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Sperm Acrosome Biogenesis and Function During Fertilization

Sperm Acrosome Biogenesis and Function During Fertilization Author Mariano G. Buffone
ISBN-10 9783319305677
Release 2016-05-19
Pages 172
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Over the last decades, acrosomal exocytosis (also called the “acrosome reaction”) has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of unfertilized eggs, based largely on in vitro fertilization studies of mouse oocytes denuded of the cumulus oophorus, has been overturned by experiments using state-of-the-art imaging of cumulus-intact oocytes and fertilization experiments where eggs were reinseminated by acrosome-reacted sperm recovered from the perivitelline space of zygotes. From a molecular point of view, acrosome exocytosis is a synchronized and tightly regulated process mediated by molecular mechanisms that are homologous to those reported in neuroendocrinal cell secretions. The authors provide a broader perspective, focusing on a limited number of important topics that are essential for understanding the molecular mechanisms governing this step in the fertilization process. They also discuss molecular aspects such as the signaling pathways leading to exocytosis, including the participation of ion channels, lipids, the fusion machinery proteins and the actin cytoskeleton as well as cellular aspects such as the site of acrosomal exocytosis and the use of gene-manipulated animals to study this process.

Nuevos y antiguos retos de la espermatolog a veterinaria

Nuevos y antiguos retos de la espermatolog  a veterinaria Author José Julián Garde López-Brea
Pages 120
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La Espermatología engloba el estudio científico de los espermatozoides y de las secreciones seminales, analizando entre otros, aspectos relativos a su Histología, Fisiología y Embriología. Igualmente contempla la aplicación de los diferentes procesos tecnológicos que permiten el empleo y la manipulación de los gametos masculinos por medio de las diferentes técnicas de reproducción asistida. La Espermatología Veterinaria hace referencia a la aplicada al estudio, conservación y manipulación de los gametos masculinos de las especies de interés ganadero o zootécnico.

Dynamics of the Mammalian Sperm Head

Dynamics of the Mammalian Sperm Head Author Kiyotaka Toshimori
ISBN-10 3540899790
Release 2009-04-28
Pages 98
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Mammalian spermatozoa have complex structures. The structure-function relationship of sperm has been studied from various viewpoints. Accumulated evidence has shown that the sperm components undergo sequential changes from the beginning of spermatogenesis to the time of fertilization/embryogenesis. Structural analyses have been performed using various new techniques of light and electron microscopy as well as immunohistochemistry and immunocytochemistry in combination with specific probes such as antibodies against sperm components. Recently developed gene-manipulation techniques have accelerated investigations on the events that govern the relationship between the structure and molecular components of sperm. In addition, animal models with gene manipulations have been shown to exhibit various morphological and functional abnormalities that lead to infertility. In this book, I discuss the events that occur in the normal sperm head and govern the structure-function relationship from the time of spermatogenesis to that of fertilization or egg activation. In this regard, I describe dynamic modifications and maturation events occurring in sperm-head components and compare the outcomes of these events with the outcomes of their failure.

Sperm Chromatin

Sperm Chromatin Author Armand Zini
ISBN-10 1441968571
Release 2011-08-04
Pages 512
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Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.

The Role of Heat Shock Proteins in Reproductive System Development and Function

The Role of Heat Shock Proteins in Reproductive System Development and Function Author Daniel J. MacPhee
ISBN-10 9783319514093
Release 2017-05-08
Pages 155
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Due to the paucity of reviews on this subject, this volume aims to be timely and promote additional basic and translational research on these proteins in reproductive system development and function within the fields of Anatomy, Embryology and Cell Biology. The breadth of the work being conducted within Reproduction is exemplified by the contributors to this series who will provide reviews on: Grp78 roles in female reproduction, small heat shock proteins/co-chaperones as players in uterine smooth muscle function, the role of heat shock proteins in sperm function and maternal contribution to oogenesis and early embryogenesis, heat shock factors and testes development, HSP90 in ovarian biology and pathology, and the role of HSP70 in regulation of autophagy in pregnancy and parturition.

