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Precision Molecular Pathology of Dermatologic Diseases

Precision Molecular Pathology of Dermatologic Diseases Author Victor G. Prieto
ISBN-10 9781493928613
Release 2015-08-10
Pages 136
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This volume is a concise yet comprehensive resource for physicians dealing with, and interested in, the field of molecular pathology in dermatopathology. The book includes descriptions of the techniques and their application to cutaneous diseases and describes possible future techniques and their use in dermatopathology. Special emphasis is also given to the practical application of these techniques to particular situations illustrated by demonstrative cases. Written by experts in their fields, Precision Molecular Pathology of Dermatologic Diseases is of great value to pathologists, dermatologists, resident and fellows, internists, and general practitioners who deal with dermatologic diseases.



Precision Molecular Pathology of Breast Cancer

Precision Molecular Pathology of Breast Cancer Author Ashraf Khan
ISBN-10 9781493928866
Release 2015-08-12
Pages 338
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This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters present morphologic and molecular correlations in precancerous and malignant breast lesions, while outlining highly practical issues that are in practice today in breast pathology, such as evaluation of estrogen, progesterone receptors, and HER-2. Written by experts in the field, Precision Molecular Pathology of Breast Cancer is a valuable resource that covers the current practice of breast pathology and looks into the future with an emphasis on the molecular basis of breast cancer.



Precision Molecular Pathology of Uterine Cancer

Precision Molecular Pathology of Uterine Cancer Author Michael T. Deavers
ISBN-10 9783319579856
Release 2017-10-28
Pages 286
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This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments that are discussed in this volume. Comprehensive chapters address essential information about endometrial carcinoma, uterine mesenchymal tumors, and cervical carcinoma and include the pathogenesis of carcinoma and discuss molecular based classification, biomarkers, therapy, prevention, and hereditary cancers of the uterus. Precision Molecular Pathology of Uterine Cancer is a unique and one of a kind resource for practicing pathologists, pathologists in training and gynecologists.



Molecular Pathology of Lung Cancer

Molecular Pathology of Lung Cancer Author Philip T. Cagle
ISBN-10 9781461431978
Release 2012-06-14
Pages 216
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As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.



Precision Molecular Pathology of Myeloid Neoplasms

Precision Molecular Pathology of Myeloid Neoplasms Author Chung-Che (Jeff) Chang
ISBN-10 9783319621463
Release 2017-09-25
Pages 427
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This volume provides a comprehensive, state-of-the art review of myeloid neoplasms. The book presents updated information on epidemiology, clinical presentation, morphologic findings, molecular genomic abnormalities, pathogenesis, and target therapies. The text helps to guide accurate diagnosis, the administration of appropriate ancillary molecular tests, patient management, and investigative efforts. The book also includes over 200 illustrations, photographs, and tables. Written by experts in the field, Precision Molecular Pathology of Myeloid Neoplasms serves as a valuable resource for pathologists, hematologists/oncologists, fellows, and researchers in understanding the molecular pathology of myeloid neoplasms.



Precision Molecular Pathology of Prostate Cancer

Precision Molecular Pathology of Prostate Cancer Author Brian D. Robinson
ISBN-10 9783319640969
Release 2018-02-13
Pages 570
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This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) and Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.



Molecular Pathology of Liver Diseases

Molecular Pathology of Liver Diseases Author Satdarshan P. S. Monga
ISBN-10 1441971076
Release 2010-12-14
Pages 931
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Cellular and Molecular Pathology of the Liver is extensive, complex and ranges from the understanding the basic molecular mechanisms that dictate everything from liver homeostasis to liver disease. Molecular Pathology of the liver is complicated due to some of the important functions inherent and unique to the Liver, including its innate ability to regenerate and the multitude of functions it plays for the wellbeing of an organism. With all this in mind, Molecular Pathology of Liver Diseases is organized in different sections, which will coherently and cohesively present the molecular basis of hepatic physiology and pathology. The first two sections are key to understanding the liver anatomy and physiology at a cellular level and go on to define the molecular mechanics in various liver cell types. These sections also cover the existing paradigms in liver development, regeneration and growth. The next section is key to understanding the Molecular Pathology unique to liver diseases and associated phenotypes. The final sections are geared towards the existing knowledge of the molecular basis of many common and uncommon liver diseases in both neoplastic and non-neoplastic areas including pathologies associated with intra-hepatic and extra-hepatic biliary tree. Thus, this textbook is a one-stop reference for comprehending the molecular mechanisms of hepatic pathobiology. It is clearly unique in its format, readability and information and thus will be an asset to many in the field of Pathology and other disciplines.



