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Oxidative Stress in Aging

Oxidative Stress in Aging Author Satomi Miwa
ISBN-10 1597454206
Release 2008-06-17
Pages 320
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Human aging is a complex phenomenon. This state-of-the-art book discusses the role of free radicals in aging in different animal models, as well as the relevance of free radicals on age-related diseases and pathological conditions in humans (following an introduction section of the basics and theory of free radicals). In addition, the major interventions trials of antioxidant supplements in age-related disease, cancer and so forth are reviewed and discussed.



Free Radicals in Biology and Medicine

Free Radicals in Biology and Medicine Author Barry Halliwell
ISBN-10 9780198717478
Release 2015-07-16
Pages 896
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Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.



Aging

Aging Author Victor R. Preedy
ISBN-10 9780124055230
Release 2014-03-06
Pages 316
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Aging: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in aging and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this. Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging. Nutritionists can apply information related to mitochondrial oxidative stress in one disease to diet-related strategies in another unrelated disease Dietitians can prescribe new foods or diets containing anti-oxidants for conditions resistant to conventional pharmacological treatments Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teams Nutritionists and dietitians will gain an understanding of cell signaling and be able to suggest new preventative or therapeutic strategies with anti-oxidant rich foods



Animal Biotechnology

Animal Biotechnology Author Ashish Verma
ISBN-10 9780123914347
Release 2013-11-04
Pages 668
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Animal Biotechnology introduces applications of animal biotechnology and implications for human health and welfare. It begins with an introduction to animal cell cultures and genome sequencing analysis and provides readers with a review of available cell and molecular tools. Topics here include the use of transgenic animal models, tissue engineering, nanobiotechnology, and proteomics. The book then delivers in-depth examples of applications in human health and prospects for the future, including cytogenetics and molecular genetics, xenografts, and treatment of HIV and cancers. All this is complemented by a discussion of the ethical and safety considerations in the field. Animal biotechnology is a broad field encompassing the polarities of fundamental and applied research, including molecular modeling, gene manipulation, development of diagnostics and vaccines, and manipulation of tissue. Given the tools that are currently available and the translational potential for these studies, animal biotechnology has become one of the most essential subjects for those studying life sciences. Highlights the latest biomedical applications of genetically modified and cloned animals with a focus on cancer and infectious diseases Provides firsthand accounts of the use of biotechnology tools, including molecular markers, stem cells, and tissue engineering



Critical Reviews of Oxidative Stress and Aging

Critical Reviews of Oxidative Stress and Aging Author Richard G. Cutler
ISBN-10 9812389962
Release 2003
Pages 1523
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This two-volume reference examines the translational research field of oxidative stress and ageing. It focuses on understanding the molecular basis of oxidative stress and its associated age-related diseases, with the goal of developing new methods for treating the human ageing processes.



Vitamin D

Vitamin D Author Adrian F. Gombart
ISBN-10 9781439850206
Release 2012-11-21
Pages 462
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Vitamin D insufficiency/deficiency is a worldwide, public health problem in both developed and developing countries. Rickets among infants has reemerged. Low levels of vitamin D are associated with increased risk and mortality from cancer. At the same time, the beneficial effects of vitamin D on a host of conditions have recently been discovered. Focusing on areas not extensively covered in other comparable books, Vitamin D: Oxidative Stress, Immunity, and Aging highlights the most recent research findings on the impact of this nutrient in oxidative stress, immunity, and aging. A state-of-the-art compilation of essential information, this book explores: Vitamin D and its genomic and nongenomic effects, the role of therapeutic analogs in treating disease, and the production of vitamin D by the body The role vitamin D plays in modulating oxidative stress—with emphasis on cancer, stress-mediated diseases, photo-protection of the skin, and energy metabolism Beneficial effects of vitamin D in regulating the immune response and its importance in protecting against autoimmune, infectious, and inflammatory diseases The role vitamin D plays in the regulation of the aging process—including aspects of oxidative stress, senescence, and mortality, as well as its role in protection against cardiovascular disease and nervous system disorders This book represents an important contribution toward understanding the mechanisms by which vitamin D promotes health, increasing awareness of the importance that vitamin D plays during development, at birth, and throughout the aging process. It is a valuable reference for researchers in academia, nutrition, medicine, and industry.



Oxidative Stress in Vertebrates and Invertebrates

Oxidative Stress in Vertebrates and Invertebrates Author Tahira Farooqui
ISBN-10 9781118148112
Release 2011-10-24
Pages 450
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This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. It offers comprehensive reviews of the current understanding of oxidative stress-mediated physiology and pathology as well as directions for future research. It also provides current information on the role of oxidative stress in neurodegenerative diseases, cardiovascular diseases, and various types of cancer mediated by oxidative stress.



