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Statistics for Epidemiology

Statistics for Epidemiology Author Nicholas P. Jewell
ISBN-10 9780203496862
Release 2003-08-26
Pages 352
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Statistical ideas have been integral to the development of epidemiology and continue to provide the tools needed to interpret epidemiological studies. Although epidemiologists do not need a highly mathematical background in statistical theory to conduct and interpret such studies, they do need more than an encyclopedia of "recipes." Statistics for Epidemiology achieves just the right balance between the two approaches, building an intuitive understanding of the methods most important to practitioners and the skills to use them effectively. It develops the techniques for analyzing simple risk factors and disease data, with step-by-step extensions that include the use of binary regression. It covers the logistic regression model in detail and contrasts it with the Cox model for time-to-incidence data. The author uses a few simple case studies to guide readers from elementary analyses to more complex regression modeling. Following these examples through several chapters makes it easy to compare the interpretations that emerge from varying approaches. Written by one of the top biostatisticians in the field, Statistics for Epidemiology stands apart in its focus on interpretation and in the depth of understanding it provides. It lays the groundwork that all public health professionals, epidemiologists, and biostatisticians need to successfully design, conduct, and analyze epidemiological studies.


Epidemiology Author Mark Woodward
ISBN-10 9781482243208
Release 2013-12-19
Pages 854
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Highly praised for its broad, practical coverage, the second edition of this popular text incorporated the major statistical models and issues relevant to epidemiological studies. Epidemiology: Study Design and Data Analysis, Third Edition continues to focus on the quantitative aspects of epidemiological research. Updated and expanded, this edition shows students how statistical principles and techniques can help solve epidemiological problems. New to the Third Edition New chapter on risk scores and clinical decision rules New chapter on computer-intensive methods, including the bootstrap, permutation tests, and missing value imputation New sections on binomial regression models, competing risk, information criteria, propensity scoring, and splines Many more exercises and examples using both Stata and SAS More than 60 new figures After introducing study design and reviewing all the standard methods, this self-contained book takes students through analytical methods for both general and specific epidemiological study designs, including cohort, case-control, and intervention studies. In addition to classical methods, it now covers modern methods that exploit the enormous power of contemporary computers. The book also addresses the problem of determining the appropriate size for a study, discusses statistical modeling in epidemiology, covers methods for comparing and summarizing the evidence from several studies, and explains how to use statistical models in risk forecasting and assessing new biomarkers. The author illustrates the techniques with numerous real-world examples and interprets results in a practical way. He also includes an extensive list of references for further reading along with exercises to reinforce understanding. Web Resource A wealth of supporting material can be downloaded from the book’s CRC Press web page, including: Real-life data sets used in the text SAS and Stata programs used for examples in the text SAS and Stata programs for special techniques covered Sample size spreadsheet

Practical Statistics for Medical Research

Practical Statistics for Medical Research Author Douglas G. Altman
ISBN-10 0412276305
Release 1990-11-22
Pages 624
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Most medical researchers, whether clinical or non-clinical, receive some background in statistics as undergraduates. However, it is most often brief, a long time ago, and largely forgotten by the time it is needed. Furthermore, many introductory texts fall short of adequately explaining the underlying concepts of statistics, and often are divorced from the reality of conducting and assessing medical research. Practical Statistics for Medical Research is a problem-based text for medical researchers, medical students, and others in the medical arena who need to use statistics but have no specialized mathematics background. The author draws on twenty years of experience as a consulting medical statistician to provide clear explanations to key statistical concepts, with a firm emphasis on practical aspects of designing and analyzing medical research. The text gives special attention to the presentation and interpretation of results and the many real problems that arise in medical research.

