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Practical Guide to ICP MS

Practical Guide to ICP MS Author Robert Thomas
ISBN-10 9781466555433
Release 2013-04-25
Pages 446
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Written by a field insider with over 20 years experience in product development, application support, and field marketing for an ICP-MS manufacturer, the third edition of Practical Guide to ICP-MS: A Tutorial for Beginners provides an updated reference that was written specifically with the novice in mind. It presents a compelling story about ICP-MS and what it has to offer, showing this powerful ultra trace-element technique in the way it was intended—a practical solution to real-world problems. New to the third edition: New chapter: Emerging ICP-MS Application Areas – covers the three most rapidly growing areas: analysis of flue gas desulfurization wastewaters, fully automated analysis of seawater samples using online chemistry procedures, and characterization of engineered nanoparticles Discussion of all the new technology commercialized since the second edition. An updated glossary of terms with more than 100 new entries Examination of nonstandard sampling accessories, which are important for enhancing the practical capabilities of ICP-MS Insight into additional applications in the environmental, clinical/biomedical, and food chemistry fields as well as new directives from the United States Pharmacopeia (USP) on determining impurities in pharmaceuticals and dietary supplements using Chapters 232, 233 and 2232 Description of the most important analytical factors for selecting an ICP-MS system, taking into consideration more recent application demands This reference describes the principles and application benefits of ICP-MS in a clear manner for laboratory managers, analytical chemists, and technicians who have limited knowledge of the technique. In addition, it offers much-needed guidance on how best to evaluate capabilities and compare with other trace element techniques when looking to purchase commercial ICP-MS instrumentation.



Practical Guide to ICP MS

Practical Guide to ICP MS Author Robert Thomas
ISBN-10 9780824758837
Release 2003-12-11
Pages 342
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Written by a field insider with more than 20 years of experience in the development and application of atomic spectroscopy instrumentation, the Practical Guide to ICP-MS offers key concepts and guidelines in a reader-friendly format that is superb for those with limited knowledge of the technique. This reference discusses the fundamental principles, analytical advantages, practical capabilities, and overall benefits of ICP-MS. It presents the most important selection criteria when evaluating commercial ICP-MS equipment and the most common application areas of ICP-MS such as the environmental, semiconductor, geochemical, clinical, nuclear, food, metallurgical, and petrochemical industries.



Measuring Elemental Impurities in Pharmaceuticals

Measuring Elemental Impurities in Pharmaceuticals Author Robert Thomas
ISBN-10 9781351984409
Release 2018-01-29
Pages 474
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Recent regulations on heavy metal testing have required the pharmaceutical industry to monitor a suite of elemental impurities in pharmaceutical raw materials, drug products and dietary supplements. These new directives s are described in the new United States Pharmacopeia (USP) Chapters , , and , together with Q3D, Step 4 guidelines for elemental impurities, drafted by the ICH (International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use), a consortium of global pharmaceutical associations, including the European Pharmacopeia (Ph.Eur.), the Japanese Pharmacopeia (JP) and the USP. This book provides a complete guide to the analytical methodology, instrumental techniques and sample preparation procedures used for measuring elemental impurities in pharmaceutical and nutraceutical materials. It offers readers the tools to better understand plasma spectrochemistry to optimize detection capability for the full suite of elemental PDE (Permitted Daily Exposure) levels in the various drug delivery categories. Other relevant information covered in the book includes: Coverage of heavy metals testing in the pharmaceutical industry from a historical perspective. Overview of current status of USP Chapters , and ICH Q3D Step 4 guidelines. An explanation of the strict validation protocols required to meet data quality objectives, including how real-world J-values are calculated. Guidelines on the optimum strategy for risk assessment. Insight on how best to prepare and present your data for regulatory inspection. An indispensable resource, the fundamental principles and practical benefits of ICP-OES and ICP-MS are covered in a reader-friendly format that a novice, who is carrying out elemental impurities testing in the pharmaceutical and nutraceutical communities, will find easy to understand.



