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Systems Biology of Clostridium

Systems Biology of Clostridium Author Peter Dürre
ISBN-10 9781783264421
Release 2014-05-05
Pages 292
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Systems Biology of Clostridium provides a comprehensive overview of system biology approaches in clostridia, especially Clostridium acetobutylicum. Systems biology is a rapidly evolving scientific discipline that allows us to understand and predict the metabolism and its changes within the bacterium as a whole. Clostridia represent one of the largest bacterial genera. This group contains organisms with metabolic properties that hold enormous potential for biotechnological processes. A model organism is Clostridium acetobutylicum that has been, and is still used in large-scale industrial production of the solvents acetone and butanol. Systems biology offers a new way to elucidate and understand the complex regulatory network controlling the different metabolic pathways and their interactions. All aspects from the development of appropriate experimental tools to mathematical modeling are covered, including a fascinating historical account on acetone-butanol fermentation in World War II. Written by world-class experts in their fields, Systems Biology of Clostridium is an essential source of reference for all biologists, biochemists, chemists, and chemical engineers working on biotechnological fermentations or industrial applications, as well as biofuels. Contents:Metabolic and Regulatory Networks in Clostridium AcetobutylicumClostridial Gene ToolsSupporting Systems Biology of Clostridium Acetobutylicum by Proteome AnalysisComparative Genomic Analysis of the General Stress Response in Clostridium Acetobutylicum ATCC 824 and Clostridium Beijerinckii NCIMB 8052Mathematical Modeling of the pH-Induced Metabolic Shift in Clostridium AcetobutylicumMathematical Models for Clostridia: From Cultivation Description to Systems BiologyModeling Agr-Dependent Quorum Sensing in Gram-Positive BacteriaComparative Genomic Analysis of the Central Metabolism of the Solventogenic Species Clostridium acetobutylicum ATCC 824 and Clostridium Beijerinckii NCIMB 8052The Strategic Importance of Biobutanol for Japan During WWII: A Case Study of the Butanol Fermentation Process in Taiwan and Japan Readership: Biologists, chemists, biochemists and chemical engineers working on biotechnological fermentations or industrial applications in biofuels. Key Features:First comprehensive overview of systems biology in the genus ClostridiumAuthors are world class experts in the fieldKeywords:Clostridium Acetobutylicum;Metabolic Network;Regulatory Network;proteome Analysis;Systems Biology



Clostridia

Clostridia Author Holger Brüggemann
ISBN-10 9781904455387
Release 2009-01-01
Pages 230
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"In this book internationally recognized Clostridium experts critically review the most important aspects of clostridial research, providing the first coherent picture of the organism's molecular and cellular biology in this post-genomic era. Essential reading for every clostridia researcher, from the PhD student to the experienced scientist, as it provides a timely review of current research." --Book Jacket.



Advances in Bacterial Pathogen Biology

Advances in Bacterial Pathogen Biology Author
ISBN-10 9780128003053
Release 2014-11-20
Pages 448
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This volume is an up-to-date overview of the physiology of selected pathogenic bacteria. Each chapter is written by experts in the field of that organism.The focus is on biochemistry and physiology but topics of clinical relevance are included. Contributions from leading authorities Informs and updates on all the latest developments in the field



The Clostridia

The Clostridia Author Julian I. Rood
ISBN-10 0080542395
Release 1997-04-30
Pages 533
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The clostridia are a group of bacteria of considerable medical and economic importance and include species responsible for generating the most potent toxins known to humans. The Clostridia: Molecular Biology and Pathogenesis is a unique work, comprising the most complete reference on the clostridia for over 20 years, bringing together the results from some of the most innovative and exciting research in the past decade. Using a principle-oriented rather than taxonomic approach, the results from molecular biology research are placed in the context of their clinical significance, and the disease process as a whole. This state-of-the-art work is truly comprehensive, covering and integrating the diverse topics of genetics, physiology, pathogenesis and cell biology. Written and edited by world-renowned authorities, material is presented to give the reader an up-to-date knowledge of the pathogenic species of this important genus. Background information is followed by details of the genetics, molecular biology, biochemistry and disease mechanisms. The structure, function and mode of action of toxins and other virulence determinants is clearly presented. As such, this work will prove essential for students, teachers, research microbiologists, infectious disease clinicians, toxin specialists, and all those working in medical or veterinary bacteriology, microbial genetics and the pharmaceutical industries. Covers appropriate medical and veterinary topics Contains authoritative contributions by international experts Presents the current state of knowledge and areas for future research Truly comprehensive--covers topics from molecular biology and physiology



