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Surface Modification of Biomaterials

Surface Modification of Biomaterials Author Rachel Williams
ISBN-10 9780857090768
Release 2010-11-25
Pages 432
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The surface modification of biomaterials plays a significant role in determining the outcome of biological-material interactions. With the appropriate modification a material’s surface can be tailored to improve biocompatibility, adhesion and cell interactions. Consequently surface modification is vital in the development and design of new biomaterials and medical devices. Surface modification of biomaterials reviews both established surface modifications and those still in the early stages of research and discusses how they can be used to optimise biological interactions and enhance clinical performance. Part one begins with chapters looking at various types and techniques of surface modification including plasma polymerisation, covalent binding of poly (ethylene glycol) (PEG), heparinisation, peptide functionalisation and calcium phosphate deposition before going on to examine metal surface oxidation and biomaterial surface topography to control cellular response with particular reference to technologies, cell behaviour and biomedical applications. Part two studies the analytical techniques and applications of surface modification with chapters on analysing biomaterial surface chemistry, surface structure, morphology and topography before moving onto discuss modifying biomaterial surfaces to optimise interactions with blood, control infection, optimise interactions with soft tissues, repair and regenerate nerve cells, control stem cell growth and differentiation and to optimise interactions with bone. The distinguished editor and international team of contributors to Surface modification of biomaterials have produced a unique overview and detailed chapters on a range of surface modification techniques which will provide an excellent resource for biomaterials researchers and scientists and engineers concerned with improving the properties of biomaterials. It will also be beneficial for academics researching surface modification. Reviews both established surface modifications and those still in the early stages of research and how they can be used to optimise biological interactions and enhance clinical performance Studies analytical techniques and applications of surface modification with chapters assessing biomaterial surface chemistry, surface structure, morphology and topography Discusses modifying biomaterial surfaces to optimise interactions with blood and soft tissues and also to repair and regenerate nerve cells and control infection



Surface Coating and Modification of Metallic Biomaterials

Surface Coating and Modification of Metallic Biomaterials Author Cuie Wen
ISBN-10 9781782423164
Release 2015-03-31
Pages 448
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Despite advances in alternative materials, metals are still the biomaterial of choice for a number of clinical applications such as dental, orthopedic and cardiac implants. However, there are a number of intrinsic problems associated with implanting metal in the biological environment, such as wear, corrosion, biocompatibility and toxicity, which must be addressed. Modern technology has enabled scientists to modify metal surfaces or apply special coatings to metals to improve their performance safety. Surface Coating and Modification of Metallic Biomaterials will discuss the most important modification techniques and coatings for metals, first covering the fundamentals of metals as a biomaterial and then exploring surface modification techniques and coatings. An expansive overview of surface modification techniques for biomedical use In-depth exploration of issues arising from metal biomaterial use Includes examples of applications in a clinical setting



Surface Modification of Magnesium and its Alloys for Biomedical Applications

Surface Modification of Magnesium and its Alloys for Biomedical Applications Author T.S.N. Sankara Narayanan
ISBN-10 9781782420828
Release 2015-01-08
Pages 380
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Surface modification of magnesium and its alloys for biomedical applications: Biological interactions, mechanical properties and testing, the first of two volumes, is an essential guide on the use of magnesium as a degradable implant material. Due to their excellent biocompatibility and biodegradability, magnesium based degradable implants provide a viable option for the permanent metallic implants. This volume focuses on the fundamental concepts of surface modification of magnesium, its biological interactions, mechanical properties and, in vitro and in vivo testing. The contents of volume 1 is organized and presented in three parts. Part 1 reviews the fundamental aspects of surface modification of magnesium, including surface design, opportunities, challenges and its role in revolutionizing biodegradable biomaterials. Part 2 addresses the biological and mechanical properties covering an in vivo approach to the bioabsorbable behavior of magnesium alloys, mechanical integrity and, the effects of amino acids and proteins on the performance of surface modified magnesium. Part 3 delves in to testing and characterization, exploring the biocompatibility and effects on fatigue life alongside the primary characteristics of surface modified magnesium. All chapters are written by experts, this two volume series provides systematic and thorough coverage of all major modification technologies and coating types of magnesium and its alloys for biomedical applications. Expert analysis of the fundamentals in surface modification of magnesium and its alloys for biomedical applications Includes biological interactions and mechanical properties Focuses on testing and characterisation, as well as biocompatibility