Applications of Microsoft Excel in Analytical Chemistry

Applications of Microsoft Excel in Analytical Chemistry Author F. James Holler
ISBN-10 9781285629575
Release 2013-02-27
Pages 480
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This supplement can be used in any analytical chemistry course. The exercises teaches you how to use Microsoft Excel using applications from statistics, data analysis equilibrium calculations, curve fitting, and more. Operations include everything from basic arithmetic and cell formatting to Solver, Goal Seek, and the Data Analysis Toolpak. The authors show you how to use a spreadsheet to construct log diagrams and to plot the results. Statistical data treatment includes descriptive statistics, linear regression, hypothesis testing, and analysis of variance. Tutorial exercises include nonlinear regression such as fitting the Van Deemter equation, fitting kinetics data, determining error coefficients in spectrophotometry, and calculating titration curves. Additional features include solving complex systems of equilibrium equations and advanced graphical methods: error bars, charts with insets, matrices and determinants, and much more. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.



Isotopic Analysis

Isotopic Analysis Author Frank Vanhaecke
ISBN-10 9783527650507
Release 2012-04-24
Pages 550
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Edited by two very well-known and respected scientists in the field, this excellent practical guide is the first to cover the fundamentals and a wide range of applications, as well as showing readers how to efficiently use this increasingly important technique. From the contents: * The Isotopic Composition of the Elements * Single-Collector ICP-MS * Multi-Collector ICP-MS * Advances in Laser Ablation - Multi-Collector ICP-MS * Correction for Instrumental Mass Discrimination in Isotope Ratio Determination with Multi-Collector ICP-MS * Reference Materials in Isotopic Analysis * Quality Control in Isotope Ratio Applications * Determination of Trace Elements and Elemental Species Using Isotope Dilution ICP-MS * Geochronological Dating * Application of Multi-Collector ICP-MS to Isotopic Analysis in Cosmochemistry * Establishing the Basis for Using Stable Isotope Ratios of Metals as Paleoredox Proxies * Isotopes as Tracers of Elements Across the Geosphere-Biosphere Interface * Archaeometric Applications * Forensics Applications * Nuclear Applications * The Use of Stable Isotope Techniques for Studying Mineral and Trace Element Metabolism in Humans * Isotopic Analysis via Multi-Collector ICP-MS in Elemental Speciation A must-have for newcomers as well as established scientists seeking an overview of isotopic analysis via ICP-MS.



Mass Spectrometry

Mass Spectrometry Author Edmond de Hoffmann
ISBN-10 9781118681947
Release 2013-04-03
Pages 504
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The latest edition of a highly successful textbook, Mass Spectrometry, Third Edition provides students with a complete overview of the principles, theories and key applications of modern mass spectrometry. All instrumental aspects of mass spectrometry are clearly and concisely described: sources, analysers and detectors. Tandem mass spectrometry is introduced early on and then developed in more detail in a later chapter. Emphasis is placed throughout the text on optimal utilisation conditions. Various fragmentation patterns are described together with analytical information that derives from the mass spectra. This new edition has been thoroughly revised and updated and has been redesigned to give the book a more contemporary look. As with previous editions it contains numerous examples, references and a series of exercises of increasing difficulty to encourage student understanding. Updates include: Increased coverage of MALDI and ESI, more detailed description of time of flight spectrometers, new material on isotope ratio mass spectrometry, and an expanded range of applications. Mass Spectrometry, Third Edition is an invaluable resource for all undergraduate and postgraduate students using this technique in departments of chemistry, biochemistry, medicine, pharmacology, agriculture, material science and food science. It is also of interest for researchers looking for an overview of the latest techniques and developments.



Interpretation of MS MS Mass Spectra of Drugs and Pesticides

Interpretation of MS MS Mass Spectra of Drugs and Pesticides Author Wilfried M. A. Niessen
ISBN-10 9781119294245
Release 2017-01-03
Pages 416
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Provides comprehensive coverage of the interpretation of LC–MS–MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns



Analytical Instrumentation Handbook Third Edition

Analytical Instrumentation Handbook  Third Edition Author Jack Cazes
ISBN-10 0849390397
Release 2004-11-30
Pages 1064
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Compiled by the editor of Dekker’s distinguished Chromatographic Science series, this reader-friendly reference is as a unique and stand-alone guide for anyone requiring clear instruction on the most frequently utilized analytical instrumentation techniques. More than just a catalog of commercially available instruments, the chapters are written from the standpoint of instrumentation as it is in use today, with an introductory description of the technique(s) and a theoretical treatment of the science and technology, wherever it is applicable or where it will facilitate an understanding of the instrumentation. Helps researchers and specialists select the most appropriate technique for their particular application.