The Bacterial Spore

The Bacterial Spore Author Adam Driks
ISBN-10 1555816754
Release 2015-11-15
Pages 397
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Presents a broad-based overview of spore biology, providing in-depth coverage of basic and applied areas of spore research. Chapters focus on important general topics as well as specialized research areas, including broad reviews of especially important topics, such as spore molecular biology, bioremediation, issues in biodefense, and food safety.



Advances in Clostridium Research and Treatment 2012 Edition

Advances in Clostridium Research and Treatment  2012 Edition Author
ISBN-10 9781464998416
Release 2012-12-26
Pages 187
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Advances in Clostridium Research and Treatment / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Clostridium. The editors have built Advances in Clostridium Research and Treatment / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Clostridium in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Clostridium Research and Treatment / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.



Emerging Policy Issues in Synthetic Biology

Emerging Policy Issues in Synthetic Biology Author OECD
ISBN-10 9789264208421
Release 2014-06-04
Pages 168
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This book examines policy issues in synthetic biology including R&D funding, company investment, PPP arrangements and innovative financing, infrastructure requirements, education and training, intellectual property (IP), regulation, and public engagement.



Molecular Medical Microbiology

Molecular Medical Microbiology Author Yi-Wei Tang
ISBN-10 9780123977632
Release 2014-09-14
Pages 2216
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The molecular age has brought about dramatic changes in medical microbiology, and great leaps in our understanding of the mechanisms of infectious disease. Molecular Medical Microbiology is the first book to synthesise the many new developments in both molecular and clinical research in a single comprehensive resource. This timely and authoritative three-volume work is an invaluable reference source of medical bacteriology. Comprising more than 100 chapters, organized into 17 major sections, the scope of this impressive work is wide-ranging. Written by experts in the field, chapters include cutting-edge information, and clinical overviews for each major bacterial group, in addition to the latest updates on vaccine development, molecular technology and diagnostic technology. Topics covered include bacterial structure, cell function, and genetics; mechanisms of pathogenesis and prevention; antibacterial agents; and infections ranging from gastrointestinal to urinary tract, centrtal nervous system, respiratory tract, and more. The first comprehensive and accessible reference on molecular medical microbiology Full color presentation througout In-depth discussion of individual pathogenic bacteria in a system-oriented approach Includes a clinical overview for each major bacterial group Presents the latest information on vaccine development, molecular technology, and diagnostic technology More than 100 chapters covering all major groups of bacteria Written by an international panel of authors who are experts in their respective disciplines



The Science and Applications of Synthetic and Systems Biology

The Science and Applications of Synthetic and Systems Biology Author Forum on Microbial Threats
ISBN-10 9780309219396
Release 2011-11-30
Pages 568
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Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.



Clostridium Difficile

Clostridium Difficile Author Peter Mullany
ISBN-10 STANFORD:36105211741256
Release 2010-06-08
Pages 241
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This book reviews the state of the art of methods available for the molecular analysis and investigation of virulence of the important human pathogen Clostridium difficile.



Bacterial Toxins

Bacterial Toxins Author Klaus Aktories
ISBN-10 9783527614608
Release 2008-09-26
Pages 334
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This is a survey of well characterized and recently discovered bacterial protein toxins. Leading investigators of the respective toxins review the various molecular mechanisms of action, ranging from toxin-induced ADP-ribosylation up to membrane perforation by pore-forming toxins. Thy also describe the consequences on host physiology before focusing on potential applications as cell biological and pharmacological tools for research and medical applications. Detailed descriptions of the methodology include the engineering and use of modified and chimeric toxins for better performance. A solid introduction to toxin structure and functions, as well as a valuable source of methodology for researchers in molecular biology, pharmacology and experimental medicine.