Advances in Polyurethane Biomaterials

Advances in Polyurethane Biomaterials Author Stuart L. Cooper
ISBN-10 9780081006221
Release 2016-01-23
Pages 718
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Advances in Polyurethane Biomaterials brings together a thorough review of advances in the properties and applications of polyurethanes for biomedical applications. The first set of chapters in the book provides an important overview of the fundamentals of this material with chapters on properties and processing methods for polyurethane. Further sections cover significant uses such as their tissue engineering and vascular and drug delivery applications Written by an international team of leading authors, the book is a comprehensive and essential reference on this important biomaterial. Brings together in-depth coverage of an important material, essential for many advanced biomedical applications Connects the fundamentals of polyurethanes with state-of-the-art analysis of significant new applications, including tissue engineering and drug delivery Written by a team of highly knowledgeable authors with a range of professional and academic experience, overseen by an editor who is a leading expert in the field



Biomaterials for Bone Regeneration

Biomaterials for Bone Regeneration Author P. Dubruel
ISBN-10 9780857098108
Release 2014-06-09
Pages 502
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Novel Biomaterials for Bone Regeneration provides a comprehensive review of currently available biomaterials and how they can be applied in bone regeneration. In recent decades, there has been a shift from the idea of using biomaterials as passive substitutes for damaged bones towards the concept of biomaterials as aids for the regeneration of a host's own bone tissue. This has generated an important field of research and a range of technological developments. Part one of this book discusses a wide range of materials, including calcium phosphate cements, hydrogels, biopolymers, synthetic polymers, and shape memory polymers. Part two then turns to the processing and surface modification of biomaterials, as well as how biomaterials can be evaluated both for their mechanical properties and for immunocompatibility with the host. Finally, part three covers a variety of cellular approaches, and production and delivery of biomaterials for bone regeneration. Chapters also consider the potential of electromagnetic and ultrasonic stimulation of biomaterials to aid in the regenerative process. Novel Biomaterials for Bone Regeneration represents an important resource for academics, clinicians, and industry professionals working in the area of biomedical materials, providing them with both an overview of the current state-of-the-art, and an indication of potential future developments. Provides comprehensive coverage of novel materials, techniques, and applications of biomaterials for bone regeneration Provides vital information on the various types of materials used in bone regeneration Discusses processing, modification, and evaluation techniques of biomaterials, and looks at cellular approaches and stimulation of biomaterials for bone regeneration



Surfaces and Interfaces for Biomaterials

Surfaces and Interfaces for Biomaterials Author Pankaj Vadgama
ISBN-10 9781845690809
Release 2005-05-27
Pages 824
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Given such problems as rejection, the interface between an implant and its human host is a critical area in biomaterials. Surfaces and interfaces for biomaterials summarises the wealth of research on understanding the surface properties of biomaterials and the way they interact with human tissue. The first part of the book reviews the way biomaterial surfaces form. Part Two discusses ways of monitoring and characterising surface structure and behaviour. The final two parts of the book look at a range of in vitro and in vivo studies of the complex interactions between biomaterials and the body. Chapters cover such topics as bone and tissue regeneration, the role of interface interactions in biodegradable biomaterials, microbial biofilm formation, vascular tissue engineering and ways of modifying biomaterial surfaces to improve biocompatibility. Surfaces and interfaces for biomaterials is a standard work on how to understand and control surface processes in ensuring biomaterials are used successfully in medicine. Complete coverage on the fundamentals of surface structure and forming to biological and clinical outcomes Includes reviews of key surface analytical techniques Edited by a renowned expert and written by an international team of authors



