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Translational Research and Discovery in Gastroenterology

Translational Research and Discovery in Gastroenterology Author Deborah L. Gumucio
ISBN-10 9781118492857
Release 2014-05-23
Pages 352
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Translational Gastroenterology: Organogenesis to Disease bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Paired chapters, written from basic science and clinical viewpoints, review the major biological pathways and molecules at work in organ ontogeny and disease. In addition to a comprehensive survey of GI organ development and pathologies, the book also highlights model organisms and new areas of research, with chapters devoted to recent advances in the field of GI stem cell biology, and the potential for tissue engineering of GI organs. The topics covered provide a unique window onto current activity in the field of gastroenterology, fostering enhanced knowledge for developmental biologists as well as for clinical practitioners. Notable features include the following: • Basic science chapters review the molecular and cellular pathways of GI organ development alongside clinical chapters examining organ-based diseases, closing the gap between the bench and the clinic. • Derivative organs – esophagus, stomach, pylorus, small intestine, colon, liver, and pancreas –as well as tissues such as serosa and enteric nervous system that are common to multiple GI organs. • Chapters detailing the use of model organisms – Drosophila, sea urchin, zebrafish, C. elegans, Xenopus – for basic discovery studies are included. • Chapters on GI stem cells and the potential for tissue engineering of the GI organs provide a view to the future of research and therapy in these organs.

Embriologia Cl nica

Embriologia Cl  nica Author Keith Moore
ISBN-10 9788535285031
Release 2016-04-11
Pages 552
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Compreenda e atualize seus estudos de embriologia humana com este livro didático orientado para a clínica, que aborda este assunto tão complexo de forma mais detalhada e visualmente sofisticada. Escrito por anatomistas mundialmente reconhecidos, apresenta vistas, de cada semana e fase, dos sistemas e órgãos fetais em desenvolvimento, explica porque e quando as malformações congênitas ocorrem e as funções da placenta e membranas fetais no desenvolvimento.• Entenda todos os mais recentes avanços na embriologia, incluindo os estudos da embriogênese normal e anormal, das causas das malformações congênitas e do papel dos genes no desenvolvimento humano.• Veja como as descobertas na biologia molecular, incluindo as novas técnicas sofisticadas de DNA recombinante e a manipulação de células-tronco, têm influenciado a prática clínica.• Prepare-se para exames de licenciamento com as apresentações de casos clínicos, destacadas em quadros especiais, que demonstram como os conceitos de embriologia se relacionam com a prática clínica.• Acesse o conteúdo completo do livro on-line em — assim como 16 incríveis animações que avivam o desenvolvimento embriológico normal e anormal, imagens para download e centenas de questões e respostas de revisão adicionais para testar o seu domínio da matéria.• Compreenda todos os detalhes da embriologia humana com o livro de conteúdo orientado para a clínica mais abrangente e ricamente ilustrado, escrito pelos principais especialistas do mundo.• Prepare-se eficientemente para exames com as questões e respostas de revisão ao final de cada capítulo.

Textbook of Gastroenterology

Textbook of Gastroenterology Author Tadataka Yamada
ISBN-10 9781444359411
Release 2011-10-13
Pages 3712
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Over the past twenty years, thousands of physicians have come to depend on Yamada’s Textbook of Gastroenterology. Its encyclopaedic discussion of the basic science underlying gastrointestinal and liver diseases as well as the many diagnostic and therapeutic modalities available to the patients who suffer from them was—and still is—beyond compare. This new edition provides the latest information on current and projected uses of major technologies in the field and a new section on diseases of the liver. Plus, it comes with a fully searchable CD ROM of the entire content.

Principles of Tissue Engineering

Principles of Tissue Engineering Author Robert Lanza
ISBN-10 9780123983701
Release 2013-10-17
Pages 1936
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Now in its fourth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fourth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system. As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material science, and engineering, among others, while also emphasizing those research areas that are likely to be of clinical value in the future. This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and other emerging technologies –such as brain-machine interfaces for controlling bionics and neuroprostheses– is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the application of tissue-engineering techniques for food production. The result is a comprehensive textbook that will be useful to students and experts alike. Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves Offers expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems Full-color presentation throughout

Human gastrointestinal development

Human gastrointestinal development Author Emanuel Lebenthal
ISBN-10 0881675210
Release 1989
Pages 824
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Human gastrointestinal development has been writing in one form or another for most of life. You can find so many inspiration from Human gastrointestinal development also informative, and entertaining. Click DOWNLOAD or Read Online button to get full Human gastrointestinal development book for free.