Brenner s Encyclopedia of Genetics

Brenner s Encyclopedia of Genetics Author Sydney Brenner
ISBN-10 9780080961569
Release 2013-03-22
Pages 4368
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The explosion of the field of genetics over the last decade, with the new technologies that have stimulated research, suggests that a new sort of reference work is needed to keep pace with such a fast-moving and interdisciplinary field. Brenner's Encyclopedia of Genetics, 2nd edition, builds on the foundation of the first edition by addressing many of the key subfields of genetics that were just in their infancy when the first edition was published. The currency and accessibility of this foundational content will be unrivalled, making this work useful for scientists and non-scientists alike. Featuring relatively short entries on genetics topics written by experts in that topic, Brenner's Encyclopedia of Genetics provides an effective way to quickly learn about any aspect of genetics, from Abortive Transduction to Zygotes. Adding to its utility, the work provides short entries that briefly define key terms, and a guide to additional reading and relevant websites for further study. Many of the entries include figures to explain difficult concepts. Key terms in related areas such as biochemistry, cell, and molecular biology are also included, and there are entries that describe historical figures in genetics, providing insights into their careers and discoveries. This 7-volume set represents a 25% expansion from the first edition, with over 1600 articles encompassing this burgeoning field. Thoroughly up-to-date, with many new topics and subfields covered that were in their infancy or not inexistence at the time of the first edition. Timely coverage of emergent areas such as epigenetics, personalized genomic medicine, pharmacogenetics, and genetic enhancement technologies Interdisciplinary and global in its outlook, as befits the field of genetics Brief articles, written by experts in the field, which not only discuss, define, and explain key elements of the field, but also provide definition of key terms, suggestions for further reading, and biographical sketches of the key people in the history of genetics.

Early Embryology of the Chick Fourth Edition

Early Embryology of the Chick  Fourth Edition Author Bradley M. Patten
ISBN-10 1434473856
Release 2008-08-01
Pages 268
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Fourth Edition. The Early Embryology of the Chick, by Bradley M. Patten, Professor of Anatomy, University of Michigan Medical School. With 102 Illustrations containing 343 Figures.

Color Atlas of Cytology Histology and Microscopic Anatomy

Color Atlas of Cytology  Histology  and Microscopic Anatomy Author Wolfgang Kühnel
ISBN-10 1588901750
Release 2003
Pages 534
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This timeless pocket atlas is the ideal visual companion to histology and cytology textbooks. First published in 1950 and translated into eight languages, Kuehnel's Pocket Atlas of Cytology, Histology and Microscopic Anatomy is a proven classic. The fully revised and updated fourth edition contains 745 full-color illustrations - almost 200 more than were included in the third edition. Superb, high-quality microphotographs and pathologic stains are accompanied by legends, informative texts, and numerous cross-references. Key features of the updated fourth edition: More than 700 high-quality illustrations using advanced techniques in histology and electron microscopy Practical, information Concise and focused text Key concepts and ideas illustrated in less than 550 pages Ideal for exam preparation, this world-class book is an indispensable visual study tool for medical, dental and biology students. It can also serve as an outstanding review and refresher text.

Cell Biology Genetics Molecular Biology

Cell Biology Genetics  Molecular Biology Author P.S. Verma
ISBN-10 8121924421
Release 2004-09-01
Pages 350
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Cell Biology Genetics Molecular Biology has been writing in one form or another for most of life. You can find so many inspiration from Cell Biology Genetics Molecular Biology also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Cell Biology Genetics Molecular Biology book for free.

Integrated Principles of Zoology

Integrated Principles of Zoology Author Allan Larson
ISBN-10 0073524212
Release 2013-09-25
Pages 912
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Emphasizing the central role of evolution in generating diversity, this best-selling text describes animal life and the fascinating adaptations that enable animals to inhabit so many ecological niches. Featuring high quality illustrations and photographs set within an engaging narrative, Integrated Principles of Zoology is considered the standard by which other texts are measured. With its comprehensive coverage of biological and zoological principles, mechanisms of evolution, diversity, physiology, and ecology, organized into five parts for easy access, this text is suitable for one- or two-semester introductory courses.

Cell Biology of Herpes Viruses

Cell Biology of Herpes Viruses Author Klaus Osterrieder
ISBN-10 9783319531687
Release 2017-06-18
Pages 224
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Herpes viruses are widely distributed in nature, causing disease in organisms as diverse as bivalves and primates, including humans. Each virus appears to have established a long-standing relationship with its host, and the viruses have the ability to manipulate and control the metabolism of host cells, as well as innate and adaptive antiviral immune responses. Herpes viruses maintain themselves within hosts in a latent state resulting in virus persistence for years – usually for the life span of the hosts. Herpes viruses comprise a large number of pathogens with diverse cellular targets and biological consequences of infection. What they have in common is their structure and the fact that they establish a dormant (latent) infection in their hosts that usually persists for life. The reviews here will highlight the general principles of herpes virus infection, with equal attention to overall principle and important difference. Also, the cell type- and life-style dependent differences in the establishment and maintenance of virus persistence will be covered.