Mass Spectrometry

Mass Spectrometry Author Jürgen H Gross
ISBN-10 9783319543987
Release 2017-06-22
Pages 968
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This book offers a balanced mixture of practice-oriented information and theoretical background as well as numerous references, clear illustrations, and useful data tables. Problems and solutions are accessible via a special website. This new edition has been completely revised and extended; it now includes three new chapters on tandem mass spectrometry, interfaces for sampling at atmospheric pressure, and inorganic mass spectrometry.



Measuring Elemental Impurities in Pharmaceuticals

Measuring Elemental Impurities in Pharmaceuticals Author Robert Thomas
ISBN-10 9781351984409
Release 2018-01-29
Pages 474
Download Link Click Here

Recent regulations on heavy metal testing have required the pharmaceutical industry to monitor a suite of elemental impurities in pharmaceutical raw materials, drug products and dietary supplements. These new directives s are described in the new United States Pharmacopeia (USP) Chapters , , and , together with Q3D, Step 4 guidelines for elemental impurities, drafted by the ICH (International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use), a consortium of global pharmaceutical associations, including the European Pharmacopeia (Ph.Eur.), the Japanese Pharmacopeia (JP) and the USP. This book provides a complete guide to the analytical methodology, instrumental techniques and sample preparation procedures used for measuring elemental impurities in pharmaceutical and nutraceutical materials. It offers readers the tools to better understand plasma spectrochemistry to optimize detection capability for the full suite of elemental PDE (Permitted Daily Exposure) levels in the various drug delivery categories. Other relevant information covered in the book includes: Coverage of heavy metals testing in the pharmaceutical industry from a historical perspective. Overview of current status of USP Chapters , and ICH Q3D Step 4 guidelines. An explanation of the strict validation protocols required to meet data quality objectives, including how real-world J-values are calculated. Guidelines on the optimum strategy for risk assessment. Insight on how best to prepare and present your data for regulatory inspection. An indispensable resource, the fundamental principles and practical benefits of ICP-OES and ICP-MS are covered in a reader-friendly format that a novice, who is carrying out elemental impurities testing in the pharmaceutical and nutraceutical communities, will find easy to understand.



Chemical Analysis

Chemical Analysis Author Francis Rouessac
ISBN-10 9781118681879
Release 2013-05-06
Pages 600
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Completely revised and updated, Chemical Analysis: Second Edition is an essential introduction to a wide range of analytical techniques and instruments. Assuming little in the way of prior knowledge, this text carefully guides the reader through the more widely used and important techniques, whilst avoiding excessive technical detail. Provides a thorough introduction to a wide range of the most important and widely used instrumental techniques Maintains a careful balance between depth and breadth of coverage Includes examples, problems and their solutions Includes coverage of latest developments including supercritical fluid chromatography and capillary electrophoresis



Applied Electrospray Mass Spectrometry

Applied Electrospray Mass Spectrometry Author Birendra N. Pramanik
ISBN-10 0203909275
Release 2002-02-28
Pages 446
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Discussing strategies to determine the structure and machanisms of numerous compound classics, this book covers new chemical and elctrophoretic techniques for rapid sample preconcentration and separation. It summarizes breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications, provides practical examples for the characterization of peptides, proteins, and glycoproteins, includes applications in proteomics, combinatorial chemistry, and drug characterization. Topics include chemical and electrophoretic techniques for rapid sample preconcentration and separation, screening processes for proteins from libraries of compounds, protein folding and dynamics, and more.