Sterilisation of Biomaterials and Medical Devices

Sterilisation of Biomaterials and Medical Devices Author Sophie Lerouge
ISBN-10 9780857096265
Release 2012-09-27
Pages 352
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The effective sterilisation of any material or device to be implanted in or used in close contact with the human body is essential for the elimination of harmful agents such as bacteria. Sterilisation of biomaterials and medical devices reviews established and commonly used technologies alongside new and emerging processes. Following an introduction to the key concepts and challenges involved in sterilisation, the sterilisation of biomaterials and medical devices using steam and dry heat, ionising radiation and ethylene oxide is reviewed. A range of non-traditional sterilisation techniques, such as hydrogen peroxide gas plasma, ozone and steam formaldehyde, is then discussed together with research in sterilisation and decontamination of surfaces by plasma discharges. Sterilisation techniques for polymers, drug-device products and tissue allografts are then reviewed, together with antimicrobial coatings for ‘self-sterilisation’ and the challenge presented by prions and endotoxins in the sterilisation of reusable medical devices. The book concludes with a discussion of future trends in the sterilisation of biomaterials and medical devices. With its distinguished editors and expert team of international contributors, Sterilisation of biomaterials and medical devices is an essential reference for all materials scientists, engineers and researchers within the medical devices industry. It also provides a thorough overview for academics and clinicians working in this area. Reviews established and commonly used technologies alongside new and emerging processes Introduces and reviews the key concepts and challenges involved in sterilisation Discusses future trends in the sterilisation of biomaterials and medical devices



Laser Surface Modification of Biomaterials

Laser Surface Modification of Biomaterials Author Rui Vilar
ISBN-10 9780081009420
Release 2016-04-15
Pages 350
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Laser Surface Modification of Biomaterials: Techniques and Applications covers this expanding field, which has many potential applications, including biomaterials. Laser surface modification of biomaterials enables the production of hybrid materials with different functionality in the bulk as well as the thin, sub-micrometer surface layer. This book will provide readers with a comprehensive review of the technology and its applications. Chapters in Part 1 look at the techniques and considerations of laser surface modification, while Part 2 reviews laser surface modification techniques of the most important classes of biomaterials, with a final set of chapters discussing application specific laser surface modification. Offers a comprehensive review of laser surface modification techniques Presents recent developments, fundamentals, and progress in laser surface modification Reviews laser surface modification applications across a range of materials Emphasizes applications in biomaterials



Switchable and Responsive Surfaces and Materials for Biomedical Applications

Switchable and Responsive Surfaces and Materials for Biomedical Applications Author Johnathan Zhang
ISBN-10 9780857097170
Release 2014-12-11
Pages 324
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Surface modification of biomaterials can ultimately determine whether a material is accepted or rejected from the human body, and a responsive surface can further make the material "smart" and "intelligent". Switchable and Responsive Surfaces and Materials for Biomedical Applications outlines synthetic and biological materials that are responsive under different stimuli, their surface design and modification techniques, and applicability in regenerative medicine/tissue engineering, drug delivery, medical devices, and biomedical diagnostics. Part one provides a detailed overview of switchable and responsive materials and surfaces, exploring thermo-responsive polymers, environmentally responsive polyelectrolytes and zwitterionic polymers, as well as peptide-based and photonic sensitive switchable materials. Further chapters include a detailed overview of the preparation and analysis of switchable polymer brushes and copolymers for biomedical application. Part two explores the biological interactions and biomedical applications of switchable surfaces, where expert analysis is provided on the interaction of switchable surfaces with proteins and cells. The interaction of stimuli-sensitive polymers for tissue engineering and drug delivery with biosurfaces is critiqued, whilst the editor provides a skillful study into the application of responsive polymers in implantable medical devices and biosensors. A comprehensive overview of switchable and responsive materials and surfaces Includes in depth analysis of thermo-responsive polymers, photonic sensitive materials and peptide-based surfaces Detailed exploration of biological interactions of responsive and switchable surfaces, covering stimuli-sensitive polymers for drug delivery, surfaces with proteins/cells and application of polymers in medical devices



