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Protein Engineering and Design

Protein Engineering and Design Author Paul R. Carey
ISBN-10 0080539971
Release 1996-06-21
Pages 361
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The design and production of novel peptides and proteins occupy pivotal positions in science and technology and will continue to do so in the 21st century. Protein Engineering and Design outlines the rapid advances in computer-based modeling, protein engineering, and methods needed for protein and peptide preparation and characterization. This indispensable reference lays the groundwork for understanding this multidisciplinary activity while providing an introduction for researchers and students to the field of protein design. Introduces and defines the techniques involved in protein engineering and design Provides a concise overview of key technologies involved and demonstrates their contributions to the specialized design and production of novel proteins and peptides



Protein Engineering and Design

Protein Engineering and Design Author Anton Torres
ISBN-10 1682864022
Release 2017-06
Pages 233
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Protein Engineering is a nascent yet rapidly expanding field of study concerned with the useful development of proteins. This book elucidates new techniques and their applications in a multidisciplinary approach. The discipline of protein engineering is a growing field of study. This book traces the progress of this field and highlights some of its key concepts and applications. This field of study is understood through two major strategies that is - rational protein design and the directed evolution. The text has combined both these strategies so as to give it a holistic approach. Those in search of information on this field to further their knowledge will be greatly assisted by this book. It includes contributions of experts and scientists from across the globe which will provide innovative insights into this field.



Protein Engineering and Design

Protein Engineering and Design Author Sheldon J. Park
ISBN-10 1420076590
Release 2009-09-25
Pages 416
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Experimental protein engineering and computational protein design are broad but complementary strategies for developing proteins with altered or novel structural properties and biological functions. By describing cutting-edge advances in both of these fields, Protein Engineering and Design aims to cultivate a synergistic approach to protein science. Experimental Protein Engineering The first half of the book discusses experimental approaches to protein engineering and starts by describing several high-throughput screening platforms for protein engineering. Key techniques used for diversity generation are also discussed. The next few chapters present examples of therapeutics, enzymes, biomaterials, and other proteins that have been engineered by rational or combinatorial approaches. The section finishes with a chapter on the use of non-natural amino acids in protein engineering. Computational Protein Design The second half of the book introduces computational protein design, beginning with a chapter on computational and informatics algorithms used in protein engineering. Core components of computational protein design are then discussed in detail, and examples of heuristic protein design are provided. Subsequent chapters present examples of how computational design has played a critical role in advancing the field of protein engineering. Concluding with a chapter outlining current challenges in the field, this book makes computational protein design and diversity-oriented protein engineering widely accessible to a broad audience in academia and industry alike.



Protein Engineering and Design

Protein Engineering and Design Author
ISBN-10 1682500551
Release
Pages 222
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Protein Engineering and Design has been writing in one form or another for most of life. You can find so many inspiration from Protein Engineering and Design also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Protein Engineering and Design book for free.



Protein Engineering Protocols

Protein Engineering Protocols Author Kristian M. Müller
ISBN-10 9781597451871
Release 2007
Pages 335
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Protein Engineering Protocols considers the general, but not mutually exclusive, strategies for protein engineering. The first is known as rational design, in which the scientist uses detailed knowledge of the structure and function of the protein to make desired changes. The second strategy is known as directed evolution. This volume provides a comprehensive guide to the methods used at every stage of the engineering process. It combines a thorough theoretical foundation with detailed protocols and will be invaluable to all research workers in the area, from graduate students to senior investigators.



Protein Engineering and Design with Non Canonical Amino Acids

Protein Engineering and Design with Non Canonical Amino Acids Author
ISBN-10 OCLC:696261233
Release 2006
Pages
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The translation machinery of cells can be exploited for the incorporation of various non canonical amino acids into proteins. In this work, different fluoro-, amino-, and methyl- containing Tryptophan and Leucine analogues were incorporated into model proteins by the use of selective pressure incorporation (SPI) method. Such isosteric replacements introduced minimal local geometry changes in indole moieties, often at the level of single atomic exchange (atomic mutation) and normally do not affect 3D structures of substituted proteins, but induce significant changes in spectral and folding properties. For example, mutants of Barstar can be stabilised by incorporation of fluorinated Tryptophan analogues, while Tryptophan-fluorescence can be abolished by 4- and 7-Fluorotryptophan. Proteins substituted by toxic analogues can be specifically intracellulary delivered and after their recycling and the release of an analogue target, cells would be directed to apoptosis or necrosis.



Protein Engineering and Design of Thermostable Biosensors

Protein Engineering and Design of Thermostable Biosensors Author Yaji Tian
ISBN-10 OCLC:153882145
Release 2007
Pages 208
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Protein Engineering and Design of Thermostable Biosensors has been writing in one form or another for most of life. You can find so many inspiration from Protein Engineering and Design of Thermostable Biosensors also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Protein Engineering and Design of Thermostable Biosensors book for free.



Protein Engineering Handbook

Protein Engineering Handbook Author Stefan Lutz
ISBN-10 9783527667017
Release 2012-07-31
Pages 1015
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Unparalleled in size and scope, this new major reference integrates academic and industrial knowledge into a single resource, allowing for a unique overview of the entire field. Adopting a systematic and practice-oriented approach, and including a wide range of technical and methodological information, this highly accessible handbook is an invaluable 'toolbox' for any bioengineer. In two massive volumes, it covers the full spectrum of current concepts, methods and application areas.



