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New Insights on Vitamin C and Cancer

New Insights on Vitamin C and Cancer Author Michael J. Gonzalez
ISBN-10 9781493918904
Release 2014-09-18
Pages 69
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Research on vitamin C and its effects on cancer is growing in popularity around the world as positive research continues to accumulate building a stronger case for its effectiveness. This concise SpringerBrief on Vitamin C and Cancer presents the latest findings on how vitamin C induces apoptosis. A high concentration of vitamin C allows for ascorbate to generate hydrogen peroxide in tissue that can selectively kill cancer cells. Research has confirmed that high-dose vitamin C is cytotoxic to a wide variety of cancer cell lines, and that it also boosts the anti-cancer activity of several common chemotherapy drugs. Vitamin C also does more than just kill cancer cells. It boosts immunity by stimulating collagen formation to help the body wall off the tumor. It inhibits hyaluronidase, an enzyme that tumors use to metastasize and invade other organs throughout the body. This concise and up-to-date Brief is geared towards cancer researchers and scientists, as well as physicians interested in the basic science and the translational potential of vitamin C in cancer therapeutics.



Cancer Nanotheranostics

Cancer Nanotheranostics Author P. Gopinath
ISBN-10 9789812874351
Release 2015-03-10
Pages 119
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This Brief provides a clear insight of the recent advances in the field of cancer theranostics with special emphasis upon nano scale carrier molecules (polymeric, protein and lipid based) and imaging agents (organic and inorganic).



Cancer Systems Biology

Cancer Systems Biology Author Edwin Wang
ISBN-10 1439811865
Release 2010-05-04
Pages 456
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The unprecedented amount of data produced with high-throughput experimentation forces biologists to employ mathematical representation and computation methods to glean meaningful information in systems-level biology. Applying this approach to the underlying molecular mechanisms of tumorigenesis, cancer researchers can uncover a series of new discoveries and biological insights. The First Cancer Systems Biology Book Designed for Computational and Experimental Biologists Unusual in its dualistic approach, Cancer Systems Biology discusses the recent progress in the understanding of cancer systems biology at a time when more and more researchers and pharmaceutical companies are looking into a systems biology approach to find drugs that can effectively be used to treat cancer patients. Includes Contributions from more than 30 International Experts Part I introduces basic concepts and theories of systems biology and their applications in cancer research, including case studies of current efforts in cancer systems biology. Part II discusses basic cancer biology and cutting-edge topics of cancer research for computational biologists. In contains an overview of genomics, cell signaling, and tumorigenesis, in addition to hot topics like molecular mechanisms of cancer metastasis and the molecular relationships between solid tumors, their microenvironments, and tumor blood vessels. Rounding out the book’s solid coverage, Part III explores a variety of computational tools and public data resources that are useful for studying cancer problems at a systems level. Cancer systems biology is still in its infancy as a field of study, but it is fast becoming indispensable in the battle to defeat cancer and develop successful new treatments. Cancer Systems Biology marks an important step toward reaching that goal.



Obesity and Breast Cancer

Obesity and Breast Cancer Author Kristy A. Brown
ISBN-10 9781489980021
Release 2013-11-21
Pages 56
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Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer. Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast. This SpringerBrief will explore all of these issues in depth and the authors are in a unique position to write about this topic, having extensive experience in the field of aromatase research.​



Ethics Dumping

Ethics Dumping Author Doris Schroeder
ISBN-10 9783319647319
Release 2017-12-04
Pages 134
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This book is published under a CC BY 4.0 license. This book provides original, up-to-date case studies of “ethics dumping” that were largely facilitated by loopholes in the ethics governance of low and middle-income countries. It is instructive even to experienced researchers since it provides a voice to vulnerable populations from the fore mentioned countries. Ensuring the ethical conduct of North-South collaborations in research is a process fraught with difficulties. The background conditions under which such collaborations take place include extreme differentials in available income and power, as well as a past history of colonialism, while differences in culture can add a new layer of complications. In this context, up-to-date case studies of unethical conduct are essential for research ethics training.



New Approaches to Natural Anticancer Drugs

New Approaches to Natural Anticancer Drugs Author Soodabeh Saeidnia
ISBN-10 9783319140278
Release 2015-02-05
Pages 106
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This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also includes discussion of new areas such as biotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have been the subject of discussion in this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.