Spatio Temporal Methods in Environmental Epidemiology

Spatio Temporal Methods in Environmental Epidemiology Author Gavin Shaddick
ISBN-10 9781482237047
Release 2015-06-17
Pages 395
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Teaches Students How to Perform Spatio-Temporal Analyses within Epidemiological Studies Spatio-Temporal Methods in Environmental Epidemiology is the first book of its kind to specifically address the interface between environmental epidemiology and spatio-temporal modeling. In response to the growing need for collaboration between statisticians and environmental epidemiologists, the book links recent developments in spatio-temporal methodology with epidemiological applications. Drawing on real-life problems, it provides the necessary tools to exploit advances in methodology when assessing the health risks associated with environmental hazards. The book’s clear guidelines enable the implementation of the methodology and estimation of risks in practice. Designed for graduate students in both epidemiology and statistics, the text covers a wide range of topics, from an introduction to epidemiological principles and the foundations of spatio-temporal modeling to new research directions. It describes traditional and Bayesian approaches and presents the theory of spatial, temporal, and spatio-temporal modeling in the context of its application to environmental epidemiology. The text includes practical examples together with embedded R code, details of specific R packages, and the use of other software, such as WinBUGS/OpenBUGS and integrated nested Laplace approximations (INLA). A supplementary website provides additional code, data, examples, exercises, lab projects, and more. Representing a major new direction in environmental epidemiology, this book—in full color throughout—underscores the increasing need to consider dependencies in both space and time when modeling epidemiological data. Students will learn how to identify and model patterns in spatio-temporal data as well as exploit dependencies over space and time to reduce bias and inefficiency.

Analysis of Longitudinal Studies in Epidemiology

Analysis of Longitudinal Studies in Epidemiology Author Nicholas P. Jewell
ISBN-10 1584885041
Release 2016-01-15
Pages 288
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Aimed at a nontechnical audience, with intuitive explanations instead of mathematical derivations, Analysis of Longitudinal Studies in Epidemiology covers a wide range of topics that include Poisson regression, survival analysis, repeated measure, clustered data, longitudinal observations, and generalized linear models such as logistic regression. The book illustrates examples through extensive case studies, placing particular emphasis on the extension of simple cross-sectional methods and exploring how they can be adapted to longitudinal settings. It also explains the importance of time-dependent confounding and introduces methods including inverse probability weighted estimators.

Understanding Advanced Statistical Methods

Understanding Advanced Statistical Methods Author Peter Westfall
ISBN-10 9781466512108
Release 2013-04-09
Pages 569
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Providing a much-needed bridge between elementary statistics courses and advanced research methods courses, Understanding Advanced Statistical Methods helps students grasp the fundamental assumptions and machinery behind sophisticated statistical topics, such as logistic regression, maximum likelihood, bootstrapping, nonparametrics, and Bayesian methods. The book teaches students how to properly model, think critically, and design their own studies to avoid common errors. It leads them to think differently not only about math and statistics but also about general research and the scientific method. With a focus on statistical models as producers of data, the book enables students to more easily understand the machinery of advanced statistics. It also downplays the "population" interpretation of statistical models and presents Bayesian methods before frequentist ones. Requiring no prior calculus experience, the text employs a "just-in-time" approach that introduces mathematical topics, including calculus, where needed. Formulas throughout the text are used to explain why calculus and probability are essential in statistical modeling. The authors also intuitively explain the theory and logic behind real data analysis, incorporating a range of application examples from the social, economic, biological, medical, physical, and engineering sciences. Enabling your students to answer the why behind statistical methods, this text teaches them how to successfully draw conclusions when the premises are flawed. It empowers them to use advanced statistical methods with confidence and develop their own statistical recipes. Ancillary materials are available on the book’s website.

Bayesian Methods in Epidemiology

Bayesian Methods in Epidemiology Author Lyle D. Broemeling
ISBN-10 9781466564978
Release 2013-08-13
Pages 464
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Written by a biostatistics expert with over 20 years of experience in the field, Bayesian Methods in Epidemiology presents statistical methods used in epidemiology from a Bayesian viewpoint. It employs the software package WinBUGS to carry out the analyses and offers the code in the text and for download online. The book examines study designs that investigate the association between exposure to risk factors and the occurrence of disease. It covers introductory adjustment techniques to compare mortality between states and regression methods to study the association between various risk factors and disease, including logistic regression, simple and multiple linear regression, categorical/ordinal regression, and nonlinear models. The text also introduces a Bayesian approach for the estimation of survival by life tables and illustrates other approaches to estimate survival, including a parametric model based on the Weibull distribution and the Cox proportional hazards (nonparametric) model. Using Bayesian methods to estimate the lead time of the modality, the author explains how to screen for a disease among individuals that do not exhibit any symptoms of the disease. With many examples and end-of-chapter exercises, this book is the first to introduce epidemiology from a Bayesian perspective. It shows epidemiologists how these Bayesian models and techniques are useful in studying the association between disease and exposure to risk factors.