Protein Engineering

Protein Engineering Author Caroline Koehrer
ISBN-10 9783540709411
Release 2009-01-07
Pages 347
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Site-specific mutagenesis of DNA, developed some thirty years ago, has proven to be one of the most important advances in biology. By allowing the site-specific replacement of any amino acid in a protein with one of the other nineteen amino acids, it ushered in the new era of "Protein Engineering". The field of protein engineering has, however, evolved rapidly since then and the last fifteen years have witnessed remarkable advances through the use of new chemical, biochemical and molecular biological tools towards the synthesis and manipulation of proteins. The chapters included in this book reflect the rapid evolution of protein engineering and its many applications in basic research, biotechnology, material sciences and therapy. This book will provide the reader with an introduction to state-of the-art concepts and methods and will be of use to anyone interested in the study of proteins, in academia as well as in industry.



Protein Engineering Techniques

Protein Engineering Techniques Author Krishna Mohan Poluri
ISBN-10 9789811027321
Release 2016-12-31
Pages 134
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This brief provides a broad overview of protein-engineering research, offering a glimpse of the most common experimental methods. It also presents various computational programs with applications that are widely used in directed evolution, computational and de novo protein design. Further, it sheds light on the advantages and pitfalls of existing methodologies and future perspectives of protein engineering techniques.



Protein Engineering Design and Selection

Protein Engineering  Design and Selection Author
ISBN-10 STANFORD:36105123121332
Release 2009
Pages
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Protein Engineering Design and Selection has been writing in one form or another for most of life. You can find so many inspiration from Protein Engineering Design and Selection also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Protein Engineering Design and Selection book for free.



Protein Engineering

Protein Engineering Author Mallorie N. Sheehan
ISBN-10 1616686499
Release 2013
Pages 221
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Protein Engineering has been writing in one form or another for most of life. You can find so many inspiration from Protein Engineering also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Protein Engineering book for free.



Protein Engineering For Industrial Biotechnology

Protein Engineering For Industrial Biotechnology Author Lilia Alberghina
ISBN-10 9781482283488
Release 2014-04-21
Pages 388
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Protein engineering has proved to be one of the more fruitful technological approaches in biotechnology, being both very powerful and able to generate valuable intellectual property. This book aims to present examples in which the application of protein engineering has successfully solved problems arising in industrial biotechnology. There is a section on its use to enhance purification of recombinant proteins. The use of protein engineering to modify the activity or the stability of industrial enzymes from lipases to proteases, from carboxypeptidases to glucanases and glucosidases, and from pectin modifying enzymes to enzymes able to degrade recalcitrant compounds is extensively covered. It is shown how areas as diverse as agrofood technology, fine chemistry, detergents, bioremediation and biosensors receive significant contributions from protein and solvent engineering. The application of protein engineering to health care is also covered, from the development of new vaccines to new potential therapeutic proteins. A specific notation is given to protein engineering in the development of target molecules for drug discovery. International in scope, the many contributions are drawn from academia and industry. The text should be of interest to students and researchers in industrial biotechnology as well as to everybody interested in basic research in protein structure, molecular genetics, bio-organic chemistry, biochemistry, agrobiotechnology, pharmaceutical sciences and medicine.



Methods in Protein Design

Methods in Protein Design Author
ISBN-10 9780123946294
Release 2013-02-14
Pages 520
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This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers methods in protein design and it has chapters on such topics as protein switch engineering by domain insertion, evolution based design of proteins, and computationally designed proteins. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers methods in protein design Contains chapters with such topics as protein switch engineering by domain insertion, evolution-based design of proteins, and computationally designed proteins



Protein Engineering

Protein Engineering Author Dan Robertson
ISBN-10 9780080497259
Release 2004-09-29
Pages 456
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This MIE volume covers methods for a multitude of topics among which are computational methods, laboratory methods, enzyme optimization, binding proteins/antibodies, and screening technologies. Table of Contents -Methodology -Applications-Opzimization and Screening -Applications-Directed Evolution of Enzymatic Function -Applications-Evolution of Biosynthetic Pathways -Devices, Antibodies and Vaccines



Pharmaceutical Biotechnology

Pharmaceutical Biotechnology Author Gary Walsh
ISBN-10 9781118685754
Release 2013-04-25
Pages 504
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Pharmaceutical Biotechnology offers students taking Pharmacy and related Medical and Pharmaceutical courses a comprehensive introduction to the fast-moving area of biopharmaceuticals. With a particular focus on the subject taken from a pharmaceutical perspective, initial chapters offer a broad introduction to protein science and recombinant DNA technology- key areas that underpin the whole subject. Subsequent chapters focus upon the development, production and analysis of these substances. Finally the book moves on to explore the science, biotechnology and medical applications of specific biotech products categories. These include not only protein-based substances but also nucleic acid and cell-based products. introduces essential principles underlining modern biotechnology- recombinant DNA technology and protein science an invaluable introduction to this fast-moving subject aimed specifically at pharmacy and medical students includes specific ‘product category chapters’ focusing on the pharmaceutical, medical and therapeutic properties of numerous biopharmaceutical products. entire chapter devoted to the principles of genetic engineering and how these drugs are developed. includes numerous relevant case studies to enhance student understanding no prior knowledge of protein structure is assumed



Enzyme Functionality

Enzyme Functionality Author Allan Svendsen
ISBN-10 9780824756918
Release 2003-10-28
Pages 712
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Enzyme Functionality serves as a conduit for trailblazing research in enzyme engineering-relating current understanding of sequence families, the new notion of enzyme structure classes, and modern methods in protein engineering, design, and directed evolution to accelerate the development of novel enzyme functionalities. This reference gathers the diverse perspectives of nearly 80 scientists from around the globe and surveys all leading rational and random approaches to the artificial evolution of enzymes. Citing more than 1500 notable works, it outlines assays for enzyme activity, stability, and specificity and a wide variety of site-directed, redesign, and evolutionary engineering methods.