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Obesity and Breast Cancer

Obesity and Breast Cancer Author Kristy A. Brown
ISBN-10 9781489980021
Release 2013-11-21
Pages 56
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Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer. Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast. This SpringerBrief will explore all of these issues in depth and the authors are in a unique position to write about this topic, having extensive experience in the field of aromatase research.​



miRNAs and Target Genes in Breast Cancer Metastasis

miRNAs and Target Genes in Breast Cancer Metastasis Author Seema Sethi
ISBN-10 3319081616
Release 2014-10-31
Pages 78
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This SpringerBrief gives the latest research on the role of miRNAs in breast cancer metastasis. MicroRNAs (miRNAs) are recently described small endogenous noncoding RNAs implicated in the posttranscriptional control of gene expression. These tiny molecules are involved in developmental, physiologic phenomenon as well as pathologic processes including cancers. In fact, miRNAs have emerged as critical regulators of cancer progression, invasion and metastasis. This is mainly because a single miRNA can affect several downstream genes and signaling pathways with oncogenic or tumor suppressor actions depending on the target genes affected. Due to this multimodal downstream signaling effects, these small endogenous molecules hold great promise in metastasis prevention and treatment. Modulating the activity of miRNAs can provide opportunities for novel cancer interventions. Targeting miRNAs could become a novel prognostic and therapeutic strategy to prevent the future development of metastasis. Thus, miRNAs could also serve as a potential targets for anti-metastatic therapy. The book explores how the expression of miRNAs in the primary tumor could be silenced using antagomirs (chemically modified anti-miRNA oligonucleotides), which could prevent the development of metastasis; whereas once metastasis develops then it could be treated with miRNA mimics for inducing its expression for the treatment. Therefore, development of miRNA-based prophylactic therapies could serve as precision and personalized medicine against future development of metastasis of breast and other cancers.



Neglected Tropical Diseases Middle East and North Africa

Neglected Tropical Diseases   Middle East and North Africa Author Mary Ann McDowell
ISBN-10 9783709116135
Release 2014-07-17
Pages 282
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The Middle East and North Africa (MENA) is highly endemic for several neglected tropical diseases (NTDs), including viral, bacterial, protozoan and helminth infections. This new volume covers the most prevalent NTDs found in about 22 MENA countries emphasizing the disease burden, clinical manifestations and control approaches. Each individual chapter deals with one specific disease and is written by a group of experts on that topic.



Breast Cancer a Heterogeneous Disease Entity

Breast Cancer  a Heterogeneous Disease Entity Author Zsuzsanna Kahán
ISBN-10 9400704895
Release 2011-02-21
Pages 313
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The volume raises attention to the need of a completely new approach to breast cancer based on the knowledge collected on early breast cancer in the past two decades. The chapters are contributed by experts of all the fields participating in the clinical research and care of breast cancer. The practical importance of such a book is underlined by the increasing number of breast cancer cases, and also the increasing proportion of early stage-cases. The ultimate goal of the book is to point to the heterogeneous nature of the disease which is more striking and has more importance in care at the very early stages than at the more advanced stages. The book recommends the utilization of all the information provided by multimodality imaging and special pathological methods, a new classification system and therapeutic guidelines since early breast cancers should not be treated based on experience obtained with palpable tumors. No similar book has been yet released to the market. The book is written for all the members of the team participating in the diagnosis and treatment of breast cancer (radiologists, pathologists, surgeons, clinical and radiation oncologists), but may be useful for medical students and residents too. The chapters are illustrated with didactic pictures, and special emphasis is given to provide a peep into the practice of the special procedures for the careful examination and individualized therapy of each case.



The Pathobiology of Breast Cancer

The Pathobiology of Breast Cancer Author Jose Russo
ISBN-10 9783319408156
Release 2016-08-10
Pages 235
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This monograph, written by well renowned breast cancer expect, Dr. Jose Russo, provides new insight on the pathobiology of breast cancer from the most current advances in the field, translational research, initiation and progression of the disease, the mechanism of invasion and metastasis and the concept of stem cells in treatment and drug resistance. The role of personalized medicine and genomic testing are also explored, which will provide a window to the future progress of cancer care.



Toxicology of Herbal Products

Toxicology of Herbal Products Author Olavi Pelkonen
ISBN-10 9783319438061
Release 2017-03-07
Pages 479
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This volume provides a comprehensive overview of the hazards inherent in herbal medicinal products, with systematic coverage of major toxicities. Topics include composition and quality control, toxicokinetics, interactions, safety pharmacology, approaches to studying complex mixtures including metabolomics and systems network pharmacology, and long-term toxicity. The volume also discusses various organ toxicities with a special emphasis on basic mechanisms of actions and the multicomponent and multi-target nature of herbal products. It concludes with a look to future challenges and opportunities. With contributions from noted experts, Toxicology of Herbal Products is a necessary resource for physicians, pharmacists, and toxicologists interested in complex plant-derived products.