Pathology and Pathobiology of Rheumatic Diseases

Pathology and Pathobiology of Rheumatic Diseases Author Hans G. Fassbender
ISBN-10 9783662048191
Release 2013-04-17
Pages 503
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Pathology and Pathobiology of Rheumatic Diseases glows with the uncommon precision of the pathologist, the clarity of the tea cher, and the unswerving commitment of the investigator. Fass bender has produced a major contribution to the literature of rheumatic diseases. The practical experience and wisdom brought together in this book, substantiated by excellent exam ples of histopathology, produce a landmark for all who have made the study of rheumatic diseases their profession. The enor mous achievements made in molecular biology, genetics, struc tural biochemistry, and clinical science have been assembled in this book to interact in a meaningful way with the anatomical histology of the rheumatic diseases. It is not easy for any single investigator to paint the picture of a disease process, from its clinical description to its mechanisms, and then to a defined hypothesis, and finally an understanding. Nonetheless, Fassbender has done this in a clear and convincing way that integrates our current knowledge of this group of dis eases. Scientific discovery in medicine moves from the bedside to the bench, back to the bedside, and then back to the bench, etc. It is this iterative process of new observation and new discovery that has given us the achievements in medicine over the past century.



Precision Molecular Pathology of Bladder Cancer

Precision Molecular Pathology of Bladder Cancer Author Donna E. Hansel
ISBN-10 9783319647692
Release 2018-01-05
Pages 243
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This succinct yet comprehensive volume describes current and emerging concepts in molecular pathology of bladder cancer. Divided into two distinct sections, the first part focuses on the general principles of molecular findings in bladder cancer, while the second part focuses on the molecular changes associated with specific histologic subtypes. The volume also addresses such topics as molecular alterations in non-invasive and invasive disease, including bladder cancer variants as appropriate, emerging molecular classifiers of bladder cancer, and molecular associations to outcome and treatment. Written by experts in the field, Precision Molecular Pathology of Bladder Cancer is a valuable resource for those in the urologic community, including urologic pathologists, urologists, urologic oncologists and radiation oncologists, who treat and manage bladder cancer.



Precision Molecular Pathology of Hodgkin Lymphoma

Precision Molecular Pathology of Hodgkin Lymphoma Author S. David Hudnall
ISBN-10 9783319680941
Release 2018-01-07
Pages 236
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This text provides a comprehensive and up-to-date overview of Hodgkin lymphoma. The volume reviews every facet of the cancer in great detail, including pathology, pathobiology, molecular genetics, microenvironment, epidemiology, treatment, and new therapeutic advances. The specific role of the lymphoma microenvironment is addressed, and the relationship of Hodgkin lymphoma to related non-Hodgkin lymphomas is covered as well. Written by experts in the field, Precision Molecular Pathology of Hodgkin Lymphoma is a valuable resource for oncologists, surgeons, pathologists, clinical trainees, and investigators engaged in the diagnosis, treatment, and research studies of this lymphoid neoplasm.



Atlas of Lymph Node Pathology

Atlas of Lymph Node Pathology Author Roberto N. Miranda
ISBN-10 9781461479598
Release 2013-08-13
Pages 530
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Atlas of Lymph Node Pathology reviews the histopathology of nodal diseases, illustrating the use of ancillary studies and includes concise discussions of pathogenesis, clinical settings and clinical significance of the pathologic diagnosis. The atlas features an overview of the benign reactive processes secondary to infectious, environmental or unknown insults, as well as relevant illustrations of virtually all primary and secondary neoplasms involving lymph nodes. The atlas also includes macroscopic images of some disorders, tables that help readers understand and comprehend diseases that look alike, and diagnostic algorithms for certain groups of diseases. Authored by highly experienced pathologists, Atlas of Lymph Node Pathology is a valuable resource that illustrates the vast majority of diseases practicing pathologists, clinicians and oncologists are likely to encounter in daily practice.



Clinical Genomics

Clinical Genomics Author Shashikant Kulkarni
ISBN-10 9780124051737
Release 2014-11-10
Pages 488
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Clinical Genomics provides an overview of the various next-generation sequencing (NGS) technologies that are currently used in clinical diagnostic laboratories. It presents key bioinformatic challenges and the solutions that must be addressed by clinical genomicists and genomic pathologists, such as specific pipelines for identification of the full range of variants that are clinically important. This book is also focused on the challenges of diagnostic interpretation of NGS results in a clinical setting. Its final sections are devoted to the emerging regulatory issues that will govern clinical use of NGS, and reimbursement paradigms that will affect the way in which laboratory professionals get paid for the testing. Simplifies complexities of NGS technologies for rapid education of clinical genomicists and genomic pathologists towards genomic medicine paradigm Tried and tested practice-based analysis for precision diagnosis and treatment plans Specific pipelines and meta-analysis for full range of clinically important variants



