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Practical Aspects of Hyaluronan Based Medical Products

Practical Aspects of Hyaluronan Based Medical Products Author J.W. Kuo
ISBN-10 9781420037647
Release 2005-09-23
Pages 240
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The ballooning body of research devoted to hyaluronan (HA) reflects its enormous potential for various medical applications. There have been many successes of varying degrees in the development of medical products based on HA, but also some setbacks. While there is obviously ample information available on the chemistry and various properties of this macromolecule, Practical Aspects of Hyaluronan Based Medical Products is the first book devoted to systematically applying this knowledge to product development. Based on the author's extensive experience working with HA, this book explores in detail the chemistry, composition, formulation, testing, safety, effectiveness, quality control, and regulatory approval of HA medical products. It begins with a survey of the historical development and recent products based on hyaluronan. Subsequent chapters detail the rheological properties of the molecule and explore the chemical principles and methods forming the technical basis of product development, illustrated by more than 50 figures of chemical structures, reaction schemes, and rheological properties. Individual chapters then consider standards, tests, and analytical methods; safety of HA-based products for their indicated applications; and clinical performance, mechanism of action, and product characteristics. Practical Aspects of Hyaluronan Based Medical Products surveys FDA review documents as well as peer-reviewed journal articles to identify the elements essential to successful product development, namely, understanding the critical issues in the regulatory path and linking clinical performance of the products to their original design.



Hyaluronic Acid

Hyaluronic Acid Author V. N. Khabarov
ISBN-10 9781118695951
Release 2014-12-22
Pages 216
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Hyaluronic acid is an essential part of connective, epithelial and neural tissues, and contributes to cell proliferation and migration. It is used as a stimulating agent for collagen synthesis and is a common ingredient in skin-care products, a multi-billion dollar industry, as it is believed to be a key factor in fighting the aging process. Hyaluronic Acid: Production, Properties, Application in Biology and Medicine consists of six chapters discussing the various issues of hyaluronic acid research. In Chapter 1, a historical analysis recounts the discovery and milestones of the research leading to the practical applications of hyaluronan. Chapter 2 is dedicated to biological role of the hyaluronic acid in nature, in particular in the human body. The chapter starts from the phylogenesis of hyaluronic acid, then describes hyaluronan functions in human ontogenesis and especially the role which hyaluronan plays in extracellular matrix of the different tissues. Chapter 3 describes the methods to manufacture and purify hyaluronic acid, including the analytical means for assessing quality of the finished product. Chapter 4 discusses the structure and rheological properties of hyaluronic acid considering effects on conformation and biological properties related to molecular weight. In Chapter 5, the physical and chemical methods for modifying the structure of hyaluronan are discussed including cross-linking using bi-functional reagents, solid-phase modification and effects of the combined action of high pressures and shift deformation. The final chapter focuses on the products derived from hyaluronic acid, including therapeutics composed of modified hyaluronan conjugated to vitamins, amino acids and oligo-peptides. The biological roles and medical applications of this polysaccharide have been extensively studied and this book provides a wealth of scientific data demonstrating the critical role of hyaluronic acid and its promise as a multifaceted bio-macromolecule. Approaching hyaluronic acid from multiple angles, this book links relationships between its biological functions, structure and physical–chemical properties. It will be an invaluable resource to researchers, both industrial and academic, involved in all aspects of hyaluronan-based technologies.



Polysaccharide Based Graft Copolymers

Polysaccharide Based Graft Copolymers Author Susheel Kalia
ISBN-10 9783642365669
Release 2013-05-23
Pages 353
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Renowned experts give all essential aspects of the techniques and applications of graft copolymers based on polysaccharides. Polysaccharides are the most abundant natural organic materials and polysaccharide based graft copolymers are of great importance and widely used in various fields. Natural polysaccharides have recently received more attention due to their advantages over synthetic polymers by being non-toxic, biodegradable and available at low cost. Modification of polysaccharides through graft copolymerization improves the properties of polysaccharides. Grafting is known to improve the characteristic properties of the backbones. Such properties include water repellency, thermal stability, flame resistance, dye-ability and resistance towards acid-base attack and abrasion. Polysaccharides and their graft copolymers find extensive applications in diversified fields. Applications of modified polysaccharides include drug delivery devices, controlled release of fungicides, selective water absorption from oil-water emulsions, purification of water etc.