Translating Regenerative Medicine to the Clinic

Translating Regenerative Medicine to the Clinic Author Jeffrey Laurence
ISBN-10 9780128005521
Release 2015-11-18
Pages 354
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Translating Regenerative Medicine to the Clinic reviews the current methodological tools and experimental approaches used by leading translational researchers, discussing the uses of regenerative medicine for different disease treatment areas, including cardiovascular disease, muscle regeneration, and regeneration of the bone and skin. Pedagogically, the book concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. It promotes cross-disciplinary communication between the sub-specialties of medicine, but remains unified in theme by emphasizing recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole. Volumes in the series include Translating Gene Therapy to the Clinic, Translating Regenerative Medicine to the Clinic, Translating MicroRNAs to the Clinic, Translating Biomarkers to the Clinic, and Translating Epigenetics to the Clinic. Encompasses the latest innovations and tools being used to develop regenerative medicine in the lab and clinic Covers the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field Contains extensive pedagogical updates aiming to improve the education of translational researchers in this field Provides a transdisciplinary approach that supports cross-fertilization between different sub-specialties of medicine

Intercellular Signaling in Development and Disease

Intercellular Signaling in Development and Disease Author Edward A. Dennis
ISBN-10 9780123822161
Release 2011-04-05
Pages 540
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Required reading for anyone involved in cell signaling research with articles written and edited by experts in the field. This title covers disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, andinflammatory bowel disease, along with up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease. Articles written and edited by experts in the field Thematic volume covering disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, and inflammatory bowel disease Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease


MicroRNAs Author Krishnarao Appasani
ISBN-10 9780521865982
Release 2008
Pages 531
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This wide-ranging reference work will be an invaluable resource for all those wishing to use miRNA techniques in their own research, both in academia and industry. From their discovery, functions and detection to their role in disease biology, this volume uniquely integrates basic miRNA biology with future applications.

Innovative Medicine

Innovative Medicine Author Kazuwa Nakao
ISBN-10 9784431556510
Release 2015-10-13
Pages 339
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This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Role of Transcription Factors in Gastrointestinal Malignancies

Role of Transcription Factors in Gastrointestinal Malignancies Author Ganji Purnachandra Nagaraju
ISBN-10 9789811067280
Release 2018-03-27
Pages 513
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This book illustrates the importance of transcription factors in gastrointestinal cancer progression and metastasis with regard to understanding the mechanism and target definition in drug discovery. Further, it describes the complex issues associated with cancer cell growth and metastasis. The respective chapters provide detailed information on the various types of transcription factors (NF-kB, HIF-1, STAT-3, E2F1, and Sp1) and gastric-associated cancers (esophagus, stomach, colorectal, liver and pancreatic cancers) in connection with specific functional studies like cell cycle, angiogenesis, migration, invasion and apoptosis. These transcription factors control the expression of several signaling pathways involved in tumor growth, making them ideal targets for gastrointestinal cancer therapy. In closing, the book provides comprehensive descriptions of the major challenges associated with gastrointestinal cancer therapy.

Value Creation in the Pharmaceutical Industry

Value Creation in the Pharmaceutical Industry Author Alexander Schuhmacher
ISBN-10 9783527339136
Release 2016-04-11
Pages 508
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This practical guide for advanced students and decision-makers in the pharma and biotech industry presents key success factors in R&D along with value creators in pharmaceutical innovation. A team of editors and authors with extensive experience in academia and industry and at some of the most prestigious business schools in Europe discusses in detail the innovation process in pharma as well as common and new research and innovation strategies. In doing so, they cover collaboration and partnerships, open innovation, biopharmaceuticals, translational medicine, good manufacturing practice, regulatory affairs, and portfolio management. Each chapter covers controversial aspects of recent developments in the pharmaceutical industry, with the aim of stimulating productive debates on the most effective and efficient innovation processes. A must-have for young professionals and MBA students preparing to enter R&D in pharma or biotech as well as for students on a combined BA/biomedical and natural sciences program.

Anti inflammatory Nutraceuticals and Chronic Diseases

Anti inflammatory Nutraceuticals and Chronic Diseases Author Subash Chandra Gupta
ISBN-10 9783319413341
Release 2016-09-26
Pages 482
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This comprehensive volume focuses on anti-inflammatory nutraceuticals and their role in various chronic diseases. Food and Drug Administration (FDA) approved drugs such as steroids, non-steroidal anti-inflammatory drugs (NSAIDS), statins and metformin have been shown to modulate inflammatory pathways, but their long-term intake has been associated with numerous side effects. This means that there is enormous potential for dietary agents that can modulate inflammatory pathways in humans. Leading experts describe the latest research on the role of anti-inflammatory nutraceuticals in preventing and treating chronic diseases.

Regulation of Organelle and Cell Compartment Signaling

Regulation of Organelle and Cell Compartment Signaling Author Ralph A. Bradshaw
ISBN-10 9780123822130
Release 2011
Pages 533
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"Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.