Precancerous Lesions of the Gynecologic Tract

Precancerous Lesions of the Gynecologic Tract Author Oluwole Fadare
ISBN-10 9783319225098
Release 2015-11-26
Pages 318
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This volume provides a concise yet comprehensive overview of precancerous lesions and gynecologic tract cancers. Each section discusses the historic evolution of a precancerous lesion, its epidemiology, the nature of the published evidence that supports its characterization as a precancerous lesion, and gives a detailed description of morphologic, immunophenotypic and molecular properties, and patient outcomes. The volume also features 2 separate chapters on the clinical management of precancerous lesions of the gynecologic tract as a well as the cytopathology of cervical precancerous lesions. Lavishly illustrated and written by some of the foremost experts in the field, Precancerous Lesions of the Gynecologic Tract: Diagnostic and Molecular Genetic Pathology is a definitive account of precancerous lesions of the gynecologic tract and is a valuable resource for pathologists, oncologists, and gynecologists.



Phenomenology of Suicide

Phenomenology of Suicide Author Maurizio Pompili
ISBN-10 9783319479767
Release 2017-10-10
Pages 217
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This book will help the reader to understand the suicidal mind from a phenomenological point of view, shedding light on the feelings of suicidal individuals and also those of clinicians. In accordance with the importance that the phenomenological approach attaches to subjectivity and sense of self as the starting points for knowledge, emphasis is placed on the need for the clinician to focus on the subjective experiences of the at-risk individual, to set aside prior assumptions, judgments, or interpretations, and to identify ways of bridging gaps in communication associated with negative emotions. The vital importance of empathy is stressed, drawing attention to the insights offered by neuroimaging studies and the role of mirror neurons in social cognition. It is widely acknowledged that when a clinician meets a person who wants to die by suicide, the clinician does not fully understand what is going on inside the mind of that individual. This book recognizes that any approach to suicide prevention must promote understanding of suicidal thoughts and feelings. The awareness that it fosters and the innovative perspectives that it presents will appeal to a wide readership.



Ultrasound in Gynecology

Ultrasound in Gynecology Author Mala Sibal
ISBN-10 9789811027147
Release 2017-03-03
Pages 543
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This atlas and guide book is focused on gynecological ultrasound, an area that has remained in the shadow of obstetric ultrasound & fetal medicine. Gynecological ultrasound has seen rapid advances owing to expanding research and improved ultrasound equipment. This book leverages these advances and provides abundant illustrations and practice points of classical and new ultrasound features. It serves as a guide for radiologists, gynecologists and sonologists for the accurate diagnosis of gynecological pathologies. The chapters of this book also serve as a comprehensive resource for various topics with hundreds of images and figures, including basic gray scale images, Doppler studies and three dimensional ultrasound illustrations. In addition, standard terms for the evaluation and reporting of gynecological pathologies are discussed. Emergencies like ovarian torsion, complex adnexal cyst are also covered.



Bioscience Lost in Translation

Bioscience   Lost in Translation Author Richard Barker
ISBN-10 9780198737780
Release 2016-09-01
Pages 240
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Medical innovation as it stands today is fundamentally unsustainable. There is a widening gap between what biomedical research promises and the impact that it is currently achieving, in terms of patient benefit and health system improvement. This book highlights the global problem of the ineffective translation of bioscience innovation into health system improvements and its consequences, analyses the underlying causative factors and provides powerful prescriptions for change to close the gap. It contrasts the progress in biomedicine with other areas of scientific and technological endeavour, such as information technology, in which there are faster and more reliable returns for society from scientific advance. It asks searching questions about whether society is right to expect so much from biomedicine and why we have become accustomed to such poor returns. Throughout the book, techniques such as stratified medicine, open innovation, adaptive development and personalised adherence are discussed and described in terms accessible to the non-specialist, and their impact on the innovation gap explored. By using examples in which bottlenecks have prevented progress, such as dementia and antibiotic-resistant infections, and in which these barriers have been overcome, such as HIV treatment, Bioscience - Lost in Translation? lays out a strategy for advancing the innovation process, presenting suggestions for how health systems can move from being passive recipients of innovation to being active participants in development.



Principles of Molecular Diagnostics and Personalized Cancer Medicine

Principles of Molecular Diagnostics and Personalized Cancer Medicine Author Dongfeng Tan
ISBN-10 9781469820644
Release 2012-12-07
Pages 992
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The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.