Inflammation Advancing Age and Nutrition

Inflammation  Advancing Age and Nutrition Author Irfan Rahman
ISBN-10 9780123978073
Release 2013-09-03
Pages 394
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The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field. Includes models of aging, including worm, mouse and human Explores the relationship of inflammation with diseases, including ocular health, Alzheimer's and Parkinson's disease, and muscle health Encompasses a variety of lifestyle impacts, including diet, exercise and nutrition Includes suggested nutritional interventions



Oxidative Stress Exercise and Aging

Oxidative Stress  Exercise and Aging Author Helaine M Alessio
ISBN-10 9781783260058
Release 2006-03-27
Pages 184
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This book brings together some of the leading researchers in the actively investigated field of oxidative stress, an area of study which is of importance to human health and disease. It examines oxidative stress in a variety of models, at rest and after exercise, in young and old. Key concepts of oxidative stress, exercise and aging are presented in clear and easy-to-understand terms. Oxidative stress in different types of exercises — isometric, isotonic and sports — is explained in detail, with several chapters focusing on acute and chronic adaptations of skeletal muscles following both aerobic and non-aerobic exercises. The book includes current knowledge of the underlying mechanisms influencing health and disease processes associated with oxidative stress. Contents:Chemistry of Reactive Oxygen Species and Antioxidants (D C Close & A E Hagerman)Oxidative Stress in Plants and Animals (D C Close & A E Hagerman)The Exercise Continuum (R L Wiley)Oxidative Stress and Muscle Size, Type, and Action (H M Alessio)Oxidative Stress Across the Exercise Continuum (H M Alessio)Oxidative Stress and Antioxidant Defense: Effects of Aging and Exercise (L L Ji)Muscle, Oxidative Stress and Aging (J S Moylan et al.)Aging, Exercise, Antioxidants, and Cardioprotection (J Quindry & S Powers)Genetic Expressions: Oxidative Stress, Exercise, and Aging (N B Schweitzer & H M Alessio) Readership: Academics, researchers, upper undergraduate and graduate students in biochemistry, biological chemistry, physiology, gerontology, and cell & molecular biology; companies that develop and market products for sports, health, antioxidants and anti-aging interventions. Key Features:Descriptions of oxidative stress reactions in plants as well as animal modelsThe role of gene expression regulation in oxidative stressDiscussion of Oxidative stress reactions in skeletal and cardiac musclesNew mechanisms for understanding positive and negative consequences of oxidative stressKeywords:Exercise;Oxidative Stress;Aging;Health;Sports;Radicals;Antioxidants;Plants and Oxidative Stress



Conn s Handbook of Models for Human Aging

Conn s Handbook of Models for Human Aging Author Jeffrey L. Ram
ISBN-10 9780128113547
Release 2018-04-05
Pages 1218
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Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students. Combines both the methods of study for human aging and animal models Provides a historical overview and discussion of model availability, key methods and ethical issues Contains over 200 full color illustrations



Topics in Biomedical Gerontology

Topics in Biomedical Gerontology Author Pramod C. Rath
ISBN-10 9789811021558
Release 2016-10-20
Pages 355
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This book presents a collection of articles on various aspects of current research on aging. These include model systems, cellular, biochemical and molecular aspects of experimental aging research, as well as selected intervention studies on age-related diseases. Aging is a global challenge to human society. Children are always in a hurry to become adults, while adults produce offspring and add to the gene pool. However, after adulthood or the attainment of reproductive maturity, all physiological parameters of the living organism start to undergo the aging process. Old age sets in slowly but surely, and usually continues for a prolonged period. If vigor and vitality are the main advantages of adulthood, old age offers the rewards of experience and maturity. Biologists ask questions such as: Why do we age? How do we become old? Is it possible to slow down, postpone or even prevent aging? In turn, medical experts ask: What are the diseases associated with old age? Are there medicines that can help affected elderly patients? In fact both groups are asking themselves how can we add more health to old age. Healthy aging is the dream of every individual. But to achieve this, it is fundamental that we first understand the cellular, biochemical and molecular basis of the aging process in mammalian cells, tissues and intact living organisms, which can serve as experimental model systems in Biomedical Gerontology. Once the biology of aging is understood at the genetic and molecular levels, interventional approaches to aging and its associated diseases may be easier to plan and implement at the preclinical level.



Handbook of the Biology of Aging

Handbook of the Biology of Aging Author Edward J. Masoro
ISBN-10 9780120883875
Release 2006
Pages 660
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This volume is a collection of 21 papers comprising conceptual and technical issues, non-mammalian models and mammalian models and including issues such as aging of the female reproductive system and computer modelling in the study of aging.



The Biology of Human Longevity

The Biology of Human Longevity Author Caleb E. Finch
ISBN-10 0080545947
Release 2010-07-28
Pages 640
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Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle. Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists Provides a novel synthesis of existing ideas about the biology of longevity and aging Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition



Polyphenols in Human Health and Disease

Polyphenols in Human Health and Disease Author Ronald Ross Watson
ISBN-10 9780123984678
Release 2013-10-26
Pages 1488
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Polyphenols in Human Health and Disease documents antioxidant actions of polyphenols in protection of cells and cell organelles, critical for understanding their health-promoting actions to help the dietary supplement industry. The book begins by describing the fundamentals of absorption, metabolism and bioavailability of polyphenols, as well as the effect of microbes on polyphenol structure and function and toxicity. It then examines the role of polyphenols in the treatment of chronic disease, including vascular and cardiac health, obesity and diabetes therapy, cancer treatment and prevention, and more. Explores neuronal protection by polyphenol metabolites and their application to medical care Defines modulation of enzyme actions to help researchers see and study polyphenols’ mechanisms of action, leading to clinical applications Includes insights on polyphenols in brain and neurological functions to apply them to the wide range of aging diseases