I Have Cancer What Should I Do

I Have Cancer  What Should I Do Author Michael J. Gonzalez
ISBN-10 1591202434
Release 2009
Pages 156
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Very few diagnoses shock patients as much as being told that they have cancer, a modern pandemic around the world. Cancer is a multifactor disease that requires a multifactor treatment plan: medical, nutritional, and lifestyle changes as well as emotional, social, and spiritual support. An effective approach for cancer must be truly integrated.This book shows that optimum nutrition and dietary supplementation should be part of every cancer treatment. Nutrition is not only preventive-it also has powerful therapeutic potential. Orthomolecular medicine restores the optimum environment in the body for fighting cancer by correcting imbalances or deficiencies.This is not your average book about cancer. The authors, in addition to being healthcare practitioners, have had personal experiences with this potentially devastating disease. I Have Cancer: What Should I Do? maps out a program the authors themselves would follow:o Anticancer dietary strategies o Relaxationo Supplements to optimize the body's immune defenseso Detoxification o Exerciseo Positive psychological/spiritual empowermentCancer patients benefit from the combination of conventional and orthomolecular therapy. Nutritional strategies can improve one's overall strength to maintain health and win the battle against cancer.



Nanozymes Next Wave of Artificial Enzymes

Nanozymes  Next Wave of Artificial Enzymes Author Xiaoyu Wang
ISBN-10 9783662530689
Release 2016-08-28
Pages 127
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This book describes the fundamental concepts, the latest developments and the outlook of the field of nanozymes (i.e., the catalytic nanomaterials with enzymatic characteristics). As one of today’s most exciting fields, nanozyme research lies at the interface of chemistry, biology, materials science and nanotechnology. Each of the book’s six chapters explores advances in nanozymes. Following an introduction to the rise of nanozymes research in the course of research on natural enzymes and artificial enzymes in Chapter 1, Chapters 2 through 5 discuss different nanomaterials used to mimic various natural enzymes, from carbon-based and metal-based nanomaterials to metal oxide-based nanomaterials and other nanomaterials. In each of these chapters, the nanomaterials’ enzyme mimetic activities, catalytic mechanisms and key applications are covered. In closing, Chapter 6 addresses the current challenges and outlines further directions for nanozymes. Presenting extensive information on nanozymes and supplemented with a wealth of color illustrations and tables, the book offers an ideal guide for readers from disparate areas, including analytical chemistry, materials science, nanoscience and nanotechnology, biomedical and clinical engineering, environmental science and engineering, green chemistry, and novel catalysis.



A Quick Guide to Cancer Epidemiology

A Quick Guide to Cancer Epidemiology Author Paolo Boffetta
ISBN-10 9783319050683
Release 2014-03-22
Pages 101
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A Quick Guide to Cancer Epidemiology is an ideal addition to Springer Briefs in Cancer Research. The Brief provides core concepts in cancer epidemiology and also gives a snapshot of the epidemiology of seventeen human cancers. The Brief aims to provide-with quantitative focus-estimates of the global burden of neoplasms, of recent and likely future trends, distribution, causes and strategies for prevention for major groups of cancers. Finally, the Brief will give an overview of severals factors that cause cancer including dietary factors, tobacco smoking, obesity and alcohol consumption.



Nanomaterial Based Drug Delivery Carriers for Cancer Therapy

Nanomaterial Based Drug Delivery Carriers for Cancer Therapy Author Tao Feng
ISBN-10 9789811032998
Release 2016-12-09
Pages 55
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This brief summarizes different types of organic and inorganic nanomaterials for drug delivery in cancer therapy. It highlights that precisely designed nanomaterials will be the next-generation therapeutic agents for cancer treatment.



Endometriosis

Endometriosis Author Sajal Gupta
ISBN-10 9783319183084
Release 2015-10-22
Pages 115
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This SpringerBrief provides an update on endometriosis research -- from the underlying mechanisms, predisposing factors, role of environmental pollutants, treatment options, impact on quality of life, and biomarkers, to emerging treatment modalities in order to help clinicians to pursue a patient-centered approach in managing the disease. This book provides clinicians with a better insight into early diagnosis and management of endometriosis. It explores the possible identification of proteins in different types of endometriosis diseases and at different stages of the progression. This may aid in the discovery of potential biomarkers for non-invasive diagnosis of these diseases. The ability to identify a protein, common between women of different races, ages and in different regions of the world will hopefully contribute to improving women’s health worldwide.