Comprehensive Biomaterials II

Comprehensive Biomaterials II Author Paul Ducheyne
ISBN-10 9780081006924
Release 2017-05-18
Pages 4858
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Comprehensive Biomaterials II, Second Edition brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications



Comprehensive Biomaterials

Comprehensive Biomaterials Author Paul Ducheyne
ISBN-10 9780080552941
Release 2015-08-28
Pages 3672
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Comprehensive Biomaterials brings together the myriad facets of biomaterials into one, major series of six edited volumes that would cover the field of biomaterials in a major, extensive fashion: Volume 1: Metallic, Ceramic and Polymeric Biomaterials Volume 2: Biologically Inspired and Biomolecular Materials Volume 3: Methods of Analysis Volume 4: Biocompatibility, Surface Engineering, and Delivery Of Drugs, Genes and Other Molecules Volume 5: Tissue and Organ Engineering Volume 6: Biomaterials and Clinical Use Experts from around the world in hundreds of related biomaterials areas have contributed to this publication, resulting in a continuum of rich information appropriate for many audiences. The work addresses the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, and strategic insights for those entering and operational in diverse biomaterials applications, research and development, regulatory management, and commercial aspects. From the outset, the goal was to review materials in the context of medical devices and tissue properties, biocompatibility and surface analysis, tissue engineering and controlled release. It was also the intent both, to focus on material properties from the perspectives of therapeutic and diagnostic use, and to address questions relevant to state-of-the-art research endeavors. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance as well as future prospects Presents appropriate analytical methods and testing procedures in addition to potential device applications Provides strategic insights for those working on diverse application areas such as R&D, regulatory management, and commercial development



The British National Bibliography

The British National Bibliography Author Arthur James Wells
ISBN-10 UOM:39015066099238
Release 2006
Pages
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The British National Bibliography has been writing in one form or another for most of life. You can find so many inspiration from The British National Bibliography also informative, and entertaining. Click DOWNLOAD or Read Online button to get full The British National Bibliography book for free.



American Book Publishing Record

American Book Publishing Record Author
ISBN-10 UOM:39015066043251
Release 2005
Pages
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American Book Publishing Record has been writing in one form or another for most of life. You can find so many inspiration from American Book Publishing Record also informative, and entertaining. Click DOWNLOAD or Read Online button to get full American Book Publishing Record book for free.



Hyaluronan

Hyaluronan Author Glyn O. Phillips
ISBN-10 1855735709
Release 2002
Pages 577
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Hyaluronan and its derivatives has developed very quickly in the last few years from a scientific novelty into an important new material for a diverse range of medical and biomaterial applications. This landmark conference focused on developments and applications in the use of hyaluronan in tissue repair and reconstruction, drug delivery systems, anti-cancer treatments and joint recovery and engineering. The entire range of hyaluronan progress is covered in depth by the more than 135 individual papers: Analytical chemistry Structural elucidation and basic chemistry Electron microscopy and atomic force microscopy Production, purification and characterisation Quality in production systems Chemical modification Derivatives and properties Cross-linking Free radical modification Physical characterisation Rheology Aggregation phenomena Interaction with water and solution properties Cell biology Control and regulation of HA synthases Cell surface chemistry HA cell receptors and cell signalling Interaction with proteins and other biological ligands Biophysical aspects Effects on pain receptors Neurobiology Role in organisation of extracellular matrix Role in development (embryogenesis): cell movement/migration Medical applications Uses in cartilage and wound repair Inflammation Wound regenerative healing Surgery and tissue engineering Viscosupplementation / osteoarthritis Viscoaugmentation and viscoprotection Anti-adhesion applications Brug delivery systems Binding onto tumour cells and metastases Outlines the proceedings of the landmark conference which focused on key developments and applications in the use of hyaluronan in tissue repair and reconstruction, among other uses The entire range of hyaluronan processes is dealt with in depth by more than 135 individual papers presented in two volumes Covers analytical chemistry, chemical modification, physical characterisation, cell biology and medical applications