Obesity Inflammation and Cancer

Obesity  Inflammation and Cancer Author Andrew J. Dannenberg
ISBN-10 9781461468196
Release 2013-05-21
Pages 433
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In addition to its metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with low grade inflammation resulting in cellular and humoral inflammatory factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion. This volume of Energy Balance and Cancer will focus on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. The volume first provides information on inflammation as an important link between obesity and insulin resistance, which is in itself linked to promotion of cancer through hyperinsulinemia. The volume then covers some of the most important mechanisms by which obesity leads to inflammation, including the novel inflammasome concept, alterations in chromatin structure, circulating inflammatory factors, unique cellular interactions between adipocytes and macrophages and the direct link of dietary fat to inflammation and cancer. Overall, this volume will provide important insight to help understand how inflammation may help modulate the linkage between obesity and cancer and serve as a platform for developing future research in this area.



Data Driven Process Discovery and Analysis

Data Driven Process Discovery and Analysis Author Karl Aberer
ISBN-10 9783642340444
Release 2013-11-19
Pages 213
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This book constitutes the thoroughly refereed proceedings of the First International Symposium on Data-Driven Process Discovery and Analysis held in Campione d'Italia, Italy, in June/July 2011. The 11 revised full papers were carefully selected from 31 submissions. In addition to the thorough review process, the lively discussions at the event itself also helped the authors to improve their papers and to foster interesting extensions. The selected papers cover a wide range of topics spanning from theoretical issues related to process representation to practical experience in process discovery and analysis.



Innovative Diagnostics and Treatment Nanorobotics and Stem Cells

Innovative Diagnostics and Treatment  Nanorobotics and Stem Cells Author Tomasz Jadczyk
ISBN-10 9789811045271
Release 2017-05-12
Pages 61
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This book focuses on nanorobotic agents and stem cells for biomedical applications.It is intended for researchers and clinicians interested in innovative diagnostic and therapeutic strategies based on nanorobots and stem cells.It presents current advances in the field of molecular machines, which could be applied to generate novel therapeutic-diagnostic systems.



Plastics in Dentistry and Estrogenicity

Plastics in Dentistry and Estrogenicity Author Theodore Eliades
ISBN-10 9783642296871
Release 2013-11-22
Pages 149
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This book provides a timely and comprehensive review of our current knowledge of BPA release from dental polymers and the potential endocrinological consequences. After a review of the history and evolution of the issue within the broader biomedical context, the estrogenicity of BPA is explained. The basic chemistry of the polymers used in dentistry is then presented in a simplified and clinically relevant manner. Key chapters in the book carefully evaluate the release of BPA from polycarbonate products and composite resins and the estrogenicity of these materials. Currently available evidence on the potential estrogenic action of dental composities, sealants, and adhesives is presented, and means are suggested by which adverse health effects can be minimized. The entire dental community will find this book to be an excellent source of information on the true risks posed by BPA, and an invaluable aid to safe practice.



Robotic Renal Surgery

Robotic Renal Surgery Author Ronney Abaza
ISBN-10 9781461465225
Release 2013-04-10
Pages 192
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Robotic Renal Surgery: Benign and Cancer Surgery for the Kidneys and Ureters provides a comprehensive review of the role of and technical considerations regarding robotic surgery for conditions of the kidney and associated conditions of the upper urinary tract. In addition to serving as a reference regarding indications, preoperative and postoperative management, complications, and evidence-based outcomes, this text also serves as a practical guide for surgeons in how to perform the complete array of robotic kidney and upper tract surgery. Included are detailed descriptions of positioning, instrumentation, and surgical steps for the surgeon newly adopting robotic surgery or for those refining their techniques. All chapters are written by recognized and published experts in the various techniques, creating an authoritative text on the subject. Robotic Renal Surgery: Benign and Cancer Surgery for the Kidneys and Ureters will be of great value to urologists, robotic surgeons, fellows in urologic oncology or endourology as well as urology residents in training and surgical nurses and other surgery team members involved in these procedures. ​



Metastasis of Breast Cancer

Metastasis of Breast Cancer Author R.E. Mansel
ISBN-10 9781402058677
Release 2007-06-17
Pages 436
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Written by experts in the subject area, the book covers a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis and diagnosis. This timely book also covers the current treatment options.