Exercises and Solutions in Biostatistical Theory

Exercises and Solutions in Biostatistical Theory Author Lawrence Kupper
ISBN-10 9781439895023
Release 2010-11-09
Pages 420
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Drawn from nearly four decades of Lawrence L. Kupper’s teaching experiences as a distinguished professor in the Department of Biostatistics at the University of North Carolina, Exercises and Solutions in Biostatistical Theory presents theoretical statistical concepts, numerous exercises, and detailed solutions that span topics from basic probability to statistical inference. The text links theoretical biostatistical principles to real-world situations, including some of the authors’ own biostatistical work that has addressed complicated design and analysis issues in the health sciences. This classroom-tested material is arranged sequentially starting with a chapter on basic probability theory, followed by chapters on univariate distribution theory and multivariate distribution theory. The last two chapters on statistical inference cover estimation theory and hypothesis testing theory. Each chapter begins with an in-depth introduction that summarizes the biostatistical principles needed to help solve the exercises. Exercises range in level of difficulty from fairly basic to more challenging (identified with asterisks). By working through the exercises and detailed solutions in this book, students will develop a deep understanding of the principles of biostatistical theory. The text shows how the biostatistical theory is effectively used to address important biostatistical issues in a variety of real-world settings. Mastering the theoretical biostatistical principles described in the book will prepare students for successful study of higher-level statistical theory and will help them become better biostatisticians.

Spatial Analysis in Epidemiology

Spatial Analysis in Epidemiology Author Dirk Pfeiffer
ISBN-10 9780198509882
Release 2008-05-29
Pages 142
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Providing a practical, comprehensive and up-to-date overview of the use of spatial statistics in epidemiology, this book examines spatial analytical methods in conjunction with GIS and remotely sensed data to provide insights into the patterns and processes that underlie disease transmission.

Measurement Error and Misclassification in Statistics and Epidemiology

Measurement Error and Misclassification in Statistics and Epidemiology Author Paul Gustafson
ISBN-10 9780203502761
Release 2003-09-25
Pages 200
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Mismeasurement of explanatory variables is a common hazard when using statistical modeling techniques, and particularly so in fields such as biostatistics and epidemiology where perceived risk factors cannot always be measured accurately. With this perspective and a focus on both continuous and categorical variables, Measurement Error and Misclassification in Statistics and Epidemiology: Impacts and Bayesian Adjustments examines the consequences and Bayesian remedies in those cases where the explanatory variable cannot be measured with precision. The author explores both measurement error in continuous variables and misclassification in discrete variables, and shows how Bayesian methods might be used to allow for mismeasurement. A broad range of topics, from basic research to more complex concepts such as "wrong-model" fitting, make this a useful research work for practitioners, students and researchers in biostatistics and epidemiology."

Modelling Survival Data in Medical Research Second Edition

Modelling Survival Data in Medical Research  Second Edition Author David Collett
ISBN-10 9781584883258
Release 2003-03-28
Pages 410
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Critically acclaimed and resoundingly popular in its first edition, Modelling Survival Data in Medical Research has been thoroughly revised and updated to reflect the many developments and advances--particularly in software--made in the field over the last 10 years. Now, more than ever, it provides an outstanding text for upper-level and graduate courses in survival analysis, biostatistics, and time-to-event analysis.The treatment begins with an introduction to survival analysis and a description of four studies that lead to survival data. Subsequent chapters then use those data sets and others to illustrate the various analytical techniques applicable to such data, including the Cox regression model, the Weibull proportional hazards model, and others. This edition features a more detailed treatment of topics such as parametric models, accelerated failure time models, and analysis of interval-censored data. The author also focuses the software section on the use of SAS, summarising the methods used by the software to generate its output and examining that output in detail. Profusely illustrated with examples and written in the author's trademark, easy-to-follow style, Modelling Survival Data in Medical Research, Second Edition is a thorough, practical guide to survival analysis that reflects current statistical practices.