The Chemistry Biology and Medical Applications of Hyaluronan and Its Derivatives

The Chemistry  Biology and Medical Applications of Hyaluronan and Its Derivatives Author T. C. Laurent
ISBN-10 CORNELL:31924081103859
Release 1998-01-01
Pages 341
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The aim of this book is to collect within one volume information on hyaluronan. This polysaccharide has received rapid attention for two reasons: it has important regulative functions within cell biology; and it has become a commercially important product because of its use in ophthalmic surgery and treatment of joint diease. A number of other practical applications are also discussed. The book covers various aspects of hyaluronan from the structure and chemistry of the polymer to its metabolism, cell biological interactions, behaviour in pathological processes, and potentially new medical applications.



A Practical Guide to Dermal Filler Procedures

A Practical Guide to Dermal Filler Procedures Author Rebecca Small
ISBN-10 9781451154504
Release 2012-01-02
Pages 176
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A Practical Guide to Dermal Filler Procedures is the second book in the new Cosmetic Procedures series especially designed for providers who would like to expand their practice to include minimally invasive cosmetic procedures. Residents or practitioners new to aesthetics and experienced providers alike can benefit from this series which focuses on current aesthetic treatments that can be readily incorporated into office practice. For the "hands on" providers, these commonly performed cosmetic procedures can make the practice of medicine more rewarding, improve patient satisfaction and increase reimbursement. This book provides thoroughly illustrated step-by-step instructions on dermal filler treatments and advice on managing common issues seen in follow up visits. Each chapter focuses on a single dermal filler procedure and reviews all relevant anatomy including target regions and areas to avoid. Injection sites are highlighted to help practitioners perform the procedures more effectively and minimize complication risks. The series foreword has be written by world renowned author, John. L. Pfenninger. Access to a companion website, http://solution.lww.com/practicalguidefillers is also included with video clips of every procedure! Look for additional titles in the series: A Practical Guide to Botulinum Toxin Procedures; A Practical Guide to Chemical Peels and Skin Care Products



Extracellular Matrix derived Implants in Clinical Medicine

Extracellular Matrix derived Implants in Clinical Medicine Author Daniel L Mooradian
ISBN-10 9780081002193
Release 2016-05-18
Pages 202
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Extracellular Matrix-Derived Implants in Clinical Medicine comprehensively covers the emergence of tissue engineering and regenerative medicine over the past few decades, along with discussions of continuous funding and research. The book provides a state-of-the-art review of this increasingly important technology and how it is translating from bench to bedside. Part One of the book looks at the historical use of human and animal tissues, focusing on the main application areas, including cardiovascular, hard and soft tissue engineering, and neurological, while Part Two examines the challenges in harvesting, processing, and manufacturing of extracellular matrices, with a final section reviewing the international regulatory environment and economics of tissue-based products. Addresses issues of tissue engineering and regenerative medicine from a biomaterials industry perspective Looks at the historical use of human and animal tissues, focusing on the main application areas, including cardiovascular, hard and soft tissue engineering, and neurological Examines the challenges in harvesting, processing, and manufacturing of extracellular matrices Reviews the international regulatory environment and economics of tissue-based products



Medical Textiles and Biomaterials for Healthcare

Medical Textiles and Biomaterials for Healthcare Author Subhash Anand
ISBN-10 1855736837
Release 2006
Pages 508
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Medical textiles and biomaterials are a significant and increasingly important part of the technical textiles industry. They cover a huge range of applications - from diapers and surgical gowns to substrates for electronic sensoring of vital life signs, external use as wound care, and more. This book addresses these applications and others in a collection of papers edited by world renown experts. Chapters cover all aspects of design and production of healthcare and hygiene products, infection control and barrier material, pressure garments and bandaging, implantable devices for biodegradable post-operative support systems, replacement of body parts through tissue engineering, smart technologies, and more.



