Typically, signaling proteins are themselves organized in networks or pathways in which they activate or inhibit each other in order to integrate the mass of information received by a single cell and to regulate the biological functions of this cell. As we can see, rather than simply being a network of neurons, the brain can be seen as a sort of “Russian doll” in which each neuron is at the same time a part of networks with other neurons and the receptacle of many networks composed of signaling proteins. Two individual genes encode two paralogous signaling proteins: Glycogen Synthase Kinase -3 alpha and beta (GSK-3a, GSK-3b), named for its ability to phosphorylate a key metabolic enzyme of glycogen synthesis, glycogen synthase. This unique “glamour and gloom” protein kinase, has been intriguing many researches for over 30 years by its unusual features, still unknown mechanisms of its activation, its regulation by multiple “key” intracellular pathways, and its capacity to influence the functions of many substrates. Since GSK-3 was discovered, there has been significant progress in elucidating its regulatory roles in the neuron and the structure and functions of the brain. Lithium has been used as a gold standard in the treatment of bipolar disorder for 60 years; and “GSK-3’s renaissance” in psychiatry began with the discovery of GSK-3 as lithium's intracellular target. Since then, GSK3 has been implicated in the pathogenesis of mood disorders, schizophrenia, Alzheimer’s disease, ADHD, multiple sclerosis, Fragile X syndrome and Huntington disease. Connections to these and other diseases has led over the last 10 years to the generation of multiple types of GSK-3 inhibitors as promising therapeutic treatments for the aforementioned pathological conditions. During last couple years new genetic models have been generated, including conventional and conditional mouse models, allowing the discovery of new roles of GSK-3 in the mechanism of neurotransmitter action, neurodevelopment, learning and memory formation, GSK-3’s gene - effect on mouse behavior, and other functions. Thus, GSK-3 has been well-established as an intracellular second messenger for several neurotransmitter systems, and as an important therapeutic target of mood stabilizers, antipsychotics and psychomimetic drugs. The proposed Specific Topic for Frontiers in Neuroscience will be focused on the latest advances from leading laboratories in this area, subdivided into 5 topics: (1) GSK-3 history, mechanism of regulation, substrate specificity and comparison between the brain function of two GSK-3 genes through new animal models and cell biology approaches; (2) role of GSK-3 in neurodevelopment and neuronal structure; (3) involvement of GSK-3 in synaptic functions, learning and memory, and in serotonin and dopamine pathways; (4) role of GSK-3 in neuroinflammation, and application to the pathogenesis of multiple sclerosis, AD, schizophrenia, Fragile X, brain tumors, stroke and bipolar disorder; (5) development of GSK-3 inhibitors and their application in psychiatry, including special discussion about the mechanism of lithium action.



Serotonin Receptors in Neurobiology

Serotonin Receptors in Neurobiology Author Amitabha Chattopadhyay
ISBN-10 1420005758
Release 2007-05-17
Pages 224
Download Link Click Here

A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from leading experts in their fields, the book explores serotonin receptors from a broad-based, multidisciplinary approach. The approaches described vary from molecular biological techniques to fluorescence microscopy and imaging, to genetic manipulation in animal models, providing a wide range of tools to study serotonergic phenomena. While each of these approaches has its own advantages and limitations, the synthesis of information and knowledge achieved from studies using multiple approaches will result in a comprehensive understanding of the underlying complex phenomena involved in serotonergic signaling and its implications in health and disease. The book provides an overall understanding of these receptors based on currently used methodologies and techniques. It describes specific experimental procedures that will be of use to researchers interested in addressing similar problems involving other G-protein-coupled receptor signaling systems.



The endocannabinoid system a key modulator of emotions and cognition

The endocannabinoid system  a key modulator of emotions and cognition Author Patrizia Campolongo
ISBN-10 9782889190850
Release
Pages
Download Link Click Here

The endocannabinoid system a key modulator of emotions and cognition has been writing in one form or another for most of life. You can find so many inspiration from The endocannabinoid system a key modulator of emotions and cognition also informative, and entertaining. Click DOWNLOAD or Read Online button to get full The endocannabinoid system a key modulator of emotions and cognition book for free.



New Developments in the Biology of Mental Disorders

New Developments in the Biology of Mental Disorders Author
ISBN-10 UVA:X004190240
Release 1994-12-30
Pages 181
Download Link Click Here

This book defines mental disorders and describes what they are. The genetics of mental disorders is also discussed, government policies and issues are summarized, and research efforts and issues are reported. The potential of and the opportunities offered by the growing neuroscience field are assessed. Topics covered include schizophrenia, mood disorders (major depression and bipolar disorder) , anxiety disorders (obsessive, compulsive, and panic disorders) , treatments, genetics, and research efforts. A glossary, acronyms, references, and an index are also included.



Rebuilding cerebellar network computations from cellular neurophysiology

Rebuilding cerebellar network computations from cellular neurophysiology Author Egidio D'Angelo
ISBN-10 9782889190751
Release
Pages
Download Link Click Here

This Research Topic is centered around the attempt to understand network activity of the brain by combining experimental and modeling techniques. A surprisingly rich set of new observations is emerging about the functions of the olivo-cerebellar cortical modules. This Research Topic will consider the critical elements of new emerging knowledge achieved using in vitro and in vivo techniques and the computational attempts at functional circuit reconstruction.



The Biology of Mental Disorders

The Biology of Mental Disorders Author
ISBN-10 MINN:31951D00293578N
Release 1992
Pages 187
Download Link Click Here

The Biology of Mental Disorders has been writing in one form or another for most of life. You can find so many inspiration from The Biology of Mental Disorders also informative, and entertaining. Click DOWNLOAD or Read Online button to get full The Biology of Mental Disorders book for free.



The Wiley Blackwell Handbook of Mindfulness

The Wiley Blackwell Handbook of Mindfulness Author Amanda Ie
ISBN-10 9781118294918
Release 2014-03-12
Pages 1248
Download Link Click Here

The Wiley Blackwell Handbook of Mindfulness brings together the latest multi-disciplinary research on mindfulness from a group of international scholars: Examines the origins and key theories of the two dominant Western approaches to mindfulness Compares, contrasts, and integrates insights from the social psychological and Eastern-derived perspectives Discusses the implications for mindfulness across a range of fields, including consciousness and cognition, education, creativity, leadership and organizational behavior, law, medical practice and therapy, well-being, and sports 2 Volumes



Neurological Research

Neurological Research Author
ISBN-10 NWU:35558003819352
Release 1996
Pages
Download Link Click Here

Neurological Research has been writing in one form or another for most of life. You can find so many inspiration from Neurological Research also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Neurological Research book for free.