Statistical Theory

Statistical Theory Author Felix Abramovich
ISBN-10 9781482211849
Release 2013-04-25
Pages 240
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Designed for a one-semester advanced undergraduate or graduate course, Statistical Theory: A Concise Introduction clearly explains the underlying ideas and principles of major statistical concepts, including parameter estimation, confidence intervals, hypothesis testing, asymptotic analysis, Bayesian inference, and elements of decision theory. It introduces these topics on a clear intuitive level using illustrative examples in addition to the formal definitions, theorems, and proofs. Based on the authors’ lecture notes, this student-oriented, self-contained book maintains a proper balance between the clarity and rigor of exposition. In a few cases, the authors present a "sketched" version of a proof, explaining its main ideas rather than giving detailed technical mathematical and probabilistic arguments. Chapters and sections marked by asterisks contain more advanced topics and may be omitted. A special chapter on linear models shows how the main theoretical concepts can be applied to the well-known and frequently used statistical tool of linear regression. Requiring no heavy calculus, simple questions throughout the text help students check their understanding of the material. Each chapter also includes a set of exercises that range in level of difficulty.

Statistical Methods for Spatial Data Analysis

Statistical Methods for Spatial Data Analysis Author Oliver Schabenberger
ISBN-10 9781482258134
Release 2017-01-27
Pages 512
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Understanding spatial statistics requires tools from applied and mathematical statistics, linear model theory, regression, time series, and stochastic processes. It also requires a mindset that focuses on the unique characteristics of spatial data and the development of specialized analytical tools designed explicitly for spatial data analysis. Statistical Methods for Spatial Data Analysis answers the demand for a text that incorporates all of these factors by presenting a balanced exposition that explores both the theoretical foundations of the field of spatial statistics as well as practical methods for the analysis of spatial data. This book is a comprehensive and illustrative treatment of basic statistical theory and methods for spatial data analysis, employing a model-based and frequentist approach that emphasizes the spatial domain. It introduces essential tools and approaches including: measures of autocorrelation and their role in data analysis; the background and theoretical framework supporting random fields; the analysis of mapped spatial point patterns; estimation and modeling of the covariance function and semivariogram; a comprehensive treatment of spatial analysis in the spectral domain; and spatial prediction and kriging. The volume also delivers a thorough analysis of spatial regression, providing a detailed development of linear models with uncorrelated errors, linear models with spatially-correlated errors and generalized linear mixed models for spatial data. It succinctly discusses Bayesian hierarchical models and concludes with reviews on simulating random fields, non-stationary covariance, and spatio-temporal processes. Additional material on the CRC Press website supplements the content of this book. The site provides data sets used as examples in the text, software code that can be used to implement many of the principal methods described and illustrated, and updates to the text itself.

Statistical Methods in Environmental Epidemiology

Statistical Methods in Environmental Epidemiology Author Duncan C. Thomas
ISBN-10 9780191552687
Release 2014-06-30
Pages 449
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Environmental epidemiology is the study of the environmental causes of disease in populations and how these risks vary in relation to intensity and duration of exposure and other factors like genetic susceptibility. As such, it is the basic science upon which governmental safety standards and compensation policies for environmental and occupational exposure are based. Profusely illustrated with examples from the epidemiologic literature on ionizing radiation and air pollution, thistext provides a systematic treatment of the statistical challenges that arise in environmental health studies and the use epidemiologic data in formulating public policy, at a level suitable for graduate students and epidemiologic researchers.After a general overview of study design and statistical methods for epidemiology generally, the book goes on to address the problems that are unique to environmental health studies, special-purpose designs like two-phase case-control studies and countermatching, statistical methods for modeling exposure-time-response relationships, longitudinal and time-series studies, spatial and ecologic methods, exposure measurement error, interactions, and mechanistic models. It also discusses studiesaimed at evaluating the public health benefits of interventions to improve the environment, the use of epidemiologic data to establish environmental safety standards and compensation policy, and concludes with emerging problems in reproductive epidemiology, natural and man-made disasters like globalwarming, and the global burden of environmentally caused disease. No other book provides such a broad perspective on the methodological challenges in this field at a level accessible to both epidemiologists and statisticians.