The Glaucoma Book

The Glaucoma Book Author Paul N. Schacknow
ISBN-10 9780387767000
Release 2010-06-10
Pages 1043
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Complete evidence-based medical and surgical management of glaucoma for both the general ophthalmologist in practice and residents The only book that covers the new generation of glaucoma procedures including trabectome, trabecular bypass and canaloplasty, by the experts who developed them Includes the latest laser treatments for glaucoma including micro diode and titanium saphire trabeculoplasty as well as laser from an external approach The most comprehensive coverage of the optic nerve and the importance of nerve fiber layer hemorrhage Provides an integrated approach to neovascular glaucoma merging treatment to the retina, with the use of new anti-VEGF drugs, tubes, and shunts to achieve the best outcome Integrates clinical science with basic science to outline the next steps in glaucoma therapy



New Scientist

New Scientist Author
ISBN-10 UCSD:31822022686554
Release 2001
Pages
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New Scientist has been writing in one form or another for most of life. You can find so many inspiration from New Scientist also informative, and entertaining. Click DOWNLOAD or Read Online button to get full New Scientist book for free.



Practical Manual of In Vitro Fertilization

Practical Manual of In Vitro Fertilization Author Zsolt Peter Nagy
ISBN-10 9781441917805
Release 2012-04-23
Pages 703
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The Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices is a unique, accessible title that provides a complete review of the most well-established and current diagnostic and treatment techniques comprising in vitro fertilization. Throughout the chapters, a uniform structure is employed, including a brief abstract, a keyword glossary, a step-by-step protocol of the laboratory procedures, several pages of expert commentary, key issues of clinical concern, and a list of references. The result is a readily accessible, high quality reference guide for reproductive endocrinologists, urologists, embryologists, biologists and research scientists. The Manual also offers an excellent description of novel procedures that will likely be employed in the near future. An indispensable resource for physicians and basic scientists, the Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices is an invaluable reference and addition to the literature.



Principles of Regenerative Medicine

Principles of Regenerative Medicine Author Anthony Atala
ISBN-10 0080555950
Release 2011-04-28
Pages 1472
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Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. * Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology * The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine * New discoveries from leading researchers on restoration of diseased tissues and organs



Joint Disease in the Horse

Joint Disease in the Horse Author C. Wayne McIlwraith
ISBN-10 9780323352895
Release 2015-08-13
Pages 424
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Dr. McIlwraith’s Joint Disease in the Horse, 2nd Edition is the only book to give you a full account of equine joint disease, combining a thorough, up-to-date survey of scientific advances with a practical guide to both medical and surgical treatments. With contributions from nationally and internationally recognized pioneers in the field, this groundbreaking text offers an overview of joint structure and function and translates the latest information on basic joint pathobiology into practical application for the clinician. Step-by-step guidance on injection techniques and medications, along with a survey of practical arthroscopic surgery and developments, make it a truly indispensable reference for all equine veterinarians treating sports and racing horses. UNIQUE! Unprecedented, state-of-the-art coverage of the pathology, pathogenesis, and clinical diagnosis of traumatic and degenerative joint disease, so you stay in the know. Section on general principles of joint pathobiology provides the background to evaluate and interpret the diagnostic and surgical aspects of disease. Explores treatments for traumatic arthritis and osteoarthritis and other joint entities, offering a broad range of options and up-to-date recommendations for problematic decisions. Addresses recent advances and results in arthroscopic surgery for the acute injury and results including fragment removal, fragment fixation, and synovectomy. Discussion of current research provides insight for difficult cases and calls out the directions in which future arthritis research is headed. More than 325 photographs and line drawings help engage and guide you through procedures and treatments. NEW! Full color throughout with new artwork and a range of new images including radiographs showing both the normal and the disease progression. NEW! Practical step-by-step approach demonstrates the authors’ preferred injections methods and shows underlying anatomic correlations. NEW and UPDATED! Restructured and substantially revised to emphasize treatment options, making it a practical, concise, and accessible reference and text. NEW! All-new chapters on drugs and new biological therapies, including stem cells, IRAP, and PRP and thoroughly updated coverage of HA and corticosteroids. NEW! Covers advanced imaging, giving you the latest information available. NEW! Expert advice from Dr. McIlwraith, three new co-editors, and new contributors — all distinguished specialists in the field of joint disease in the horse. Lameness and surgical clinicians describe how to approach the various, specific disease conditions. Equine specific radiologists provide their opinions on the best imaging techniques for defining the disease and making interpretations.