Brocklehurst s Textbook of Geriatric Medicine and Gerontology E Book

Brocklehurst s Textbook of Geriatric Medicine and Gerontology E Book Author Howard M. Fillit
ISBN-10 9781437720754
Release 2010-05-10
Pages 1152
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Popular with generations of practitioners, Brocklehurst's Textbook of Geriatric Medicine and Gerontology has been the definitive reference of choice in the field of geriatric care. The new 7th Edition, by Howard M. Fillit, MD, Kenneth Rockwood, MD, and Kenneth Woodhouse, carries on this tradition with an increased clinical focus and updated coverage to help you meet the unique challenges posed by this growing patient population. Consistent discussions of clinical manifestations, diagnosis, prevention, treatment, and more make reference quick and easy, while over 255 illustrations compliment the text to help you find what you need on a given condition. Examples of the latest imaging studies depict the effects of aging on the brain, and new algorithms further streamline decision making. Emphasizes the clinical relevance of the latest scientific findings to help you easily apply the material to everyday practice. Features consistent discussions of clinical manifestations, diagnosis, prevention, treatment, and more that make reference quick and easy. Includes over 255 illustrations—including algorithms, photographs, and tables—that compliment the text to help you find what you need on a given condition. Provides summary boxes at the end of each chapter that highlight important points. Features the work of an expert author team, now led by Dr. Howard M. Fillit who provides an American perspective to complement the book’s traditional wealth of British expertise. Includes an expanded use of algorithms to streamline decision making. Presents more color images in the section on aging skin, offering a real-life perspective of conditions for enhanced diagnostic accuracy. Includes examples of the latest imaging studies to help you detect and classify changes to the brain during aging. Offers Grade A evidence-based references keyed to the relevant text.



Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases

Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases Author Tahira Farooqui
ISBN-10 9780128119600
Release 2017-11-03
Pages 484
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Role of the Mediterranean Diet in the Brain and Neurodegenerative Disease provides a comprehensive overview of the effects of all components of the Mediterranean diet on the brain, along with its beneficial effects in neurodegenerative diseases. It covers topics on neurodegenerative diseases (Alzheimer disease (AD), Parkinson disease, (PD) Huntington disease (HD) and Amyotrophic Lateral Sclerosis (ALS), also providing information on how cardiovascular disease, Type 2 Diabetes, and Metabolic Syndrome become risk factors for neurodegenerative diseases. This book focuses on how the Mediterranean diet suppresses oxidative stress and neuroinflammation in neurodegenerative diseases as well as signal transduction. The Mediterranean diet is characterized by the abundant consumption of olive oil, high consumption of plant foods (fruits, vegetables, pulses, cereals, nuts and seeds); frequent and moderate intake of wine (mainly with meals); moderate consumption of fish, seafood, yogurt, cheese, poultry and eggs; and low consumption of red meat and processed meat products. High consumption of dietary fiber, low glycemic index and glycemic load, anti-inflammatory effects, and antioxidant compounds may act together to produce favorable effects on health status. Collective evidence suggests that Mediterranean diet not only increases longevity by lowering cardiovascular disease, inhibiting cancer growth, but also by protecting the body from age-dependent cognitive decline. Comprehensively provides an overview of the effects of the Mediterranean diet on the brain and its beneficial effects in neurodegenerative diseases Discusses the relationship among Type 2 Diabetes, Metabolic Syndrome and Alzheimer's Disease, and the effect of the Mediterranean diet on normal aging, longevity, and other neurodegenerative diseases Focuses on how the Mediterranean diet suppresses oxidative stress and neuroinflammation in neurodegenerative disease



Molecular Basis of Nutrition and Aging

Molecular Basis of Nutrition and Aging Author Marco Malavolta
ISBN-10 9780128018279
Release 2016-04-15
Pages 784
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Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health. In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and cellular targets of nutrition in aging, with chapters exploring lipid peroxidation, inflammaging, anabolic and catabolic signaling, epigenetics, DNA damage and repair, redox homeostasis, and insulin sensitivity, among others. Part Three looks at system-level and organ targets of nutrition in aging, including a variety of tissues, systems, and diseases, such as immune function, the cardiovascular system, the brain and dementia, muscle, bone, lung, and many others. Finally, Part Four focuses on the health effects of specific dietary compounds and dietary interventions in aging, including vitamin D, retinol, curcumin, folate, iron, potassium, calcium, magnesium, zinc, copper, selenium, iodine, vitamin B, fish oil, vitamin E, resveratrol, polyphenols, vegetables, and fruit, as well as the current nutritional recommendations. Offers updated information and a perspectives on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of aging Explores how nutritional factors are involved in the pathogenesis of aging across body systems Investigates the molecular and genetic basis of aging and cellular senescence through the lens of the rapidly evolving field of molecular nutrition