Gamma Glutamyl Transpeptidases

Gamma Glutamyl Transpeptidases Author Immacolata Castellano
ISBN-10 9783034806824
Release 2013-07-09
Pages 57
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Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). γ-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.γ-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson’s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of γ-GTs and gives information about applications of γ-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.​



Nanomedicine for Cancer Therapy

Nanomedicine for Cancer Therapy Author Piyush Kumar
ISBN-10 9783319458267
Release 2016-11-21
Pages 68
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This Brief focuses on the cancer therapy available till date, from conventional drug delivery to nanomedicine in clinical trial. In addition, it reports on future generation based nanotherapeutics and cancer theranostic agent for effective therapeutic diagnosis and treatment. Breast cancer was chosen as the model system in this review. The authors give emphasis to multiple drug resistance (MDR) and its mechanism and how to overcome it using the nanoparticle approach.



Dietary Supplement Regulation in the United States

Dietary Supplement Regulation in the United States Author Taylor C. Wallace
ISBN-10 9783319015026
Release 2013-10-01
Pages 43
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Contrary to the common belief that dietary supplements are “unregulated” in the United States, nutrients and other dietary ingredient-containing products have been regulated in this country for a little over a century at least in some capacity, initially through the Pure Food and Drug Act (PFDA) of 1906 and culminating with the many anticipated regulations to be implemented following the recent enactment of the Food Safety Modernization Act of 2010 (FSMA). The goal of this brief is to review and discuss the current statutes and regulations surrounding the ingredients, manufacturing standards, safety, and labeling of dietary supplements for the purpose of protecting consumers. ​



Techniques for Nanoencapsulation of Food Ingredients

Techniques for Nanoencapsulation of Food Ingredients Author C. Anandharamakrishnan
ISBN-10 9781461493877
Release 2013-11-26
Pages 89
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Nanoencapsulation has the potential to improve human health through its capacity to both protect bioactive compounds and release them at a specific time and location into various substances, including food. Numerous nanoencapsulation technologies have emerged in recent years, each with its own advantages and disadvantages. The goal of this Brief is to discuss the various nanoencapsulation technologies, such as emulsification, coacervation, inclusion encapsulation, anti-solvent precipitation, nanoprecipitation, freeze drying, and spray drying, including their limitations. Recent safety and regulatory issues concerning the various nanoencapsulation technologies will also be covered.



Distributed Computing and Monitoring Technologies for Older Patients

Distributed Computing and Monitoring Technologies for Older Patients Author Juris Klonovs
ISBN-10 9783319270241
Release 2016-01-21
Pages 102
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This book summarizes various approaches for the automatic detection of health threats to older patients at home living alone. The text begins by briefly describing those who would most benefit from healthcare supervision. The book then summarizes possible scenarios for monitoring an older patient at home, deriving the common functional requirements for monitoring technology. Next, the work identifies the state of the art of technological monitoring approaches that are practically applicable to geriatric patients. A survey is presented on a range of such interdisciplinary fields as smart homes, telemonitoring, ambient intelligence, ambient assisted living, gerontechnology, and aging-in-place technology. The book discusses relevant experimental studies, highlighting the application of sensor fusion, signal processing and machine learning techniques. Finally, the text discusses future challenges, offering a number of suggestions for further research directions.



Cryosurgery

Cryosurgery Author Paola Pasquali
ISBN-10 9783662439395
Release 2014-10-01
Pages 315
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This book aims to fill the gap created by the lack of formal training in cryosurgery, which leads not only to an underutilization of the technique but also to inappropriate uses with unpleasant consequences for patients. The book covers all practical aspects of cryosurgery and also offers a theoretical foundation for practice. Basic principles, equipment, and techniques are described, and procedures are explained step by step for a range of applications, including common benign lesions, vascular lesions, premalignant conditions, and malignancies. An important feature is the coverage of the latest advances in combination treatments such as topical drugs and cryosurgery, ultrasound and cryosurgery, photography and cryosurgery, cryobiopsy, and immuno cryosurgery. Use of cryosurgery as palliative treatment is also discussed, and the closing chapters consider postoperative care, complications, and future directions.