Tryptophan Metabolism Implications for Biological Processes Health and Disease

Tryptophan Metabolism  Implications for Biological Processes  Health and Disease Author Atilla Engin
ISBN-10 9783319156309
Release 2015-04-28
Pages 382
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This book discusses the relationship between cellular immunity and tryptophan metabolism, as well as its products, serotonin and melatonin, in the development of several diseases and reappraises the common signal transduction pathways of the neurodegenerative diseases, carcinogenesis, immune tolerance, inflammation, hypersensitivity reactions, neuropsychiatric disorders, in addition to bacterial tryptophan biosynthesis and novel antimicrobials. Tryptophan Metabolism: Implications for Biological Processes, Health and Disease presents fundamental information on tryptophan related metabolic pathways and metabolites, implications of these products for specific biological processes, diseases and conditions. This book focuses on effects of tryptophan metabolites on human health and will appeal to researchers, clinicians and students within this field.



New Insights on Vitamin C and Cancer

New Insights on Vitamin C and Cancer Author Michael J. Gonzalez
ISBN-10 9781493918904
Release 2014-09-18
Pages 69
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Research on vitamin C and its effects on cancer is growing in popularity around the world as positive research continues to accumulate building a stronger case for its effectiveness. This concise SpringerBrief on Vitamin C and Cancer presents the latest findings on how vitamin C induces apoptosis. A high concentration of vitamin C allows for ascorbate to generate hydrogen peroxide in tissue that can selectively kill cancer cells. Research has confirmed that high-dose vitamin C is cytotoxic to a wide variety of cancer cell lines, and that it also boosts the anti-cancer activity of several common chemotherapy drugs. Vitamin C also does more than just kill cancer cells. It boosts immunity by stimulating collagen formation to help the body wall off the tumor. It inhibits hyaluronidase, an enzyme that tumors use to metastasize and invade other organs throughout the body. This concise and up-to-date Brief is geared towards cancer researchers and scientists, as well as physicians interested in the basic science and the translational potential of vitamin C in cancer therapeutics.



The Coming Conquest of England

The Coming Conquest of England Author August Niemann
ISBN-10 NYPL:33433075739718
Release 1904
Pages 384
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The Coming Conquest of England has been writing in one form or another for most of life. You can find so many inspiration from The Coming Conquest of England also informative, and entertaining. Click DOWNLOAD or Read Online button to get full The Coming Conquest of England book for free.



Mouse Models of Allergic Disease

Mouse Models of Allergic Disease Author Irving C. Allen
ISBN-10 1627034951
Release 2013-08-23
Pages 326
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Over the last half century, a dramatic increase in allergic diseases has been observed throughout industrialized nations, which has resulted in significant worldwide socio-economic challenges. In Mouse Models of Allergic Disease: Methods and Protocols, a wide range of expert contributors provide detailed protocols for the design and execution of experiments to thoroughly analyze critical elements associated with a diverse range of allergic diseases, all through the lens of mouse models that accurately recapitulate clinically relevant aspects of the respective human disease. The volume opens with a section featuring techniques essential for effective ex vivo cell isolation and evaluation of specific cell types relevant to a diverse range of allergic diseases, and the book then moves on to cover in vivo protocols to evaluate prevalent mouse models of human allergic diseases, including mouse models of systemic anaphylaxis, contact hypersensitivity, allergic rhinitis, and asthma, as well as a collection of chapters on in vivo and ex vivo protocols used to assess indirect mediators of allergic diseases, such as the nervous system, non-hematopoietic cells, and the composition of the gut microbiome. Written in the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Timely and authoritative, Mouse Models of Allergic Disease: Methods and Protocols serves as an essential collection of protocols that allow both novice and expert researchers the ability to accurately develop, evaluate, and characterize the mechanisms associated with these disorders.



Systems Biology

Systems Biology Author Ales Prokop
ISBN-10 9789400768031
Release 2013-08-28
Pages 553
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Growth in the pharmaceutical market has slowed down – almost to a standstill. One reason is that governments and other payers are cutting costs in a faltering world economy. But a more fundamental problem is the failure of major companies to discover, develop and market new drugs. Major drugs losing patent protection or being withdrawn from the market are simply not being replaced by new therapies – the pharmaceutical market model is no longer functioning effectively and most pharmaceutical companies are failing to produce the innovation needed for success. This multi-authored new book looks at a vital strategy which can bring innovation to a market in need of new ideas and new products: Systems Biology (SB). Modeling is a significant task of systems biology. SB aims to develop and use efficient algorithms, data structures, visualization and communication tools to orchestrate the integration of large quantities of biological data with the goal of computer modeling. It involves the use of computer simulations of biological systems, such as the networks of metabolites comprise signal transduction pathways and gene regulatory networks to both analyze and visualize the complex connections of these cellular processes. SB involves a series of operational protocols used for performing research, namely a cycle composed of theoretical, analytic or computational modeling to propose specific testable hypotheses about a biological system, experimental validation, and then using the newly acquired quantitative description of cells or cell processes to refine the computational model or theory.