Zinc Signaling in Physiology and Pathogenesis

Zinc Signaling in Physiology and Pathogenesis Author Toshiyuki Fukada
ISBN-10 9783038428213
Release 2018-05-04
Pages 292
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This book is a printed edition of the Special Issue "Zinc Signaling in Physiology and Pathogenesis" that was published in IJMS

VEGF mediated vascular functions in health and disease

VEGF mediated vascular functions in health and disease Author Ziquan Cao
ISBN-10 9789175190792
Release 2015-04-24
Pages 69
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Angiogenesis is essential for physiological processes including embryonic development, tissue regeneration, and reproduction. Under various pathological conditions the same angiogenic process contribute to the onset, development, and progression of many human diseases including cancer, diabetic complications, ocular disease, chronic inflammation and cardiovascular disease. Vascular endothelial growth factor (VEGF) is a key angiogenic factor for physiological and pathological angiogenesis. In addition to its strong angiogenic activity, VEGF also potently induces vascular permeability, often causing tissue edema in various pathological tissues. VEGF transduces its vascular signal through two tyrosine kinase receptors-VEGFR1 and VEGFR2, the latter being a functional receptor that mediates both angiogenic and vascular permeability effects. To study physiological and pathological functions of VEGF, we developed novel zebrafish disease models that permit us to study hypoxia-induced retinopathy and cancer metastasis processes. We have also administered anti-VEGF and anti-VEGFR specific antibodies to healthy mice to study the homeostatic role of VEGF in the maintenance of vascular integrity and its functions in various tissues and organs. Finally, using a zebrafish model, we evaluated if VEGF expression is regulated by circadian clock genes. In paper I, we developed protocols that create hypoxia-induced retinopathy in adult zebrafish. Adult fli1:EGFP zebrafish were placed in hypoxic water for 3-10 days with retinal neovascularization being analyzed using confocal microscopy. This model provides a unique opportunity to kinetically study the development of retinopathy in adult animals using non-invasive protocols and to assess the therapeutic efficacy of orally administered anti-angiogenic drugs. In paper II, we developed a zebrafish metastasis model to dissect the complex events of hypoxia-induced tumor cell invasion and metastasis in association with angiogenesis at the single-cell level. In this model, fluorescent DiI-labeled human or mouse tumor cells were implanted into the perivitelline cavity of 48-hour-old zebrafish embryos, which were subsequently placed in hypoxic water for 3 days. Tumor cell invasion, metastasis and pathological angiogenesis were analyzed using fluorescent microscopy in the living fish. The average experimental time for this model is 7 days. Our protocol offers an opportunity to study molecular mechanisms of hypoxia-induced cancer metastasis. In paper III, we show that systemic delivery of an anti-VEGF or an anti-VEGF receptor (VEGFR)-2 neutralizing antibody cause global vascular regression in mice. Among all examined tissues, the vasculature in endocrine glands, intestinal villi, and the uterus are most affected in response to VEGF or VEGFR-2 blockades. Pro-longed anti-VEGF treatment resulted in a significant decrease in the circulating levels of the predominant thyroid hormone, free thyroxine, but not the minimal isoform of triiodothyronine, suggesting that chronic anti-VEGF treatment impairs thyroid function. These findings provide structural and functional bases of anti-VEGF-specific druginduced side effects in relation to vascular changes in healthy tissues. In paper IV, we show that disruption of the circadian clock by constant exposure to light coupled with genetic manipulation of key genes in the zebrafish led to impaired developmental angiogenesis. A bmal1-specific morpholino inhibited developmental angiogenesis in zebrafish embryos without causing obvious nonvascular phenotypes. Conversely, a period2 morpholino accelerated angiogenic vessel growth, suggesting that Bmal1 and Period2 display opposing angiogenic effects. These results offer mechanistic insights into the role of the circadian clock in regulation of developmental angiogenesis, and our findings may be reasonably extended to other types of physiological or pathological angiogenesis. Overall, the results in this thesis provide further insight to angiogenic mechanistic properties in tissues and suggest possible novel therapeutic targets for the treatment of various angiogenesis-dependent diseases.

Liver Disease in Children

Liver Disease in Children Author Frederick J. Suchy
ISBN-10 9781107013797
Release 2014-02-20
Pages 752
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Provides comprehensive and authoritative coverage of every aspect of liver disease affecting infants, children and adolescents.

Rare Diseases Epidemiology Update and Overview

Rare Diseases Epidemiology  Update and Overview Author Manuel Posada de la Paz
ISBN-10 9783319671444
Release 2017-12-06
Pages 667
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The fields of rare diseases research and orphan products development continue to expand with more products in research and development status. In recent years, the role of the patient advocacy groups has evolved into a research partner with the academic research community and the bio-pharmaceutical industry. Unique approaches to research and development require epidemiological data not previously available to assist in protocol study design and patient recruitment for clinical trials required by regulatory agencies prior to approval for access by patents and practicing physicians.