Practical Instrumental Analysis

Practical Instrumental Analysis Author Sergio Petrozzi
ISBN-10 9783527665914
Release 2012-09-24
Pages 492
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This practical book in instrumental analytics conveys an overview of important methods of analysis and enables the reader to realistically learn the (principally technology-independent) working techniques the analytical chemist uses to develop methods and conduct validation. What is to be conveyed to the student is the fact that analysts in their capacity as problem-solvers perform services for certain groups of customers, i.e., the solution to the problem should in any case be processed in such a way as to be "fit for purpose". The book presents sixteen experiments in analytical chemistry laboratory courses. They consist of the classical curriculum used at universities and universities of applied sciences with chromatographic procedures, atom spectrometric methods, sensors and special methods (e.g. field flow fractionation , flow injection analysis and N-determination according to Kjeldahl). The carefully chosen combination of theoretical description of the methods of analysis and the detailed instructions given are what characterizes this book. The instructions to the experiments are so detailed that the measurements can, for the most part, be taken without the help of additional literature. The book is complemented with tips for effective literature and database research on the topics of organisation and the practical workflow of experiments in analytical laboratory, on the topic of the use of laboratory logs as well as on writing technical reports and grading them (Evaluation Guidelines for Laboratory Experiments). A small introduction to Quality Management, a brief glance at the history of analytical chemistry as well as a detailed appendix on the topic of safety in analytical laboratories and a short introduction to the new system of grading and marking chemicals using the "Globally Harmonized System of Classification and Labelling of Chemicals (GHS)", round off this book. This book is therefore an indispensable workbook for students, internship assistants and lecturers (in the area of chemistry, biotechnology, food technology and environmental technology) in the basic training programme of analytics at universities and universities of applied sciences.



Practical Spectroscopy

Practical Spectroscopy Author Paul R. Young
ISBN-10 0534372309
Release 2000-01-01
Pages 158
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Based on the spectroscopy modules in Organic Chemistry Online 2.0 CD-ROM, this workbook contains proton and carbon NMR, infrared, and mass spectra for 100 organic molecules along with expanded tutorial sections to aid undergraduate students in analysis.



Confocal Raman Microscopy

Confocal Raman Microscopy Author Jan Toporski
ISBN-10 9783319753805
Release 2018-03-01
Pages 596
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This second edition provides a cutting-edge overview of physical, technical and scientific aspects related to the widely used analytical method of confocal Raman microscopy. The book includes expanded background information and adds insights into how confocal Raman microscopy, especially 3D Raman imaging, can be integrated with other methods to produce a variety of correlative microscopy combinations. The benefits are then demonstrated and supported by numerous examples from the fields of materials science, 2D materials, the life sciences, pharmaceutical research and development, as well as the geosciences.



Metallomics

Metallomics Author Yasumitsu Ogra
ISBN-10 9784431564638
Release 2017-03-01
Pages 364
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This book focuses on recent topics in metallomics, a study of the metallome, or metal-containing biomolecules. Metals can induce various physiological and toxicological effects in a very small amounts, in other words, the concentrations of biometals are very low in organisms. Thus, analytical techniques for a trace amount of metal are crucial to understand the biological and toxicological functions of metals.This volume begins with an overview of metallomics including the history and development of the field. Subsequent parts provide basic and advanced techniques for metallomics. Speciation and imaging of metals are basic approaches to reveal the function of the metallome. The applications of speciation using an HPLC hyphenated with inductively coupled plasma mass spectrometry (LC-ICP-MS) and flow cytometry ICP-MS are described. As advanced approaches, the applications using a micro-flow injection-ICP-MS, an ICP-triple quadrupole mass spectrometer, an ICP-sector field mass spectrometer, and an ICP-multi-collector mass spectrometer are mentioned. For the imaging of metals, basic principles and applications of several techniques such as scanning X-ray fluorescence microscopy and ICP-MS equipped with laser ablation (LA-ICP-MS) are presented. Speciation analyses using electrospray ionization mass spectrometry (ESI-MS), X-ray Absorption Spectroscopy (XAS), and nuclear magnetic resonance spectroscopy (NMR) are also introduced. The last part highlights the medical and pharmaceutical applications of metallomics. Molecular biological approaches to reveal the effects of toxic metals, metal functions in brain and neurodegenerative diseases, and metallodrugs are explained. The topic of metal transporters is also presented.



Handbook of X Ray Spectrometry Second Edition

Handbook of X Ray Spectrometry  Second Edition Author Rene Van Grieken
ISBN-10 0203908708
Release 2001-11-27
Pages 1016
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"Updates fundamentals and applications of all modes of x-ray spectrometry, including total reflection and polarized beam x-ray fluorescence analysis, and synchrotron radiation induced x-ray emission. Promotes the accurate measurement of samples while reducing the scattered background in the x-ray spectrum."