Flow Cytometry in Microbiology

Flow Cytometry in Microbiology Author Martin G. Wilkinson
ISBN-10 9781910190128
Release 2015-09-15
Pages 230
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Flow cytometry is a powerful technique for the rapid analysis of single cells in a mixture. In microbiology, flow cytometry permits the reliable and rapid detection of single or multiple microbes and can provide information about their distribution within cell populations. Flow cytometry may also lead to a faster means of viability counting of microorganisms while at the same time enabling a better understanding of all bacterial cells within a given population. Specially adapted commercial cytometers for microbial detection are being developed. In this text renowned authors have brought together a wealth of experience demonstrating the power and limitations of flow cytometry as it currently stands in the field of microbiology. The book commences with an overview of flow cytometry from Professor Howard Shapiro one of the most eminent scientists in the area of flow cytometry. Further chapters discuss cytometry technology and applications in environmental biotechnology, microbial community fingerprinting, clinical microbiology, lactic acid bacteria, spore forming bacteria, yeasts and fungi, water analysis and chip-based cytometry assays. The final chapter describes the adoption of flow cytometry to routine water quality analysis in Switzerland and provides a fascinating case study of how this emerging microbial technology overcame technical, regulatory and practical issues to become a standard rapid quality control methodology. The book provides a thorough description of flow cytometry and includes practical and up-to-date information aimed specifically at microbiologists. A major work on flow ctyometry for microbiologists, this book should be available in all microbiology libraries.



Developing Biofuel Bioprocesses Using Systems and Synthetic Biology

Developing Biofuel Bioprocesses Using Systems and Synthetic Biology Author Sylvia M. Clay
ISBN-10 9781461455806
Release 2012-09-25
Pages 68
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Advances in technological and analytical methods have fostered rapid growth of systems biology and synthetic biology. There continues to be rapid changes and discoveries in both fields with a small number of recent peer-reviewed reviews indicating some of the relationships between systems biology and synthetic biology. This proposed SpringerBrief will cover core concepts of systems biology and synthetic biology and illustrate the implementation of associated research methodologies for an integrated approach to specifically address engineering microorganisms for biofuel production.​



Advances in Endospore Forming Bacteria Research and Application 2013 Edition

Advances in Endospore Forming Bacteria Research and Application  2013 Edition Author
ISBN-10 9781481694704
Release 2013-06-21
Pages 87
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Advances in Endospore-Forming Bacteria Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Advances in Endospore-Forming Bacteria Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Endospore-Forming Bacteria Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.



The Comprehensive Sourcebook of Bacterial Protein Toxins

The Comprehensive Sourcebook of Bacterial Protein Toxins Author Joseph E. Alouf
ISBN-10 9780128005897
Release 2015-05-29
Pages 1200
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The Comprehensive Sourcebook of Bacterial Protein Toxins 4th Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content. Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them. Focused chapters on toxin applications and common properties or general features of toxins.



Handbook on Clostridia

Handbook on Clostridia Author Peter Duerre
ISBN-10 0203489810
Release 2005-03-29
Pages 920
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Clostridia is one of the largest bacterial genera with an enormous potential for biotechnical and medical applications. Despite growing scientific, medical, and industrial interest, information on basic methods, biochemical fundamentals, clinical practice, industrial applications, and novel developments remains scattered in a variety of research articles, reviews, and book chapters. Responding to this gap in the literature, Handbook on Clostridia combines all of these topics into a single volume. The editor takes a global approach by presenting information on both Clostridia of biotechnological importance and Clostridia of medical importance. Experts in the field summarize methods, physiology, medical significance, regulation, ecosystems, genomics, and current and potential applications. Providing a comprehensive resource on the complete field of Clostridium, this book also serves as a compilation of critical reviews on the advantages of using Clostridia for new medical and biotechnological applications. It is a valuable reference for every specialist, researcher, and student involved in this promising field.



Systems Metabolic Engineering

Systems Metabolic Engineering Author Christoph Wittmann
ISBN-10 9789400745346
Release 2012-06-15
Pages 388
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Systems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production. Integrating systems biology and biotechnology with new concepts from synthetic biology enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story – from genomes and networks via discovery and design to industrial implementation practises. This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundaments to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter this exiting research field.