Surface Modification of Magnesium and its Alloys for Biomedical Applications

Surface Modification of Magnesium and its Alloys for Biomedical Applications Author T.S.N. Sankara Narayanan
ISBN-10 9781782420835
Release 2015-01-30
Pages 460
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The development of biodegradable implants which can remain in the human body to fix a problem and subsequently dissolve, or be absorbed, consumed or excreted, without warranting a secondary surgery, is very appealing to scientists. Due to their excellent biocompatibility and biodegradability, magnesium implants provide a viable option many problems associated with permanent metallic implants such as, restenosis, thrombosis, permanent physical irritation, and inability to adapt to growth and changes in human body. Volume 2 of this important new book explores practical issues of magnesium and magnesium alloys, physical and mechanical modification and coatings to enhance this material for biomedical applications. Includes expert analysis on chemical solution deposition of hydroxyapatite (HAp) and octacalcium (OCP) phosphate coatings for magnesium Comprehensive coverage of biomimetic modifications, surface functionalization of biomolecules, natural, conducting and biodegradable polymeric coatings Lucid dissection of chemical, physical, mechanical and electromechanical modifications of magnesium and its alloys for biomedical applications



The Hip Resurfacing Handbook

The Hip Resurfacing Handbook Author K De Smet
ISBN-10 9780857096203
Release 2013-04-22
Pages 576
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Hip resurfacing arthroplasty (HRA) using metal-on-metal bearings is an established but specialised technique in joint surgery. Based on the experience of leading experts in the field, The hip resurfacing handbook provides a comprehensive reference for all aspects of this important procedure. The first part of the book reviews and compares all the major hip resurfacing prostheses, their key design features, relevant surgical techniques and clinical results. Part two discusses clinical follow-up of the hip resurfacing patient, including pre- and post-operative examination, acoustic phenomena and rehabilitation. It also covers the use of techniques such as radiography and metal ion measurement, as well as bone scans, ultrasound, CT, MRI, PET and DEXA, to evaluate hip resurfacings. Part three reviews best practice in surgical technique, including the modified posterior and anterior approaches, as well as instrumentation, anaesthesia and revision surgery. Based on extensive retrieval studies, Part four includes examples of the main failure modes in HRA. The final part of the book includes patients’ own experiences, a comparison of HRA with total hip arthroplasty (THA), regulatory issues and relevant web sites. Comprehensive in its scope and authoritative in its coverage, The hip resurfacing handbook is a standard work for orthopaedic surgeons and all those involved in HRA. A standard work for orthopaedic surgeons and all those involved in HRA Reviews and compares all the major hip resurfacing prostheses, their key design features, relevant surgical techniques and clinical results Clinical follow-up of the patient is discussed



Fundamental Biomaterials Polymers

Fundamental Biomaterials  Polymers Author Sabu Thomas
ISBN-10 9780081021958
Release 2018-03-20
Pages 352
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Fundamental Biomaterials: Polymers provides current information on findings and developments of biopolymers and their conversion from base materials to medical devices. Chapters analyze the types of polymers and discuss a range of biomedical applications. It is the first title in a three volume set, with each reviewing the most important and commonly used classes of biomaterials and providing comprehensive information on classification, materials properties, behavior, biocompatibility and applications. The book concludes with essential information on wear, lifetime prediction and cytotoxicity of biomaterials. This title will be of use to researchers and professionals in development stages, but will also help medical researchers understand and effectively communicate the requirements of a biomaterial for a specific application. Further, with the recent introduction of a number of interdisciplinary bio-related undergraduate and graduate programs, this book will be an appropriate reference volume for large number of students at undergraduate and post graduate levels. Provides current information on findings and developments of biopolymers and their conversion from base materials to medical devices Includes analyses of the types of polymers and a discussion of a range of biomedical applications Presents essential information on wear, lifetime prediction and cytotoxicity of biomaterials Explores both theoretical and practical aspects of polymers in biomaterials