Bayesian Disease Mapping

Bayesian Disease Mapping Author Andrew B. Lawson
ISBN-10 9781466504813
Release 2013-03-18
Pages 396
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Since the publication of the first edition, many new Bayesian tools and methods have been developed for space-time data analysis, the predictive modeling of health outcomes, and other spatial biostatistical areas. Exploring these new developments, Bayesian Disease Mapping: Hierarchical Modeling in Spatial Epidemiology, Second Edition provides an up-to-date, cohesive account of the full range of Bayesian disease mapping methods and applications. A biostatistics professor and WHO advisor, the author illustrates the use of Bayesian hierarchical modeling in the geographical analysis of disease through a range of real-world datasets. New to the Second Edition Three new chapters on regression and ecological analysis, putative hazard modeling, and disease map surveillance Expanded material on case event modeling and spatiotemporal analysis New and updated examples Two new appendices featuring examples of integrated nested Laplace approximation (INLA) and conditional autoregressive (CAR) models In addition to these new topics, the book covers more conventional areas such as relative risk estimation, clustering, spatial survival analysis, and longitudinal analysis. After an introduction to Bayesian inference, computation, and model assessment, the text focuses on important themes, including disease map reconstruction, cluster detection, regression and ecological analysis, putative hazard modeling, analysis of multiple scales and multiple diseases, spatial survival and longitudinal studies, spatiotemporal methods, and map surveillance. It shows how Bayesian disease mapping can yield significant insights into georeferenced health data. WinBUGS and R are used throughout for data manipulation and simulation.

Applied Categorical and Count Data Analysis

Applied Categorical and Count Data Analysis Author Wan Tang
ISBN-10 9781439806241
Release 2012-06-04
Pages 384
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Developed from the authors’ graduate-level biostatistics course, Applied Categorical and Count Data Analysis explains how to perform the statistical analysis of discrete data, including categorical and count outcomes. The authors describe the basic ideas underlying each concept, model, and approach to give readers a good grasp of the fundamentals of the methodology without using rigorous mathematical arguments. The text covers classic concepts and popular topics, such as contingency tables, logistic models, and Poisson regression models, along with modern areas that include models for zero-modified count outcomes, parametric and semiparametric longitudinal data analysis, reliability analysis, and methods for dealing with missing values. R, SAS, SPSS, and Stata programming codes are provided for all the examples, enabling readers to immediately experiment with the data in the examples and even adapt or extend the codes to fit data from their own studies. Designed for a one-semester course for graduate and senior undergraduate students in biostatistics, this self-contained text is also suitable as a self-learning guide for biomedical and psychosocial researchers. It will help readers analyze data with discrete variables in a wide range of biomedical and psychosocial research fields.

Applied Spatial Statistics for Public Health Data

Applied Spatial Statistics for Public Health Data Author Lance A. Waller
ISBN-10 0471662674
Release 2004-07-29
Pages 520
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An application-based introduction to the statistical analysis of spatially referenced health data Sparked by the growing interest in statistical methods for the analysis of spatially referenced data in the field of public health, Applied Spatial Statistics for Public Health Data fills the need for an introductory, application-oriented text on this timely subject. Written for practicing public health researchers as well as graduate students in related fields, the text provides a thorough introduction to basic concepts and methods in applied spatial statistics as well as a detailed treatment of some of the more recent methods in spatial statistics useful for public health studies that have not been previously covered elsewhere. Assuming minimal knowledge of spatial statistics, the authors provide important statistical approaches for assessing such questions as: Are newly occurring cases of a disease "clustered" in space? Do the cases cluster around suspected sources of increased risk, such as toxic waste sites or other environmental hazards? How do we take monitored pollution concentrations measured at specific locations and interpolate them to locations where no measurements were taken? How do we quantify associations between local disease rates and local exposures? After reviewing traditional statistical methods used in public health research, the text provides an overview of the basic features of spatial data, illustrates various geographic mapping and visualization tools, and describes the sources of publicly available spatial data that might be useful in public health applications.