Biomaterials and Medical Device Associated Infections

Biomaterials and Medical Device   Associated Infections Author L Barnes
ISBN-10 9780857097224
Release 2014-11-21
Pages 278
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Despite advances in materials and sterilisation, patients who receive biomaterials of medical device implants are still at risk of developing an infection around the implantation site. This book reviews the fundamentals of biomaterials and medical device related infections and methods and materials for the treatment and prevention of infection. The first part of the book provides readers with an introduction to the topic including analyses of biofilms, diagnosis and treatment of infection, pathology and topography. The second part of the book discusses a range of established and novel technologies and materials which have been designed to prevent infection. Provides analysis of biofilms and their relevance to implant associated infections. Assesses technologies for controlling biofilms. Considers advantages and disadvantages of in vivo infection studies.



Self assembling Biomaterials

Self assembling Biomaterials Author Helena S. Azevedo
ISBN-10 9780081020128
Release 2018-04-17
Pages 612
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Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field. Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration. Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community. Explores both theoretical and practical aspects of self-assembly in biomaterials Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials Examines the use of dynamic self-assembling biomaterials



Coatings for Biomedical Applications

Coatings for Biomedical Applications Author Mike Driver
ISBN-10 9780857093677
Release 2012-02-22
Pages 376
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The biomaterials sector is rapidly expanding and significant advances have been made in the technology of biomedical coatings and materials, which provide a means to improve the wear of joints, change the biological interaction between implant and host and combine the properties of various materials to improve device performance. Coatings for biomedical applications provides an extensive review of coating types and surface modifications for biomedical applications. The first part of the book explores a range of coating types and their biomedical applications. Chapters look at hydrophilic, mineral and pyrolytic carbon coatings in and ex vivo orthopaedic applications and finally at surface modification and preparation techniques. Part two presents case studies of orthopaedic and ophthalmic coatings, and biomedical applications including vascular stents, cardiopulomonary by-pass equipment and ventricular assist devices. With its clear structure and comprehensive review of research, Coatings for biomedical applications is a valuable resource to researchers, scientists and engineers in the biomedical industry. It will also benefit anyone studying or working within the biomedical sector, particularly those specialising in biomedical coatings. Provides an extensive review of coating types and surface modifications for biomedical applications Chapters look at hydrophilic coatings for biomedical applications in and ex vivo, mineral coatings for orthopaedic applications, pyrolytic carbon coating and other commonly-used biomedical coatings Presents case studies of orthopaedic and ophthalmic coatings, and biomedical applications including vascular stents, cardiopulomonary by-pass equipment and ventricular assist devices



Hemocompatibility of Biomaterials for Clinical Applications

Hemocompatibility of Biomaterials for Clinical Applications Author Christopher Siedlecki
ISBN-10 9780081004999
Release 2018-03-05
Pages 482
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Hemocompatibility of Biomaterials for Clinical Applications: Blood-Biomaterials Interactions summarizes the state-of-the-art on this important subject. The first part of the book reviews the latest research on blood composition and response, mechanisms of coagulation, test standards and methods. Next, the book assesses techniques for modifying biomaterial surfaces and developing coatings to improve hemocompatibility. In the final sections, users will find discussions on ways to improve the hemocompatibility of particular classes of biomaterials and a review of methods for improving medical devices. Provides comprehensive information on the fundamentals of hemocompatibility and new technologies Combines research in the biomaterials field in a digestible format for clinical applications Provides a complete overview biomaterials in current use and test methods



Bone Response to Dental Implant Materials

Bone Response to Dental Implant Materials Author Adriano Piattelli
ISBN-10 9780081002889
Release 2016-10-27
Pages 284
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Bone Response to Dental Implant Materials examines the oral environment and the challenges associated with dental biomaterials. Understanding different in vivo and in vitro responses is essential for engineers to successfully design and tailor implant materials which will withstand the different challenges of this unique environment. This comprehensive book reviews the fundamentals of bone responses in a variety of implant materials and presents strategies to tailor and control them. Presents a specific focus on the development and use of biomaterials in the oral environment Discusses the basic science of the dental interface and its clinical applications Contains important coverage on the monitoring and analysis of the dental implant interface